Detailed information for compound 1285257

Basic information

Technical information
  • TDR Targets ID: 1285257
  • Name: (5Z)-3-(1,1-dioxothiolan-3-yl)-5-[[1-phenyl-3 -(4-propoxyphenyl)pyrazol-4-yl]methylidene]-2 -sulfanylidene-1,3-thiazolidin-4-one
  • MW: 539.689 | Formula: C26H25N3O4S3
  • H donors: 0 H acceptors: 4 LogP: 5.05 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCOc1ccc(cc1)c1nn(cc1/C=C/1\SC(=S)N(C1=O)C1CCS(=O)(=O)C1)c1ccccc1
  • InChi: 1S/C26H25N3O4S3/c1-2-13-33-22-10-8-18(9-11-22)24-19(16-28(27-24)20-6-4-3-5-7-20)15-23-25(30)29(26(34)35-23)21-12-14-36(31,32)17-21/h3-11,15-16,21H,2,12-14,17H2,1H3/b23-15-
  • InChiKey: LIYTVFAOBHTWGS-HAHDFKILSA-N  


Substructure search Similarity search

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Synonyms

  • 3-(1,1-dioxothiolan-3-yl)-5-[[1-phenyl-3-(4-propoxyphenyl)pyrazol-4-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
  • (5Z)-3-(1,1-dioxothiolan-3-yl)-5-[[1-phenyl-3-(4-propoxyphenyl)pyrazol-4-yl]methylene]-2-thioxo-thiazolidin-4-one
  • 3-(1,1-dioxothiolan-3-yl)-5-[[1-phenyl-3-(4-propoxyphenyl)pyrazol-4-yl]methylene]-2-thioxo-thiazolidin-4-one
  • (5Z)-3-(1,1-dioxo-3-thiolanyl)-5-[[1-phenyl-3-(4-propoxyphenyl)-4-pyrazolyl]methylene]-2-thioxo-4-thiazolidinone
  • 3-(1,1-dioxo-3-thiolanyl)-5-[[1-phenyl-3-(4-propoxyphenyl)-4-pyrazolyl]methylene]-2-thioxo-4-thiazolidinone
  • (5Z)-3-(1,1-diketothiolan-3-yl)-5-[[1-phenyl-3-(4-propoxyphenyl)pyrazol-4-yl]methylene]-2-thioxo-thiazolidin-4-one
  • 3-(1,1-diketothiolan-3-yl)-5-[[1-phenyl-3-(4-propoxyphenyl)pyrazol-4-yl]methylene]-2-thioxo-thiazolidin-4-one
  • 3-(1,1-Dioxo-tetrahydro-1lambda*6*-thiophen-3-yl)-5-[1-[1-phenyl-3-(4-propoxy-phenyl)-1H-pyrazol-4-yl] -meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one
  • ST5040698
  • SMR000149784
  • MLS000595261

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus Eph receptor A4 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K05109 Eph receptor A8, putative Get druggable targets OG5_126715 All targets in OG5_126715
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) TK/EPH protein kinase Get druggable targets OG5_126715 All targets in OG5_126715
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126715 All targets in OG5_126715
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126715 All targets in OG5_126715
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ephrin type A receptor 4 A Get druggable targets OG5_126715 All targets in OG5_126715
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi ephrin receptor 1 precursor Get druggable targets OG5_126715 All targets in OG5_126715
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ephrin receptor Get druggable targets OG5_126715 All targets in OG5_126715
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis ephrin type A receptor 4 A Get druggable targets OG5_126715 All targets in OG5_126715
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126715 All targets in OG5_126715
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0403 0.1777
Echinococcus multilocularis cysteine protease 0.002 0.0225 0.0225
Plasmodium vivax tyrosine kinase-like protein, putative 0.001 0.0017 0.0053
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.176 0.2487
Plasmodium vivax vivapain-2 0.002 0.0225 0.1593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0206 0.0927
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2162 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1359 0.1921
Loa Loa (eye worm) hypothetical protein 0.0014 0.0087 0.0123
Schistosoma mansoni hypothetical protein 0.0354 0.711 0.711
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0015 0.012 0.0169
Leishmania major cathepsin L-like protease 0.002 0.0225 0.0097
Loa Loa (eye worm) hypothetical protein 0.0075 0.1359 0.1921
Schistosoma mansoni hypothetical protein 0.0033 0.0484 0.0484
Trichomonas vaginalis importin beta-1, putative 0.0027 0.036 0.1639
Toxoplasma gondii ABC1 family protein 0.0075 0.1359 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1397 0.6427
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.1956 0.2765
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0206 0.0858
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1397 0.6427
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0403 0.1777
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0403 0.2926
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0562 0.0562
Brugia malayi PHD-finger family protein 0.0059 0.1033 0.3166
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.1359 0.6276
Leishmania major cathepsin L-like protease 0.0077 0.1397 0.6092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Mycobacterium leprae Probable lipase LipE 0.0075 0.1359 1
Onchocerca volvulus Cathepsin F homolog 0.002 0.0225 0.0665
Trypanosoma cruzi ISWI complex protein 0.0033 0.0484 0.2159
Plasmodium falciparum cysteine proteinase falcipain 1 0.001 0.0023 0.0078
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.2162 0.6628
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2162 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1321 0.9669
Schistosoma mansoni zinc finger protein 0.0033 0.0484 0.0484
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0206 0.0927
Echinococcus granulosus ephrin type A receptor 4 A 0.0078 0.1412 0.1412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0225 0.1014
Brugia malayi Inositol-1 0.0045 0.0728 0.2233
Loa Loa (eye worm) hypothetical protein 0.0014 0.0087 0.0123
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0309 0.0525
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.005 0.0846 0.0846
Brugia malayi hypothetical protein 0.0029 0.0403 0.1235
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0087 0.0301
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1321 0.1321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1397 0.6427
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0728 0.3298
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0309 0.1337
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.1359 0.1359
Echinococcus granulosus cathepsin L 0.001 0.0023 0.0023
Schistosoma mansoni zinc finger protein 0.0048 0.0797 0.0797
Schistosoma mansoni cpg binding protein 0.0035 0.0523 0.0523
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0075 0.0075
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1359 0.6276
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.3063 0.3063
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0728 0.5333
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1321 0.1321
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0206 0.0291
Schistosoma mansoni hypothetical protein 0.0071 0.1276 0.1276
Toxoplasma gondii exonuclease III APE 0.0019 0.0206 0.147
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0488 0.2178
Loa Loa (eye worm) hypothetical protein 0.0071 0.1276 0.1804
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.176 0.176
Leishmania major cathepsin L-like protease 0.002 0.0225 0.0097
Echinococcus multilocularis fetal alzheimer antigen, falz 0.005 0.0846 0.0846
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0225 0.1014
Entamoeba histolytica hypothetical protein 0.0035 0.0527 0.2356
Echinococcus multilocularis snurportin 1 0.0352 0.7074 0.7074
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0134 0.2571 0.2571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0087 0.0374
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0309 0.0947
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.176 0.176
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0728 0.0728
Echinococcus granulosus snurportin 1 0.0352 0.7074 0.7074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1397 0.6427
Loa Loa (eye worm) hypothetical protein 0.0082 0.1505 0.2127
Brugia malayi cathepsin L-like precursor 0.0014 0.0087 0.0267
Entamoeba histolytica hypothetical protein 0.0035 0.0527 0.2356
Echinococcus granulosus cysteine protease 0.001 0.0023 0.0023
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0053 0.0897 0.4134
Leishmania major cathepsin L-like protease 0.0077 0.1397 0.6092
Schistosoma mansoni hypothetical protein 0.0033 0.0487 0.0487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Loa Loa (eye worm) TK/EPH protein kinase 0.0099 0.1847 0.261
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1359 0.6248
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.036 0.1639
Brugia malayi Cathepsin L-like precursor 0.002 0.0225 0.069
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0527 0.0527
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.176 0.5395
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0523 0.074
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Schistosoma mansoni ran 0.0024 0.0309 0.0309
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2162 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Echinococcus multilocularis zinc finger protein 0.0048 0.0797 0.0797
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0206 0.0858
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1397 0.6427
Onchocerca volvulus Cathepsin L homolog 0.002 0.0225 0.0665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1397 0.6427
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0087 0.0087
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.1359 0.1921
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0225 0.0946
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0728 0.0728
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.1359 0.1212
Leishmania major hypothetical protein, conserved 0.0029 0.0403 0.1006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0728 0.3298
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.2162 0.3055
Mycobacterium tuberculosis Conserved protein 0.0075 0.1359 0.1212
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0728 0.3349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0087 0.0374
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.2162 0.2162
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0711 0.258
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0403 0.1777
Brugia malayi Cathepsin L-like precursor 0.002 0.0225 0.069
Leishmania major importin beta-1 subunit, putative 0.0027 0.036 0.0786
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0487 0.1495
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.2629 0.3716
Echinococcus granulosus GPCR family 2 0.0033 0.0487 0.0487
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0225 0.1014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0403 0.0569
Mycobacterium tuberculosis Possible penicillin-binding protein 0.048 0.9718 1
Brugia malayi ephrin receptor 1 precursor 0.0037 0.0573 0.1757
Mycobacterium tuberculosis Conserved protein 0.0075 0.1359 0.1212
Schistosoma mansoni importin beta-1 0.0033 0.0488 0.0488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Plasmodium vivax vivapain-1 0.001 0.0023 0.0093
Brugia malayi hypothetical protein 0.0019 0.0192 0.0589
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1321 0.9718
Trypanosoma brucei ISWI complex protein 0.0033 0.0484 0.2159
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0225 0.2996
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0711 1
Leishmania major cathepsin L-like protease 0.002 0.0225 0.0097
Mycobacterium ulcerans lipase LipD 0.0075 0.1359 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1359 0.1921
Loa Loa (eye worm) cysteine protease 0.002 0.0225 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0225 0.1014
Onchocerca volvulus 0.002 0.0225 0.0665
Brugia malayi CXXC zinc finger family protein 0.0035 0.0523 0.1605
Schistosoma mansoni hypothetical protein 0.0033 0.0487 0.0487
Onchocerca volvulus 0.002 0.0225 0.0665
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0075 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0023 0.0076
Echinococcus multilocularis cpg binding protein 0.0041 0.0649 0.0649
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.2629 0.3716
Mycobacterium ulcerans beta-lactamase 0.0075 0.1359 1
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.1359 0.1212
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.1359 0.1212
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.2162 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.036 0.1639
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.126 0.5783
Echinococcus granulosus fetal alzheimer antigen falz 0.005 0.0846 0.0846
Onchocerca volvulus 0.002 0.0225 0.0665
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1359 0.6248
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.1359 0.4167
Mycobacterium leprae conserved hypothetical protein 0.0075 0.1359 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0225 0.1014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1321 0.9669
Schistosoma mansoni cpg binding protein 0.0041 0.0649 0.0649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1397 0.6427
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0487 0.0689
Schistosoma mansoni hypothetical protein 0.0352 0.7074 0.7074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0578 0.0578
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.176 0.176
Leishmania major cysteine peptidase A (CPA) 0.002 0.0225 0.0097
Brugia malayi acetyltransferase, GNAT family protein 0.0167 0.3261 1
Schistosoma mansoni hypothetical protein 0.0013 0.0075 0.0075
Leishmania major cathepsin L-like protease 0.002 0.0225 0.0097
Schistosoma mansoni hypothetical protein 0.0044 0.072 0.072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1397 0.6427
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0632 0.0447
Trichomonas vaginalis bromodomain-containing protein, putative 0.0053 0.0897 0.4134
Brugia malayi Bromodomain containing protein 0.0167 0.3248 0.9959
Trypanosoma brucei polo-like protein kinase 0.0114 0.2162 1
Echinococcus multilocularis GPCR, family 2 0.0033 0.0487 0.0487
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.2162 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0053 0.0897 0.6578
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0029 0.0029
Schistosoma mansoni inositol monophosphatase 0.0045 0.0728 0.0728
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0206 0.0632
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0728 0.3298
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1397 0.6427
Echinococcus granulosus geminin 0.0354 0.711 0.711
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0728 0.3349
Brugia malayi beta-lactamase 0.0075 0.1359 0.4167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0225 0.1014
Plasmodium vivax unspecified product 0.001 0.0023 0.0093
Trichomonas vaginalis esterase, putative 0.0075 0.1359 0.6276
Echinococcus granulosus zinc finger protein 0.0048 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.002 0.0225 0.0318
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0728 0.4528
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0029 0.0029
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0728 0.267
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.072 0.1018
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0225 0.0225
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.2162 0.2162
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0225 0.069
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.1359 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1359 0.1921
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.1359 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0309 0.0309
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1397 0.6427
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0309 0.0309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1397 0.6427
Echinococcus multilocularis ephrin type A receptor 4 A 0.0078 0.1412 0.1412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1397 0.6427
Onchocerca volvulus 0.002 0.0225 0.0665
Trichomonas vaginalis ran, putative 0.0024 0.0309 0.1403
Onchocerca volvulus 0.0075 0.1359 0.6131
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2162 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2162 1
Leishmania major hypothetical protein, conserved 0.0033 0.0484 0.1424
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.1359 0.1212
Brugia malayi Importin beta-1 subunit 0.0033 0.0488 0.1498
Loa Loa (eye worm) bromodomain containing protein 0.0042 0.0671 0.0949
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0309 0.1337
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1321 0.5701
Brugia malayi Cathepsin L-like precursor 0.002 0.0225 0.069
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0728 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0225 0.0225
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0578 0.0578
Onchocerca volvulus 0.002 0.0225 0.0665
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0352 0.7074 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0225 0.0225
Plasmodium vivax hypothetical protein, conserved 0.0075 0.1359 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0225 0.1014
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0973 0.4485
Schistosoma mansoni kinase 0.0058 0.1004 0.1004
Loa Loa (eye worm) hypothetical protein 0.0104 0.1956 0.2765
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0167 0.3261 0.3261
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0309 0.0436
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0023 0.0023
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0309 0.1337
Schistosoma mansoni hypothetical protein 0.0033 0.0487 0.0487
Loa Loa (eye worm) hypothetical protein 0.0014 0.0087 0.0123
Loa Loa (eye worm) hypothetical protein 0.0033 0.0487 0.0689
Leishmania major cathepsin L-like protease 0.0077 0.1397 0.6092
Toxoplasma gondii histone lysine methyltransferase SET1 0.0075 0.135 0.9936
Schistosoma mansoni ap endonuclease 0.0019 0.0206 0.0206
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0206 0.2723
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0487 0.1495
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1397 0.6427
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.1956 0.5997
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.176 0.176
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0728 0.3349
Brugia malayi RNA, U transporter 1 0.0094 0.1743 0.5346
Onchocerca volvulus 0.0075 0.1359 0.6131
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0225 0.0225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1397 0.6427
Entamoeba histolytica Ran family GTPase 0.0024 0.0309 0.1337
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0206 0.0206
Loa Loa (eye worm) beta-lactamase 0.0075 0.1359 0.1921
Mycobacterium ulcerans hypothetical protein 0.0075 0.1359 1
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0403 0.2911
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1321 0.1321
Brugia malayi beta-lactamase family protein 0.0075 0.1359 0.4167
Schistosoma mansoni hypothetical protein 0.0035 0.0527 0.0527
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.1359 0.1212
Schistosoma mansoni bromodomain containing protein 0.0015 0.012 0.012
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1359 0.6276
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0527 0.0527
Echinococcus multilocularis cysteine protease 0.002 0.0225 0.0225
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0077 0.1397 0.1397
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0225 0.0225
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0487 0.0487
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0206 0.0858
Schistosoma mansoni bromodomain containing protein 0.0142 0.273 0.273
Onchocerca volvulus 0.0077 0.1394 0.6301
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0097 0.1817 0.2568
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0023 0.007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1321 0.9669
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0578 0.0578
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0711 0.3216
Loa Loa (eye worm) hypothetical protein 0.0075 0.1359 0.1921
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.0091 0.1692 0.2391
Schistosoma mansoni hypothetical protein 0.0354 0.711 0.711
Loa Loa (eye worm) hypothetical protein 0.0033 0.0488 0.069
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0206 0.0858
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0023 0.0023
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0206 0.1453
Leishmania major cathepsin L-like protease 0.002 0.0225 0.0097
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0023 0.0023
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0225 0.2996
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2162 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0225 0.1014
Loa Loa (eye worm) hypothetical protein 0.0077 0.1394 0.1971
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1326 0.1326
Loa Loa (eye worm) acetyltransferase 0.0167 0.3261 0.461
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0562 0.0562
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0225 0.0318
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.1359 0.1359
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0134 0.2571 0.2571
Leishmania major hypothetical protein, conserved 0.0075 0.1359 0.5896
Entamoeba histolytica hypothetical protein 0.0035 0.0527 0.2356
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0225 0.0225
Plasmodium vivax importin-beta 2, putative 0.0033 0.0488 0.3546
Plasmodium vivax vivapain-2 0.002 0.0225 0.1593
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0403 0.5561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0023 0.0076
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0309 0.2214
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0973 0.4485
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0023 0.007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0487 0.0487
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0225 0.1014
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0029 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2162 1
Brugia malayi Cathepsin L-like precursor 0.0014 0.0087 0.0267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0225 0.1014
Entamoeba histolytica hypothetical protein 0.0035 0.0527 0.2356
Schistosoma mansoni ephrin receptor 0.0078 0.1412 0.1412
Echinococcus granulosus importin subunit beta 1 0.0033 0.0488 0.0488
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0111 0.034
Mycobacterium tuberculosis Conserved protein 0.0075 0.1359 0.1212
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.0039 0.0615 0.087
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.1276 0.3913
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.1359 0.1212
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0225 0.0318
Trypanosoma cruzi ISWI complex protein 0.0033 0.0484 0.2159
Brugia malayi Cathepsin L-like precursor 0.0014 0.0087 0.0267
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0225 0.0946
Onchocerca volvulus 0.002 0.0225 0.0665
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0225 0.0946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0488 0.0488
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.1359 0.1359
Onchocerca volvulus Cathepsin L homolog 0.002 0.0225 0.0665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.1359 0.6276
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1397 0.6427
Brugia malayi Cathepsin L-like precursor 0.002 0.0225 0.069
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0206 0.5
Brugia malayi Cathepsin L-like precursor 0.002 0.0225 0.069
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0488 0.2178
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2162 1
Onchocerca volvulus 0.0075 0.1359 0.6131
Loa Loa (eye worm) fibroinase 0.002 0.0225 0.0318
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0225 0.1014
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0023 0.0023
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.1359 0.1212
Echinococcus granulosus cathepsin l1 0.0014 0.0087 0.0087
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0487 0.0487
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.176 0.176
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.1359 0.6248
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0309 0.223
Onchocerca volvulus 0.002 0.0225 0.0665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0488 0.3559
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2162 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0728 0.3298
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0053 0.0897 0.6585
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.2162 0.2162
Entamoeba histolytica cysteine protease, putative 0.002 0.0225 0.0946
Schistosoma mansoni cpg binding protein 0.0041 0.0649 0.0649
Echinococcus granulosus cpg binding protein 0.0041 0.0649 0.0649
Schistosoma mansoni inositol monophosphatase 0.0045 0.0728 0.0728
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.036 0.1576
Schistosoma mansoni ran 0.0024 0.0309 0.0309
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0403 0.5561
Echinococcus granulosus cathepsin l1 0.002 0.0225 0.0225
Plasmodium falciparum importin beta, putative 0.0033 0.0488 0.6796
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1359 0.6276
Toxoplasma gondii cathepsin CPL 0.002 0.0225 0.161
Echinococcus multilocularis cathepsin L 0.001 0.0023 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.176 0.176
Brugia malayi hypothetical protein 0.0035 0.0527 0.1614
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0225 0.0225
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1057 0.4837
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0225 0.2996
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Loa Loa (eye worm) hypothetical protein 0.0075 0.1359 0.1921
Schistosoma mansoni hypothetical protein 0.0033 0.0487 0.0487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0578 0.0817
Giardia lamblia Kinase, PLK 0.0114 0.2162 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0487 0.0487
Brugia malayi Cathepsin L-like precursor 0.002 0.0225 0.069
Echinococcus granulosus histone acetyltransferase KAT2B 0.0053 0.0897 0.0897
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0077 0.1397 0.1397
Schistosoma mansoni ap endonuclease 0.0019 0.0206 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.176 0.176
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.1359 0.1359
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0309 0.4204
Leishmania major GTP-binding protein, putative 0.0024 0.0309 0.0525
Loa Loa (eye worm) inositol-1 0.0045 0.0728 0.1029
Loa Loa (eye worm) hypothetical protein 0.0152 0.2936 0.415
Plasmodium vivax vivapain-3 0.001 0.0023 0.0093
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.2162 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1321 0.1172
Brugia malayi beta-lactamase family protein 0.0075 0.1359 0.4167
Brugia malayi Bromodomain containing protein 0.0086 0.1584 0.4856
Entamoeba histolytica hypothetical protein 0.0027 0.036 0.1576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0225 0.1014
Loa Loa (eye worm) ctsf protein 0.002 0.0225 0.0318
Onchocerca volvulus 0.0035 0.0523 0.2103
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0087 0.0267
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.1956 0.5997
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0053 0.0897 0.6585
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0167 0.3261 0.3261
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0578 0.0578
Brugia malayi MH2 domain containing protein 0.0137 0.2629 0.806
Echinococcus multilocularis geminin 0.0354 0.711 0.711
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0562 0.0562

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 12 um PUBCHEM_BIOASSAY: Colorimetric assay for HTS discovery of chemical inhibitors of EphA4 receptor antagonists. Secondary screen (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 50 um PUBCHEM_BIOASSAY: Counter Screen for Placental Alkaline Phosphatase-based Assays Positives. (Class of assay: confirmatory) [Related pubchem assays: 689 ] ChEMBL. No reference
Potency (functional) = 0.0631 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.4467 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.003 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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