Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2153 | 0.2153 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4688 | 0.4688 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.0453 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.8077 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.8077 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0127 | 0.0127 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.2153 | 0.2238 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.8077 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7362 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.7362 | 0.9 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7362 | 0.7362 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7362 | 0.7362 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7362 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.2153 | 0.2238 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7362 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.2153 | 0.2238 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5335 | 0.616 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.7362 | 0.8997 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0542 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.2153 | 0.1704 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7362 | 0.7362 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.8077 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.2153 | 0.1681 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4403 | 0.4403 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5335 | 0.5335 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2153 | 0.2153 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4688 | 0.6015 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.2153 | 0.2238 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4688 | 0.6015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Onchocerca volvulus | 0.0035 | 0.4403 | 0.5 | |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.2153 | 0.2238 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4688 | 0.4688 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2153 | 0.2153 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.2153 | 0.2238 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.0453 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5335 | 0.615 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8869 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.2153 | 0.1681 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2153 | 0.2153 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4403 | 0.4856 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.2153 | 0.1704 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7362 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0651 | 0.0651 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4403 | 0.4842 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.7783 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 20.7865 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.