Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0036 | 0.0128 | 0.5 |
Brugia malayi | hypothetical protein | 0.0071 | 0.1244 | 0.421 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0128 | 0.0434 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.2047 | 0.2047 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0036 | 0.0128 | 0.0128 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.2172 | 0.735 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.2172 | 0.735 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.1244 | 0.1244 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0128 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.2172 | 0.735 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.2047 | 0.2047 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2955 | 0.2955 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0161 | 0.4097 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.2047 | 0.2047 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0128 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.1167 | 0.3948 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1244 | 0.1244 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.2047 | 0.2047 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.1167 | 0.1167 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 0.0128 | 0.0128 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 0.0128 | 0.0128 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1244 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.1244 | 0.1244 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.2955 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.2047 | 0.2047 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1244 | 1 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0036 | 0.0128 | 0.0128 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0096 | 0.2047 | 0.6927 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.2955 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.2047 | 0.2047 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0036 | 0.0128 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.1244 | 0.1244 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 0.0128 | 0.0128 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.2955 | 0.2955 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2955 | 0.2955 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.2955 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2955 | 0.2955 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1167 | 0.3948 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 0.0128 | 0.5 |
Brugia malayi | RNA binding protein | 0.0125 | 0.2955 | 1 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0161 | 0.4097 | 0.5 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 0.0128 | 0.5 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0128 | 0.5 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 0.0128 | 0.0128 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1244 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.2172 | 0.735 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.2955 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0096 | 0.2047 | 0.6927 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.2955 | 0.2955 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2955 | 0.2955 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.2047 | 0.2047 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2955 | 0.2955 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0036 | 0.0128 | 0.0434 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.2955 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0036 | 0.0128 | 0.0128 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0036 | 0.0128 | 0.0128 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0128 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1244 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.