Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4666 | 0.8686 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4666 | 0.8686 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.4666 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.4666 | 0.4666 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.5371 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.4666 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0079 | 0.5371 | 0.5371 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.4666 | 0.4666 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.4666 | 0.4666 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4666 | 0.8686 |
Brugia malayi | RNA binding protein | 0.0073 | 0.4666 | 0.4666 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.4666 | 0.4666 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4666 | 0.8686 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.4666 | 0.4666 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5371 | 0.5371 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4666 | 0.8686 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.5623 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.