Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | l(3)mbt-like 1 (Drosophila) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Lethal(3)malignant brain tumor-like 4 protein, putative | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Schistosoma japonicum | Lethal(3)malignant brain tumor-like 3 protein, putative | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0442 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0075 | 0 | 0.5 |
Onchocerca volvulus | 0.0075 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0442 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0075 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0442 | 1 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0227 | 0.4145 | 0.4145 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.7498 | 0.7498 |
Onchocerca volvulus | 0.0075 | 0 | 0.5 | |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0227 | 0.4145 | 0.4145 |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0442 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0442 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0442 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0442 | 1 | 1 |
Onchocerca volvulus | 0.0075 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0075 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0442 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0075 | 0 | 0.5 |
Onchocerca volvulus | 0.0075 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0075 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0442 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0075 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0442 | 1 | 1 |
Onchocerca volvulus | 0.0075 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.