Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0083 | 0.0917 | 0.0917 |
Brugia malayi | Carboxylesterase family protein | 0.0083 | 0.0917 | 0.0917 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0083 | 0.0917 | 0.0917 |
Echinococcus multilocularis | acetylcholinesterase | 0.0491 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0083 | 0.0917 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0491 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.012 | 0.1752 | 0.1752 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0917 | 0.0917 |
Brugia malayi | Carboxylesterase family protein | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 0.1752 | 0.1752 |
Brugia malayi | Carboxylesterase family protein | 0.0083 | 0.0917 | 0.0917 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0083 | 0.0917 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0491 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.0903 | 0.0903 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0083 | 0.0917 | 0.0917 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0083 | 0.0917 | 0.0917 |
Echinococcus granulosus | neuroligin | 0.0083 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0917 | 0.0917 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0083 | 0.0917 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0083 | 0.0917 | 0.0917 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.026 | 0.4862 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0917 | 0.0917 |
Brugia malayi | Carboxylesterase family protein | 0.0083 | 0.0917 | 0.0917 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0083 | 0.0917 | 0.0917 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0083 | 0.0917 | 0.0917 |
Onchocerca volvulus | 0.0083 | 0.0917 | 0.5 | |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0042 | 0 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1752 | 0.1752 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0917 | 0.0917 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0083 | 0.0917 | 0.0917 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0903 | 0.0903 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0083 | 0.0917 | 0.0917 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0083 | 0.0917 | 0.0917 |
Onchocerca volvulus | 0.0083 | 0.0917 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0083 | 0.0917 | 0.0917 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0083 | 0.0917 | 0.0917 |
Schistosoma mansoni | acetylcholinesterase | 0.0083 | 0.0917 | 0.0917 |
Echinococcus multilocularis | acetylcholinesterase | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0903 | 0.0903 |
Loa Loa (eye worm) | carboxylesterase | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0491 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0083 | 0.0917 | 0.0917 |
Onchocerca volvulus | 0.0083 | 0.0917 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0917 | 0.0917 |
Onchocerca volvulus | 0.0083 | 0.0917 | 0.5 | |
Schistosoma mansoni | gliotactin | 0.0083 | 0.0917 | 0.0917 |
Brugia malayi | Carboxylesterase family protein | 0.0083 | 0.0917 | 0.0917 |
Onchocerca volvulus | 0.0083 | 0.0917 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0491 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 0.1752 | 0.1752 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0083 | 0.0917 | 0.0917 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0083 | 0.0917 | 0.0917 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3162 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.