Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.0516 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0036 | 0.3798 | 0.3461 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5134 | 0.5134 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0051 | 0.739 | 0.7248 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.0516 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.9682 | 0.9665 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0051 | 0.739 | 0.739 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.739 | 0.7248 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.9682 | 0.9682 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5134 | 0.4869 |
Schistosoma mansoni | DNA polymerase eta | 0.0051 | 0.739 | 0.7248 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.2576 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.2576 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0051 | 0.739 | 0.7248 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.0516 | 0.0516 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.2576 | 0.2172 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.2576 | 0.2172 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2576 | 0.2172 |
Leishmania major | DNA polymerase eta, putative | 0.0051 | 0.739 | 0.7248 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.9682 | 0.9665 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.9682 | 0.9682 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5134 | 0.4869 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0036 | 0.3798 | 0.1647 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.2576 | 0.2172 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0022 | 0.0516 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.2576 | 0.2576 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.2576 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.2576 | 0.2172 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0051 | 0.739 | 0.7248 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0.0516 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0051 | 0.739 | 0.7248 |
Leishmania major | DNA polymerase eta, putative | 0.0036 | 0.3798 | 0.3461 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.0516 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.9953 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.