Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.1146 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.1388 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.1388 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2795 | 0.3353 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0761 | 0.0786 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.806 | 0.806 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0039 | 0.0708 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2795 | 0.3353 |
Schistosoma mansoni | rotamase | 0.004 | 0.0761 | 0.0761 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.004 | 0.0761 | 0.0913 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2795 | 0.3353 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.0708 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2795 | 0.3353 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.1388 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.1388 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2795 | 0.2795 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.8336 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0039 | 0.0708 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.8336 | 0.8336 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.0708 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2795 | 0.2795 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.1388 | 0.1388 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2795 | 0.2795 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.1146 | 1 |
Echinococcus multilocularis | expressed protein | 0.004 | 0.0761 | 0.0761 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.1388 | 0.5 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.1146 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.8336 | 0.8336 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2795 | 0.2795 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2795 | 0.2795 |
Trichomonas vaginalis | rotamase, putative | 0.004 | 0.0761 | 0.0786 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.8336 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2795 | 0.3353 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2795 | 0.2795 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2795 | 0.2795 |
Echinococcus granulosus | expressed protein | 0.004 | 0.0761 | 0.0761 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.004 | 0.0761 | 0.0913 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2795 | 0.3353 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0046 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.1836 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.