Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus multilocularis | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus granulosus | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuroligin | 0.0222 | 0.0836 | 0.0836 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0222 | 0.0836 | 0.0836 |
Echinococcus granulosus | caspase 2 | 0.0175 | 0.0441 | 0.0441 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0222 | 0.0836 | 0.5 |
Onchocerca volvulus | 0.0222 | 0.0836 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0222 | 0.0836 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.0836 | 0.0836 |
Echinococcus multilocularis | neuroligin | 0.0222 | 0.0836 | 0.0836 |
Brugia malayi | Carboxylesterase family protein | 0.1315 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 0.0836 | 0.0836 |
Schistosoma mansoni | acetylcholinesterase | 0.0222 | 0.0836 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.0836 | 0.0836 |
Echinococcus granulosus | carboxylesterase 5A | 0.1315 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0222 | 0.0836 | 0.0836 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0222 | 0.0836 | 0.0836 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0222 | 0.0836 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.0836 | 0.0836 |
Echinococcus multilocularis | acetylcholinesterase | 0.1315 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1315 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0222 | 0.0836 | 0.0836 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0175 | 0.0441 | 0.5275 |
Loa Loa (eye worm) | hypothetical protein | 0.1315 | 1 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0175 | 0.0441 | 0.0441 |
Schistosoma mansoni | gliotactin | 0.0222 | 0.0836 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0441 | 0.0441 |
Brugia malayi | hypothetical protein | 0.0286 | 0.1367 | 0.1367 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0222 | 0.0836 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1367 | 0.1367 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0222 | 0.0836 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.0836 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.0836 | 0.0836 |
Brugia malayi | hypothetical protein | 0.0222 | 0.0836 | 0.0836 |
Echinococcus granulosus | acetylcholinesterase | 0.1315 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0222 | 0.0836 | 0.0836 |
Loa Loa (eye worm) | carboxylesterase | 0.0222 | 0.0836 | 0.0836 |
Echinococcus multilocularis | acetylcholinesterase | 0.1315 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1315 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0222 | 0.0836 | 0.0836 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0222 | 0.0836 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.0836 | 0.0836 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1315 | 1 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0175 | 0.0441 | 0.0441 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.1367 | 0.1367 |
Echinococcus granulosus | acetylcholinesterase | 0.1315 | 1 | 1 |
Onchocerca volvulus | 0.0222 | 0.0836 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1315 | 1 | 1 |
Onchocerca volvulus | 0.0222 | 0.0836 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0222 | 0.0836 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 0.0836 | 0.0836 |
Onchocerca volvulus | 0.0222 | 0.0836 | 1 | |
Onchocerca volvulus | 0.0222 | 0.0836 | 1 | |
Echinococcus multilocularis | caspase 2 | 0.0175 | 0.0441 | 0.0441 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0222 | 0.0836 | 0.0836 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0222 | 0.0836 | 0.0836 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.1302 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.1367 | 0.1367 |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 0.0836 | 0.0836 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1315 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.0836 | 0.0836 |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 0.0836 | 0.0836 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.