Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1504 | 0.1504 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.212 | 0.212 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2801 | 0.9491 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1223 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.212 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.212 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.212 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1223 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.212 | 0.7182 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.212 | 0.212 |
Brugia malayi | hypothetical protein | 0.0037 | 0.1223 | 0.4144 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.177 | 0.177 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.177 | 0.177 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.212 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0.212 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.212 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.177 | 0.5997 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.1223 | 0.1223 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2801 | 0.9491 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2951 | 0.2951 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.212 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.212 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.212 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.212 | 0.212 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.2951 | 0.2951 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1504 | 0.5095 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.212 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1504 | 0.5095 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.212 | 0.212 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.1223 | 0.1223 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.212 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.177 | 0.177 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.2951 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.2951 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.177 | 0.5997 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1223 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1223 | 0.1223 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.2951 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.212 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.2951 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2951 | 0.2951 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2951 | 0.2951 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2951 | 0.2951 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.1223 | 0.1223 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.2951 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0.212 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2801 | 0.9491 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.212 | 0.7182 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2801 | 0.9491 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.177 | 0.177 |
Brugia malayi | RNA binding protein | 0.0062 | 0.2951 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.177 | 0.177 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1223 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.212 | 0.212 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.177 | 0.177 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2951 | 0.2951 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.2951 | 0.2951 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.212 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Confirmation of Cherrypicks. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.2119 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.