Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0086 | 0.0759 | 0.1033 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0035 | 0.0003 | 0.0004 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0474 | 0.0645 |
Brugia malayi | RNA binding protein | 0.0067 | 0.0474 | 0.05 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0066 | 0.0467 | 0.0683 |
Brugia malayi | nuclear receptor RXR | 0.0035 | 0.0003 | 0.0003 |
Schistosoma mansoni | nuclear hormone receptor | 0.0066 | 0.0467 | 0.0635 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0003 | 0.0003 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0042 | 0.0108 | 0.5 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0467 | 0.0492 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0086 | 0.0759 | 0.0801 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.0474 | 0.05 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0066 | 0.0467 | 0.0635 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0042 | 0.0108 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0066 | 0.0467 | 0.0492 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0066 | 0.0467 | 0.0683 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.0474 | 0.0645 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0066 | 0.0467 | 0.0635 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0066 | 0.0467 | 0.0492 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0042 | 0.0108 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0066 | 0.0467 | 0.0635 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0035 | 0.0003 | 0.0004 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0066 | 0.0467 | 0.0492 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.0474 | 0.05 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0066 | 0.0467 | 0.0492 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0672 | 0.9481 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0066 | 0.0467 | 0.0635 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0042 | 0.0108 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0003 | 0.0003 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0066 | 0.0467 | 0.0635 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0467 | 0.0492 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0042 | 0.0108 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0066 | 0.0467 | 0.0492 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0066 | 0.0467 | 0.0492 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.0108 | 0.0147 |
Trypanosoma brucei | protein kinase, putative | 0.0042 | 0.0108 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0066 | 0.0467 | 0.0635 |
Brugia malayi | nuclear receptor NHR-88 | 0.0066 | 0.0467 | 0.0492 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0066 | 0.0467 | 0.0635 |
Schistosoma mansoni | thyroid hormone receptor | 0.0066 | 0.0467 | 0.0635 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0042 | 0.0108 | 0.0147 |
Brugia malayi | MAP kinase sur-1 | 0.0042 | 0.0108 | 0.0114 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0066 | 0.0467 | 0.0635 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0003 | 0.0003 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0474 | 0.0645 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0066 | 0.0467 | 0.0492 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0035 | 0.0003 | 0.0004 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0066 | 0.0467 | 0.0492 |
Brugia malayi | nuclear hormone receptor | 0.0672 | 0.9481 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0066 | 0.0467 | 0.0492 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0086 | 0.0759 | 0.1033 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0066 | 0.0467 | 0.0492 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0086 | 0.0759 | 0.1033 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0467 | 0.0492 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0066 | 0.0467 | 0.0683 |
Brugia malayi | nuclear hormone receptor | 0.0066 | 0.0467 | 0.0492 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0066 | 0.0467 | 0.0635 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0042 | 0.0108 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0042 | 0.0108 | 0.0147 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0066 | 0.0467 | 0.0635 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.0474 | 0.05 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0066 | 0.0467 | 0.0683 |
Brugia malayi | hypothetical protein | 0.0129 | 0.1399 | 0.1476 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0042 | 0.0108 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0035 | 0.0003 | 0.0004 |
Echinococcus granulosus | FTZ F1 alpha | 0.0066 | 0.0467 | 0.0635 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0066 | 0.0467 | 0.0683 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.135 | 0.1424 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0003 | 0.0003 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0066 | 0.0467 | 0.0492 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0066 | 0.0467 | 0.0635 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0066 | 0.0467 | 0.0635 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0066 | 0.0467 | 0.0635 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0474 | 0.0645 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0066 | 0.0467 | 0.0492 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0467 | 0.0492 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0066 | 0.0467 | 0.0492 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0066 | 0.0467 | 0.0492 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0066 | 0.0467 | 0.0492 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0474 | 0.0645 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0467 | 0.0492 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0086 | 0.0759 | 0.1033 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0066 | 0.0467 | 0.0492 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0042 | 0.0108 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0066 | 0.0467 | 0.0492 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0467 | 0.0492 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.0474 | 0.0694 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1399 | 0.1476 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0066 | 0.0467 | 0.0492 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.0474 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0641 | 0.9017 | 0.9511 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.135 | 0.1424 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0035 | 0.0003 | 0.0003 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0042 | 0.0108 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.135 | 0.1424 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0467 | 0.0492 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0003 | 0.0003 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0086 | 0.0759 | 0.1033 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0066 | 0.0467 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0467 | 0.0492 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0066 | 0.0467 | 0.0683 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0066 | 0.0467 | 0.0683 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0042 | 0.0108 | 0.0114 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0066 | 0.0467 | 0.0635 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0529 | 0.7352 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0042 | 0.0108 | 0.0158 |
Brugia malayi | ecdysteroid receptor | 0.0066 | 0.0467 | 0.0492 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0474 | 0.0645 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.0474 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0003 | 0.0003 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0066 | 0.0467 | 0.0683 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0086 | 0.0759 | 0.0801 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0042 | 0.0108 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0066 | 0.0467 | 0.0492 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0042 | 0.0108 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0042 | 0.0108 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0066 | 0.0467 | 0.0492 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0086 | 0.0759 | 0.1111 |
Onchocerca volvulus | Huntingtin homolog | 0.0129 | 0.1399 | 0.0978 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0066 | 0.0467 | 0.0492 |
Schistosoma mansoni | coup transcription factor | 0.0066 | 0.0467 | 0.0635 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0066 | 0.0467 | 0.0492 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0066 | 0.0467 | 0.0492 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0066 | 0.0467 | 0.0492 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0066 | 0.0467 | 0.0635 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0494 | 0.6832 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1399 | 0.1476 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0529 | 0.7352 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0129 | 0.1399 | 0.0978 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0042 | 0.0108 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0086 | 0.0759 | 0.1111 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0035 | 0.0003 | 0.0003 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0035 | 0.0003 | 0.0003 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0066 | 0.0467 | 0.0635 |
Brugia malayi | steroid hormone receptor | 0.0066 | 0.0467 | 0.0492 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0042 | 0.0108 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.