Detailed information for compound 1282333

Basic information

Technical information
  • TDR Targets ID: 1282333
  • Name: 1-(3-fluorophenyl)-4-phenyl-4,7-dihydro-3H-fu ro[3,4-e]pyridine-2,5-dione
  • MW: 323.318 | Formula: C19H14FNO3
  • H donors: 0 H acceptors: 2 LogP: 2.39 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)N1C(=O)CC(C2=C1COC2=O)c1ccccc1
  • InChi: 1S/C19H14FNO3/c20-13-7-4-8-14(9-13)21-16-11-24-19(23)18(16)15(10-17(21)22)12-5-2-1-3-6-12/h1-9,15H,10-11H2
  • InChiKey: BKVTYQKEXWXOPB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-fluorophenyl)-4-phenyl-4,7-dihydro-3H-furo[3,4-e]pyridine-2,5-quinone
  • SMR000307539
  • A3711/0157197
  • 1-(3-fluorophenyl)-4-phenyl-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione
  • MLS000729261

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nAChR subunit 0.0097 0.0077 0.0077
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0189 0.016 0.016
Brugia malayi hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 1.1203 1 1
Echinococcus granulosus cpg binding protein 0.0031 0.0019 0.0019
Schistosoma mansoni histamine h1 receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0017 0.0017
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0011 0.0011
Entamoeba histolytica protein kinase, putative 0.0033 0.002 0.1227
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0011 0.0011
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0012 0.0012
Trypanosoma brucei glucose transporter, putative 0.0034 0.0021 0.8107
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0011 0.0011
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0011 0.0011
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0021 0.0098
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.1893 0.1682 0.1682
Trypanosoma brucei glucose transporter, putative 0.0034 0.0021 0.8107
Onchocerca volvulus 0.0015 0.0004 0.0025
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0011 0.0011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0011 0.0011
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0004 0.5
Schistosoma mansoni glucose transporter 0.0015 0.0004 0.0004
Onchocerca volvulus 0.1893 0.1682 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.002 0.0329
Echinococcus granulosus voltage dependent calcium channel subunit 0.0384 0.0333 0.0333
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0023 0.0023
Echinococcus multilocularis solute carrier family 22 0.0015 0.0004 0.0004
Mycobacterium ulcerans sugar transporter 0.0015 0.0004 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Leishmania major protein kinase, putative 0.0033 0.002 0.7919
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.002 0.0617
Echinococcus multilocularis solute carrier family 22 0.0015 0.0004 0.0004
Schistosoma mansoni nAChR subunit 0.0092 0.0073 0.0073
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.002 0.0404
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0011 0.0011
Brugia malayi AKH receptor 0.0023 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0023 0.0011 0.0011
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0001 0.5
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0021 0.0098
Mycobacterium ulcerans oxidoreductase 0.0021 0.0009 0.005
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0011 0.0011
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.002 0.002
Onchocerca volvulus 0.0036 0.0023 0.0134
Plasmodium falciparum protein kinase 7 0.0305 0.0263 0.6542
Brugia malayi hypothetical protein 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0097 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Brugia malayi hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0011 0.0011
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.1893 0.1682 0.1682
Brugia malayi Serotonin receptor 0.0023 0.0011 0.0011
Onchocerca volvulus 0.0189 0.016 0.095
Loa Loa (eye worm) hypothetical protein 1.1203 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0011 0.0011
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0007 0.1383
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.002 0.0095
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Schistosoma mansoni amine GPCR 0.0344 0.0298 0.0298
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0021 0.0098
Echinococcus multilocularis sex peptide receptor 0.0023 0.0011 0.0011
Brugia malayi Sugar transporter family protein 0.0015 0.0004 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0108 0.0087 0.0087
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0041 0.1418
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0011 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0014 0.4825
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0097 0.0077 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0009 0.0193
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.005 0.005
Echinococcus granulosus glycine receptor subunit beta 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0097 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0097 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0011 0.0011
Echinococcus multilocularis glycine receptor subunit beta 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0133 0.0109 0.0109
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0011 0.0011
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.0866 0.0866
Onchocerca volvulus 0.0015 0.0004 0.0025
Onchocerca volvulus 0.0023 0.0011 0.0068
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0024 0.0779
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0014 0.0376
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0189 0.016 0.016
Onchocerca volvulus 0.0023 0.0011 0.0068
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Brugia malayi hypothetical protein 0.0092 0.0073 0.0073
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0011 0.0011
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.002 0.002
Schistosoma mansoni amine GPCR 0.0023 0.0011 0.0011
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0003 0.0003
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0036 0.0023 0.0109
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0009 0.0009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0011 0.0011
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0021 0.8107
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0009 0.0009
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Brugia malayi hypothetical protein 0.0092 0.0073 0.0073
Plasmodium falciparum plasmepsin VIII, putative 0.0036 0.0023 0.0462
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Leishmania major glucose transporter, lmgt2 0.0034 0.0021 0.8107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0092 0.0073 0.0073
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0011 0.0011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0011 0.0011
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0092 0.0073 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0011 0.0011
Echinococcus granulosus glycine receptor subunit beta 0.0189 0.016 0.016
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0012 0.0067
Schistosoma mansoni amine GPCR 0.0023 0.0011 0.0011
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0014 0.0246
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.0021
Echinococcus granulosus nAChR subunit 0.0097 0.0077 0.0077
Brugia malayi Carboxylesterase family protein 0.1893 0.1682 0.1682
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0011 0.0011
Echinococcus granulosus acetylcholinesterase 1.1203 1 1
Toxoplasma gondii protein kinase, putative 0.0305 0.0263 1
Schistosoma mansoni nAChR subunit 0.0189 0.016 0.016
Brugia malayi hypothetical protein 0.0092 0.0073 0.0073
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0189 0.016 0.016
Schistosoma mansoni neuropeptide receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Brugia malayi hypothetical protein 0.0015 0.0004 0.0004
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0023 0.0011 0.0255
Brugia malayi Carboxylesterase family protein 0.1893 0.1682 0.1682
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0009 0.0126
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0175 0.0147 0.5495
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Schistosoma mansoni BC026374 protein (S09 family) 0.1893 0.1682 0.1682
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.002 0.0404
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0011 0.0011
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0021 0.8107
Brugia malayi Dopamine receptor protein 2 0.0023 0.0011 0.0011
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0023
Onchocerca volvulus 0.0023 0.0011 0.0068
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0295 0.0254 0.1507
Onchocerca volvulus 0.0023 0.0011 0.0068
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Plasmodium falciparum plasmepsin VII 0.0036 0.0023 0.0462
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0011 0.0011
Plasmodium vivax CDK-related protein kinase 6, putative 0.0459 0.04 0.8155
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0011 0.0011
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0097 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Onchocerca volvulus 0.0015 0.0004 0.0025
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0009 0.0028
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Brugia malayi Cam kinase protein 1 0.0033 0.002 0.002
Echinococcus granulosus glycine receptor subunit alpha 1 0.0189 0.016 0.016
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Schistosoma mansoni transient receptor potential channel 4 0.01 0.008 0.008
Onchocerca volvulus 0.0023 0.0011 0.0068
Onchocerca volvulus 0.0023 0.0011 0.0068
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0011 0.0011
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0011 0.0011
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0004 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0023 0.0023
Onchocerca volvulus 0.0015 0.0004 0.0025
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.0087 0.0087
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1893 0.1682 1
Onchocerca volvulus 0.0092 0.0073 0.0434
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0011 0.0011
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1893 0.1682 0.1682
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0021 0.0098
Onchocerca volvulus 0.0023 0.0011 0.0068
Trypanosoma brucei glucose transporter, putative 0.0034 0.0021 0.8107
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0023
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0009 0.0028
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.002 0.002
Schistosoma mansoni cathepsin D (A01 family) 0.0036 0.0023 0.0023
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0189 0.016 0.016
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Echinococcus granulosus nAChR subunit 0.0189 0.016 0.016
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0024 0.0416
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1893 0.1682 1
Brugia malayi Cation transporter family protein 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0097 0.0077 0.0077
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0011 0.0011
Echinococcus multilocularis acetylcholinesterase 1.1203 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0014 0.4825
Onchocerca volvulus 0.0015 0.0004 0.0025
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0011 0.0011
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0011 0.0011
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0084 0.0066 0.0066
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.002 0.0329
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Leishmania major hypothetical protein, conserved 0.0026 0.0014 0.4825
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.005 0.005
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0097 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus granulosus neuropeptide receptor 0.0023 0.0011 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0011 0.0011
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0189 0.016 0.016
Echinococcus granulosus neuroligin 0.1893 0.1682 0.1682
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Brugia malayi larval opioid receptor 0.0023 0.0011 0.0011
Trypanosoma brucei glucose transporter 1E 0.0034 0.0021 0.8107
Schistosoma mansoni neurotransmitter gated ion channel 0.0097 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Onchocerca volvulus 0.1893 0.1682 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0011 0.0011
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0097 0.0077 0.0077
Brugia malayi major facilitator superfamily protein 0.0015 0.0004 0.0004
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0011 0.0011
Brugia malayi Melatonin receptor type 1A 0.0023 0.0011 0.0011
Schistosoma mansoni neuroligin 3 (S09 family) 0.1893 0.1682 0.1682
Brugia malayi Serotonin receptor 0.0023 0.0011 0.0011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0247 0.0212 0.0212
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0011 0.0011
Echinococcus multilocularis somatostatin receptor 0.0023 0.0011 0.0011
Plasmodium vivax hexose transporter 0.0108 0.0087 0.1708
Echinococcus granulosus transient receptor potential ion channel A 0.0097 0.0077 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Brugia malayi excitatory GABA receptor EXP-1A 0.0189 0.016 0.016
Brugia malayi hypothetical protein 0.0036 0.0023 0.0023
Loa Loa (eye worm) ACC-1 protein 0.0189 0.016 0.016
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0011 0.0011
Schistosoma mansoni acetylcholine receptor subunit beta 0.0092 0.0073 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0011 0.0011
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0189 0.016 0.016
Plasmodium vivax aspartyl protease, putative 0.0036 0.0023 0.0377
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0097 0.0077 0.0077
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.002
Onchocerca volvulus 0.0015 0.0004 0.0025
Trypanosoma brucei glucose transporter, putative 0.0034 0.0021 0.8107
Brugia malayi hypothetical protein 0.1893 0.1682 0.1682
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0384 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0092 0.0073 0.0073
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0012 0.0001 0.0001
Echinococcus multilocularis 0.0021 0.0009 0.0009
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0189 0.016 0.016
Loa Loa (eye worm) sugar transporter 0.0015 0.0004 0.0004
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0014 0.4825
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Brugia malayi Dopamine receptor 0.0023 0.0011 0.0011
Plasmodium vivax aspartyl proteinase, putative 0.0036 0.0023 0.0377
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.002 0.002
Onchocerca volvulus 0.0189 0.016 0.095
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Schistosoma mansoni neuropeptide receptor 0.0023 0.0011 0.0011
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0036 0.0023 0.0706
Leishmania major glucose transporter, lmgt3 0.0034 0.0021 0.8107
Brugia malayi hypothetical protein 0.0023 0.0011 0.0011
Plasmodium vivax aspartyl proteinase, putative 0.0036 0.0023 0.0377
Schistosoma mansoni hypothetical protein 0.0423 0.0369 0.0369
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0047 0.0047
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0189 0.016 0.016
Brugia malayi G-protein coupled receptor 0.0023 0.0011 0.0011
Entamoeba histolytica protein kinase, putative 0.0033 0.002 0.1227
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0097 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0189 0.016 0.016
Onchocerca volvulus 0.0023 0.0011 0.0068
Echinococcus multilocularis General substrate transporter 0.0093 0.0074 0.0074
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0009 0.7365
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.002 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0189 0.016 0.016
Brugia malayi G protein-coupled receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Onchocerca volvulus 0.1893 0.1682 1
Schistosoma mansoni sugar transporter 0.0015 0.0004 0.0004
Brugia malayi Carboxylesterase family protein 1.1203 1 1
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0274 0.0236 0.138
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0004 0.0004
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0009 0.2473
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.0087 0.0087
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.0087 0.0087
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.1893 0.1682 0.1682
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0004 0.0004
Onchocerca volvulus 0.0015 0.0004 0.0025
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 1.1203 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0011 0.0011
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0012 0.5182
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Brugia malayi hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.1893 0.1682 0.1682
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0189 0.016 0.016
Onchocerca volvulus 0.0023 0.0011 0.0068
Leishmania major UDP-galactopyranose mutase 0.0021 0.0009 0.2473
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.0012
Schistosoma mansoni nAChR subunit 0.0189 0.016 0.016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0011 0.0011
Onchocerca volvulus 0.003 0.0017 0.0102
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0011 0.0011
Brugia malayi SWIRM domain containing protein 0.0021 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0004 0.002
Loa Loa (eye worm) hypothetical protein 0.0077 0.006 0.006
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0189 0.016 0.016
Echinococcus granulosus dnaJ subfamily B 0.0423 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Onchocerca volvulus 0.0189 0.016 0.095
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0097 0.0077 0.0077
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.002 1
Brugia malayi G-protein coupled receptor 0.0023 0.0011 0.0011
Plasmodium vivax aspartyl protease, putative 0.0036 0.0023 0.0377
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0011 0.0011
Echinococcus multilocularis acetylcholinesterase 1.1203 1 1
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0167 0.014 0.014
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Plasmodium falciparum mitogen-activated protein kinase 2 0.0175 0.0147 0.3595
Brugia malayi neuropeptide F receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0189 0.016 0.016
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0011 0.0011
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.002 0.0404
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.002 0.0329
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0024 1
Loa Loa (eye worm) sugar transporter 0.0108 0.0087 0.0087
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0011 0.0011
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1893 0.1682 0.1682
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0011 0.0011
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0114 0.0093 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0009 0.0103
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0011 0.0011
Schistosoma mansoni nAChR subunit 0.0189 0.016 0.016
Echinococcus granulosus allatostatin A receptor 0.0023 0.0011 0.0011
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Schistosoma mansoni gliotactin 0.1893 0.1682 0.1682
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.002 0.002
Schistosoma mansoni glucose transport protein 0.0108 0.0087 0.0087
Echinococcus granulosus General substrate transporter 0.0093 0.0074 0.0074
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0092 0.0073 0.0073
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.002 0.0404
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0295 0.0254 0.1507
Trypanosoma brucei glucose transporter 2A 0.0034 0.0021 0.8107
Schistosoma mansoni nAChR subunit 0.0189 0.016 0.016
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0014
Echinococcus granulosus g protein coupled receptor 0.0023 0.0011 0.0011
Echinococcus multilocularis nAChR subunit 0.0189 0.016 0.016
Brugia malayi Pepsin A precursor 0.0036 0.0023 0.0023
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0004 0.002
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Echinococcus granulosus solute carrier family 22 0.0015 0.0004 0.0004
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0011 0.0011
Echinococcus granulosus somatostatin receptor 0.0023 0.0011 0.0011
Onchocerca volvulus 0.0036 0.0023 0.0134
Trichomonas vaginalis spcc417.12 protein, putative 0.1893 0.1682 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0014
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0004 0.0004
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0189 0.016 0.016
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0011 0.0011
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Plasmodium vivax plasmepsin V, putative 0.0036 0.0023 0.0377
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0009 0.0009
Brugia malayi hypothetical protein 0.0023 0.0011 0.0011
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.002 0.0617
Plasmodium vivax plasmepsin IV, putative 0.0036 0.0023 0.0377
Loa Loa (eye worm) acetylcholine receptor protein 0.0092 0.0073 0.0073
Echinococcus multilocularis serotonin receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) GABA receptor subunit 0.0097 0.0077 0.0077
Echinococcus granulosus glycine receptor subunit alpha 1 0.0189 0.016 0.016
Echinococcus granulosus acetylcholinesterase 1.1203 1 1
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0024 0.0024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0092 0.0073 0.0073
Schistosoma mansoni biogenic amine receptor 0.0023 0.0011 0.0011
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0189 0.016 0.016
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0024 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0011 0.0011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.0087 0.0087
Schistosoma mansoni sugar transporter 0.0015 0.0004 0.0004
Brugia malayi hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus multilocularis transient receptor potential ion channel A 0.0097 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0601 0.0527 0.0527
Trypanosoma brucei glucose transporter, putative 0.0034 0.0021 0.8107
Brugia malayi hypothetical protein 0.0023 0.0011 0.0011
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0036 0.0023 0.0023
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0009 0.005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Schistosoma mansoni nAChR subunit 0.0092 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Brugia malayi putative neuropeptide receptor 0.0023 0.0011 0.0011
Toxoplasma gondii facilitative glucose transporter GT1 0.0108 0.0087 0.3201
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0097 0.0077 0.0077
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0189 0.016 0.016
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.002 0.0404
Onchocerca volvulus 0.0097 0.0077 0.0461
Onchocerca volvulus 0.0015 0.0004 0.0025
Brugia malayi Cache domain containing protein 0.0077 0.006 0.006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Plasmodium falciparum plasmepsin I 0.0036 0.0023 0.0462
Brugia malayi Carboxylesterase family protein 0.1893 0.1682 0.1682
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0092 0.0073 0.0073
Plasmodium falciparum plasmepsin V 0.0036 0.0023 0.0462
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.002 0.002
Mycobacterium ulcerans dehydrogenase 0.0021 0.0009 0.005
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0036 0.0023 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0011 0.0011
Toxoplasma gondii aspartyl protease ASP3 0.0036 0.0023 0.0706
Brugia malayi hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) carboxylesterase 0.1893 0.1682 0.1682
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Schistosoma mansoni adenoreceptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.1893 0.1682 0.1682
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.002 0.002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0189 0.016 0.016
Loa Loa (eye worm) ACC-1 protein 0.0189 0.016 0.016
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0011 0.0011
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0012 0.0048
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0024 0.0024
Brugia malayi neuropeptide F receptor 0.0023 0.0011 0.0011
Schistosoma mansoni neuropeptide receptor 0.0023 0.0011 0.0011
Echinococcus granulosus solute carrier family 22 0.0015 0.0004 0.0004
Schistosoma mansoni biogenic amine receptor 0.0023 0.0011 0.0011
Mycobacterium tuberculosis Carboxylesterase LipT 0.1893 0.1682 1
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.005 0.005
Schistosoma mansoni hypothetical protein 0.009 0.0071 0.0071
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0092 0.0073 0.0073
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0092 0.0073 0.0073
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0092 0.0073 0.0073
Echinococcus granulosus solute carrier family 22 0.0015 0.0004 0.0004
Onchocerca volvulus 0.1893 0.1682 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0021 0.0098
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Onchocerca volvulus 0.0015 0.0004 0.0025
Brugia malayi hypothetical protein 0.0021 0.0009 0.0009
Plasmodium falciparum plasmepsin VI 0.0036 0.0023 0.0462
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0108 0.0087 0.0087
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.002 0.002
Plasmodium falciparum plasmepsin IX 0.0036 0.0023 0.0462
Onchocerca volvulus 0.0015 0.0004 0.0025
Onchocerca volvulus 0.0023 0.0011 0.0068
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0011 0.0068
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0189 0.016 0.016
Schistosoma mansoni nAChR subunit 0.0189 0.016 0.016
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0023 0.0023
Loa Loa (eye worm) LGC-31 protein 0.0189 0.016 0.016
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0011 0.0011
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0011 0.0011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0023 0.0023
Echinococcus granulosus carboxylesterase 5A 1.1203 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0011 0.0011
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0021 0.8107
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0018 0.0018
Brugia malayi hypothetical protein 0.0036 0.0023 0.0023
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0189 0.016 0.016
Schistosoma mansoni hypothetical protein 0.0023 0.0011 0.0011
Echinococcus granulosus glycine receptor subunit alpha 1 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0033 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0693 0.061 0.061
Echinococcus multilocularis cpg binding protein 0.0031 0.0019 0.0019
Schistosoma mansoni sugar transporter 0.0015 0.0004 0.0004
Onchocerca volvulus 0.0023 0.0011 0.0068
Brugia malayi sulfakinin receptor protein 0.0023 0.0011 0.0011
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Schistosoma mansoni cpg binding protein 0.0031 0.0019 0.0019
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0097 0.0077 0.0077
Brugia malayi hypothetical protein 0.0023 0.0011 0.0011
Brugia malayi ORL1-like opioid receptor 0.0023 0.0011 0.0011
Schistosoma mansoni memapsin-2 (A01 family) 0.0888 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0021 0.0098
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0011 0.0011
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0189 0.016 0.016
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0021 0.8107
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.01 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.1893 0.1682 0.1682
Brugia malayi CXXC zinc finger family protein 0.003 0.0017 0.0017
Echinococcus granulosus solute carrier family 22 0.0015 0.0004 0.0004
Loa Loa (eye worm) carboxylesterase 0.1893 0.1682 0.1682
Schistosoma mansoni opsin-like receptor 0.0023 0.0011 0.0011
Onchocerca volvulus 0.0015 0.0004 0.0025
Schistosoma mansoni sugar transporter 0.0015 0.0004 0.0004
Brugia malayi major facilitator superfamily protein 0.0015 0.0004 0.0004
Schistosoma mansoni glucose transport protein 0.0108 0.0087 0.0087
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0011 0.0011
Brugia malayi Sugar transporter family protein 0.0108 0.0087 0.0087
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0092 0.0073 0.0073
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0175 0.0147 0.2932
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0011 0.0011
Plasmodium falciparum plasmepsin IV 0.0036 0.0023 0.0462
Onchocerca volvulus 0.0015 0.0004 0.0025
Onchocerca volvulus 0.0189 0.016 0.095
Echinococcus granulosus fmrfamide receptor 0.0023 0.0011 0.0011
Onchocerca volvulus 0.0023 0.0011 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Schistosoma mansoni neurotransmitter gated ion channel 0.0092 0.0073 0.0073
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0559 0.049 1
Schistosoma mansoni protein kinase 0.0033 0.002 0.002
Onchocerca volvulus 0.0097 0.0077 0.0461
Loa Loa (eye worm) aspartyl protease 6 0.0036 0.0023 0.0023
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0011 0.0011
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0011 0.0011
Loa Loa (eye worm) acetylcholinesterase 1 1.1203 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1893 0.1682 0.1682
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.008 0.008
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0011 0.0011
Brugia malayi Cation transporter family protein 0.0189 0.016 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.001 0.0032
Schistosoma mansoni cathepsin D (A01 family) 0.0036 0.0023 0.0023
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0693 0.061 0.061
Trypanosoma cruzi hexose transporter 0.0034 0.0021 0.8107
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Schistosoma mansoni amine GPCR 0.0023 0.0011 0.0011
Brugia malayi hypothetical protein 0.0023 0.0011 0.0011
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0063 0.0047 0.0047
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0011 0.0011
Plasmodium falciparum plasmepsin X 0.0036 0.0023 0.0462
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0024 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Schistosoma mansoni myosin xvIII 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Schistosoma mansoni neurotransmitter gated ion channel 0.0092 0.0073 0.0073
Brugia malayi aspartic protease BmAsp-1, identical 0.0036 0.0023 0.0023
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0011 0.0011
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0189 0.016 0.016
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0189 0.016 0.016
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0014 0.0246
Echinococcus granulosus hypothetical protein 0.0023 0.0011 0.0011
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0021 0.8107
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0092 0.0073 0.0073
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.002 0.002
Onchocerca volvulus 0.0015 0.0004 0.0025
Echinococcus multilocularis serotonin receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0023 0.0023
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0011 0.0011
Schistosoma mansoni serine-rich repeat protein 0.009 0.0071 0.0071
Brugia malayi hypothetical protein 0.0015 0.0004 0.0004
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0009 0.0103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0011 0.0011
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0189 0.016 0.016
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0011 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Toxoplasma gondii aspartyl protease ASP1 0.0036 0.0023 0.0706
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0004 0.0004
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0092 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus multilocularis solute carrier family 22 0.0015 0.0004 0.0004
Onchocerca volvulus 0.0189 0.016 0.095
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0189 0.016 0.016
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.002 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0011 0.0011
Onchocerca volvulus 0.1893 0.1682 1
Schistosoma mansoni acetylcholine receptor-related 0.0092 0.0073 0.0073
Brugia malayi aspartic protease BmAsp-2, identical 0.0036 0.0023 0.0023
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0011 0.0011
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.002 0.002
Echinococcus multilocularis BC026374 protein (S09 family) 0.1893 0.1682 0.1682
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0823 0.0726 0.0726
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0011 0.0011
Onchocerca volvulus 0.0023 0.0011 0.0068
Schistosoma mansoni protein kinase 0.0033 0.002 0.002
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0189 0.016 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Echinococcus granulosus orexin receptor type 2 0.0023 0.0011 0.0011
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0004 0.0004
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0011 0.0011
Echinococcus granulosus neuropeptide receptor 0.0023 0.0011 0.0011
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.0087 0.0087
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0011 0.0011
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0009 0.0103
Onchocerca volvulus 0.0092 0.0073 0.0434
Echinococcus multilocularis solute carrier family 22 0.0015 0.0004 0.0004
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0021 0.8107
Loa Loa (eye worm) hypothetical protein 0.0189 0.016 0.016
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0011 0.0011
Brugia malayi Eukaryotic aspartyl protease family protein 0.0036 0.0023 0.0023
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0011 0.0011
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0021 0.8107
Schistosoma mansoni hypothetical protein 0.0023 0.0011 0.0011
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0009 0.003
Echinococcus granulosus family S9 non peptidase ue S09 family 0.1893 0.1682 0.1682
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Schistosoma mansoni transient receptor potential channel 0.0066 0.005 0.005
Leishmania major glucose transporter, lmgt1 0.0034 0.0021 0.8107
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0011 0.0011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0011 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0189 0.016 0.016
Loa Loa (eye worm) carboxylesterase 1.1203 1 1
Schistosoma mansoni neuropeptide receptor 0.0023 0.0011 0.0011
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.002 0.002
Plasmodium falciparum protein kinase 6 0.0459 0.04 1
Brugia malayi Dopamine receptor protein 1 0.0023 0.0011 0.0011
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.002 0.7919
Schistosoma mansoni amine oxidase 0.0021 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Brugia malayi RE15519p 0.0023 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.002 0.0617
Echinococcus multilocularis carboxylesterase 5A 1.1203 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0011 0.0011
Echinococcus granulosus sex peptide receptor 0.0023 0.0011 0.0011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0011 0.0011
Onchocerca volvulus 0.0023 0.0011 0.0068
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0011 0.0011
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0012 0.395
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.1893 0.1682 0.1682
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0024 0.051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Onchocerca volvulus 0.0021 0.0009 0.0055
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.002 0.002
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.1893 0.1682 1
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0012 0.0201
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0011 0.0011
Onchocerca volvulus 0.0023 0.0011 0.0068
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0174 0.0147 0.0147
Onchocerca volvulus Putative transporter 0.0015 0.0004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Schistosoma mansoni protein kinase 0.0033 0.002 0.002
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0011 0.0068
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0011 0.0011
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0009 0.2473
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0189 0.016 0.016
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Schistosoma mansoni cpg binding protein 0.003 0.0017 0.0017
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Plasmodium falciparum plasmepsin II 0.0036 0.0023 0.0462
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.1893 0.1682 0.1682
Trypanosoma brucei glucose transporter, putative 0.0034 0.0021 0.8107
Schistosoma mansoni acetylcholinesterase 0.1893 0.1682 0.1682
Brugia malayi hypothetical protein 0.0092 0.0073 0.0073
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0189 0.016 0.016
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0009 0.005
Entamoeba histolytica hypothetical protein 0.0097 0.0077 1
Onchocerca volvulus 0.0092 0.0073 0.0434
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0004 0.0004
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0189 0.016 0.016
Toxoplasma gondii aspartyl protease 0.0036 0.0023 0.0706
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.002 0.002
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0011 0.0011
Plasmodium falciparum plasmepsin III 0.0036 0.0023 0.0462
Mycobacterium ulcerans carboxylesterase, LipT 0.1893 0.1682 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0011 0.0011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0011 0.0011
Schistosoma mansoni transient receptor potential channel 0.01 0.008 0.008
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0009 0.0009
Schistosoma mansoni cpg binding protein 0.0031 0.0019 0.0019
Onchocerca volvulus 0.0015 0.0004 0.0025
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0009 0.0009
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Brugia malayi hypothetical protein 0.0026 0.0014 0.0014
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0024 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0012 0.395
Echinococcus granulosus g protein coupled receptor 0.0023 0.0011 0.0011
Schistosoma mansoni amine oxidase 0.0021 0.0009 0.0009
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0036 0.0023 0.0706
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0189 0.016 0.016
Echinococcus multilocularis glycine receptor subunit beta 0.0189 0.016 0.016
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0189 0.016 0.016
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0011 0.0011
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0011 0.0011
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0189 0.016 0.016
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0023 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0009 0.0103
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0036 0.0023 0.0023
Echinococcus granulosus BC026374 protein S09 family 0.1893 0.1682 0.1682
Schistosoma mansoni transient receptor potential channel 0.0066 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0066 0.005 0.005
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0021 0.0098
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0023 0.0023
Brugia malayi Cation transporter family protein 0.0189 0.016 0.016
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0189 0.016 0.016
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0092 0.0073 0.0073
Brugia malayi Carboxylesterase family protein 0.1893 0.1682 0.1682
Onchocerca volvulus 0.0189 0.016 0.095
Echinococcus multilocularis para nitrobenzyl esterase 0.1893 0.1682 0.1682
Schistosoma mansoni nAChR subunit 0.0189 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0087 0.0494
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0314 0.0271 0.0271
Trypanosoma brucei glucose transporter, putative 0.0034 0.0021 0.8107
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0014 0.0201
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0023 0.0011 0.0011
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.0087 0.0087
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0189 0.016 0.016
Schistosoma mansoni glucose transport protein 0.0108 0.0087 0.0087
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0009 0.0009
Plasmodium falciparum hexose transporter 0.0108 0.0087 0.2094
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0012 0.395
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0011 0.0011
Plasmodium vivax aspartyl protease, putative 0.0036 0.0023 0.0377
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0021 0.0009 0.0249
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0024
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Schistosoma mansoni amine GPCR 0.0023 0.0011 0.0011
Brugia malayi GnHR receptor homolog 0.0023 0.0011 0.0011
Echinococcus granulosus voltage dependent calcium channel subunit 0.0174 0.0147 0.0147
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0036 0.0023 0.0023
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0012 0.0164
Onchocerca volvulus 0.0015 0.0004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0092 0.0073 0.0073
Onchocerca volvulus 0.0015 0.0004 0.0025
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0012 0.0308
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0009 0.0126
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0024 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0097 0.0077 0.0077
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0009 0.0126
Schistosoma mansoni opsin-like receptor 0.0023 0.0011 0.0011
Echinococcus granulosus serotonin receptor 0.0023 0.0011 0.0011
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.008 0.008
Echinococcus granulosus para nitrobenzyl esterase 0.1893 0.1682 0.1682
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0012 0.0067
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.002 0.1135
Onchocerca volvulus 0.0023 0.0011 0.0068
Schistosoma mansoni biogenic amine receptor 0.0023 0.0011 0.0011
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.002 0.0329
Brugia malayi follicle stimulating hormone receptor 0.0023 0.0011 0.0011
Onchocerca volvulus Putative nachr subunit 0.0189 0.016 0.095
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0009 0.003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0011 0.0011
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0011 0.0011
Onchocerca volvulus 0.0023 0.0011 0.0068
Echinococcus granulosus g protein coupled receptor 0.0023 0.0011 0.0011
Echinococcus multilocularis neuroligin 0.1893 0.1682 0.1682
Schistosoma mansoni opsin-like receptor 0.0023 0.0011 0.0011
Trypanosoma brucei glucose transporter, putative 0.0034 0.0021 0.8107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Brugia malayi hypothetical protein 0.0092 0.0073 0.0073
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0009 0.0009
Brugia malayi Sugar transporter family protein 0.0015 0.0004 0.0004
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0012 0.3046
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0004 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0011 0.0011
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0001 0.0001
Schistosoma mansoni nAChR subunit 0.0189 0.016 0.016
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0012 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0189 0.016 0.016

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0026 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.1577 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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