TDR Targets

Basic information

Technical information

TDR Targets ID: 1282227
Name: 2-(4-chlorophenyl)sulfonylpyridine
MW: 253.705 | Formula: C11H8ClNO2S
H donors: 0 H acceptors: 3 LogP: 2.61 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)S(=O)(=O)c1ccccn1
InChi: 1S/C11H8ClNO2S/c12-9-4-6-10(7-5-9)16(14,15)11-3-1-2-8-13-11/h1-8H
InChiKey: MRHBASRZECIVCE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

MLS000056517
SMR000065532
T0501-4485
ZINC00078105

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0146	0.3149	0.3149
Echinococcus granulosus	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Mycobacterium tuberculosis	Possible two component transcriptional regulatory protein (probably LuxR-family)	0.0245	0.6283	0.5
Brugia malayi	hypothetical protein	0.0146	0.3149	0.7714
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0146	0.3149	0.7714
Echinococcus multilocularis	neuropeptide receptor A26	0.0146	0.3149	0.3149
Schistosoma mansoni	amine GPCR	0.0146	0.3149	0.7714
Echinococcus granulosus	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Brugia malayi	hypothetical protein	0.0146	0.3149	0.7714
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0146	0.3149	0.3149
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0146	0.3149	0.7714
Schistosoma mansoni	hypothetical protein	0.0146	0.3149	0.7714
Brugia malayi	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0146	0.3149	0.7714
Echinococcus granulosus	neuropeptide FF receptor 2	0.0146	0.3149	0.3149
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0146	0.3149	0.7714
Echinococcus multilocularis	G protein coupled receptor 139	0.0146	0.3149	0.3149
Echinococcus granulosus	Metazoa galactosyltransferase	0.0175	0.4082	0.4082
Brugia malayi	putative neuropeptide receptor	0.0146	0.3149	0.7714
Onchocerca volvulus		0.0146	0.3149	0.5
Brugia malayi	hypothetical protein	0.0146	0.3149	0.7714
Schistosoma mansoni	neuropeptide receptor	0.0146	0.3149	0.7714
Loa Loa (eye worm)	melatonin receptor type 1A	0.0146	0.3149	0.7714
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus granulosus	g-protein coupled receptor	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Mycobacterium ulcerans	putative regulatory protein	0.0245	0.6283	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Onchocerca volvulus		0.0146	0.3149	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0146	0.3149	0.7714
Brugia malayi	Dopamine receptor protein 1	0.0146	0.3149	0.7714
Schistosoma mansoni	neuropeptide receptor	0.0146	0.3149	0.7714
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0146	0.3149	0.3149
Onchocerca volvulus		0.0146	0.3149	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0146	0.3149	0.7714
Schistosoma mansoni	neuropeptide receptor	0.0146	0.3149	0.7714
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Schistosoma mansoni	hypothetical protein	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Schistosoma mansoni	biogenic amine receptor	0.0146	0.3149	0.7714
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0146	0.3149	0.7714
Echinococcus multilocularis	allatostatin A receptor	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus granulosus	g protein coupled receptor	0.0146	0.3149	0.3149
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0146	0.3149	0.3149
Echinococcus granulosus	tm gpcr rhodopsin	0.0146	0.3149	0.3149
Mycobacterium tuberculosis	Possible transcriptional regulatory protein	0.0245	0.6283	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0146	0.3149	0.7714
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Onchocerca volvulus		0.0146	0.3149	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0146	0.3149	0.3149
Onchocerca volvulus		0.0146	0.3149	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0146	0.3149	0.3149
Mycobacterium ulcerans	nitrate/nitrite response regulator protein NarL	0.0245	0.6283	0.5
Schistosoma mansoni	myosin xvIII	0.0146	0.3149	0.7714
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0146	0.3149	0.7714
Brugia malayi	hypothetical protein	0.0146	0.3149	0.7714
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0146	0.3149	0.7714
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0146	0.3149	0.7714
Brugia malayi	Melatonin receptor type 1A	0.0146	0.3149	0.7714
Brugia malayi	follicle stimulating hormone receptor	0.0146	0.3149	0.7714
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0146	0.3149	0.7714
Schistosoma mansoni	amine GPCR	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Onchocerca volvulus		0.0146	0.3149	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0146	0.3149	0.3149
Echinococcus granulosus	Ribosomal protein L34a	0.0129	0.2628	0.2628
Echinococcus multilocularis	neuropeptides capa receptor	0.0146	0.3149	0.3149
Echinococcus multilocularis	serotonin receptor	0.0146	0.3149	0.3149
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Onchocerca volvulus		0.0146	0.3149	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0146	0.3149	0.3149
Echinococcus granulosus	tm gpcr rhodopsin	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0146	0.3149	0.3149
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0146	0.3149	0.7714
Echinococcus granulosus	neuropeptides capa receptor	0.0146	0.3149	0.3149
Onchocerca volvulus		0.0146	0.3149	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0146	0.3149	0.7714
Schistosoma mansoni	amine GPCR	0.0146	0.3149	0.7714
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0146	0.3149	0.7714
Onchocerca volvulus		0.0146	0.3149	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0146	0.3149	0.3149
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Brugia malayi	G-protein coupled receptor	0.0146	0.3149	0.7714
Echinococcus multilocularis	Metazoa galactosyltransferase	0.0175	0.4082	0.4082
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Brugia malayi	Dopamine receptor	0.0146	0.3149	0.7714
Mycobacterium ulcerans	two component transcriptional regulatory protein DevR	0.0245	0.6283	0.5
Echinococcus granulosus	g protein coupled receptor	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Brugia malayi	G protein-coupled receptor F59B2.13	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus granulosus	neuropeptide Y receptor	0.0146	0.3149	0.3149
Brugia malayi	putative neuropeptide receptor NPR1	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Mycobacterium tuberculosis	Possible nitrate/nitrite response transcriptional regulatory protein NarL	0.0245	0.6283	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Brugia malayi	sulfakinin receptor protein	0.0146	0.3149	0.7714
Echinococcus granulosus	somatostatin receptor	0.0146	0.3149	0.3149
Echinococcus multilocularis	somatostatin receptor	0.0146	0.3149	0.3149
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0146	0.3149	0.7714
Schistosoma mansoni	opsin-like receptor	0.0146	0.3149	0.7714
Echinococcus multilocularis	expressed protein	0.0363	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Loa Loa (eye worm)	galactosyltransferase	0.0175	0.4082	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0146	0.3149	0.3149
Onchocerca volvulus		0.0146	0.3149	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0146	0.3149	0.7714
Schistosoma mansoni	adenoreceptor	0.0146	0.3149	0.7714
Echinococcus multilocularis	g protein coupled receptor	0.0146	0.3149	0.3149
Echinococcus granulosus	neuropeptide receptor	0.0146	0.3149	0.3149
Echinococcus granulosus	orexin receptor type 2	0.0146	0.3149	0.3149
Echinococcus multilocularis	g protein coupled receptor	0.0146	0.3149	0.3149
Loa Loa (eye worm)	TYRA-2 protein	0.0146	0.3149	0.7714
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0146	0.3149	0.3149
Onchocerca volvulus		0.0146	0.3149	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0146	0.3149	0.7714
Echinococcus multilocularis	Metazoa galactosyltransferase	0.0148	0.3224	0.3224
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Schistosoma mansoni	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0146	0.3149	0.3149
Schistosoma mansoni	biogenic amine receptor	0.0146	0.3149	0.7714
Echinococcus multilocularis	dro:myosuppressin receptor	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0146	0.3149	0.7714
Echinococcus granulosus	fmrfamide receptor	0.0146	0.3149	0.3149
Echinococcus granulosus	g protein coupled receptor	0.0146	0.3149	0.3149
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0146	0.3149	0.7714
Brugia malayi	hypothetical protein	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Brugia malayi	hypothetical protein	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Onchocerca volvulus		0.0146	0.3149	0.5
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus multilocularis	fmrfamide receptor	0.0146	0.3149	0.3149
Brugia malayi	GnHR receptor homolog	0.0146	0.3149	0.7714
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (LuxR-family)	0.0245	0.6283	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0146	0.3149	0.3149
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0146	0.3149	0.7714
Schistosoma mansoni	amine GPCR	0.0146	0.3149	0.7714
Schistosoma mansoni	histamine h1 receptor	0.0146	0.3149	0.7714
Echinococcus granulosus	allatostatin A receptor	0.0146	0.3149	0.3149
Echinococcus granulosus	dro:myosuppressin receptor	0.0146	0.3149	0.3149
Loa Loa (eye worm)	neuropeptide F receptor	0.0146	0.3149	0.7714
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0146	0.3149	0.3149
Brugia malayi	Galactosyltransferase family protein	0.0175	0.4082	1
Echinococcus granulosus	neuropeptides capa receptor	0.0146	0.3149	0.3149
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0146	0.3149	0.5
Brugia malayi	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0146	0.3149	0.3149
Brugia malayi	Dopamine receptor protein 2	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0146	0.3149	0.3149
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0146	0.3149	0.7714
Mycobacterium leprae	PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	0.0245	0.6283	0.5
Brugia malayi	larval opioid receptor	0.0146	0.3149	0.7714
Echinococcus multilocularis	sex peptide receptor	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Schistosoma mansoni	neuropeptide f receptor 76f	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus granulosus	G protein coupled receptor 139	0.0146	0.3149	0.3149
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0146	0.3149	0.7714
Echinococcus multilocularis	neuropeptide receptor	0.0146	0.3149	0.3149
Echinococcus multilocularis	orexin receptor type 2	0.0146	0.3149	0.3149
Toxoplasma gondii	hypothetical protein	0.0046	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0146	0.3149	0.3149
Onchocerca volvulus		0.0146	0.3149	0.5
Echinococcus multilocularis	serotonin receptor	0.0146	0.3149	0.3149
Onchocerca volvulus		0.0146	0.3149	0.5
Echinococcus granulosus	serotonin receptor	0.0146	0.3149	0.3149
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Brugia malayi	neuropeptide F receptor	0.0146	0.3149	0.7714
Echinococcus multilocularis	fmrfamide receptor	0.0146	0.3149	0.3149
Brugia malayi	ORL1-like opioid receptor	0.0146	0.3149	0.7714
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0146	0.3149	0.7714
Schistosoma mansoni	opsin-like receptor	0.0146	0.3149	0.7714
Echinococcus multilocularis	g-protein coupled receptor	0.0146	0.3149	0.3149
Mycobacterium ulcerans	hypothetical protein	0.0245	0.6283	0.5
Brugia malayi	hypothetical protein	0.0146	0.3149	0.7714
Schistosoma mansoni	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus granulosus	sex peptide receptor	0.0146	0.3149	0.3149
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (probably LuxR/UhpA-family)	0.0245	0.6283	0.5
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Loa Loa (eye worm)	neuropeptide F receptor	0.0146	0.3149	0.7714
Loa Loa (eye worm)	G-protein coupled receptor	0.0146	0.3149	0.7714
Echinococcus granulosus	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Onchocerca volvulus		0.0146	0.3149	0.5
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus granulosus	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Echinococcus granulosus	neuropeptide receptor	0.0146	0.3149	0.3149
Onchocerca volvulus		0.0146	0.3149	0.5
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Brugia malayi	Serotonin receptor	0.0146	0.3149	0.7714
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Schistosoma mansoni	beta-14-galactosyltransferase	0.0175	0.4082	1
Echinococcus multilocularis	Ribosomal protein L34a	0.0129	0.2628	0.2628
Schistosoma mansoni	neuropeptide F-like receptor	0.0146	0.3149	0.7714
Echinococcus granulosus	neuropeptide s receptor	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus multilocularis	g protein coupled receptor	0.0146	0.3149	0.3149
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0146	0.3149	0.7714
Brugia malayi	neuropeptide F receptor	0.0146	0.3149	0.7714
Mycobacterium ulcerans	two component transcriptional regulator	0.0245	0.6283	0.5
Schistosoma mansoni	beta-14-galactosyltransferase	0.0175	0.4082	1
Mycobacterium tuberculosis	Probable transcriptional regulatory protein	0.0245	0.6283	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0146	0.3149	0.7714
Brugia malayi	G protein-coupled receptor	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0146	0.3149	0.3149
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0146	0.3149	0.7714
Brugia malayi	G-protein coupled receptor	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0146	0.3149	0.7714
Echinococcus granulosus	7tm_1 domain containing protein	0.0146	0.3149	0.3149
Schistosoma mansoni	opsin-like receptor	0.0146	0.3149	0.7714
Schistosoma mansoni	biogenic amine receptor	0.0146	0.3149	0.7714
Schistosoma mansoni	growth hormone secretagogue receptor	0.0146	0.3149	0.7714
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0146	0.3149	0.3149
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0146	0.3149	0.7714
Echinococcus multilocularis	neuropeptide Y receptor	0.0146	0.3149	0.3149
Schistosoma mansoni	amine GPCR	0.0146	0.3149	0.7714
Brugia malayi	hypothetical protein	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0146	0.3149	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0146	0.3149	0.3149
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0146	0.3149	0.3149
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0146	0.3149	0.7714
Echinococcus granulosus	neuropeptide receptor A26	0.0146	0.3149	0.3149
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus granulosus	neuropeptide Y receptor	0.0146	0.3149	0.3149
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0146	0.3149	0.3149
Brugia malayi	Serotonin receptor	0.0146	0.3149	0.7714
Brugia malayi	RE15519p	0.0146	0.3149	0.7714
Loa Loa (eye worm)	G-protein coupled receptor	0.0146	0.3149	0.7714
Echinococcus granulosus	biogenic amine 5HT receptor	0.0146	0.3149	0.3149
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Echinococcus granulosus	rhodopsin orphan GPCR	0.0146	0.3149	0.3149
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0146	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0146	0.3149	0.7714
Echinococcus granulosus	hypothetical protein	0.0146	0.3149	0.3149
Echinococcus multilocularis	neuropeptide Y receptor	0.0146	0.3149	0.3149
Schistosoma mansoni	neuropeptide receptor	0.0146	0.3149	0.7714
Brugia malayi	AKH receptor	0.0146	0.3149	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3149	0.7714
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0146	0.3149	0.3149
Onchocerca volvulus		0.0146	0.3149	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0146	0.3149	0.3149

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1393499

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1282227