Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1391 | 0.4103 | 0.4103 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.2881 | 0.2881 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1585 | 0.4679 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1391 | 0.4103 | 0.4103 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0032 | 0.0032 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.0164 | 0.0164 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0032 | 0.0032 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.3379 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.0331 | 0.0331 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1585 | 0.4679 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0164 | 0.0164 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.014 | 0.014 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.3379 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0032 | 0.0032 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0154 | 0.0154 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.014 | 0.014 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.3379 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.014 | 0.014 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0164 | 0.0164 |
Brugia malayi | RNA binding protein | 0.0064 | 0.0164 | 0.0164 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1585 | 0.4679 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.0164 | 0.0164 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.014 | 0.014 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1391 | 0.4103 | 0.4103 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.014 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0032 | 0.0032 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1391 | 0.4103 | 0.4103 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0032 | 0.0032 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.014 | 0.014 |
Schistosoma mansoni | patched 1 | 0.1391 | 0.4103 | 0.4103 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.014 | 0.014 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0098 | 0.0098 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0164 | 0.0164 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.0331 | 0.0331 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.0331 | 0.0331 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0032 | 0.0032 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1391 | 0.4103 | 0.4103 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.0164 | 0.0164 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.014 | 0.014 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0032 | 0.0032 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.014 | 0.014 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1585 | 0.4679 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0032 | 0.0032 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0164 | 0.0164 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1391 | 0.4103 | 0.4103 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0098 | 0.0098 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3379 | 1 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.3379 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3379 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3379 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.3379 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.1391 | 0.4103 | 0.4103 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.0164 | 0.0164 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0032 | 0.0032 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0032 | 0.0032 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1391 | 0.4103 | 0.4103 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0032 | 0.0032 |
Echinococcus multilocularis | protein patched | 0.1391 | 0.4103 | 0.4103 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1391 | 0.4103 | 0.4103 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.0164 | 0.0164 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0164 | 0.0164 |
Brugia malayi | CHE-14 protein | 0.1391 | 0.4103 | 0.4103 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0154 | 0.0154 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3379 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.2589 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.