TDR Targets

Basic information

Technical information

TDR Targets ID: 1281805
Name: (5R)-1-(4-cyclohexylbutyl)-5-[(4-hydroxypheny l)methyl]imidazolidine-2-thione
MW: 346.53 | Formula: C20H30N2OS
H donors: 1 H acceptors: 1 LogP: 5.65 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)C[C@@H]1CN=C(N1CCCCC1CCCCC1)S
InChi: 1S/C20H30N2OS/c23-19-11-9-17(10-12-19)14-18-15-21-20(24)22(18)13-5-4-8-16-6-2-1-3-7-16/h9-12,16,18,23H,1-8,13-15H2,(H,21,24)/t18-/m1/s1
InChiKey: GGUQPJAJDWJTCO-GOSISDBHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5R)-1-(4-cyclohexylbutyl)-5-[(4-hydroxyphenyl)methyl]-2-imidazolidinethione
(5R)-1-(4-cyclohexylbutyl)-5-(4-hydroxybenzyl)imidazolidine-2-thione
MLS000862776
SMR000444676

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Sus scrofa	Calpain 2	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	family C2 unassigned peptidase C02 family	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Calpain-A, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Calpain-1 catalytic subunit, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	calpain family protein 1, d	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Onchocerca volvulus		Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	ko:K08585 calpain, invertebrate, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	calpain C (C02 family)	Calpain 2	324 aa	319 aa	27.3 %
Plasmodium vivax	hypothetical protein, conserved	Calpain 2	324 aa	277 aa	19.9 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Echinococcus multilocularis	calpain	Calpain 2	324 aa	320 aa	31.9 %
Echinococcus granulosus	calpain	Calpain 2	324 aa	322 aa	31.7 %
Schistosoma japonicum	Calpain-9, putative	Calpain 2	324 aa	275 aa	27.6 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Echinococcus multilocularis	hypothetical protein	Calpain 2	324 aa	297 aa	27.9 %
Echinococcus granulosus	calpain A	Calpain 2	324 aa	297 aa	27.6 %
Schistosoma mansoni	calpain (C02 family)	Calpain 2	324 aa	318 aa	24.2 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0082	0.1901	0.2333
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0059	0.1165	0.1165
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0817	0.1003
Echinococcus granulosus	CREB binding protein	0.0202	0.5813	0.7136
Schistosoma mansoni	hypothetical protein	0.0205	0.5884	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0057	0.1092	0.1092
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0817	0.1388
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0157	0.4337	0.4337
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1165	0.143
Loa Loa (eye worm)	CBP-B	0.0141	0.3808	0.4675
Schistosoma mansoni	hypothetical protein	0.0056	0.1064	0.1808
Onchocerca volvulus		0.0175	0.4934	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0817	0.1388
Echinococcus granulosus	CREB binding protein	0.0125	0.3298	0.4048
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0157	0.4337	0.4337
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0449	0.0552
Echinococcus multilocularis	CREB binding protein	0.0139	0.375	0.4605
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0332	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0584	0.0717
Brugia malayi	hypothetical protein	0.0274	0.8145	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1021	0.1254
Onchocerca volvulus		0.0056	0.1064	0.0109
Schistosoma mansoni	hypothetical protein	0.0041	0.0584	0.0992
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0332	1	1
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0059	0.1165	0.1165
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3487	0.5925
Plasmodium vivax	calpain, putative	0.0023	0	0.5
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.017	0.4747	0.5828
Echinococcus multilocularis	tar DNA binding protein	0.0131	0.3487	0.4281
Brugia malayi	MH2 domain containing protein	0.0144	0.3924	0.4818
Toxoplasma gondii	transporter, cation channel family protein	0.0059	0.1165	1
Echinococcus granulosus	survival motor neuron protein 1	0.0274	0.8145	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.1201	0.1475
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.017	0.4747	0.5828
Brugia malayi	calpain family protein 1	0.0078	0.1772	0.2175
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0332	1	1
Echinococcus multilocularis	calpain A	0.0082	0.1901	0.2333
Echinococcus granulosus	CREB binding protein	0.0033	0.0326	0.04
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.017	0.4747	0.8068
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0059	0.1165	0.143
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0817	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1021	0.1254
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0082	0.1901	0.323
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0817	0.1003
Echinococcus granulosus	voltage dependent calcium channel	0.017	0.4747	0.5828
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0934	0.1146
Loa Loa (eye worm)	calcium channel	0.017	0.4747	0.5828
Loa Loa (eye worm)	hypothetical protein	0.006	0.1201	0.1475
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3487	0.5925
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.1323	0.1323
Brugia malayi	TAR-binding protein	0.0131	0.3487	0.4281
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0934	0.1146
Mycobacterium ulcerans	hypothetical protein	0.0175	0.4912	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0584	0.0717
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0175	0.4912	0.5
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.017	0.4747	0.5828
Schistosoma mansoni	voltage-gated cation channel	0.017	0.4747	0.8068
Echinococcus multilocularis	voltage dependent calcium channel	0.017	0.4747	0.5828
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0817	0.1003
Brugia malayi	TAZ zinc finger family protein	0.0202	0.5813	0.7136
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.3924	0.4818
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0078	0.1772	0.3011
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3487	0.5925
Echinococcus multilocularis	CREB binding protein	0.0033	0.0326	0.04
Brugia malayi	RNA binding protein	0.0131	0.3487	0.4281
Echinococcus granulosus	calpain A	0.0082	0.1901	0.2333
Loa Loa (eye worm)	calpain family protein 1	0.0055	0.1021	0.1254
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.017	0.4747	0.5828
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.017	0.4747	0.5828
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0056	0.1064	0.1306
Echinococcus granulosus	geminin	0.0205	0.5884	0.7224
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1772	0.2175
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0817	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1772	0.2175
Loa Loa (eye worm)	calpain family protein 1	0.0078	0.1772	0.2175
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0131	0.3487	0.4281
Brugia malayi	hypothetical protein	0.0175	0.4934	0.6058
Schistosoma mansoni	hypothetical protein	0.0205	0.5884	1
Loa Loa (eye worm)	RNA binding protein	0.0131	0.3487	0.4281
Echinococcus multilocularis	geminin	0.0205	0.5884	0.7224
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.1323	0.1323
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2331	0.2861
Echinococcus multilocularis	survival motor neuron protein 1	0.0274	0.8145	1
Loa Loa (eye worm)	hypothetical protein	0.0175	0.4934	0.6058
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0064	0.1323	1
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0064	0.1323	0.1624
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0064	0.1323	0.1624
Echinococcus multilocularis	voltage dependent calcium channel	0.017	0.4747	0.5828
Loa Loa (eye worm)	hypothetical protein	0.017	0.4747	0.5828
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0064	0.1323	0.1624
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0047	0.0761	0.0761
Echinococcus multilocularis	CREB binding protein	0.0033	0.0326	0.04
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0064	0.1323	0.1624
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0157	0.4337	0.4337
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0817	0.1388
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.1323	0.1323
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.017	0.4747	0.5828
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0082	0.1901	0.2333
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0064	0.1323	0.2248
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0047	0.0761	0.0761
Echinococcus granulosus	tar DNA binding protein	0.0131	0.3487	0.4281
Schistosoma mansoni	survival motor neuron protein	0.0056	0.1064	0.1808
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.017	0.4747	0.8068
Schistosoma mansoni	CREB-binding protein 1 (SmCBP1)	0.0202	0.5813	0.9878
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0047	0.0761	0.0761
Echinococcus granulosus	voltage dependent calcium channel	0.0059	0.1165	0.143
Echinococcus granulosus	CREB binding protein	0.0033	0.0326	0.04
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.017	0.4747	0.5828
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0817	0.1003
Brugia malayi	calpain family protein 1	0.0078	0.1772	0.2175
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0064	0.1323	0.1323
Echinococcus multilocularis	CREB binding protein	0.0033	0.0326	0.04
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.1201	0.1475
Loa Loa (eye worm)	TAR-binding protein	0.0131	0.3487	0.4281
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.3924	0.4818
Loa Loa (eye worm)	hypothetical protein	0.0274	0.8145	1
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0449	0.0552
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3487	0.5925
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3487	0.5925
Echinococcus multilocularis	calpain family protein 1, d	0.0055	0.1021	0.1254
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0047	0.0761	0.0761
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0082	0.1901	0.323
Toxoplasma gondii	hypothetical protein	0.0053	0.0983	0.2156
Schistosoma mansoni	CREB-binding protein 2	0.0202	0.5813	0.9878
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.017	0.4747	0.5828
Brugia malayi	RNA recognition motif domain containing protein	0.0131	0.3487	0.4281
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.1201	0.1475

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 12.24095627 um	PUBCHEM_BIOASSAY: Dose Response Confirmation for Calpain Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1236 (Primary screen preceding this confirmatory assay.)]	ChEMBL.	No reference
Potency (functional)	0.8199 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1391764

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1281805