Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.122 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2368 | 0.2368 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0392 | 0.0392 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.2614 | 0.2614 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.2614 | 0.2614 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2614 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0392 | 0.0392 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4409 | 0.4409 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0392 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0392 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0392 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.4409 | 0.4409 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.122 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2614 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0392 | 0.0392 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.4409 | 0.4409 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0392 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0392 | 0.0392 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2614 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0392 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.122 | 0.122 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.122 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.122 | 0.122 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.4409 | 0.4409 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.2614 | 0.2614 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.2368 | 0.2368 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0392 | 0.0392 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.122 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0392 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.2614 | 0.2614 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0065 | 0.0065 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.122 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.2614 | 0.2614 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.122 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2614 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0392 | 0.0392 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0392 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2368 | 0.2368 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.122 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.122 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.