Detailed information for compound 1285535

Basic information

Technical information
  • TDR Targets ID: 1285535
  • Name: 6-(1,3-benzodioxol-5-yl)-4-(4-methylpiperazin -1-yl)quinazoline
  • MW: 348.398 | Formula: C20H20N4O2
  • H donors: 0 H acceptors: 2 LogP: 3.25 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)c1ncnc2c1cc(cc2)c1ccc2c(c1)OCO2
  • InChi: 1S/C20H20N4O2/c1-23-6-8-24(9-7-23)20-16-10-14(2-4-17(16)21-12-22-20)15-3-5-18-19(11-15)26-13-25-18/h2-5,10-12H,6-9,13H2,1H3
  • InChiKey: COJGNGNVZMGINY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-(1,3-benzodioxol-5-yl)-4-(4-methyl-1-piperazinyl)quinazoline
  • NCGC00010631
  • PCOP-208095

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0074 0.0461 0.0751
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0473 0.3723 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0225 0.0225
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0725 0.0752
Giardia lamblia Kinase, CMGC CLK 0.0074 0.0461 0.1765
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0196 0.0475
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0473 0.3723 0.6065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0167 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0173 0.0412
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0144 0.1038 0.1076
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.1848 0.1916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0101
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0473 0.3723 0.3723
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0044 0.0216 0.0216
Onchocerca volvulus 0.003 0.0105 0.0133
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0343
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.022 0.0228
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.022 0.0536
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0135 0.014
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0417 0.1056
Brugia malayi Cytochrome P450 family protein 0.0017 0.0001 0.0001
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.022 0.022
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0044 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0045 0.0225 0.0234
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0459 0.0459
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0252 0.0252
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0168 0.1235 0.1235
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0078
Loa Loa (eye worm) cytochrome P450 0.0017 0.0001 0.0001
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0168 0.1235 0.3316
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0108 0.0745 0.0744
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0109
Onchocerca volvulus 0.0035 0.0144 0.0236
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0473 0.3723 0.3723
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0086
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0044 0.0216 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0082 0.0173
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0082 0.0173
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0225 0.0043
Toxoplasma gondii carbamoylphosphate synthetase 0.0107 0.0734 0.0733
Brugia malayi Carboxyl transferase domain containing protein 0.1199 0.9645 1
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0044 0.0216 0.0216
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0168 0.1235 0.3316
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0108 0.0745 0.0744
Schistosoma mansoni cpg binding protein 0.0041 0.0192 0.0192
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0074 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0056 0.0321 0.0333
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0168 0.1235 0.3316
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0168 0.1235 0.3316
Treponema pallidum pyruvate carboxylase subunit B 0.0044 0.0216 0.5
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0107 0.0734 0.1476
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0135 0.0135
Toxoplasma gondii histone lysine methyltransferase SET1 0.0073 0.0455 0.0454
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0055 0.0055
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0107 0.0734 0.1195
Echinococcus multilocularis Biotin lipoyl attachment 0.0044 0.0216 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0461 0.0461
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0087 0.0141
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.0745 0.1213
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0216 0.0224
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.022 0.022
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0648 0.0648
Brugia malayi CXXC zinc finger family protein 0.0035 0.0144 0.0149
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0225 0.0225
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0135 0.014
Echinococcus multilocularis chromobox protein 1 0.0068 0.0417 0.0417
Schistosoma mansoni chromobox protein 0.0068 0.0417 0.0417
Trypanosoma cruzi ISWI complex protein 0.0031 0.0116 0.0188
Schistosoma mansoni hypothetical protein 0.0494 0.3891 0.3891
Loa Loa (eye worm) hypothetical protein 0.0107 0.0736 0.0763
Echinococcus multilocularis zinc finger protein 0.0042 0.0203 0.0203
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0072 0.0452 0.0452
Echinococcus granulosus cpg binding protein 0.0041 0.0192 0.0192
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0147 0.0146
Echinococcus multilocularis lamin 0.0056 0.0321 0.0321
Schistosoma mansoni rab6-interacting 0.0024 0.0055 0.0055
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0044 0.0216 0.0351
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0044 0.0216 0.0351
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0087 0.009
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0083 0.0083
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.022 0.022
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0168 0.1235 0.3316
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.1345 0.1394
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.0871 0.0871
Leishmania major carbamoyl-phosphate synthase, putative 0.0107 0.0734 0.0733
Brugia malayi hypoxia-induced factor 1 0.0182 0.1345 0.1394
Onchocerca volvulus 0.0484 0.381 1
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0044 0.0216 0.0579
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0044 0.0216 0.0216
Schistosoma mansoni cytochrome P450 0.0017 0.0001 0.0001
Echinococcus granulosus lamin dm0 0.0056 0.0321 0.0321
Onchocerca volvulus 0.0043 0.0216 0.0427
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0473 0.3723 1
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0216 0.0216
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0212 0.159 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0054 0.0101
Brugia malayi Bromodomain containing protein 0.0155 0.1125 0.1167
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0044 0.0216 0.0216
Brugia malayi chromobox protein homolog 3 0.0038 0.0173 0.0179
Echinococcus multilocularis chromobox protein 1 0.0068 0.0417 0.0417
Brugia malayi Cytochrome P450 family protein 0.0028 0.0087 0.009
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0168 0.1235 0.1235
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0725 0.0752
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0054 0.0101
Schistosoma mansoni zinc finger protein 0.0031 0.0116 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0343
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0197 0.1469 0.1523
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0364 0.0364
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0225 0.0225
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0473 0.3723 0.3723
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0473 0.3723 0.3723
Trypanosoma cruzi acetyl-CoA carboxylase 0.0769 0.6138 1
Leishmania major protein kinase, putative 0.0074 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0072 0.0452 0.0469
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0168 0.1235 0.3316
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0044 0.0216 0.0216
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0044 0.0216 0.0351
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0044 0.0216 0.0224
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.034 0.034
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0044 0.0216 0.0225
Trypanosoma cruzi ISWI complex protein 0.0031 0.0116 0.0188
Brugia malayi Pre-SET motif family protein 0.0425 0.3331 0.3454
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0252 0.0252
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0087 0.0141
Loa Loa (eye worm) hypothetical protein 0.0048 0.0256 0.0265
Leishmania major cytochrome p450-like protein 0.0028 0.0087 0.0086
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0135
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0725 0.0752
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0044 0.0216 0.0216
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0473 0.3723 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0225 0.0225
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0168 0.1235 0.3316
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0044 0.0216 0.0216
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0087 0.0086
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0044 0.0216 0.0216
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0031 0.003
Echinococcus granulosus dual specificity 0.0108 0.0745 0.0745
Schistosoma mansoni cpg binding protein 0.0035 0.0144 0.0144
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0417 0.1056
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0108 0.0112
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0648 0.0648
Echinococcus multilocularis RUN 0.0024 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0135
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.048 0.048
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0044 0.0216 0.0216
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0168 0.1235 0.3233
Brugia malayi MH2 domain containing protein 0.0244 0.1848 0.1916
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0087 0.009
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0108 0.0112
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0044 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0343
Echinococcus multilocularis dual specificity protein kinase clk2 0.0074 0.0461 0.0461
Onchocerca volvulus 0.0056 0.0321 0.0708
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.1848 0.1916
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0417 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0343
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0044 0.0216 0.0579
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0145 0.0145
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0044 0.0216 0.0225
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0452 0.0469
Loa Loa (eye worm) hypothetical protein 0.0083 0.0539 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0225 0.0552
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0055 0.0055
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.022 0.0219
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0087 0.0232
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0145 0.0145
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0168 0.1235 0.2011
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0225 0.0225
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0074 0.0461 0.0751
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0044 0.0216 0.0224
Echinococcus granulosus RUN 0.0024 0.0055 0.0055
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0461 0.1174
Echinococcus multilocularis cpg binding protein 0.0041 0.0192 0.0192
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.022 0.0219
Plasmodium falciparum carbamoyl phosphate synthetase 0.0107 0.0734 0.095
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0108 0.0745 0.0772
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0146 0.0343
Schistosoma mansoni lipoxygenase 0.0142 0.1023 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0102 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0173 0.0412
Brugia malayi Heterochromatin protein 1 0.0068 0.0417 0.0432
Brugia malayi hypothetical protein 0.0024 0.0055 0.0057
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0044 0.0216 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Entamoeba histolytica hypothetical protein 0.0108 0.0745 0.3833
Trichomonas vaginalis set domain proteins, putative 0.0484 0.381 1
Schistosoma mansoni bromodomain containing protein 0.0131 0.093 0.093
Echinococcus multilocularis musashi 0.0056 0.0321 0.0321
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0225 0.0234
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0055 0.0055
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0168 0.1235 0.1235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0094 0.0205
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.022 0.0228
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0473 0.3723 1
Brugia malayi PAS domain containing protein 0.0059 0.034 0.0353
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0128 0.0127
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0225 0.0043
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0168 0.1235 0.3316
Brugia malayi Bromodomain containing protein 0.0078 0.0499 0.0517
Trypanosoma brucei ISWI complex protein 0.0031 0.0116 0.0115
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0044 0.0216 0.0579
Brugia malayi Cytochrome P450 family protein 0.0028 0.0087 0.009
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0224
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0168 0.1235 0.2905
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0074 0.0461 0.0461
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0321 0.0333
Loa Loa (eye worm) hypothetical protein 0.0107 0.0736 0.0763
Mycobacterium ulcerans pyruvate carboxylase 0.0473 0.3723 1
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0044 0.0216 0.0225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0078
Loa Loa (eye worm) hypothetical protein 0.0072 0.0452 0.0469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0075 0.0156
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0044 0.0216 0.0225
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0107 0.0734 0.0733
Echinococcus multilocularis 0.0017 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0225 0.0552
Schistosoma mansoni single-minded 0.0059 0.034 0.034
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0101
Echinococcus granulosus dnaJ subfamily B 0.0494 0.3891 0.3891
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0473 0.3723 0.3723
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0168 0.1235 0.3316
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0044 0.0216 0.0224
Schistosoma mansoni hypothetical protein 0.0042 0.0205 0.0205
Plasmodium vivax SET domain protein, putative 0.0062 0.0364 0.0432
Echinococcus multilocularis 0.0072 0.0452 0.0452
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0168 0.1235 0.3316
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0225 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.022 0.0536
Schistosoma mansoni hypothetical protein 0.0017 0.0001 0.0001
Echinococcus granulosus tumor protein p63 0.033 0.2556 0.2556
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0173 0.0312
Schistosoma mansoni aspartate carbamoyltransferase 0.0107 0.0734 0.0734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0075 0.0156
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0212 0.159 1
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0044 0.0216 0.0351
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0459 0.0459
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.022 0.0357
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0225 0.0225
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0107 0.0734 0.0734
Entamoeba histolytica protein kinase, putative 0.0108 0.0745 0.3833
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0135 0.014
Schistosoma mansoni chromobox protein 0.0068 0.0417 0.0417
Entamoeba histolytica protein kinase, putative 0.0108 0.0745 0.3833
Brugia malayi Doublecortin family protein 0.0024 0.0055 0.0057
Echinococcus granulosus hypothetical protein 0.0072 0.0452 0.0452
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0321 0.0333
Schistosoma mansoni lamin 0.0056 0.0321 0.0321
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0168 0.1235 0.1235
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0135 0.0135
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0044 0.0216 0.0225
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0055 0.0057
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0216 0.0578
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0364 0.0364
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0168 0.1235 0.1235
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0135 0.0135
Brugia malayi cytochrome P450 0.0017 0.0001 0.0001
Echinococcus granulosus zinc finger protein 0.0042 0.0203 0.0203
Toxoplasma gondii pyruvate carboxylase 0.0473 0.3723 0.3723
Plasmodium vivax serine/threonine kinase-1, putative 0.0074 0.0461 0.0568
Schistosoma mansoni loxhd1 0.0024 0.0055 0.0055
Echinococcus multilocularis GPCR, family 2 0.0034 0.0135 0.0135
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0087 0.009
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0044 0.0216 0.0216
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0168 0.1235 0.3316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0073 0.015
Brugia malayi hypothetical protein 0.0197 0.1469 0.1523
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0044 0.0216 0.0216
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0107 0.0734 0.1195
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0745 0.0745
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0044 0.0216 0.0216
Echinococcus multilocularis dual specificity 0.0108 0.0745 0.0745
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0145 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0101
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.022 0.0219
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0899 0.7198 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0224
Schistosoma mansoni intermediate filament proteins 0.0056 0.0321 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0054 0.0101
Schistosoma mansoni cpg binding protein 0.0041 0.0192 0.0192
Echinococcus multilocularis lamin dm0 0.0056 0.0321 0.0321
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.034 0.034
Onchocerca volvulus 0.0048 0.0256 0.0533
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0321 0.0333
Echinococcus granulosus dual specificity protein kinase clk2 0.0074 0.0461 0.0461
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0899 0.7198 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.014
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0083 0.0083
Echinococcus granulosus intermediate filament protein 0.0056 0.0321 0.0321
Schistosoma mansoni lamin 0.0056 0.0321 0.0321
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0168 0.1235 0.2011
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0107 0.0734 0.0734
Schistosoma mansoni rab6-interacting 0.0024 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0031 0.0116 0.0116
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0044 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.0745 0.1213
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0044 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.022 0.0536
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0648 0.0648
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.3331 0.3454
Plasmodium falciparum protein serine/threonine kinase-1 0.0074 0.0461 0.0568
Trypanosoma brucei unspecified product 0.0311 0.24 0.24
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0461 0.0461
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0074 0.0461 0.0478
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0473 0.3723 0.6065
Loa Loa (eye worm) hypothetical protein 0.0038 0.0173 0.0179
Leishmania major hypothetical protein, conserved 0.0031 0.0116 0.0115
Entamoeba histolytica protein kinase domain containing protein 0.0108 0.0745 0.3833
Brugia malayi Protein kinase domain containing protein 0.0108 0.0745 0.0772
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0168 0.1235 0.1235
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0044 0.0216 0.0216
Echinococcus granulosus single minded 2 0.0043 0.0216 0.0216
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0074 0.0461 0.0751
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0205 0.0212
Echinococcus granulosus GPCR family 2 0.0034 0.0135 0.0135
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0107 0.0734 0.095
Loa Loa (eye worm) hypothetical protein 0.0096 0.0648 0.0672
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0107 0.0734 0.197
Echinococcus granulosus Biotin lipoyl attachment 0.0044 0.0216 0.0216
Brugia malayi Pre-SET motif family protein 0.0062 0.0364 0.0378
Echinococcus granulosus chromobox protein 1 0.0068 0.0417 0.0417
Schistosoma mansoni pyruvate carboxylase 0.0473 0.3723 0.3723
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0473 0.3723 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.0871 0.0871
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0225 0.0225
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0364 0.0364
Schistosoma mansoni polycystin 1-related 0.0024 0.0055 0.0055
Echinococcus granulosus chromobox protein 1 0.0068 0.0417 0.0417
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0044 0.0216 0.0579
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0473 0.3723 0.3723
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0225 0.0225
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0168 0.1235 0.1235
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0455 0.0455
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0225 0.0225
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.3891 0.3891
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1023 0.1023
Mycobacterium ulcerans hypothetical protein 0.0044 0.0216 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0101
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0145 0.0145
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0256 0.0256
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0473 0.3723 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0147 0.0146
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.022 0.0357
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0196 0.0475
Onchocerca volvulus 0.0073 0.0455 0.1065
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0196 0.0375
Leishmania major protein kinase, putative 0.0074 0.0461 0.0461
Brugia malayi PHD-finger family protein 0.0053 0.0292 0.0303
Loa Loa (eye worm) hypothetical protein 0.0106 0.0725 0.0752
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0147 0.0238
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0135
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0044 0.0216 0.0351
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0473 0.3723 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0075 0.0156
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0078 0.05 0.0518
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.1199 0.9645 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0225 0.0552
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0044 0.0216 0.0216
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0044 0.0216 0.0216
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0135
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0473 0.3723 0.3723
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0225 0.0366
Brugia malayi Cytochrome P450 family protein 0.004 0.0189 0.0196
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0001 0.0001
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0055 0.0055
Chlamydia trachomatis biotin carboxylase 0.043 0.3368 1
Brugia malayi Protein kinase domain containing protein 0.0074 0.0461 0.0478
Schistosoma mansoni lipoxygenase 0.01 0.0673 0.0673
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0074 0.0461 0.0461
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0128 0.0294
Schistosoma mansoni zinc finger protein 0.0042 0.0203 0.0203
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0044 0.0216 0.0579
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.022 0.0219
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0155 0.0161
Echinococcus granulosus lamin 0.0056 0.0321 0.0321
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0044 0.0216 0.0351
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0648 0.0648
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1023 0.1023
Schistosoma mansoni hypothetical protein 0.0024 0.0055 0.0055
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0168 0.1235 0.2011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0073 0.015
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0189 0.0196
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0074 0.0461 0.0751
Brugia malayi hypothetical protein 0.0024 0.0055 0.0057
Leishmania major carboxylase, putative 0.0473 0.3723 0.3723
Loa Loa (eye worm) hypothetical protein 0.0055 0.0313 0.0324
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0044 0.0216 0.0579
Onchocerca volvulus 0.0056 0.0321 0.0708
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0044 0.0216 0.0579
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0044 0.0216 0.0216
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0144 0.0149
Brugia malayi intermediate filament protein 0.0056 0.0321 0.0333
Echinococcus multilocularis tumor protein p63 0.033 0.2556 0.2556
Loa Loa (eye worm) hypothetical protein 0.0089 0.0587 0.0609

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.251188643 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.511886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.943282347 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 39.81071706 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 0.1585 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (ADP-FP Assay). (Class of assay: confirmatory) [Related pubchem assays: 1771, 1770 ] ChEMBL. No reference
Potency (functional) = 0.2512 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 0.2512 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (Kinase-Glo Assay). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (ADP-Glo Assay). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 915 ] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 914 ] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.