Detailed information for compound 1281965

Basic information

Technical information
  • TDR Targets ID: 1281965
  • Name: N-(9-oxo-7,8-dihydro-6H-dibenzofuran-2-yl)qui noline-8-sulfonamide
  • MW: 392.428 | Formula: C21H16N2O4S
  • H donors: 1 H acceptors: 4 LogP: 3.25 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCCc2c1c1cc(ccc1o2)NS(=O)(=O)c1cccc2c1nccc2
  • InChi: 1S/C21H16N2O4S/c24-16-6-2-7-18-20(16)15-12-14(9-10-17(15)27-18)23-28(25,26)19-8-1-4-13-5-3-11-22-21(13)19/h1,3-5,8-12,23H,2,6-7H2
  • InChiKey: CEYISJWRSXTATM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(9-oxo-7,8-dihydro-6H-dibenzofuran-2-yl)-8-quinolinesulfonamide
  • N-(9-keto-7,8-dihydro-6H-dibenzofuran-2-yl)quinoline-8-sulfonamide
  • MLS000716204
  • SMR000277721
  • BAS 09618232
  • Quinoline-8-sulfonic acid (9-oxo-6,7,8,9-tetrahydro-dibenzofuran-2-yl)-amide
  • ZINC00816415

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major DNA polymerase eta, putative 0.0022 0.008 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0856 0.2227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0475 0.0686
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.2532 0.312
Schistosoma mansoni hypothetical protein 0.0035 0.0445 0.1157
Leishmania major cathepsin L-like protease 0.0072 0.1465 0.1589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0475 0.0585
Mycobacterium tuberculosis Conserved hypothetical protein 0.0185 0.4609 0.7856
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0062 0.0161
Onchocerca volvulus 0.0036 0.0475 0.0923
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.126 0.126
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.008 0.1215
Brugia malayi hypothetical protein 0.004 0.0599 0.0738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Entamoeba histolytica hypothetical protein 0.004 0.0599 0.9146
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0158 0.3842 0.3842
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0062 0.0076
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0445 0.0548
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.028 0.0345
Toxoplasma gondii FATC domain-containing protein 0.0029 0.028 0.1514
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0629 0.0629
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0086 0.1847 0.1847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.028 0.0345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0856 0.2227
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.105 0.1139
Brugia malayi beta-lactamase family protein 0.0036 0.0475 0.0585
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5145 0.634
Leishmania major mitochondrial DNA polymerase beta 0.0352 0.9218 1
Echinococcus granulosus tar DNA binding protein 0.0129 0.3047 0.3047
Loa Loa (eye worm) beta-lactamase 0.0036 0.0475 0.0585
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0762 0.0762
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.8115 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0021 0.0062 0.0944
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0475 0.0686
Schistosoma mansoni DNA polymerase eta 0.0022 0.008 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.1293 0.1402
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0021 0.0062 0.0062
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.2532 0.312
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0086 0.1847 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0848 0.092
Toxoplasma gondii ABC1 family protein 0.0036 0.0475 0.2572
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.008 0.0019
Loa Loa (eye worm) TAR-binding protein 0.0129 0.3047 0.3755
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.545 0.6716
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0629 0.1213
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0108 0.0582
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0108 0.0108
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.008 0.0098
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0021 0.0062 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.008 0.0019
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.008 0.0207
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.1847 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.1465 0.1533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0108 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.1465 0.1533
Mycobacterium ulcerans hypothetical protein 0.0036 0.0475 0.0873
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.1031 0.165
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.105 0.5686
Brugia malayi beta-lactamase family protein 0.0036 0.0475 0.0585
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0063 0.0068
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.1847 0.5
Brugia malayi beta-lactamase 0.0036 0.0475 0.0585
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0062 0.0076
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0475 0.0475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.008 0.0019
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.1216 0.3165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0856 0.0856
Brugia malayi hypothetical protein 0.0037 0.0493 0.0608
Toxoplasma gondii hypothetical protein 0.0029 0.0295 0.1595
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.008 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0848 0.092
Brugia malayi hypothetical protein 0.0134 0.3189 0.393
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0629 0.0682
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0475 0.0585
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.008 0.0019
Echinococcus multilocularis dna polymerase kappa 0.0022 0.008 0.008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.1148 0.1245
Loa Loa (eye worm) hypothetical protein 0.0134 0.3189 0.393
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0475 0.0873
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.1216 0.1216
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3047 0.7932
Leishmania major hypothetical protein, conserved 0.0036 0.0475 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.126 0.3279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.008 0.0086
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0352 0.9218 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0475 0.0686
Loa Loa (eye worm) hypothetical protein 0.0086 0.1847 0.2276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.1465 0.1533
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0475 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0021 0.0062 0.0067
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0021 0.0062 0.0062
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5145 0.634
Mycobacterium leprae Probable lipase LipE 0.0036 0.0475 0.1162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1509 0.3928
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.008 0.0086
Entamoeba histolytica hypothetical protein 0.004 0.0599 0.9146
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0475 0.0515
Onchocerca volvulus 0.0056 0.1019 0.198
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3047 0.7932
Brugia malayi Probable ClpP-like protease 0.0086 0.1847 0.2276
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0021 0.0062 0.0067
Schistosoma mansoni hypothetical protein 0.0035 0.0445 0.1157
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0295 0.1595
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0856 0.1054
Trypanosoma brucei unspecified product 0.0022 0.008 0.0019
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0475 0.0873
Loa Loa (eye worm) hypothetical protein 0.0022 0.008 0.0098
Loa Loa (eye worm) hypothetical protein 0.0036 0.0475 0.0585
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0021 0.0062 0.0067
Trypanosoma cruzi target of rapamycin kinase 3 0.0021 0.0062 0.0067
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5145 0.634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Mycobacterium ulcerans beta-lactamase 0.0036 0.0475 0.0873
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.1847 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.008 0.0086
Onchocerca volvulus Huntingtin homolog 0.0134 0.3189 0.6198
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.008 0.0019
Echinococcus granulosus dna polymerase eta 0.0022 0.008 0.008
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.126 0.3279
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.5145 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.1216 0.1319
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0108 0.0117
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0475 0.0585
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.8115 1
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.105 0.5686
Schistosoma mansoni hypothetical protein 0.0025 0.0184 0.0478
Echinococcus multilocularis serine protein kinase ATM 0.0029 0.028 0.028
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.8115 1
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3047 0.7932
Mycobacterium tuberculosis Conserved protein 0.0036 0.0475 0.0686
Brugia malayi RNA binding protein 0.0129 0.3047 0.3755
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.1847 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.1465 0.1533
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1509 0.3156
Mycobacterium ulcerans lipase LipD 0.0036 0.0475 0.0873
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0062 0.0067
Echinococcus multilocularis GPCR, family 2 0.0035 0.0445 0.0445
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0108 0.1642
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.008 0.0019
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0629 0.0682
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.1031 0.165
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0108 0.0133
Entamoeba histolytica hypothetical protein 0.004 0.0599 0.9146
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0848 0.0859
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0856 0.2227
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.008 0.008
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.1465 0.1589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.8115 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.008 0.0207
Trichomonas vaginalis esterase, putative 0.0036 0.0475 0.0585
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0445 0.0548
Brugia malayi jmjC domain containing protein 0.0064 0.126 0.1553
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.1465 0.1533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Schistosoma mansoni ap endonuclease 0.0023 0.0108 0.028
Loa Loa (eye worm) hypothetical protein 0.0036 0.0475 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.1465 0.1533
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.1216 0.2509
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.008 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.1465 0.1533
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0475 0.0686
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.1031 0.1031
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0086 0.1847 0.1847
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2532 0.312
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1509 0.1509
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0108 0.0062
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.105 0.1139
Schistosoma mansoni hypothetical protein 0.004 0.0599 0.1559
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.008 0.0098
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.008 0.0098
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.5844 1
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.3047 0.3755
Loa Loa (eye worm) hypothetical protein 0.0036 0.0475 0.0585
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.8115 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1566 0.1929
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0475 0.0475
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.1019 0.2652
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0599 0.1559
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0762 0.4124
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5145 0.634
Loa Loa (eye worm) hypothetical protein 0.0036 0.0475 0.0585
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0166 0.4088 0.4397
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.8115 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0762 0.4124
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0508 0.0744
Schistosoma mansoni hypothetical protein 0.0075 0.1566 0.4075
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0762 0.0939
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0856 0.1054
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0029 0.028 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.008 0.0019
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.1465 0.1589
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.126 0.1553
Leishmania major cathepsin L-like protease 0.0072 0.1465 0.1589
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0108 0.005
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.1847 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1509 0.1509
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0029 0.028 0.0728
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1509 0.1637
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0057 0.105 0.1294
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.105 0.5686
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.1216 0.2509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.008 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.4088 0.4435
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.126 0.126
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0475 0.0686
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0475 0.0585
Loa Loa (eye worm) hypothetical protein 0.0134 0.3189 0.393
Brugia malayi hypothetical protein 0.0057 0.105 0.1294
Brugia malayi acetyltransferase, GNAT family protein 0.0158 0.3842 0.4734
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0167 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1509 0.3928
Leishmania major DNA polymerase kappa, putative 0.0022 0.008 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.1465 0.1533
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.008 0.0019
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0655 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0352 0.9218 1
Toxoplasma gondii hypothetical protein 0.0057 0.1049 0.5682
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0655 0.3545
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0086 0.1847 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0629 0.9602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Entamoeba histolytica hypothetical protein 0.004 0.0599 0.9146
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0629 0.0619
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0629 0.0775
Schistosoma mansoni ap endonuclease 0.0023 0.0108 0.028
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0629 0.0682
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.126 0.126
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.3719 0.3719
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0629 0.0775
Onchocerca volvulus 0.0036 0.0475 0.0923
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0029 0.028 0.0303
Echinococcus multilocularis dna polymerase eta 0.0022 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0035 0.0445 0.1157
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.4088 0.4435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0599 0.0599
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0629 0.3404
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.105 0.5686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Schistosoma mansoni peptidase Clp (S14 family) 0.0086 0.1847 0.4808
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0108 0.0117
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.1847 0.3902
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0063 0.0068
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0445 0.0445
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.126 0.126
Schistosoma mansoni inositol monophosphatase 0.0042 0.0629 0.1637
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.008 0.0098
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0475 0.1162
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0475 0.0686
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0108 0.0049
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0062 0.0067
Leishmania major hypothetical protein, conserved 0.0057 0.105 0.1139
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0158 0.3842 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.1216 0.1499
Brugia malayi jmjC domain containing protein 0.0064 0.126 0.1553
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0508 0.1376
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5145 0.634
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0108 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0475 0.2572
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.008 0.0019
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.1216 0.1971
Echinococcus multilocularis tumor protein p63 0.038 1 1
Echinococcus granulosus GPCR family 2 0.0035 0.0445 0.0445
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0475 0.0585
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.008 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0475 0.1237
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5145 0.634
Toxoplasma gondii exonuclease III APE 0.0023 0.0108 0.0582
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.105 0.1079
Echinococcus granulosus dna polymerase kappa 0.0022 0.008 0.008
Schistosoma mansoni jumonji domain containing protein 0.0064 0.126 0.3279
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0599 0.0599
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0108 0.0133
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0445 0.0445
Loa Loa (eye worm) hypothetical protein 0.0056 0.1019 0.1255
Loa Loa (eye worm) hypothetical protein 0.0036 0.0475 0.0585
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.008 0.0086
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0762 0.0939
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0108 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3047 0.7932
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0856 0.0856
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.2532 0.312
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0295 0.1595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5145 0.634
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.8115 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0021 0.0062 0.0067
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0629 0.0629
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0475 0.0585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.1465 0.1533
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0184 0.0184
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0062 0.0076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0475 0.1237
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0856 0.0856
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0021 0.0062 0.0067
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.104 0.1128
Brugia malayi Inositol-1 0.0042 0.0629 0.0775
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.545 0.6716
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.1465 0.1589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0475 0.0686
Brugia malayi TAR-binding protein 0.0129 0.3047 0.3755
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0475 0.0585
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0295 0.1075
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0062 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3047 0.7932
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.1216 0.1216
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0629 0.0775
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0062 0.0067
Loa Loa (eye worm) hypothetical protein 0.0025 0.0167 0.0206
Mycobacterium ulcerans hypothetical protein 0.0185 0.4609 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Mycobacterium tuberculosis Conserved protein 0.0036 0.0475 0.0686
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.1847 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.1566 0.1929
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.8115 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0629 0.2996
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.008 0.0086
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0445 0.0445
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1509 0.248
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0848 0.092
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0475 0.0451
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.008 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.1465 0.1533
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0021 0.0062 0.0067
Mycobacterium tuberculosis Conserved protein 0.0036 0.0475 0.0686
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0352 0.9218 1
Entamoeba histolytica hypothetical protein 0.0029 0.028 0.4271
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1509 0.3156
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.3047 0.3755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.1847 0.3902
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.1465 0.1589
Echinococcus granulosus serine protein kinase ATM 0.0029 0.028 0.028
Schistosoma mansoni hypothetical protein 0.0035 0.0445 0.1157
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.1099 0.1354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Loa Loa (eye worm) acetyltransferase 0.0158 0.3842 0.4734
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.008 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0062 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.008 0.0019
Echinococcus multilocularis tar DNA binding protein 0.0129 0.3047 0.3047
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0108 0.0108
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0445 0.0548
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0062 0.0076
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0108 0.0582
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0762 0.4124
Schistosoma mansoni inositol monophosphatase 0.0042 0.0629 0.1637
Giardia lamblia DINP protein human, muc B family 0.0022 0.008 0.0299
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.1847 0.5
Loa Loa (eye worm) inositol-1 0.0042 0.0629 0.0775
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1509 0.8171
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0021 0.0062 0.0944
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.1031 0.4744
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.008 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.1465 0.1533
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1509 0.3156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0036 0.0475 0.0585
Loa Loa (eye worm) hypothetical protein 0.0035 0.0445 0.0548
Toxoplasma gondii target of rapamycin (TOR), putative 0.0021 0.0062 0.0335
Loa Loa (eye worm) RNA binding protein 0.0129 0.3047 0.3755
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0445 0.0445
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.1031 0.1031
Onchocerca volvulus Huntingtin homolog 0.0134 0.3189 0.6198
Onchocerca volvulus 0.0036 0.0475 0.0923
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0108 0.0771
Leishmania major cathepsin L-like protease 0.0072 0.1465 0.1589

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0000708 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) [Related pubchem assays: 1705 (qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) ), 2324 (Probe Development Summary of Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1707 (Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Validation Assay), 2517 (qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1708 (Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV)] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) = 18.8699 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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