Detailed information for compound 1286587

Basic information

Technical information
  • TDR Targets ID: 1286587
  • Name: N-[4-[4-[5-(2-fluorophenyl)1,3-oxazole-4-carb onyl]piperazin-1-yl]sulfonylphenyl]acetamide
  • MW: 472.489 | Formula: C22H21FN4O5S
  • H donors: 1 H acceptors: 5 LogP: 1.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)c1ncoc1c1ccccc1F
  • InChi: 1S/C22H21FN4O5S/c1-15(28)25-16-6-8-17(9-7-16)33(30,31)27-12-10-26(11-13-27)22(29)20-21(32-14-24-20)18-4-2-3-5-19(18)23/h2-9,14H,10-13H2,1H3,(H,25,28)
  • InChiKey: GWWMUUFTRCPWIV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[4-[5-(2-fluorophenyl)oxazole-4-carbonyl]piperazin-1-yl]sulfonylphenyl]acetamide
  • N-[4-[[4-[[5-(2-fluorophenyl)-4-oxazolyl]-oxomethyl]-1-piperazinyl]sulfonyl]phenyl]acetamide
  • N-[4-[4-[[5-(2-fluorophenyl)-1,3-oxazol-4-yl]carbonyl]piperazin-1-yl]sulfonylphenyl]ethanamide
  • ASN 10400397

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis methionine--tRNA ligase 0.0347 0.1443 1
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0153 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0333 0.1024
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.116 0.116
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0039 0.01 0.0306
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0105 0.0324
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0333 0.2146
Leishmania major hypothetical protein, conserved 0.0041 0.0105 0.0641
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.116 0.2174
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.002 0.0074
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0038 0.0092 0.0092
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0029 0.0135
Brugia malayi methionyl-tRNA synthetase 0.0055 0.0169 0.0507
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0084 0.0257
Schistosoma mansoni ran 0.0021 0.002 0.0037
Schistosoma mansoni aspartyl-tRNA synthetase 0.0038 0.0092 0.0172
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.0039 0.01 0.0293
Schistosoma mansoni hypothetical protein 0.0332 0.1377 0.258
Schistosoma mansoni cpg binding protein 0.0122 0.046 0.0861
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0038 0.0092 0.0637
Treponema pallidum methionyl-tRNA synthetase 0.0347 0.1443 1
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0411 0.1723 0.3229
Schistosoma mansoni aspartyl-tRNA synthetase 0.0038 0.0092 0.0172
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0082 0.0237
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0012 0.0086
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0055 0.0169 0.1063
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0009 0.0009
Loa Loa (eye worm) 63kd antigen 0.0038 0.0092 0.0282
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.0144
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0024 0.0035 0.0173
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0292 0.1202 0.3695
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0282 0.116 0.3566
Schistosoma mansoni aspartyl-tRNA synthetase 0.0038 0.0092 0.0172
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0105 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.0129
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0012
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0153 0.0286
Echinococcus granulosus methionine tRNA synthetase 0.0055 0.0169 0.0169
Schistosoma mansoni aspartyl-tRNA synthetase 0.0038 0.0092 0.0172
Mycobacterium tuberculosis Conserved protein 0.0041 0.0105 0.0905
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0012 0.0012
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0047 0.0253
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0024 0.0035 0.0106
Trypanosoma cruzi Replication factor A protein 1 0.0365 0.1522 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0038 0.0092 0.0172
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0039 0.0206
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0055 0.0169 0.052
Echinococcus multilocularis leucyl tRNA synthetase 0.0055 0.0169 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.0129
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0282 0.116 0.3557
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0039 0.0206
Brugia malayi protein ZK524.3 0.0055 0.0169 0.0507
Brugia malayi mbt repeat family protein 0.0052 0.0153 0.0456
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0038 0.0092 0.0777
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 0.0024 0.0035 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.0129
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0042 0.0129
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0105 0.0324
Loa Loa (eye worm) hypothetical protein 0.0039 0.01 0.0306
Schistosoma mansoni DNA polymerase eta 0.0019 0.001 0.0019
Mycobacterium ulcerans beta-lactamase 0.0041 0.0105 0.5983
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0024 0.0035 0.0106
Plasmodium vivax asparagine--tRNA ligase, putative 0.0038 0.0092 0.0552
Leishmania major methionyl-tRNA synthetase, putative 0.0055 0.0169 0.1063
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0024 0.0035 0.0106
Onchocerca volvulus 0.0041 0.0105 0.0335
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0105 0.5983
Echinococcus granulosus glutathione S transferase 0.0018 0.0008 0.0008
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0039 0.01 0.0293
Echinococcus multilocularis cpg binding protein 0.0122 0.046 0.046
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.0039 0.01 0.01
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0038 0.0092 0.0092
Schistosoma mansoni aspartyl-tRNA synthetase 0.0038 0.0092 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0009 0.0005
Toxoplasma gondii lysine-tRNA ligase 0.0038 0.0092 0.0552
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0047 0.0253
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.001 0.0019
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0055 0.0169 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0184 0.0552
Leishmania major replication Factor A 28 kDa subunit, putative 0.0038 0.0092 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.001 0.0031
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0024 0.0035 0.0173
Leishmania major DNA polymerase eta, putative 0.0019 0.001 0.0012
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0038 0.0092 0.0282
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0024 0.0035 0.0092
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0039 0.01 0.0306
Echinococcus multilocularis snurportin 1 0.0305 0.1257 0.1257
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.0038 0.0092 0.5193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Schistosoma mansoni importin beta-1 0.0029 0.0052 0.0098
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0153 0.0499
Schistosoma mansoni protein phosphatase-1 0.0024 0.0035 0.0065
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0038 0.0092 0.0092
Echinococcus multilocularis dna polymerase eta 0.0019 0.001 0.001
Echinococcus multilocularis dnaJ subfamily B 0.124 0.5338 0.5338
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0105 0.0324
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.002 0.0074
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0012 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0012
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0038 0.0092 0.0092
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0047 0.0253
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0042 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.0129
Trypanosoma brucei unspecified product 0.0019 0.001 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0029 0.0089
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Toxoplasma gondii histone lysine methyltransferase SET1 0.0218 0.0881 0.5765
Plasmodium falciparum aspartate--tRNA ligase 0.0038 0.0092 0.0552
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0105 0.0905
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0105 0.0641
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0105 0.0105
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0012 0.0299
Brugia malayi RNA, U transporter 1 0.0081 0.0282 0.0854
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.0039 0.01 0.01
Schistosoma mansoni methionine-tRNA synthetase 0.0347 0.1443 0.2704
Entamoeba histolytica Ran family GTPase 0.0021 0.002 0.0135
Mycobacterium tuberculosis Conserved protein 0.0041 0.0105 0.0905
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.0039 0.01 0.0603
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0009 0.0005
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.0027
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0105 0.0905
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.0129
Plasmodium falciparum nucleic acid binding protein, putative 0.0038 0.0092 0.0552
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0009 0.0014
Brugia malayi methionyl-tRNA synthetase 0.0347 0.1443 0.4429
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0052 0.0291
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0052 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0121
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0024 0.0102
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0333 0.1024
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0038
Plasmodium vivax lysine--tRNA ligase, putative 0.0038 0.0092 0.0552
Giardia lamblia Elongation factor 1-gamma 0.0018 0.0008 0.0202
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0009 0.0005
Echinococcus granulosus dna polymerase kappa 0.0019 0.001 0.001
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0184 0.0344
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0012 0.0139
Leishmania major lysyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0333 0.1024
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0324
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0009 0.0005
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0725 0.3089 0.9496
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0024 0.0035 0.0173
Trichomonas vaginalis protein phosphatase-1, putative 0.0039 0.01 0.0306
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0042 0.0129
Trypanosoma brucei Replication factor A protein 1 0.0365 0.1522 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0053 0.0053
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.0038 0.0092 0.0552
Loa Loa (eye worm) apoptosis regulator protein 0.0411 0.1723 0.5297
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0191 0.0764 0.4989
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0031
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0009 0.0005
Leishmania major importin beta-1 subunit, putative 0.0023 0.0029 0.0135
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0324
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0411 0.1723 0.1723
Brugia malayi beta-lactamase family protein 0.0041 0.0105 0.031
Brugia malayi beta-lactamase 0.0041 0.0105 0.031
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.0012
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.027 0.1105 0.3397
Plasmodium falciparum methionine--tRNA ligase 0.0055 0.0169 0.1063
Schistosoma mansoni protein phosphatase type 1 0.0039 0.01 0.0187
Plasmodium vivax importin-beta 2, putative 0.0029 0.0052 0.0291
Schistosoma mansoni lysyl-tRNA synthetase 0.0038 0.0092 0.0172
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0105 0.0905
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0009 0.0005
Giardia lamblia Hypothetical protein 0.0111 0.0414 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0038 0.0092 0.0552
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.0039 0.01 0.01
Plasmodium falciparum asparagine--tRNA ligase 0.0038 0.0092 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Toxoplasma gondii serine/threonine phosophatase PP1 0.0039 0.01 0.0603
Trichomonas vaginalis protein phosphatase-1, putative 0.0024 0.0035 0.0106
Echinococcus granulosus glycyl tRNA synthetase 0.027 0.1105 0.1105
Brugia malayi beta-lactamase family protein 0.0041 0.0105 0.031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0012
Schistosoma mansoni protein phosphatase-1 0.0039 0.01 0.0187
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0161
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0038 0.0092 0.5138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Brugia malayi replication factor A 73 kDa subunit 0.0762 0.3253 1
Schistosoma mansoni cpg binding protein 0.0122 0.046 0.0861
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.116 0.116
Schistosoma mansoni elongation factor 1-gamma 0.0018 0.0008 0.0016
Brugia malayi Elongation factor 1 gamma, conserved domain containing protein 0.0018 0.0008 0.0012
Giardia lamblia Leucyl-tRNA synthetase 0.0055 0.0169 0.4085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Onchocerca volvulus 0.0041 0.0105 0.0335
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0038 0.0092 0.0269
Schistosoma mansoni hypothetical protein 0.0411 0.1723 0.3229
Schistosoma mansoni hypothetical protein 0.0332 0.1377 0.258
Mycobacterium tuberculosis Possible penicillin-binding protein 0.026 0.1062 1
Leishmania major serine/threonine protein phosphatase pp1(5.9), putative 0.0024 0.0035 0.0173
Schistosoma mansoni hypothetical protein 0.0411 0.1723 0.3229
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0024 0.0035 0.0106
Loa Loa (eye worm) hypothetical protein 0.0074 0.025 0.0769
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0009 0.0009
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0105 0.0905
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0009 0.0005
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0762 0.3253 0.3253
Brugia malayi hypothetical protein 0.0018 0.0008 0.0012
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.001 0.0017
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0153 0.0153
Brugia malayi CXXC zinc finger family protein 0.0115 0.0431 0.1312
Plasmodium falciparum replication protein A1, large subunit 0.0365 0.1522 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0052 0.0291
Echinococcus multilocularis glycyl tRNA synthetase 0.027 0.1105 0.1105
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.116 0.116
Giardia lamblia GTOR 0.0019 0.0009 0.0221
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0047 0.0253
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0039 0.0206
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.001 0.0012
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.001 0.001
Echinococcus granulosus importin subunit beta 1 0.0029 0.0052 0.0052
Echinococcus granulosus snurportin 1 0.0305 0.1257 0.1257
Leishmania major replication factor A, 51kDa subunit, putative 0.0365 0.1522 1
Trypanosoma brucei polo-like protein kinase 0.0093 0.0333 0.2146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.0129
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0024 0.0035 0.0173
Leishmania major aspartyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.002 0.0074
Schistosoma mansoni replication factor A 1 rfa1 0.0762 0.3253 0.6095
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0324
Entamoeba histolytica hypothetical protein 0.0038 0.0092 0.0637
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0324
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0105 0.0197
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0012
Toxoplasma gondii tRNA ligases class I (M) protein 0.0055 0.0169 0.1063
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0324
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0153 0.0286
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.002 0.002
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0762 0.3253 1
Toxoplasma gondii aspartate-tRNA ligase 0.0038 0.0092 0.0552
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0009 0.0005
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0009 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.0129
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.0012
Schistosoma mansoni aspartyl-tRNA synthetase 0.0038 0.0092 0.0172
Plasmodium falciparum methionine--tRNA ligase, putative 0.0055 0.0169 0.1063
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.006
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0027
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0411 0.1723 0.529
Plasmodium vivax methionine--tRNA ligase, putative 0.0055 0.0169 0.1063
Mycobacterium ulcerans lipase LipD 0.0041 0.0105 0.5983
Entamoeba histolytica serine/threonine protein phosphatase PP1, putative 0.0024 0.0035 0.024
Mycobacterium tuberculosis Conserved protein 0.0041 0.0105 0.0905
Entamoeba histolytica replication factor A, putative 0.0074 0.025 0.1734
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.001 0.0019
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Mycobacterium leprae Probable lipase LipE 0.0041 0.0105 0.1739
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0038 0.0092 0.0092
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0009 0.0005
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0047 0.0253
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0024 0.0035 0.0106
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0047 0.0253
Loa Loa (eye worm) BRCA2 repeat family protein 0.0154 0.06 0.1843
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.001 0.007
Echinococcus granulosus eukaryotic translation elongation factor 1 0.0018 0.0008 0.0008
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0333 0.2146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0411 0.1723 0.5297
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0682 0.2904 1
Treponema pallidum asparaginyl-tRNA synthetase 0.0038 0.0092 0.0556
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0762 0.3253 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.001 0.0012
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0347 0.1443 0.4437
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0047 0.0253
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.0027
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0009 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0053 0.0099
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0009 0.0009
Echinococcus multilocularis geminin 0.0332 0.1377 0.1377
Echinococcus multilocularis dna polymerase kappa 0.0019 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0012
Leishmania major hypothetical protein, conserved 0.0027 0.0047 0.0253
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0084 0.0084
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0012 0.025
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0053 0.0053
Giardia lamblia Lysyl-tRNA synthetase 0.0038 0.0092 0.2219
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0169 0.1063
Brugia malayi Serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0024 0.0035 0.0092
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0055 0.0169 0.1063
Echinococcus granulosus dna polymerase eta 0.0019 0.001 0.001
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0038 0.0092 0.5138
Schistosoma mansoni aspartyl-tRNA synthetase 0.0038 0.0092 0.0172
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Leishmania major asparaginyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Plasmodium falciparum lysine--tRNA ligase 0.0038 0.0092 0.0552
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0333 0.1024
Plasmodium vivax methionine--tRNA ligase, putative 0.0055 0.0169 0.1063
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0024 0.0035 0.0106
Leishmania major GTP-binding protein, putative 0.0021 0.002 0.0074
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0055 0.0169 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0012
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0333 0.0333
Treponema pallidum leucyl-tRNA synthetase 0.0055 0.0169 0.1096
Giardia lamblia Kinase, PLK 0.0093 0.0333 0.8042
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0024 0.0035 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0333 0.1024
Echinococcus granulosus stringent starvation protein A 0.0018 0.0008 0.0008
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0333 0.1122
Toxoplasma gondii ABC1 family protein 0.0041 0.0105 0.0641
Onchocerca volvulus 0.0041 0.0105 0.0335
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0012 0.0038
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0039 0.01 0.01
Schistosoma mansoni protein phosphatase-1 0.0024 0.0035 0.0065
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0038 0.0092 0.0092
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0012 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Leishmania major aspartyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0084 0.0084
Entamoeba histolytica hypothetical protein 0.0026 0.0039 0.0274
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0029 0.0089
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0012 0.0024
Echinococcus multilocularis glutathione S transferase 0.0018 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0009 0.0009
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0009 0.0005
Schistosoma mansoni hypothetical protein 0.0305 0.1257 0.2355
Brugia malayi putative serine/threonine phosphatase 0.0024 0.0035 0.0092
Giardia lamblia Aspartyl-tRNA synthetase 0.0038 0.0092 0.2219
Loa Loa (eye worm) hypothetical protein 0.0055 0.0169 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Trypanosoma brucei protein phosphatase 1 0.0024 0.0035 0.0173
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0105 0.5983
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0411 0.1723 0.1723
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.027 0.1105 0.3387
Toxoplasma gondii exonuclease III APE 0.0019 0.0012 0.0027
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0024 0.0035 0.0092
Brugia malayi glycyl-tRNA synthetase 0.027 0.1105 0.3387
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0039 0.01 0.01
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0009 0.0005
Toxoplasma gondii hypothetical protein 0.008 0.0277 0.1776
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Schistosoma mansoni leucyl-tRNA synthetase 0.0055 0.0169 0.0317
Onchocerca volvulus 0.0052 0.0153 0.0499
Leishmania major DNA polymerase kappa, putative 0.0019 0.001 0.0012
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.001 0.001
Echinococcus granulosus geminin 0.0332 0.1377 0.1377
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0092 0.0552
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0009 0.0028
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Trypanosoma brucei protein phosphatase 1, putative 0.0039 0.01 0.0603
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0024 0.0035 0.0173
Entamoeba histolytica hypothetical protein 0.0023 0.0029 0.02
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0129 0.0395
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0055 0.0169 1
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0153 0.0286
Toxoplasma gondii methionyl-tRNA synthetase 0.0055 0.0169 0.1063
Loa Loa (eye worm) hypothetical protein 0.0052 0.0153 0.0469
Trichomonas vaginalis esterase, putative 0.0041 0.0105 0.0324
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0009 0.0014
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0762 0.3253 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0012 0.0012
Plasmodium falciparum asparagine--tRNA ligase 0.0038 0.0092 0.0552
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0106
Schistosoma mansoni ran 0.0021 0.002 0.0037
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0009 0.0006
Onchocerca volvulus 0.0115 0.0431 0.1459
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0024 0.0035 0.0106
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0333 0.1024
Loa Loa (eye worm) CXXC zinc finger family protein 0.0115 0.0431 0.1325
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0207 0.0831 0.0831
Leishmania major lysyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0347 0.1443 1
Giardia lamblia Asparaginyl-tRNA synthetase 0.0038 0.0092 0.2219
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0012 0.0021
Echinococcus multilocularis lysyl tRNA synthetase 0.0038 0.0092 0.0092
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0042 0.0129
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0845 0.3617 0.3617
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0105 0.0905
Echinococcus granulosus dnaJ subfamily B 0.124 0.5338 0.5338
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0074 0.025 0.0835
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0039 0.01 0.0306
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.116 0.2174
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0153 0.0469
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0012
Schistosoma mansoni protein phosphatase type 1 0.0039 0.01 0.0187
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0153 0.0153
Schistosoma mansoni protein phosphatase type 1 0.0024 0.0035 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0042 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0207 0.0831 0.0831
Trichomonas vaginalis protein phosphatase-1, putative 0.0024 0.0035 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Brugia malayi Glutathione S-transferase, N-terminal domain containing protein 0.0018 0.0008 0.0012
Entamoeba histolytica replication factor A protein 1, putative 0.0328 0.1358 0.9408
Loa Loa (eye worm) hypothetical protein 0.0055 0.0169 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0105 0.0105
Echinococcus multilocularis eukaryotic translation elongation factor 1 0.0018 0.0008 0.0008
Schistosoma mansoni aspartyl-tRNA synthetase 0.0038 0.0092 0.0172
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0105 0.0197
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0055 0.0169 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Schistosoma mansoni hypothetical protein 0.0317 0.1312 0.2457
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0333 0.0624
Brugia malayi Aspartyl-tRNA synthetase 0.0038 0.0092 0.0269
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0038 0.0092 0.0282
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0009 0.0005
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0009 0.0063
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0105 0.0905
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0472
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0038
Loa Loa (eye worm) beta-lactamase 0.0041 0.0105 0.0324
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0038 0.0092 0.0092
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0105 0.0641
Trichomonas vaginalis protein phosphatase-5, putative 0.0024 0.0035 0.0106
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.0039 0.01 0.01
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0024 0.0035 0.0173
Leishmania major leucyl-tRNA synthetase, putative 0.0055 0.0169 0.1063
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0184 0.0184
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0009 0.0005
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0184 0.0184
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0055 0.0169 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0009 0.0017
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0024 0.0035 0.0106
Loa Loa (eye worm) MBCTL1 0.0059 0.0184 0.0565
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0105 0.0324
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0105 0.0905
Schistosoma mansoni hypothetical protein 0.0038 0.0092 0.0172
Trypanosoma brucei protein phosphatase 1 0.0024 0.0035 0.0173
Brugia malayi Serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0024 0.0035 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0333 0.1024
Loa Loa (eye worm) hypothetical protein 0.0059 0.0184 0.0565
Loa Loa (eye worm) hypothetical protein 0.0038 0.0092 0.0282
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0024 0.0035 0.0173
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0053 0.0053
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0046
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0042 0.0129
Trichomonas vaginalis ran, putative 0.0021 0.002 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0039 0.01 0.0306
Schistosoma mansoni hypothetical protein 0.0411 0.1723 0.3229
Plasmodium vivax asparagine--tRNA ligase, putative 0.0038 0.0092 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Schistosoma mansoni methionine-tRNA synthetase 0.0055 0.0169 0.0317
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0039 0.0039
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0009 0.0028
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0365 0.1522 0.4678
Schistosoma mansoni protein phosphatase-1 0.0039 0.01 0.0187
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0042 0.0129
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0024 0.0035 0.0173
Schistosoma mansoni kinase 0.0047 0.0134 0.0251
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0105 0.0641
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0347 0.1443 0.1443
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0039 0.01 0.0306
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0245 0.0995 0.1864
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0039 0.0107
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0105 0.0641
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0039 0.0039
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.0039 0.01 0.01
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0105 0.1739
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.001 0.0012
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0055 0.0169 0.052
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0333 0.1024
Brugia malayi lysyl-tRNA synthetase 0.0038 0.0092 0.0269
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0026
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.0039 0.01 0.0603
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0762 0.3253 0.3253
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0039 0.01 0.01
Trichomonas vaginalis helicase, putative 0.0026 0.0042 0.0129
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Giardia lamblia DINP protein human, muc B family 0.0019 0.001 0.0246
Schistosoma mansoni apoptosis regulator bax 0.0411 0.1723 0.3229
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0012
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0055 0.0169 0.1513
Brugia malayi Importin beta-1 subunit 0.0029 0.0052 0.0147
Echinococcus multilocularis methionine tRNA synthetase 0.0055 0.0169 0.0169
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0024 0.0035 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0012
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0105 0.0324
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0039 0.01 0.01
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0009 0.0005
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0365 0.1522 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0038 0.0092 0.5138
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit 0.0039 0.01 0.2405
Mycobacterium ulcerans hypothetical protein 0.0041 0.0105 0.5983
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0333 0.2146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.001 0.0031
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0009 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0024 0.0035 0.0173
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0038 0.0092 0.0777
Treponema pallidum aspartyl-tRNA synthetase 0.0038 0.0092 0.0556
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0052 0.0052
Plasmodium vivax replication protein A1, large subunit, putative 0.0365 0.1522 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0073
Giardia lamblia Methionyl-tRNA synthetase 0.0055 0.0169 0.4085
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0038 0.0092 0.0282
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.001 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0105 0.0324
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0039 0.01 0.0306
Chlamydia trachomatis leucine--tRNA ligase 0.0055 0.0169 0.0572
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.116 0.2174
Brugia malayi BRCA2 repeat family protein 0.0154 0.06 0.1831
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0039 0.0074
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.1257 0.3863
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0053 0.0053
Schistosoma mansoni glycyl-tRNA synthetase 0.027 0.1105 0.207
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0029 0.0089
Loa Loa (eye worm) glycyl-tRNA synthetase 0.027 0.1105 0.3397
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0009 0.0005
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0333 0.2308
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0038 0.0092 0.0637
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0184 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028
Entamoeba histolytica hypothetical protein 0.0038 0.0092 0.0637
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0042 0.0129
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0184 0.0184
Brugia malayi mbt repeat family protein 0.0052 0.0153 0.0456
Schistosoma mansoni hypothetical protein 0.124 0.5338 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.002 0.002
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0333 0.0333
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0333 0.1011
Echinococcus granulosus cpg binding protein 0.0122 0.046 0.046
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0129 0.0395
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.002 0.0074
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.0039 0.01 0.0603
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.116 0.116
Plasmodium vivax aspartate--tRNA ligase, putative 0.0038 0.0092 0.0552
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0347 0.1443 0.1443
Schistosoma mansoni cpg binding protein 0.0115 0.0431 0.0807
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.0129
Echinococcus granulosus lysyl tRNA synthetase 0.0038 0.0092 0.0092
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0039 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0324
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0012
Plasmodium falciparum importin beta, putative 0.0029 0.0052 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.0026
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.002 0.0074
Schistosoma mansoni aspartyl-tRNA synthetase 0.0038 0.0092 0.0172
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0038 0.0092 0.0552
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0024 0.0035 0.0173
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0009 0.0006
Brugia malayi hypothetical protein 0.0027 0.0047 0.013
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.0039 0.01 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0028

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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