Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Neospora caninum | Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma japonicum | ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4678 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.2139 | 0.372 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4393 | 0.4331 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4393 | 0.4856 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0939 | 0.0754 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4678 | 0.4619 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0634 | 0.0531 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4678 | 0.4619 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2139 | 0.2052 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.8073 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.2139 | 0.372 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.8073 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.8073 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5326 | 0.616 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5326 | 0.5275 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5326 | 0.615 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.8073 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4678 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2139 | 0.2052 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0939 | 0.0754 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4393 | 0.4842 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.2139 | 0.1704 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.2139 | 0.1704 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.2139 | 0.372 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.2139 | 0.372 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.2139 | 0.372 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.2139 | 0.372 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2139 | 0.2052 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.2139 | 0.1681 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.2139 | 0.1681 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2139 | 0.2052 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Onchocerca volvulus | 0.0035 | 0.4393 | 0.5 | |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8867 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.