Detailed information for compound 1285399

Basic information

Technical information
  • TDR Targets ID: 1285399
  • Name: 1-[5-(4-chlorophenyl)furan-2-yl]-N-(pyridin-2 -ylmethyl)methanamine hydrochloride
  • MW: 335.228 | Formula: C17H16Cl2N2O
  • H donors: 1 H acceptors: 1 LogP: 3.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1ccc(o1)CNCc1ccccn1.Cl
  • InChi: 1S/C17H15ClN2O.ClH/c18-14-6-4-13(5-7-14)17-9-8-16(21-17)12-19-11-15-3-1-2-10-20-15;/h1-10,19H,11-12H2;1H
  • InChiKey: YUYSBVXZDZHQDQ-UHFFFAOYSA-N  


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Synonyms

  • 1-[5-(4-chlorophenyl)-2-furyl]-N-(2-pyridylmethyl)methanamine hydrochloride
  • [5-(4-chlorophenyl)-2-furyl]methyl-(2-pyridylmethyl)amine hydrochloride
  • [5-(4-Chloro-phenyl)-furan-2-ylmethyl]-pyridin-2-ylmethyl-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens EYA transcriptional coactivator and phosphatase 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative Get druggable targets OG5_129664 All targets in OG5_129664
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni eyes absent homolog Get druggable targets OG5_129664 All targets in OG5_129664
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.039 0.0678
Schistosoma mansoni retinoic acid receptor RXR 0.0063 0.108 0.251
Schistosoma mansoni hypothetical protein 0.0066 0.1147 0.2668
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.1147 0.2668
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.021 0.1713
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.055 0.0848
Brugia malayi hypothetical protein 0.0026 0.021 0.0366
Schistosoma mansoni zinc finger protein 0.0018 0.0044 0.0086
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0597 0.0934
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0063 0.108 0.1078
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0063 0.108 0.1878
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0278 0.0354
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0246 0.0559
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0063 0.108 0.1878
Schistosoma mansoni tar DNA-binding protein 0.0202 0.4282 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0723 0.1675
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0093 0.02
Loa Loa (eye worm) MH2 domain-containing protein 0.0248 0.5344 0.5341
Schistosoma mansoni tar DNA-binding protein 0.0202 0.4282 1
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.1018 0.9708
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.1853 0.322
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.108 0.251
Onchocerca volvulus 0.004 0.055 0.0547
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.003 0.0307 0.0702
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.1018 0.09
Trichomonas vaginalis set domain proteins, putative 0.0235 0.5055 0.8661
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.039 0.0678
Entamoeba histolytica peptidase, C54 family 0.0061 0.1018 0.3883
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.3222 0.752
Schistosoma mansoni autophagin-1 (C54 family) 0.0061 0.1018 0.2365
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0063 0.108 0.1878
Schistosoma mansoni hypothetical protein 0.0049 0.0753 0.1746
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0266 0.5752 0.5749
Loa Loa (eye worm) hypothetical protein 0.0106 0.2076 0.207
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.1018 0.09
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0278 0.2339
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1047 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1047 0.1753
Toxoplasma gondii ABC1 family protein 0.004 0.055 0.4373
Echinococcus multilocularis thyroid hormone receptor alpha 0.0063 0.108 0.251
Echinococcus multilocularis GPCR, family 2 0.0066 0.1147 0.2668
Plasmodium falciparum cysteine protease ATG4, putative 0.0024 0.0163 0.1071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0278 0.0354
Schistosoma mansoni hypothetical protein 0.0018 0.0044 0.0086
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0063 0.108 0.251
Loa Loa (eye worm) steroid hormone receptor 0.0063 0.108 0.1074
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.5752 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.039 0.0383
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.03
Brugia malayi Steroid receptor seven-up type 2 0.0063 0.108 0.1878
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.2102 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1047 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0723 0.1675
Loa Loa (eye worm) hypothetical protein 0.0029 0.0278 0.0272
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0063 0.108 0.251
Brugia malayi Bromodomain containing protein 0.005 0.0772 0.1342
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0202 0.4282 0.4278
Loa Loa (eye worm) hypothetical protein 0.0063 0.108 0.1074
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3642 0.5945
Brugia malayi nuclear receptor RXR 0.003 0.0307 0.0534
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.055 0.127
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.1853 0.322
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.03
Loa Loa (eye worm) hypothetical protein 0.0095 0.1803 0.1797
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.2364 0.411
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0571 0.1852
Onchocerca volvulus Phospholipase A2 homolog 0.0095 0.1803 0.18
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0063 0.108 0.251
Plasmodium vivax hypothetical protein, conserved 0.004 0.055 0.7161
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0063 0.108 0.251
Loa Loa (eye worm) hypothetical protein 0.0063 0.108 0.1074
Brugia malayi beta-lactamase family protein 0.004 0.055 0.0956
Loa Loa (eye worm) RNA binding protein 0.0202 0.4282 0.4278
Echinococcus multilocularis nuclear receptor nhr 48 0.003 0.0307 0.0702
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0093 0.02
Schistosoma mansoni hypothetical protein 0.0043 0.0621 0.1436
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0063 0.108 0.251
Mycobacterium leprae conserved hypothetical protein 0.004 0.055 0.1488
Echinococcus multilocularis ecdysone induced protein 78C 0.0063 0.108 0.251
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0024 0.0163 0.119
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0093 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0063 0.108 0.1074
Schistosoma mansoni eyes absent homolog 0.0106 0.2076 0.4839
Plasmodium vivax SET domain protein, putative 0.003 0.0302 0.3119
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.03
Echinococcus multilocularis expressed conserved protein 0.0112 0.2197 0.5124
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.055 0.4686
Leishmania major trypanothione reductase 0.0042 0.0597 0.5514
Schistosoma mansoni hypothetical protein 0.0049 0.0753 0.1746
Loa Loa (eye worm) beta-lactamase 0.004 0.055 0.0543
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1047 0.2433
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.03
Plasmodium vivax glutathione reductase, putative 0.0042 0.0597 0.7933
Echinococcus granulosus tar DNA binding protein 0.0202 0.4282 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1047 0.2433
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0093 0.02
Loa Loa (eye worm) hypothetical protein 0.0063 0.108 0.1074
Loa Loa (eye worm) hypothetical protein 0.0062 0.1061 0.1055
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.3859 0.6361
Brugia malayi MH1 domain containing protein 0.0017 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.004 0.055 0.0543
Loa Loa (eye worm) hypothetical protein 0.0063 0.108 0.1074
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.1018 0.09
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.055 0.127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0063 0.108 0.1074
Entamoeba histolytica hypothetical protein 0.0043 0.0621 0.2079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0104
Brugia malayi beta-lactamase 0.004 0.055 0.0956
Echinococcus multilocularis FTZ F1 alpha 0.0063 0.108 0.251
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0278 0.0523
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0302 0.069
Loa Loa (eye worm) hypothetical protein 0.0063 0.108 0.1074
Loa Loa (eye worm) hypothetical protein 0.0061 0.1018 0.1012
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.5752 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.061 0.1411
Loa Loa (eye worm) hypothetical protein 0.0046 0.0687 0.0681
Loa Loa (eye worm) hypothetical protein 0.0033 0.039 0.0383
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.039 0.0895
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0621 0.1436
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.4395 0.4391
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.021 0.1713
Loa Loa (eye worm) TAR-binding protein 0.0202 0.4282 0.4278
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0063 0.108 0.251
Schistosoma mansoni thyroid hormone receptor 0.0063 0.108 0.251
Echinococcus granulosus FTZ F1 alpha 0.0063 0.108 0.251
Brugia malayi Pre-SET motif family protein 0.0207 0.4395 0.7641
Echinococcus granulosus Peptidase C54 0.0061 0.1018 0.2365
Mycobacterium tuberculosis Conserved protein 0.004 0.055 0.0848
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0278 0.1787
Schistosoma mansoni zinc finger protein 0.003 0.0307 0.0702
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0111 0.5
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0796 0.0789
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0723 0.634
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.003 0.0307 0.0702
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.055 0.0848
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0307 0.0304
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0723 0.1675
Schistosoma mansoni nuclear receptor 0.003 0.0307 0.0702
Brugia malayi photoreceptor-specific nuclear receptor 0.0063 0.108 0.1878
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0063 0.108 0.251
Schistosoma mansoni hypothetical protein 0.0066 0.1147 0.2668
Brugia malayi MH2 domain containing protein 0.0017 0.0007 0.0012
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1047 0.2433
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0209 0.4455 0.7744
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0796 0.1845
Onchocerca volvulus Bile acid receptor homolog 0.0063 0.108 0.1078
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0302 0.1573
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0024 0.0163 0.1226
Loa Loa (eye worm) hypothetical protein 0.004 0.055 0.0543
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0278 0.0484
Schistosoma mansoni hypothetical protein 0.0066 0.1147 0.2668
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.2924 0.5083
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0571 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0302 0.069
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.5752 1
Leishmania major hypothetical protein, conserved 0.0026 0.021 0.1663
Brugia malayi TAR-binding protein 0.0202 0.4282 0.7444
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0796 0.1845
Brugia malayi hypothetical protein 0.003 0.0307 0.0534
Loa Loa (eye worm) hypothetical protein 0.004 0.055 0.0543
Onchocerca volvulus Protein ultraspiracle homolog 0.0063 0.108 0.1078
Loa Loa (eye worm) hypothetical protein 0.0063 0.108 0.1074
Echinococcus granulosus geminin 0.0168 0.3507 0.8188
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.061 0.1411
Loa Loa (eye worm) nuclear receptor nhr-7B 0.003 0.0307 0.03
Brugia malayi Phospholipase A2 family protein 0.0095 0.1803 0.3134
Brugia malayi nuclear receptor NHR-88 0.0063 0.108 0.1878
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0278 0.2339
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0796 0.1845
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0278 0.1787
Schistosoma mansoni nuclear receptor nhr-48 0.003 0.0307 0.0702
Loa Loa (eye worm) hypothetical protein 0.0119 0.2364 0.2359
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.5577 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.1853 0.322
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1047 0.2433
Brugia malayi ecdysteroid receptor 0.0063 0.108 0.1878
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0307 0.0702
Onchocerca volvulus 0.003 0.0307 0.0304
Brugia malayi RNA binding protein 0.0202 0.4282 0.7444
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.055 0.0848
Brugia malayi nuclear receptor NHR-88 0.003 0.0307 0.0534
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.3222 0.752
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0778 0.1804
Schistosoma mansoni patched 1 0.0051 0.0796 0.1845
Schistosoma mansoni hypothetical protein 0.0168 0.3507 0.8188
Schistosoma mansoni steroid hormone receptor ad4bp 0.0063 0.108 0.251
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.003 0.0307 0.0702
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0597 0.568
Brugia malayi RNA recognition motif domain containing protein 0.0202 0.4282 0.7444
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.03
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.108 0.251
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.039 0.0895
Schistosoma mansoni nuclear hormone receptor 0.003 0.0307 0.0702
Loa Loa (eye worm) hypothetical protein 0.0033 0.039 0.0383
Loa Loa (eye worm) acetyltransferase 0.0156 0.3222 0.3217
Brugia malayi Smad1 0.0017 0.0007 0.0012
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0278 0.0523
Loa Loa (eye worm) hypothetical protein 0.004 0.055 0.0543
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0597 0.059
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0024 0.0163 0.1226
Brugia malayi Bromodomain containing protein 0.0094 0.1796 0.3123
Toxoplasma gondii thioredoxin reductase 0.0042 0.0597 0.4908
Echinococcus granulosus expressed conserved protein 0.0112 0.2197 0.5124
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3642 0.5945
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.03
Brugia malayi Thioredoxin reductase 0.0042 0.0597 0.1038
Schistosoma mansoni hypothetical protein 0.0066 0.1147 0.2668
Mycobacterium ulcerans hypothetical protein 0.0029 0.0278 0.1787
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0246 0.0559
Onchocerca volvulus 0.003 0.0302 0.0299
Onchocerca volvulus 0.004 0.055 0.0547
Echinococcus granulosus GPCR family 2 0.0066 0.1147 0.2668
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0723 0.0334
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.5752 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0796 0.0789
Schistosoma mansoni nuclear receptor 0.003 0.0307 0.0702
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0063 0.108 0.1878
Brugia malayi hypothetical protein 0.0043 0.0621 0.1079
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.3642 0.3641
Schistosoma mansoni hypothetical protein 0.0049 0.0753 0.1746
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0278 0.1787
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.3859 0.6361
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.055 0.5194
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.1147 0.2668
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.1147 0.2668
Loa Loa (eye worm) hypothetical protein 0.0085 0.159 0.1584
Brugia malayi Pre-SET motif family protein 0.003 0.0302 0.0525
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0278 0.1787
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0063 0.108 0.1878
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0619 0.1433
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.1018 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.021 0.2047
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1047 1
Mycobacterium tuberculosis Probable reductase 0.0097 0.1853 0.322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0063 0.108 0.1074
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.03
Plasmodium falciparum thioredoxin reductase 0.0042 0.0597 1
Mycobacterium tuberculosis Probable hydrolase 0.004 0.055 0.0848
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0063 0.108 0.1878
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.03
Loa Loa (eye worm) hypothetical protein 0.0063 0.108 0.1074
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0104
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.2364 0.5514
Loa Loa (eye worm) hypothetical protein 0.0033 0.039 0.0383
Brugia malayi Nuclear hormone receptor E75 0.003 0.0307 0.0534
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0621 0.1436
Loa Loa (eye worm) glutathione reductase 0.0042 0.0597 0.059
Brugia malayi glutathione reductase 0.0042 0.0597 0.1038
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0063 0.108 0.1878
Echinococcus multilocularis cysteine protease atg4b 0.0061 0.1018 0.2365
Echinococcus multilocularis Peptidase C54 0.0061 0.1018 0.2365
Echinococcus granulosus thyroid hormone receptor alpha 0.003 0.0307 0.0702
Schistosoma mansoni tar DNA-binding protein 0.0202 0.4282 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.021 0.1713
Schistosoma mansoni tar DNA-binding protein 0.0202 0.4282 1
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.1018 0.09
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0307 0.0702
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.039 0.0895
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0723 0.1675
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.108 0.251
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.055 0.127
Brugia malayi nuclear receptor NHR-67 0.003 0.0307 0.0534
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.108 0.251
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.3057 0.7133
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0778 0.1804
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0278 0.1787
Schistosoma mansoni bromodomain containing protein 0.008 0.1469 0.3421
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0619 0.1433
Brugia malayi nuclear hormone receptor family member odr-7 0.003 0.0307 0.0534
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3642 0.5945
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0278 0.1787
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.055 0.0956
Onchocerca volvulus 0.0063 0.108 0.1078
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0209 0.4455 0.4451
Mycobacterium tuberculosis Conserved protein 0.004 0.055 0.0848
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0307 0.0702
Echinococcus granulosus zinc finger protein 0.0027 0.025 0.0568
Loa Loa (eye worm) hypothetical protein 0.0143 0.2924 0.2919
Schistosoma mansoni nuclear hormone receptor 0.0063 0.108 0.251
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.2102 0.3674
Entamoeba histolytica hypothetical protein 0.0043 0.0621 0.2079
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.055 0.0543
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0063 0.108 0.1878
Loa Loa (eye worm) hypothetical protein 0.0055 0.0893 0.0887
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0061 0.1018 0.2365
Brugia malayi MH2 domain containing protein 0.0248 0.5344 0.9291
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3642 0.5945
Brugia malayi Nuclear hormone receptor-like 1 0.0063 0.108 0.1878
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0266 0.5752 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0209 0.4455 0.7744
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0196 0.019
Loa Loa (eye worm) hypothetical protein 0.005 0.0778 0.0772
Brugia malayi hypothetical protein 0.003 0.0307 0.0534
Brugia malayi nuclear hormone receptor family member nhr-6 0.003 0.0307 0.0534
Mycobacterium leprae Probable lipase LipE 0.004 0.055 0.1488
Trypanosoma brucei trypanothione reductase 0.0042 0.0597 0.568
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.2364 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0063 0.108 0.251
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0063 0.108 0.1878
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0111 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0723 0.1675
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.003 0.0307 0.0702
Loa Loa (eye worm) DR-78 0.003 0.0307 0.03
Brugia malayi hypothetical protein 0.0033 0.039 0.0678
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0063 0.108 0.251
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0063 0.108 0.1074
Echinococcus granulosus cysteine protease atg4b 0.0061 0.1018 0.2365
Brugia malayi MH1 domain containing protein 0.0017 0.0007 0.0012
Schistosoma mansoni hypothetical protein 0.0025 0.0192 0.0434
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0063 0.108 0.251
Entamoeba histolytica hypothetical protein 0.0043 0.0621 0.2079
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.03
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0063 0.108 0.1074
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.2364 0.5514
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0796 0.0473
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.1369 0.3187
Onchocerca volvulus 0.004 0.055 0.0547
Loa Loa (eye worm) hypothetical protein 0.0106 0.2076 0.207
Echinococcus granulosus nuclear receptor nhr 48 0.003 0.0307 0.0702
Mycobacterium ulcerans beta-lactamase 0.004 0.055 0.4686
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0723 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.1147 0.1995
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0307 0.0702
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0307 0.0702
Brugia malayi beta-lactamase family protein 0.004 0.055 0.0956
Schistosoma mansoni coup transcription factor 0.0063 0.108 0.251
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0723 0.1257
Echinococcus multilocularis geminin 0.0168 0.3507 0.8188
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0063 0.108 0.251
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.03
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.003 0.0307 0.0534
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0278 0.1787
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.055 0.127
Echinococcus granulosus ecdysone induced protein 78C 0.0063 0.108 0.251
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3642 0.5945
Brugia malayi nuclear hormone receptor 0.003 0.0307 0.0534
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0307 0.0304
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0723 0.1675
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3642 0.5945
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1047 1
Brugia malayi nuclear hormone receptor 0.0063 0.108 0.1878
Brugia malayi hypothetical protein 0.0033 0.039 0.0678
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0723 0.0717
Brugia malayi nuclear receptor RXR 0.0033 0.039 0.0678
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0571 0.9462
Echinococcus multilocularis protein dispatched 1 0.0058 0.0962 0.2235
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0063 0.108 0.251
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.1018 0.09
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0302 0.069
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.2102 0.3674
Schistosoma mansoni hypothetical protein 0.0168 0.3507 0.8188
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0278 0.0523
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.003 0.0307 0.0702
Loa Loa (eye worm) hypothetical protein 0.0209 0.4455 0.4451
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0723 0.1676
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.1853 0.322
Brugia malayi Nuclear hormone receptor E75 0.003 0.0307 0.0534
Mycobacterium ulcerans hypothetical protein 0.004 0.055 0.4686
Onchocerca volvulus 0.0029 0.0278 0.0276
Schistosoma mansoni nuclear hormone receptor 0.003 0.0307 0.0702
Brugia malayi MH2 domain containing protein 0.0017 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.03
Loa Loa (eye worm) hypothetical protein 0.0026 0.021 0.0204
Schistosoma mansoni zinc finger protein 0.0027 0.025 0.0568
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0778 0.1804
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.5752 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.2407 0.5613
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.1147 0.2668
Loa Loa (eye worm) hypothetical protein 0.0053 0.084 0.0834
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0063 0.108 0.251
Mycobacterium ulcerans lipase LipD 0.004 0.055 0.4686
Schistosoma mansoni RAR-like nuclear receptor 0.0063 0.108 0.251
Schistosoma mansoni tar DNA-binding protein 0.0202 0.4282 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0104
Loa Loa (eye worm) hypothetical protein 0.0029 0.0278 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0063 0.108 0.1074
Onchocerca volvulus 0.0235 0.5055 0.5054
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0061 0.1018 0.2365
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.039 0.0895
Brugia malayi hypothetical protein 0.0106 0.2076 0.3609
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3642 0.5945
Leishmania major hypothetical protein, conserved 0.004 0.055 0.5043
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.055 0.5194
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0278 0.0484
Brugia malayi tailless protein 0.003 0.0307 0.0534
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.03
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0278 0.2339
Echinococcus multilocularis tar DNA binding protein 0.0202 0.4282 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0723 0.634
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0307 0.0702
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0278 0.0484
Brugia malayi orphan nuclear receptor NR2E1 0.003 0.0307 0.0534
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0723 0.0334
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0597 0.7933
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0063 0.108 0.1878
Loa Loa (eye worm) hypothetical protein 0.0029 0.0278 0.0272
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.055 0.0848
Loa Loa (eye worm) hypothetical protein 0.004 0.055 0.0543
Echinococcus multilocularis protein patched 0.0051 0.0796 0.1845
Loa Loa (eye worm) hypothetical protein 0.0033 0.039 0.0383
Loa Loa (eye worm) hypothetical protein 0.0063 0.108 0.1074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0063 0.108 0.1878
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.5752 1
Brugia malayi conserved hypotetical protein 0.003 0.0307 0.0534
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.1147 0.1141
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0104
Brugia malayi PHD-finger family protein 0.0034 0.0399 0.0693
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.1018 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.055 0.4686
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0192 0.0186
Echinococcus multilocularis zinc finger protein 0.0027 0.025 0.0568
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.055 0.0848
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1047 1
Mycobacterium tuberculosis Conserved protein 0.004 0.055 0.0848
Brugia malayi Peptidase family C54 containing protein 0.0061 0.1018 0.1769
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0063 0.108 0.1878
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.03
Loa Loa (eye worm) nuclear hormone receptor 0.003 0.0307 0.03
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.2102 0.3674
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.3543 0.8272
Schistosoma mansoni hypothetical protein 0.0049 0.0753 0.1746
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.1853 0.8632
Brugia malayi Latrophilin receptor protein 2 0.0066 0.1147 0.1995
Loa Loa (eye worm) nuclear receptor NHR-67 0.003 0.0307 0.03
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0723 0.1675
Entamoeba histolytica hypothetical protein 0.0043 0.0621 0.2079
Trypanosoma brucei hypothetical protein, conserved 0.004 0.055 0.5194
Plasmodium falciparum glutathione reductase 0.0042 0.0597 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0277 0.0631
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.3543 0.8272
Loa Loa (eye worm) transcription factor SMAD2 0.0248 0.5344 0.5341
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0024 0.0163 0.1226
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.1853 0.322
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.055 0.0848
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0246 0.0559
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0063 0.108 0.251
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0063 0.108 0.1878
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.021 0.2047
Schistosoma mansoni hypothetical protein 0.0143 0.2924 0.6823
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.3222 0.5601
Onchocerca volvulus 0.003 0.0307 0.0304
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0063 0.108 0.251
Brugia malayi CHE-14 protein 0.0051 0.0796 0.1383
Schistosoma mansoni thyroid hormone receptor 0.0063 0.108 0.251
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0778 0.1804
Loa Loa (eye worm) hypothetical protein 0.0066 0.1147 0.1141
Loa Loa (eye worm) hypothetical protein 0.0033 0.039 0.0383
Brugia malayi steroid hormone receptor 0.0063 0.108 0.1878
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.021 0.1623
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0621 0.1436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0063 0.108 0.1074
Brugia malayi ecdysone receptor 0.003 0.0307 0.0534
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.1369 0.3187
Loa Loa (eye worm) hypothetical protein 0.004 0.055 0.0543
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.021 0.0536

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.0596 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 15.104 uM PubChem BioAssay. qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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