Detailed information for compound 1285129

Basic information

Technical information
  • TDR Targets ID: 1285129
  • Name: 6-methoxy-2-methylquinoline-3-carbohydrazide
  • MW: 231.251 | Formula: C12H13N3O2
  • H donors: 2 H acceptors: 2 LogP: 1.09 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNC(=O)c1cc2cc(OC)ccc2nc1C
  • InChi: 1S/C12H13N3O2/c1-7-10(12(16)15-13)6-8-5-9(17-2)3-4-11(8)14-7/h3-6H,13H2,1-2H3,(H,15,16)
  • InChiKey: FIBNRQLTJHSITF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-methoxy-2-methyl-quinoline-3-carbohydrazide
  • 6-Methoxy-2-methyl-3-quinolinecarbohydrazide
  • AF-407/31882052
  • ZINC00268732
  • Oprea1_634306
  • MLS000699643
  • SMR000225383
  • Quinoline-3-carbohydrazide, 6-methoxy-2-methyl-
  • A2137/0089740

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.089 0.089
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0017 0.001 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Brugia malayi Carboxylesterase family protein 0.0017 0.001 0.001
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0026 0.0175 0.0196
Plasmodium falciparum exported lipase 2 0.0026 0.0175 0.0196
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0257 0.0279
Giardia lamblia Ribosomal protein L19 0.0027 0.0195 0.0543
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0257 0.0279
Mycobacterium ulcerans hypothetical protein 0.0049 0.0598 0.0766
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.126 0.2544
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0198 0.3336 0.4333
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0148 0.018
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0997 0.0997
Echinococcus multilocularis Phospholipase carboxylesterase 0.0026 0.0175 0.0354
Entamoeba histolytica hypothetical protein 0.0035 0.0346 0.0396
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0098 0.1508 0.1935
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0027 0.0195 0.0241
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0059 0.0786 0.1011
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0257 0.0348
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.056 1 1
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.017 0.0342
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0263 0.0532
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0243 0.049
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.009 0.136 0.1723
Toxoplasma gondii FATC domain-containing protein 0.0025 0.017 0.0217
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0048 0.0049
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.014 0.0127
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0148 0.018
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.126 0.2544
Trypanosoma cruzi heat shock protein, putative 0.0067 0.0928 0.1157
Loa Loa (eye worm) carboxylesterase 0.0017 0.001 0.001
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0607 0.0778
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.0175 0.0216
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.0175 0.0216
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.05 0.05
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0329 0.0456
Brugia malayi nuclear receptor NHR-88 0.002 0.0064 0.0064
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0142 0.0176
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.0175 0.0216
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Onchocerca volvulus 0.0058 0.0775 0.1855
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.017 0.0165
Trypanosoma brucei heat shock protein 90, putative 0.01 0.1545 0.1965
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0048 0.0049
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0064 0.0064
Echinococcus granulosus neuroligin 0.0017 0.001 0.002
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0086 0.1279 0.2584
Trichomonas vaginalis heat shock protein, putative 0.0094 0.1432 0.1853
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0029 0.0238 0.0254
Schistosoma mansoni 60S ribosomal protein L19 0.0027 0.0195 0.0407
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0329 0.0374
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0598 0.0726
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0175 0.0216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0018 0.0011
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0026 0.0175 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0026 0.0175 0.0173
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0043 0.0043
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0048 0.0049
Onchocerca volvulus 0.0241 0.4135 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0064 0.013
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0329 0.0329
Schistosoma mansoni tar DNA-binding protein 0.0064 0.089 0.1857
Echinococcus granulosus ribosomal protein L19 0.0027 0.0195 0.0393
Plasmodium falciparum pyruvate kinase 0.0034 0.0329 0.0396
Giardia lamblia PHD finger protein 15 0.0034 0.0331 0.0978
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0331 0.0459
Entamoeba histolytica hypothetical protein 0.0024 0.0142 0.013
Schistosoma mansoni peptidase 0.0026 0.0175 0.0366
Plasmodium vivax unspecified product 0.0026 0.0175 0.0196
Loa Loa (eye worm) hypothetical protein 0.0027 0.0195 0.0195
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0257 0.0302
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0148 0.0138
Entamoeba histolytica hypothetical protein 0.0026 0.0175 0.0173
Loa Loa (eye worm) hypothetical protein 0.0046 0.0543 0.0543
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0094 0.1432 0.171
Trypanosoma brucei trypanothione reductase 0.0087 0.1297 0.164
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0064 0.013
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.141 0.1823
Chlamydia trachomatis hydrolase 0.0026 0.0175 0.1051
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Trypanosoma brucei heat shock protein 90, putative 0.01 0.1545 0.1965
Trichomonas vaginalis chromobox protein, putative 0.0081 0.12 0.1551
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0036 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0257 0.0279
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.022 0.3741 0.4861
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.009 0.136 0.136
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0048 0.0006
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0064 0.0134
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0462 0.0462
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0257 0.0279
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0148 0.0148
Echinococcus multilocularis citrate lyase subunit beta protein 0.0049 0.0598 0.1208
Loa Loa (eye worm) hypothetical protein 0.0022 0.0104 0.0104
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1052 0.2197
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.3597 0.3597
Echinococcus granulosus geminin 0.0172 0.2874 0.5804
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0067 0.0928 0.1873
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Brugia malayi hypothetical protein 0.0286 0.4952 0.4952
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.05 0.0597
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0064 0.0134
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0434 0.7686 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0362 0.0362
Echinococcus multilocularis pyruvate kinase 0.0017 0.0025 0.0051
Leishmania major hypothetical protein, conserved 0.0026 0.0175 0.0173
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0048 0.0099
Toxoplasma gondii heat shock protein HSP90 0.01 0.1545 0.2284
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0175 0.0196
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0043 0.009
Schistosoma mansoni tar DNA-binding protein 0.0064 0.089 0.1857
Chlamydia trachomatis pyruvate kinase 0.0034 0.0329 0.221
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.003 0.0253 0.0275
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0198 0.3336 0.4333
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0187 0.3148 0.6358
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0576 0.1163
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.4952 1
Echinococcus multilocularis acetylcholinesterase 0.0098 0.151 0.3049
Loa Loa (eye worm) hypothetical protein 0.0125 0.1996 0.1996
Toxoplasma gondii hypothetical protein 0.0026 0.0175 0.0226
Onchocerca volvulus Serine\/threonine kinase homolog 0.0187 0.3148 0.7608
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1052 0.1358
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.009 0.136 0.1723
Trypanosoma cruzi heat shock protein 90, putative 0.01 0.1545 0.1965
Loa Loa (eye worm) glutathione reductase 0.0087 0.1297 0.1297
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0048 0.0049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0198 0.3336 0.4333
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0048 0.0006
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0048 0.0006
Plasmodium falciparum esterase, putative 0.0026 0.0175 0.0196
Plasmodium falciparum epoxide hydrolase 2 0.0026 0.0175 0.0196
Plasmodium falciparum glutathione reductase 0.003 0.0257 0.0302
Schistosoma mansoni heat shock protein 0.0067 0.0928 0.1936
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0257 0.0302
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0148 0.018
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0329 0.0773
Onchocerca volvulus 0.0085 0.126 0.303
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.009 0.136 0.2747
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0148 0.018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0175
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0148 0.018
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.009 0.136 1
Onchocerca volvulus 0.002 0.0064 0.0132
Onchocerca volvulus Alhambra homolog 0.0034 0.0331 0.0777
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0462 0.0965
Echinococcus granulosus para nitrobenzyl esterase 0.0017 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Loa Loa (eye worm) acetylcholinesterase 1 0.0098 0.151 0.151
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0257 0.0302
Echinococcus granulosus endoplasmin 0.0094 0.1432 0.2892
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0064 0.0064
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.009 0.136 0.2839
Entamoeba histolytica hypothetical protein 0.0026 0.0175 0.0173
Echinococcus multilocularis pyruvate kinase 0.0017 0.0025 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Trichomonas vaginalis heat shock protein, putative 0.0073 0.1041 0.1343
Echinococcus granulosus CREB binding protein 0.0178 0.2981 0.6019
Trichomonas vaginalis heat shock protein, putative 0.0086 0.1279 0.1654
Schistosoma mansoni thyroid hormone receptor 0.002 0.0064 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0064 0.0064
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0329 0.0374
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0098 0.1508 0.1935
Onchocerca volvulus 0.0024 0.0148 0.0336
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Echinococcus multilocularis dna polymerase eta 0.0043 0.05 0.1009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0064 0.0064
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0094 0.1432 0.1817
Loa Loa (eye worm) carboxylesterase 0.0017 0.001 0.001
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0257 0.0886
Plasmodium vivax PST-A protein 0.0026 0.0175 0.0196
Echinococcus multilocularis pyruvate kinase 0.0034 0.0329 0.0664
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.017 0.0354
Trypanosoma cruzi hypothetical protein, conserved 0.0422 0.746 0.9704
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0598 0.0726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0148 0.0148
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0331 0.0668
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Loa Loa (eye worm) heat shock protein 90 0.01 0.1545 0.1545
Echinococcus granulosus pyruvate kinase 0.0034 0.0329 0.0664
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0329 0.0415
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0187 0.3148 0.3148
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0098 0.1508 0.1951
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0257 0.0279
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0067 0.0928 0.1873
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0064 0.0134
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0329 0.0247
Schistosoma mansoni coup transcription factor 0.002 0.0064 0.0134
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0048 0.0096
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0175 0.0196
Echinococcus multilocularis ribosomal protein L19 0.0027 0.0195 0.0393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0064 0.013
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0331 0.0331
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0142 0.013
Plasmodium falciparum heat shock protein 90, putative 0.038 0.668 0.8687
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0198 0.3336 0.4234
Trypanosoma cruzi serine peptidase, putative 0.0026 0.0175 0.0173
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0329 0.0396
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1938 0.1938
Brugia malayi PHD-finger family protein 0.0034 0.0331 0.0331
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0067 0.0928 0.2225
Loa Loa (eye worm) hypothetical protein 0.0024 0.0148 0.0148
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0048 0.0096
Brugia malayi steroid hormone receptor 0.002 0.0064 0.0064
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.017 0.0165
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0434 0.7686 1
Toxoplasma gondii thioredoxin reductase 0.0087 0.1297 0.1911
Schistosoma mansoni tar DNA-binding protein 0.0064 0.089 0.1857
Leishmania major trypanothione reductase 0.0087 0.1297 0.164
Trypanosoma brucei unspecified product 0.0019 0.0048 0.0006
Brugia malayi glutathione reductase 0.0087 0.1297 0.1297
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Plasmodium falciparum lysophospholipase, putative 0.0026 0.0175 0.0196
Echinococcus multilocularis pyruvate kinase 0.0017 0.0025 0.0051
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0098 0.1508 0.1951
Echinococcus multilocularis thioredoxin glutathione reductase 0.0087 0.1306 0.2638
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0064 0.013
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0142 0.013
Leishmania major monoglyceride lipase, putative 0.0434 0.7686 1
Entamoeba histolytica hypothetical protein 0.0025 0.017 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0298 0.0376
Echinococcus multilocularis heat shock protein 90 0.01 0.1545 0.3121
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0094 0.1432 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0044 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.001 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0434 0.7686 1
Plasmodium vivax PST-A protein 0.0026 0.0175 0.0196
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Schistosoma mansoni gliotactin 0.0017 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0175
Echinococcus granulosus acetylcholinesterase 0.0098 0.151 0.3049
Schistosoma mansoni hypothetical protein 0.0172 0.2874 0.5999
Trypanosoma cruzi hypothetical protein, conserved 0.0422 0.746 0.9704
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0059 0.0786 0.1143
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0064 0.0134
Echinococcus granulosus dna polymerase kappa 0.0019 0.0048 0.0096
Plasmodium vivax PST-A protein 0.0026 0.0175 0.0196
Entamoeba histolytica serine/threonine protein kinase, putative 0.0187 0.3148 0.4063
Schistosoma mansoni hypothetical protein 0.0035 0.0346 0.0723
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Toxoplasma gondii protein c14orf29, putative 0.0026 0.0175 0.0226
Leishmania major pyruvate kinase 0.0034 0.0329 0.0374
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0064 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0064 0.013
Echinococcus multilocularis peregrin 0.0034 0.0331 0.0668
Echinococcus multilocularis BC026374 protein (S09 family) 0.0017 0.001 0.002
Onchocerca volvulus Huntingtin homolog 0.0125 0.1996 0.4815
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0434 0.7686 1
Toxoplasma gondii phospholipase 0.0026 0.0175 0.0226
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0434 0.7686 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0148 0.0138
Loa Loa (eye worm) hypothetical protein 0.0051 0.0637 0.0637
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0064 0.0064
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0026 0.0175 0.0196
Brugia malayi hypothetical protein 0.0017 0.001 0.001
Mycobacterium ulcerans hypothetical protein 0.0434 0.7686 1
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0027 0.0195 0.0241
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0098 0.151 0.3152
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0329 0.0374
Loa Loa (eye worm) hypothetical protein 0.0286 0.4952 0.4952
Plasmodium vivax PST-A protein 0.0026 0.0175 0.0196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0064 0.0064
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0175 0.0196
Entamoeba histolytica hypothetical protein 0.0035 0.0346 0.0396
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0043 0.009
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Mycobacterium tuberculosis Probable oxidoreductase 0.022 0.3741 0.4861
Leishmania major 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Plasmodium falciparum phd finger protein, putative 0.0034 0.0331 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0064 0.0064
Onchocerca volvulus 0.0036 0.0362 0.0854
Plasmodium vivax PST-A protein 0.0026 0.0175 0.0196
Loa Loa (eye worm) heat shock protein 75 0.0067 0.0928 0.0928
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.011 0.011
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0257 0.0321
Echinococcus granulosus ribosomal protein L19 0.0027 0.0195 0.0393
Plasmodium falciparum lysophospholipase, putative 0.0434 0.7686 1
Schistosoma mansoni acetylcholinesterase 0.0017 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0331 0.0668
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0026 0.0175 0.0173
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Trypanosoma cruzi heat shock protein 90, putative 0.0042 0.0476 0.0566
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0257 0.0279
Plasmodium falciparum 60S ribosomal protein L19 0.0027 0.0195 0.0221
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Loa Loa (eye worm) hypothetical protein 0.0024 0.014 0.014
Trypanosoma cruzi monoglyceride lipase, putative 0.0434 0.7686 1
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Brugia malayi glucose-6-phosphate dehydrogenase 0.009 0.136 0.136
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0043 0.0087
Echinococcus granulosus acetylcholinesterase 0.0098 0.151 0.3049
Plasmodium falciparum heat shock protein 90 0.01 0.1545 0.1984
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0064 0.0064
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0026 0.0175 0.0173
Echinococcus granulosus dna polymerase eta 0.0043 0.05 0.1009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.017 0.017
Trichomonas vaginalis heat shock protein, putative 0.0094 0.1432 0.1853
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0148 0.0138
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0026 0.0175 0.0366
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0607 0.1447
Brugia malayi Bromodomain containing protein 0.0034 0.0331 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0064 0.0064
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0329 0.0415
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0257 0.0886
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0178 0.2981 0.6221
Echinococcus granulosus serine protein kinase ATM 0.0025 0.017 0.0342
Toxoplasma gondii hypothetical protein 0.0026 0.0175 0.0226
Plasmodium falciparum BEM46-like protein, putative 0.0026 0.0175 0.0196
Toxoplasma gondii Hsp90 domain-containing protein 0.038 0.668 1
Entamoeba histolytica hypothetical protein 0.0035 0.0346 0.0396
Echinococcus multilocularis tar DNA binding protein 0.0064 0.089 0.1797
Plasmodium vivax PST-A protein 0.0434 0.7686 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0064 0.013
Loa Loa (eye worm) CBP-B 0.0178 0.2981 0.2981
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0026 0.0175 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Leishmania major 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Echinococcus granulosus thioredoxin glutathione reductase 0.0087 0.1306 0.2638
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0257 0.0536
Schistosoma mansoni neuroligin 3 (S09 family) 0.0017 0.001 0.0021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0064 0.0064
Giardia lamblia Heat shock protein HSP 90-alpha 0.0086 0.1279 0.4016
Mycobacterium tuberculosis Possible lysophospholipase 0.0434 0.7686 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0048 0.0072
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0026 0.0175 0.0216
Trypanosoma cruzi heat shock protein 85, putative 0.0086 0.1279 0.1618
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0187 0.3148 0.6358
Brugia malayi nuclear hormone receptor 0.002 0.0064 0.0064
Loa Loa (eye worm) endoplasmin 0.01 0.1545 0.1545
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1052 0.2125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0035 0.0342 0.0342
Loa Loa (eye worm) TAR-binding protein 0.0064 0.089 0.089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Brugia malayi Pre-SET motif family protein 0.003 0.0263 0.0263
Echinococcus granulosus peregrin 0.0034 0.0331 0.0668
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0346 0.0699
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0024 0.0148 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Leishmania major DNA polymerase eta, putative 0.0043 0.05 0.0597
Echinococcus multilocularis heat shock protein 0.01 0.1545 0.3121
Plasmodium falciparum lysophospholipase, putative 0.0026 0.0175 0.0196
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0027 0.0195 0.0241
Echinococcus granulosus Phospholipase carboxylesterase 0.0026 0.0175 0.0354
Schistosoma mansoni heat shock protein 0.01 0.1545 0.3226
Echinococcus multilocularis ribosomal protein L19 0.0027 0.0195 0.0393
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0049 0.0598 0.0766
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0142 0.0153
Plasmodium vivax thioredoxin reductase, putative 0.0087 0.1297 0.166
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0026 0.0175 0.0366
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0434 0.7686 1
Schistosoma mansoni pyruvate kinase 0.0034 0.0329 0.0686
Echinococcus multilocularis para nitrobenzyl esterase 0.0017 0.001 0.002
Echinococcus granulosus heat shock protein 90 0.0086 0.1279 0.2584
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0043 0.0043
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0142 0.0153
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0329 0.0329
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0434 0.7686 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0064 0.013
Brugia malayi TAZ zinc finger family protein 0.0178 0.2981 0.2981
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0064 0.0134
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0142 0.0801
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0187 0.3148 0.4063
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0048 0.0049
Plasmodium vivax alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0048 0.0096
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0148 0.0138
Brugia malayi MGC83647 protein 0.0026 0.0175 0.0175
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0142 0.0176
Mycobacterium ulcerans heat shock protein 90 0.0094 0.1432 0.1853
Plasmodium falciparum heat shock protein 90, putative 0.0058 0.0775 0.0978
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0064 0.0134
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0434 0.7686 1
Giardia lamblia Kinase, PLK 0.0187 0.3148 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.022 0.3741 0.4861
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0142 0.0172
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0148 0.0008
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0331 0.0459
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0087 0.1297 0.1676
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0064 0.0064
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0048 0.0048
Onchocerca volvulus Huntingtin homolog 0.0125 0.1996 0.4815
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0064 0.013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0637 0.0637
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0064 0.0064
Echinococcus granulosus chromobox protein 1 0.0081 0.12 0.2424
Chlamydia trachomatis acyltransferase family protein 0.0026 0.0175 0.1051
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0462 0.0934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0329 0.0773
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1052 0.1543
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.141 0.1823
Trypanosoma brucei polo-like protein kinase 0.0187 0.3148 0.4063
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Echinococcus multilocularis chromobox protein 1 0.0081 0.12 0.2424
Entamoeba histolytica hypothetical protein 0.0035 0.0346 0.0396
Echinococcus granulosus pyruvate kinase 0.0017 0.0025 0.0051
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0462 0.0965
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0148 0.018
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0543 0.0695
Echinococcus granulosus abhydrolase domain containing protein 13 0.0026 0.0175 0.0354
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Echinococcus multilocularis neuroligin 0.0017 0.001 0.002
Schistosoma mansoni hypothetical protein 0.0034 0.0331 0.069
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0257 0.0279
Brugia malayi Protein C20orf22 0.0026 0.0175 0.0175
Echinococcus multilocularis geminin 0.0172 0.2874 0.5804
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0329 0.0773
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0064 0.0064
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Brugia malayi hypothetical protein 0.0125 0.1996 0.1996
Schistosoma mansoni CREB-binding protein 2 0.0178 0.2981 0.6221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0043 0.05 0.05
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.4952 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0064 0.013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0064 0.0064
Leishmania major heat shock protein, putative 0.0067 0.0928 0.1157
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0607 0.0778
Onchocerca volvulus 0.0044 0.0508 0.1207
Trichomonas vaginalis endoplasmin, putative 0.0073 0.1041 0.1343
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0264 0.0358
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Brugia malayi Carboxylesterase family protein 0.0098 0.151 0.151
Brugia malayi Carboxylesterase family protein 0.0017 0.001 0.001
Echinococcus granulosus heat shock protein 90 0.01 0.1545 0.3121
Loa Loa (eye worm) hypothetical protein 0.0098 0.151 0.151
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0098 0.1508 0.4747
Echinococcus granulosus heat shock protein 0.01 0.1545 0.3121
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0036 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.009 0.136 0.1759
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0026 0.0175 0.0173
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Trichomonas vaginalis heat shock protein, putative 0.0058 0.0775 0.0996
Trichomonas vaginalis conserved hypothetical protein 0.0434 0.7686 1
Giardia lamblia GTOR 0.0018 0.0043 0.0058
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0043 0.0027
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.011 0.011
Plasmodium vivax glutathione reductase, putative 0.0087 0.1297 0.166
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0026 0.0175 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0543 0.0695
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0043 0.0043
Treponema pallidum heat shock protein 90 0.0094 0.1432 1
Plasmodium vivax endoplasmin, putative 0.01 0.1545 0.1984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.089 0.089
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0198 0.3336 0.4333
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Trypanosoma cruzi Heat shock protein 83, putative 0.01 0.1545 0.1965
Schistosoma mansoni tar DNA-binding protein 0.0064 0.089 0.1857
Loa Loa (eye worm) RNA binding protein 0.0064 0.089 0.089
Echinococcus multilocularis pyruvate kinase 0.0027 0.0197 0.0399
Brugia malayi Carboxylesterase family protein 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Toxoplasma gondii hypothetical protein 0.0026 0.0175 0.0226
Echinococcus multilocularis carboxylesterase 5A 0.0098 0.151 0.3049
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0257 0.0302
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0175
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0036 0.0014
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0048 0.0099
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0331 0.069
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0064 0.0132
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0434 0.7686 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Echinococcus granulosus pyruvate kinase 0.0017 0.0025 0.0051
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0098 0.1508 0.2228
Plasmodium falciparum lysophospholipase, putative 0.0434 0.7686 1
Trypanosoma cruzi heat shock protein 85, putative 0.01 0.1545 0.1965
Brugia malayi serine/threonine-protein kinase plk-2 0.0187 0.3148 0.3148
Schistosoma mansoni chromobox protein 0.0081 0.12 0.2505
Loa Loa (eye worm) carboxylesterase 0.0098 0.151 0.151
Schistosoma mansoni BC026374 protein (S09 family) 0.0017 0.001 0.0021
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0064 0.0132
Echinococcus multilocularis chromobox protein 1 0.0081 0.12 0.2424
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0027 0.0195 0.0241
Brugia malayi Carboxylesterase family protein 0.0098 0.151 0.151
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0331 0.0399
Toxoplasma gondii hypothetical protein 0.0026 0.0175 0.0226
Echinococcus granulosus pyruvate kinase 0.0034 0.0329 0.0664
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.3148 0.4063
Entamoeba histolytica ;Alias 0.0026 0.0175 0.0173
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0257 0.0518
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0148 0.018
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0148 0.0008
Brugia malayi Pre-SET motif family protein 0.0212 0.3597 0.3597
Toxoplasma gondii peptidase S15, putative 0.0026 0.0175 0.0226
Plasmodium vivax lysophospholipase, putative 0.0026 0.0175 0.0196
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Trichomonas vaginalis heat shock protein, putative 0.01 0.1545 0.2
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0036 0.0014
Trypanosoma brucei Heat shock protein 83, putative 0.01 0.1545 0.1965
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0257 0.0321
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0112 0.1754 0.3542
Trypanosoma cruzi heat shock protein 85, putative 0.01 0.1545 0.1965
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0026 0.0175 0.0354
Loa Loa (eye worm) hypothetical protein 0.0125 0.1996 0.1996
Echinococcus multilocularis endoplasmin 0.0094 0.1432 0.2892
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Loa Loa (eye worm) thioredoxin reductase 0.0087 0.1297 0.1297
Brugia malayi MGC79044 protein 0.0026 0.0175 0.0175
Trichomonas vaginalis chromobox protein, putative 0.0081 0.12 0.1551
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0064 0.0064
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0257 0.0518
Brugia malayi TAR-binding protein 0.0064 0.089 0.089
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.0175 0.0216
Trypanosoma cruzi serine peptidase, putative 0.0026 0.0175 0.0173
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0637 0.0637
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0462 0.0934
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.017 0.0208
Brugia malayi Carboxylesterase family protein 0.0017 0.001 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0148 0.0138
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0346 0.0723
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0064 0.013
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0049 0.0598 0.0766
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0264 0.0288
Brugia malayi heat shock protein 90 0.01 0.1545 0.1545
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0064 0.0064
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0043 0.0087
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0175
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0043 0.0087
Mycobacterium ulcerans hypothetical protein 0.0049 0.0598 0.0766
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0058 0.0778 0.0778
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1052 0.1358
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0067 0.0928 0.1157
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0543 0.1293
Schistosoma mansoni thyroid hormone receptor 0.002 0.0064 0.0134
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.001 0.0021
Plasmodium vivax heat shock protein 86, putative 0.01 0.1545 0.1984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0257 0.0348
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Brugia malayi 60S ribosomal protein L19 0.0027 0.0195 0.0195
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Plasmodium vivax 60S ribosomal protein L19, putative 0.0027 0.0195 0.0221
Echinococcus granulosus pyruvate kinase 0.0017 0.0025 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Trypanosoma cruzi heat shock protein 85, putative 0.01 0.1545 0.1965
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0064 0.013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0064 0.0064
Brugia malayi Hsp90 protein 0.0067 0.0928 0.0928
Schistosoma mansoni survival motor neuron protein 0.0058 0.0775 0.1618
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Echinococcus granulosus FTZ F1 alpha 0.002 0.0064 0.013
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0104 0.008
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0044 0.0001
Echinococcus granulosus carboxylesterase 5A 0.0098 0.151 0.3049
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Echinococcus granulosus abhydrolase domain containing 3 0.0026 0.0175 0.0354
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0775 0.0775
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0026 0.0175 0.0173
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.022 0.3741 0.4771
Schistosoma mansoni tar DNA-binding protein 0.0064 0.089 0.1857
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0257 0.0257
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0329 0.0415
Plasmodium falciparum thioredoxin reductase 0.003 0.0257 0.0302
Toxoplasma gondii phospholipase/carboxylesterase 0.0026 0.0175 0.0226
Plasmodium falciparum esterase, putative 0.0026 0.0175 0.0196
Plasmodium vivax lysophospholipase, putative 0.0026 0.0175 0.0196
Plasmodium vivax lysophospholipase, putative 0.0026 0.0175 0.0196
Leishmania major hypothetical protein, conserved 0.0026 0.0175 0.0173
Mycobacterium tuberculosis Probable dehydrogenase 0.0198 0.3336 0.4333
Leishmania major DNA polymerase eta, putative 0.003 0.0264 0.0288
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0049 0.0598 0.0766
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0026 0.0175 0.0226
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0064 0.013
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0048 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0263 0.0532
Brugia malayi Thioredoxin reductase 0.0087 0.1297 0.1297
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Trypanosoma brucei monoglyceride lipase, putative 0.0434 0.7686 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0048 0.0049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0175
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0064 0.0134
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0257 0.0321
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.126 0.263
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0064 0.0134
Toxoplasma gondii heat shock protein 75, putative 0.0067 0.0928 0.1356
Brugia malayi RNA binding protein 0.0064 0.089 0.089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0064 0.0064
Brugia malayi hypothetical protein 0.0035 0.0346 0.0346
Leishmania major hypothetical protein, conserved 0.0422 0.746 0.9704
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0257 0.0741
Toxoplasma gondii ribosomal protein RPL19 0.0027 0.0195 0.0255
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Mycobacterium tuberculosis Conserved protein 0.0049 0.0598 0.0766
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0026 0.0175 0.0226
Plasmodium falciparum glutathione reductase 0.0087 0.1297 0.166
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0064 0.013
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0026 0.0175 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.0175 0.0216
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1052 0.1358
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0329 0.0374
Echinococcus multilocularis CREB binding protein 0.0178 0.2981 0.6019
Schistosoma mansoni hypothetical protein 0.0035 0.0342 0.0715
Mycobacterium tuberculosis Probable reductase 0.0198 0.3336 0.4333
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0017 0.001 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0263 0.0358
Plasmodium falciparum thioredoxin reductase 0.0087 0.1297 0.166
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1052 0.2125
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0508 0.106
Schistosoma mansoni pyruvate kinase 0.0017 0.0025 0.0053
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Trypanosoma brucei hypothetical protein, conserved 0.0422 0.746 0.9704
Schistosoma mansoni nuclear hormone receptor 0.002 0.0064 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Echinococcus granulosus citrate lyase subunit beta protein 0.0049 0.0598 0.1208
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.009 0.136 0.9442
Echinococcus granulosus chromobox protein 1 0.0081 0.12 0.2424
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0064 0.0064
Brugia malayi ecdysteroid receptor 0.002 0.0064 0.0064
Mycobacterium ulcerans hydrolase 0.0026 0.0175 0.0216
Entamoeba histolytica heat shock protein 90, putative 0.01 0.1545 0.1965
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0026 0.0175 0.0481
Echinococcus multilocularis abhydrolase domain containing 3 0.0026 0.0175 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0263 0.0532
Plasmodium vivax SET domain protein, putative 0.003 0.0263 0.0311
Loa Loa (eye worm) hypothetical protein 0.0098 0.151 0.151
Plasmodium falciparum endoplasmin, putative 0.0073 0.1041 0.1326
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.05 0.0597
Schistosoma mansoni hypothetical protein 0.0172 0.2874 0.5999
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.3148 0.6572
Plasmodium vivax heat shock protein, putative 0.038 0.668 0.8687
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Leishmania major pyruvate kinase 0.0034 0.0329 0.0374
Trypanosoma brucei heat shock protein 84, putative 0.0067 0.0928 0.1157
Loa Loa (eye worm) hypothetical protein 0.0085 0.126 0.126
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.1297 0.164
Mycobacterium ulcerans hypothetical protein 0.0026 0.0175 0.0216
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0346 0.0699
Plasmodium falciparum prodrug activation and resistance esterase 0.0026 0.0175 0.0196
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0598 0.0726
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0257 0.0279
Brugia malayi chromobox protein homolog 3 0.0046 0.0543 0.0543
Plasmodium falciparum exported lipase 1 0.0026 0.0175 0.0196
Echinococcus multilocularis pyruvate kinase 0.0034 0.0329 0.0664
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1052 0.2197
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0018 0.0011
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0257 0.1664
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0064 0.0064
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0112 0.1754 0.3542
Brugia malayi jmjC domain containing protein 0.0041 0.0462 0.0462
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0048 0.0048
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0026 0.0175 0.0226
Plasmodium vivax heat shock protein 90, putative 0.0067 0.0928 0.1178
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0329 0.0329
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0048 0.0006
Echinococcus granulosus tar DNA binding protein 0.0064 0.089 0.1797
Schistosoma mansoni endoplasmin 0.01 0.1545 0.3226
Echinococcus multilocularis acetylcholinesterase 0.0098 0.151 0.3049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.055
Plasmodium falciparum lysophospholipase, putative 0.0434 0.7686 1
Brugia malayi jmjC domain containing protein 0.0112 0.1754 0.1754
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0043 0.0087
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0142 0.0172
Brugia malayi MH2 domain containing protein 0.0122 0.1938 0.1938
Echinococcus granulosus CREB binding protein 0.0178 0.2981 0.6019
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0049 0.0598 0.0766
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0018 0.0011
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0257 0.0321
Giardia lamblia Heat shock protein HSP 90-alpha 0.01 0.1545 0.4867
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0257 0.0321
Entamoeba histolytica heat shock protein 90, putative 0.01 0.1545 0.1965
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0064 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0576 0.1163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0298 0.0376
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0342 0.0342
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0148 0.0138
Loa Loa (eye worm) hypothetical protein 0.003 0.0263 0.0263
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0329 0.0415
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0257 0.0321
Mycobacterium ulcerans hypothetical protein 0.0026 0.0175 0.0216
Trypanosoma cruzi heat shock protein 90, putative 0.0086 0.1279 0.1618
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0148 0.0148
Schistosoma mansoni DNA polymerase eta 0.0043 0.05 0.1043
Trypanosoma brucei monoglyceride lipase, putative 0.0434 0.7686 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0026 0.0175 0.0173
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0064 0.0132
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0049 0.0598 0.0766
Echinococcus granulosus BC026374 protein S09 family 0.0017 0.001 0.002
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.009 0.136 0.1723
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0031 0.0279 0.0351
Echinococcus multilocularis heat shock protein 90 0.0086 0.1279 0.2584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0064 0.013
Schistosoma mansoni chromobox protein 0.0081 0.12 0.2505
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0148 0.018
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Schistosoma mansoni endoplasmin 0.01 0.1545 0.3226
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Toxoplasma gondii heat shock protein 90, putative 0.01 0.1545 0.2284
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.001 0.0021
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0026 0.0175 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.055
Mycobacterium ulcerans hypothetical protein 0.0024 0.0148 0.018
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.009 0.136 0.2747
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0148 0.0148
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0094 0.1432 0.1853
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0026 0.0175 0.0354
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0064 0.013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0637 0.0637
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1938 0.1938
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1052 0.132
Plasmodium vivax alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Mycobacterium ulcerans lysophospholipase 0.0434 0.7686 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.126 0.126
Schistosoma mansoni pyruvate kinase 0.0034 0.0329 0.0686
Schistosoma mansoni hypothetical protein 0.0058 0.0775 0.1618
Plasmodium vivax unspecified product 0.0026 0.0175 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0434 0.7686 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0026 0.0175 0.0216
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Brugia malayi Endoplasmin precursor 0.01 0.1545 0.1545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0329 0.0329
Schistosoma mansoni heat shock protein 0.01 0.1545 0.3226
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0018 0.0011
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0257 0.0279
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0329 0.0329
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0064 0.013
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0026 0.0175 0.0216
Plasmodium falciparum esterase, putative 0.0434 0.7686 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1052 0.1358
Loa Loa (eye worm) hypothetical protein 0.0034 0.0331 0.0331
Treponema pallidum NADH oxidase 0.003 0.0257 0.0886
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0098 0.1508 0.1951
Schistosoma mansoni jumonji domain containing protein 0.0089 0.1333 0.2783
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0142 0.0172
Trichomonas vaginalis set domain proteins, putative 0.0241 0.4135 0.5374
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0148 0.018
Loa Loa (eye worm) heterochromatin protein 1 0.0081 0.12 0.12
Giardia lamblia Pyruvate kinase 0.0034 0.0329 0.0972
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.3148 0.4063
Giardia lamblia Grp94/Hsp90 0.0094 0.1432 0.4505
Loa Loa (eye worm) hypothetical protein 0.0034 0.0329 0.0329
Brugia malayi Heterochromatin protein 1 0.0081 0.12 0.12
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0064 0.0134
Schistosoma mansoni kinase 0.0095 0.1455 0.3037

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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