Detailed information for compound 1286802

Basic information

Technical information
  • TDR Targets ID: 1286802
  • Name: 6-[4-(4-methylbenzoyl)-1,4-diazepan-1-yl]-[1, 3]dioxolo[4,5-g]quinoline-7-carbonitrile
  • MW: 414.456 | Formula: C24H22N4O3
  • H donors: 0 H acceptors: 3 LogP: 3.83 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc2cc3OCOc3cc2nc1N1CCCN(CC1)C(=O)c1ccc(cc1)C
  • InChi: 1S/C24H22N4O3/c1-16-3-5-17(6-4-16)24(29)28-8-2-7-27(9-10-28)23-19(14-25)11-18-12-21-22(31-15-30-21)13-20(18)26-23/h3-6,11-13H,2,7-10,15H2,1H3
  • InChiKey: AVONPLRMXZPJON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[4-[(4-methylphenyl)-oxomethyl]-1,4-diazepan-1-yl]-[1,3]dioxolo[4,5-g]quinoline-7-carbonitrile
  • 6-[4-(4-methylphenyl)carbonyl-1,4-diazepan-1-yl]-[1,3]dioxolo[4,5-g]quinoline-7-carbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) 6-phosphofructokinase 0.043 0.2162 0.214
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.05 0.253 0.2518
Trypanosoma brucei PAB1-binding protein , putative 0.0127 0.0585 0.0706
Onchocerca volvulus Serine\/threonine kinase homolog 0.0761 0.3893 0.8384
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0058 0.022 0.0283
Echinococcus multilocularis chromobox protein 1 0.0069 0.0278 0.0369
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0142 0.066 0.0933
Loa Loa (eye worm) hypothetical protein 0.007 0.0285 0.0258
Echinococcus granulosus histone acetyltransferase KAT2B 0.07 0.3574 0.5226
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0063 0.0072
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.018 0.0163
Trichomonas vaginalis bromodomain containing protein, putative 0.0027 0.006 0.006
Trichomonas vaginalis bromodomain containing protein, putative 0.0027 0.006 0.006
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0221 0.1074 0.1514
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.018 0.0153
Loa Loa (eye worm) hypothetical protein 0.0233 0.1137 0.1112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.018 0.0153
Echinococcus granulosus hexokinase 0.0652 0.3322 0.4855
Brugia malayi Bromodomain containing protein 0.0316 0.1569 0.1545
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0142 0.066 0.0933
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0164 0.0201
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0043 0.0043
Brugia malayi hypothetical protein 0.0127 0.0585 0.0559
Loa Loa (eye worm) hypothetical protein 0.0279 0.1378 0.1354
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.018 0.03
Trypanosoma brucei 6-phosphogluconolactonase 0.005 0.0182 0.0185
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.1371 0.7076 0.7076
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0071 0.0289 0.0273
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0063 0.0035
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0063 0.0046
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0063 0.0023
Toxoplasma gondii histone acetyltransferase TAF1/250 0.0027 0.006 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.018 0.0153
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0071 0.0289 0.0289
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0116 0.0525 0.0705
Trichomonas vaginalis CAMK family protein kinase 0.0761 0.3893 0.3893
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1424 0.1424
Trypanosoma brucei bromodomain factor 2 protein, putative 0.0027 0.006 0.0027
Onchocerca volvulus 0.0652 0.3322 0.714
Loa Loa (eye worm) hypothetical protein 0.0039 0.012 0.0093
Brugia malayi jmjC domain containing protein 0.0053 0.0194 0.0167
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0116 0.0525 0.0748
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0014
Echinococcus granulosus lysine specific demethylase 5A 0.0207 0.1 0.1433
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 0.0071 0.0289 0.0297
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0415 0.0399
Brugia malayi MH1 domain containing protein 0.0032 0.0085 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0053 0.0194 0.0174
Leishmania major 6-phosphogluconolactonase 0.005 0.0182 0.0185
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0028 0.0063 0.0072
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0042 0.0021
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative 0.0741 0.3789 0.4854
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.0408 0.114
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.018 0.0153
Toxoplasma gondii bromodomain-containing protein 0.0027 0.006 0.0083
Leishmania major hypothetical protein, conserved 0.1503 0.7764 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0285 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0093 0.0093
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0053 0.0194 0.0272
Echinococcus granulosus FTZ F1 alpha 0.005 0.018 0.0224
Schistosoma mansoni smad1 5 8 and 0.0058 0.022 0.0203
Brugia malayi tailless protein 0.0024 0.0042 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0112 0.0506 0.049
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0035
Brugia malayi ecdysteroid receptor 0.005 0.018 0.0153
Onchocerca volvulus 0.0652 0.3322 0.714
Entamoeba histolytica ankyrin repeat protein, putative 0.0027 0.006 0.0032
Schistosoma mansoni hypothetical protein 0.006 0.0235 0.0218
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.0063 0.0023
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0042 0.0021
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0043 0.0015
Schistosoma mansoni jumonji/arid domain-containing protein 0.0207 0.1 0.0985
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.1186 0.6109 0.6098
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.018 0.0153
Loa Loa (eye worm) hypothetical protein 0.0243 0.1187 0.1163
Plasmodium vivax bromodomain protein, putative 0.0027 0.006 0.0081
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0164 0.0148
Echinococcus multilocularis JmjC domain containing protein 4 0.0053 0.0194 0.0245
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0063 0.003
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0027 0.006 0.006
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0116 0.0525 0.0705
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0112 0.0506 0.0705
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0053 0.0194 0.0174
Trichomonas vaginalis CAMK family protein kinase 0.0761 0.3893 0.3893
Brugia malayi nuclear receptor NHR-88 0.0024 0.0042 0.0014
Echinococcus multilocularis mothers against decapentaplegic 2 0.0026 0.0054 0.0038
Brugia malayi phosphofructokinase 0.043 0.2162 0.214
Brugia malayi Bromodomain containing protein 0.0027 0.006 0.0033
Echinococcus granulosus smad 0.0058 0.022 0.0283
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0164 0.023
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Echinococcus granulosus hexokinase type 2 0.0652 0.3322 0.4855
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0042 0.0014
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.007 0.0285 0.0757
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.018 0.0224
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0063 0.005
Trichomonas vaginalis phosphofructokinase, putative 0.043 0.2162 0.2162
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.0033
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 0.0071 0.0289 0.0323
Toxoplasma gondii phosphomannose isomerase type I protein 0.1186 0.6109 0.8633
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.0275 0.0364
Loa Loa (eye worm) RNA binding protein 0.0448 0.2256 0.2235
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.003 0.0074 0.0074
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0278 0.0278
Echinococcus granulosus bromodomain containing protein 8 0.0027 0.006 0.0048
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.1321 0.6813 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0256 0.1253 0.1806
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.004 0.0053
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0042 0.0014
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0173 0.0823 0.1014
Brugia malayi 6-phosphogluconolactonase family protein 0.005 0.0182 0.0155
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0106 0.0089
Trypanosoma cruzi aspartyl aminopeptidase, putative 0.0071 0.0289 0.0297
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0168 0.014
Trypanosoma cruzi phosphomannomutase, putative 0.0177 0.0844 0.1018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.018 0.0224
Schistosoma mansoni transcription initiation factor tfiid 0.0027 0.006 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0415 0.0399
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.0525 0.0717
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0063 0.003
Entamoeba histolytica acetyltransferase, GNAT family 0.0194 0.0933 0.1376
Brugia malayi polybromodomain protein 0.0027 0.006 0.0033
Echinococcus granulosus CREB binding protein 0.0027 0.006 0.0048
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0435 0.2192 0.319
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.018 0.0153
Schistosoma mansoni hypothetical protein 0.0115 0.0521 0.0505
Echinococcus granulosus Smad4 0.0058 0.022 0.0283
Echinococcus multilocularis peregrin 0.0142 0.0662 0.0934
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0094 0.0408 0.037
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0164 0.0201
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0761 0.3893 0.5697
Brugia malayi nuclear receptor RXR 0.0024 0.0042 0.0014
Plasmodium falciparum JmjC domain-containing protein, putative 0.0053 0.0194 0.0236
Echinococcus multilocularis phosphomannomutase 0.0177 0.0844 0.1204
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.018 0.0163
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0021 0.0028 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Toxoplasma gondii PHD-finger domain-containing protein 0.0115 0.0521 0.0733
Loa Loa (eye worm) PHD-finger family protein 0.0115 0.0521 0.0494
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0408 0.0382
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.018 0.0153
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.0063 0.0023
Brugia malayi follicle stimulating hormone receptor 0.0228 0.1112 0.1087
Plasmodium falciparum histone acetyltransferase GCN5 0.0194 0.0933 0.1284
Loa Loa (eye worm) hypothetical protein 0.005 0.018 0.0153
Echinococcus granulosus microtubule associated protein 2 0.0681 0.3472 0.5077
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0116 0.0525 0.0525
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0071 0.0289 0.0289
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0173 0.0823 0.099
Plasmodium falciparum bromodomain protein, putative 0.0027 0.006 0.0046
Schistosoma mansoni mannose-6-phosphate isomerase 0.1186 0.6109 0.6102
Schistosoma mansoni serine/threonine protein kinase 0.0761 0.3893 0.3883
Schistosoma mansoni hypothetical protein 0.0027 0.006 0.0043
Onchocerca volvulus Putative phosphomannomutase 0.0177 0.0844 0.1747
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.073 0.3728 0.3717
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0063 0.0035
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0043 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0377 0.1886 0.1886
Echinococcus multilocularis jumonji domain containing 1A 0.0053 0.0194 0.0245
Schistosoma mansoni protein phosphatase 2C 0.0053 0.0194 0.0178
Leishmania major hypothetical protein, conserved,predicted bromodomain protein 0.0027 0.006 0.0027
Echinococcus granulosus 6 phosphogluconolactonase 0.005 0.0182 0.0228
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0347 0.0321
Brugia malayi hypothetical protein 0.0233 0.1137 0.1112
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.018 0.0153
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Echinococcus granulosus bromodomain containing 2 0.0027 0.006 0.0048
Loa Loa (eye worm) hypothetical protein 0.005 0.018 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Brugia malayi nuclear receptor NHR-67 0.0024 0.0042 0.0014
Echinococcus multilocularis hexokinase 0.0652 0.3322 0.4855
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0019 0.0019
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0259 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0038 0.0116 0.0099
Loa Loa (eye worm) hypothetical protein 0.0112 0.0506 0.048
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.012 0.017
Trichomonas vaginalis bromodomain containing protein, putative 0.0027 0.006 0.006
Echinococcus granulosus jumonji domain containing protein 0.016 0.0756 0.1074
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0259 0.0341
Brugia malayi ecdysone receptor 0.0024 0.0042 0.0014
Brugia malayi glucose-6-phosphate dehydrogenase 0.1321 0.6813 0.6804
Loa Loa (eye worm) hypothetical protein 0.005 0.018 0.0153
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.018 0.0224
Schistosoma mansoni tar DNA-binding protein 0.0448 0.2256 0.2243
Loa Loa (eye worm) hypothetical protein 0.0094 0.0408 0.0382
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.1186 0.6109 0.6093
Plasmodium falciparum ataxin-2 like protein, putative 0.0127 0.0585 0.079
Brugia malayi latrophilin 2 splice variant baaae 0.0243 0.1187 0.1163
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0173 0.0823 0.0786
Echinococcus granulosus mothers against decapentaplegic 6 0.0026 0.0054 0.0038
Loa Loa (eye worm) hypothetical protein 0.005 0.018 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.018 0.0153
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.005 0.0182 0.0441
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Toxoplasma gondii PHD-finger domain-containing protein 0.0115 0.0521 0.0733
Echinococcus multilocularis muscleblind protein 1 0.018 0.0861 0.1228
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0063 0.0086
Onchocerca volvulus 0.0027 0.006 0.0039
Loa Loa (eye worm) hypothetical protein 0.018 0.0861 0.0836
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.005 0.0182 0.0158
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1424 0.1424
Trypanosoma brucei hypothetical protein, conserved 0.1503 0.7764 1
Brugia malayi Aspartyl aminopeptidase 0.0071 0.0289 0.0262
Schistosoma mansoni tar DNA-binding protein 0.0448 0.2256 0.2243
Plasmodium vivax ataxin-2 like protein, putative 0.0127 0.0585 0.0823
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0033 0.0093 0.0093
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0525 0.0525
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0033 0.0093 0.0093
Schistosoma mansoni phd finger protein 0.0027 0.006 0.0043
Loa Loa (eye worm) latrophilin receptor protein 2 0.0112 0.0506 0.048
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0127 0.0585 0.0559
Echinococcus multilocularis thyroid hormone receptor alpha 0.005 0.018 0.0224
Onchocerca volvulus 0.0652 0.3322 0.714
Entamoeba histolytica hexokinase 2 0.0652 0.3322 0.5055
Mycobacterium ulcerans 6-phosphogluconolactonase 0.005 0.0182 0.0143
Schistosoma mansoni hypothetical protein 0.0082 0.0345 0.0329
Trichomonas vaginalis CAMK family protein kinase 0.0761 0.3893 0.3893
Brugia malayi RNA binding protein 0.0448 0.2256 0.2235
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0164 0.0161
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.0275 0.0364
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.0033
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Brugia malayi hypothetical protein 0.0026 0.0057 0.0029
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0042 0.0021
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.1186 0.6109 0.8628
Trypanosoma brucei ISWI complex protein 0.006 0.0235 0.0253
Echinococcus multilocularis phd:f box containing protein 0.0053 0.0194 0.0245
Brugia malayi isocitrate dehydrogenase 0.0047 0.0164 0.0137
Onchocerca volvulus 0.0409 0.2054 0.438
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0232 0.0215
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.0235 0.0235
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.1267 0.6533 0.9232
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0232 0.0301
Trichomonas vaginalis phosphofructokinase, putative 0.043 0.2162 0.2162
Brugia malayi MH1 domain containing protein 0.0058 0.022 0.0192
Loa Loa (eye worm) phosphofructokinase 0.043 0.2162 0.214
Loa Loa (eye worm) hexokinase 0.0409 0.2054 0.2032
Leishmania major hypothetical protein, conserved 0.0127 0.0585 0.0706
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.0057 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Echinococcus granulosus global transcription activator snf2l2 0.0027 0.006 0.0048
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0038 0.0116 0.0099
Schistosoma mansoni hypothetical protein 0.05 0.253 0.2518
Trypanosoma cruzi polo-like protein kinase, putative 0.0761 0.3893 0.4975
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.018 0.0224
Echinococcus granulosus histone acetyltransferase KAT2B 0.0221 0.1074 0.1542
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0071 0.0289 0.0323
Schistosoma mansoni 6-phosphofructokinase 0.043 0.2162 0.2148
Brugia malayi Heterochromatin protein 1 0.0069 0.0278 0.0251
Trypanosoma cruzi hexokinase, putative 0.0652 0.3322 0.4233
Trichomonas vaginalis bromodomain containing protein, putative 0.0027 0.006 0.006
Onchocerca volvulus 0.0028 0.0063 0.0045
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.1371 0.7076 1
Trichomonas vaginalis CAMK family protein kinase 0.0761 0.3893 0.3893
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1424 0.2132
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.5031 0.7374
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.1321 0.6813 0.8765
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0058
Loa Loa (eye worm) hypothetical protein 0.0355 0.1774 0.1751
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.003 0.0074 0.0074
Schistosoma mansoni 6-phosphofructokinase 0.043 0.2162 0.2148
Trichomonas vaginalis CAMK family protein kinase 0.0761 0.3893 0.3893
Brugia malayi Bromodomain containing protein 0.0027 0.006 0.0033
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0067 0.0271 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.1371 0.7076 0.7076
Trypanosoma brucei Bromodomain factor 1 0.0027 0.006 0.0027
Brugia malayi 6-phosphofructokinase 0.043 0.2162 0.214
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.0235 0.0305
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0019 0.0019
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Brugia malayi MH2 domain containing protein 0.0844 0.4327 0.4311
Loa Loa (eye worm) hypothetical protein 0.007 0.0285 0.0258
Echinococcus granulosus JmjC domain containing protein 4 0.0053 0.0194 0.0245
Brugia malayi ATPase, AAA family protein 0.0027 0.006 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0232 0.0215
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0062 0.0062
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.004 0.0127 0.014
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.007 0.0285 0.0362
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.018 0.0224
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0408 0.0477
Brugia malayi phosphomannomutase 2 0.0177 0.0844 0.0819
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.018 0.0224
Trypanosoma brucei Bromodomain, putative 0.0027 0.006 0.0027
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0115 0.0521 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.018 0.0153
Mycobacterium ulcerans hypothetical protein 0.0094 0.0408 0.037
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0063 0.0023
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0063 0.0072
Loa Loa (eye worm) TAR-binding protein 0.0448 0.2256 0.2235
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0063 0.0086
Schistosoma mansoni hypothetical protein 0.0057 0.0218 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0063 0.0023
Trypanosoma brucei hexokinase 0.0652 0.3322 0.4249
Schistosoma mansoni zinc finger protein 0.0097 0.0426 0.0409
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.043 0.2162 0.6559
Onchocerca volvulus Alhambra homolog 0.0115 0.0521 0.1042
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0164 0.0135
Trichomonas vaginalis hypothetical protein 0.0027 0.006 0.006
Mycobacterium ulcerans hypothetical protein 0.0173 0.0823 0.0786
Schistosoma mansoni nuclear receptor 0.0024 0.0042 0.0025
Loa Loa (eye worm) hypothetical protein 0.0179 0.0852 0.0826
Loa Loa (eye worm) hypothetical protein 0.0207 0.1001 0.0976
Brugia malayi nuclear hormone receptor 0.0024 0.0042 0.0014
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.0033
Brugia malayi hexokinase 0.0652 0.3322 0.3303
Loa Loa (eye worm) bromodomain containing protein 0.0027 0.006 0.0033
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0408 0.0382
Entamoeba histolytica bromodomain-containing protein 0.0027 0.006 0.0032
Trypanosoma cruzi phosphomannose isomerase, putative 0.1186 0.6109 0.7851
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0014
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0047 0.0164 0.0228
Echinococcus granulosus PHD finger protein rhinoceros 0.0115 0.0521 0.0727
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.1321 0.6813 0.8768
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0164 0.023
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0042 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0265 0.0696
Toxoplasma gondii LsmAD domain-containing protein 0.0127 0.0585 0.0824
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.1137 0.1635
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.043 0.2162 0.2747
Trichomonas vaginalis phosphomannomutase, putative 0.0177 0.0844 0.0844
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0173 0.0823 0.0786
Leishmania major macrophage migration inhibitory factor-like protein 0.1267 0.6533 0.8405
Schistosoma mansoni smad 0.0058 0.022 0.0203
Onchocerca volvulus 0.0094 0.0408 0.0797
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0063 0.0072
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.004 0.0052
Brugia malayi hypothetical protein 0.0026 0.0057 0.0029
Echinococcus granulosus protein kinase C binding protein 1 0.0027 0.006 0.0048
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.005 0.0182 0.0158
Brugia malayi chromobox protein homolog 3 0.0039 0.012 0.0093
Echinococcus granulosus tar DNA binding protein 0.0448 0.2256 0.3284
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0026 0.0054 0.0025
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.004 0.5
Plasmodium vivax bromodomain protein, putative 0.0027 0.006 0.0081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0014
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0543 0.2753 0.4179
Leishmania major DNA-binding protein, putative,predicted bromodomain protein 0.0027 0.006 0.0027
Loa Loa (eye worm) hexokinase type II 0.0652 0.3322 0.3303
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.1186 0.6109 0.6098
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.0194 0.0167
Plasmodium vivax hypothetical protein, conserved 0.0027 0.006 0.0081
Schistosoma mansoni 6-phosphogluconolactonase 0.005 0.0182 0.0166
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.018 0.0163
Brugia malayi PHD-finger family protein 0.0115 0.0521 0.0494
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.018 0.0224
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0057 0.004
Brugia malayi 6-phosphofructokinase 0.043 0.2162 0.214
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0106 0.0115
Onchocerca volvulus 0.0035 0.01 0.0127
Brugia malayi TAR-binding protein 0.0448 0.2256 0.2235
Loa Loa (eye worm) hypothetical protein 0.005 0.018 0.0153
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0164 0.0161
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0027 0.006 0.006
Plasmodium falciparum phd finger protein, putative 0.0115 0.0521 0.0699
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0094 0.0408 0.114
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0408 0.037
Loa Loa (eye worm) hexokinase 0.0202 0.0972 0.0947
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0027 0.006 0.0048
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0112 0.0506 0.0705
Toxoplasma gondii hexokinase 0.0652 0.3322 0.4693
Schistosoma mansoni cpg binding protein 0.0035 0.01 0.0084
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.0057 0.0029
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0525 0.0525
Brugia malayi PHD-finger family protein 0.0118 0.0536 0.0509
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0063 0.0003
Brugia malayi hypothetical protein 0.0036 0.0106 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0093 0.0093
Schistosoma mansoni nuclear hormone receptor 0.005 0.018 0.0163
Echinococcus granulosus peregrin 0.0142 0.0662 0.0934
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.005 0.0182 0.0158
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0019 0.0019
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Echinococcus granulosus geminin 0.05 0.253 0.3689
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Loa Loa (eye worm) transcription factor SMAD2 0.0844 0.4327 0.4311
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.043 0.2162 0.6559
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1424 0.1424
Echinococcus multilocularis Smad4 0.0058 0.022 0.0283
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.018 0.0224
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0027 0.006 0.0083
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0042 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.1267 0.6533 0.6533
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.018 0.0224
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1424 0.2132
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.1424 0.2044
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0259 0.0341
Trichomonas vaginalis phosphofructokinase, putative 0.043 0.2162 0.2162
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0173 0.0823 0.0823
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0415 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.018 0.0153
Onchocerca volvulus 0.0903 0.4635 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0014
Echinococcus granulosus hexokinase 0.0652 0.3322 0.4855
Echinococcus multilocularis Bromodomain containing protein 0.0027 0.006 0.0048
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0042 0.0025
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0063 0.0086
Plasmodium vivax phosphomannomutase, putative 0.0177 0.0844 0.119
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0232 0.0193
Brugia malayi Latrophilin receptor protein 2 0.0112 0.0506 0.048
Schistosoma mansoni hexokinase 0.0652 0.3322 0.331
Trypanosoma brucei phosphomannose isomerase 0.1186 0.6109 0.7857
Loa Loa (eye worm) hypothetical protein 0.0094 0.0408 0.0382
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0232 0.0249
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0033 0.0093 0.0093
Loa Loa (eye worm) 6-phosphofructokinase 0.043 0.2162 0.214
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0232 0.0325
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.043 0.2162 0.3133
Toxoplasma gondii bromodomain-containing protein 0.0027 0.006 0.0083
Entamoeba histolytica phosphomannomutase, putative 0.0177 0.0844 0.1239
Schistosoma mansoni hypothetical protein 0.0048 0.0168 0.0151
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Onchocerca volvulus 0.003 0.0077 0.0076
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0057 0.0029
Loa Loa (eye worm) 6-phosphogluconolactonase 0.005 0.0182 0.0155
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0654 0.19
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0093 0.0093
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0259 0.0338
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0038 0.0116 0.0161
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0347 0.0331
Giardia lamblia Macrophage migration inhibitory factor 0.1267 0.6533 0.9226
Loa Loa (eye worm) hypothetical protein 0.005 0.018 0.0153
Echinococcus multilocularis mothers against decapentaplegic 5 0.0058 0.022 0.0283
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.018 0.0224
Toxoplasma gondii PHD-finger domain-containing protein 0.0038 0.0116 0.0161
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0014
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.1371 0.7076 0.7076
Trypanosoma brucei polo-like protein kinase 0.0761 0.3893 0.4988
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0014
Loa Loa (eye worm) hypothetical protein 0.0071 0.0289 0.0262
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0063 0.0072
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0042 0.0021
Trypanosoma brucei phosphomannomutase 0.0177 0.0844 0.1042
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.018 0.0163
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Entamoeba histolytica bromodomain-containing protein 0.0027 0.006 0.0032
Entamoeba histolytica hypothetical protein 0.0036 0.0106 0.0102
Brugia malayi hypothetical protein 0.0903 0.4635 0.462
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0063 0.0072
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0094 0.0408 0.114
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0415 0.0571
Echinococcus multilocularis cpg binding protein 0.0044 0.015 0.018
Brugia malayi jmjC domain containing protein 0.0053 0.0194 0.0167
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0057 0.0218 0.028
Brugia malayi steroid hormone receptor 0.005 0.018 0.0153
Entamoeba histolytica phosphofructokinase, putative 0.043 0.2162 0.3268
Echinococcus granulosus cpg binding protein 0.0044 0.015 0.018
Trypanosoma brucei AAA ATPase, putative 0.0027 0.006 0.0027
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0047 0.0164 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.018 0.0153
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0027 0.006 0.0081
Echinococcus multilocularis tar DNA binding protein 0.0448 0.2256 0.3284
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.0033
Schistosoma mansoni hypothetical protein 0.0112 0.0506 0.049
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.1321 0.6813 0.68
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0232 0.0301
Echinococcus granulosus lysine specific demethylase 6a 0.0053 0.0194 0.0245
Brugia malayi hypothetical protein 0.0082 0.0349 0.0322
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0232 0.0193
Brugia malayi DnaJ domain containing protein 0.006 0.0235 0.0208
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.1321 0.6813 1
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0042 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0063 0.0023
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.0235 0.0305
Schistosoma mansoni hypothetical protein 0.0027 0.006 0.0043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0265 0.0696
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0654 0.19
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0063 0.0023
Loa Loa (eye worm) PHD-finger family protein 0.0082 0.0345 0.0318
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.018 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0164 0.0201
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.1321 0.6813 0.6804
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0063 0.0072
Loa Loa (eye worm) RecQ helicase 0.0024 0.0043 0.0015
Entamoeba histolytica hypothetical protein 0.0036 0.0106 0.0102
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2498 0.364
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.018 0.0153
Brugia malayi serine/threonine-protein kinase plk-2 0.0761 0.3893 0.3876
Echinococcus granulosus PH interacting protein 0.0027 0.006 0.0048
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0116 0.013
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0053 0.0194 0.02
Toxoplasma gondii 6-phosphofructokinase 0.0116 0.0525 0.074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0063 0.0072
Loa Loa (eye worm) hypothetical protein 0.0068 0.0275 0.0248
Toxoplasma gondii bromodomain-containing protein 0.0027 0.006 0.0083
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0259 0.0284
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0525 0.0525
Echinococcus granulosus mothers against decapentaplegic 5 0.0058 0.022 0.0283
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Giardia lamblia Kinase, PLK 0.0761 0.3893 0.5463
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0425 0.2137 0.2696
Entamoeba histolytica acyl-CoA synthetase, putative 0.0094 0.0408 0.0568
Schistosoma mansoni hypothetical protein 0.0494 0.2498 0.2485
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0259 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0275 0.0259
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0112 0.0506 0.0705
Loa Loa (eye worm) BRM protein 0.0027 0.006 0.0033
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0063 0.0035
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.1267 0.6533 1
Echinococcus multilocularis geminin 0.05 0.253 0.3689
Brugia malayi PHD-finger family protein 0.0047 0.0166 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.018 0.0153
Loa Loa (eye worm) hypothetical protein 0.0152 0.0711 0.0685
Echinococcus multilocularis jumonji domain containing protein 0.016 0.0756 0.1074
Loa Loa (eye worm) macrophage migration inhibitory factor 0.1267 0.6533 0.6523
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.054 0.274 0.272
Entamoeba histolytica hexokinase 1 0.0652 0.3322 0.5055
Giardia lamblia Histone acetyltransferase GCN5 0.0194 0.0933 0.1244
Mycobacterium tuberculosis Conserved protein 0.0173 0.0823 0.242
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0063 0.003
Schistosoma mansoni smad 0.0026 0.0054 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0259 0.0258
Giardia lamblia Glucosamine-6-phosphate deaminase 0.005 0.0182 0.0174
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0043 0.001
Schistosoma mansoni chromobox protein 0.0069 0.0278 0.0262
Brugia malayi hexokinase type II 0.0207 0.1001 0.0976
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0063 0.0035
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Schistosoma mansoni nuclear receptor 0.0024 0.0042 0.0025
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.018 0.0163
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0116 0.0525 0.0717
Echinococcus granulosus mothers against decapentaplegic 2 0.0026 0.0054 0.0038
Loa Loa (eye worm) hypothetical protein 0.0082 0.0347 0.0321
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1424 0.1424
Schistosoma mansoni coup transcription factor 0.005 0.018 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0207 0.1 0.0985
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0063 0.0063
Plasmodium vivax acyl-CoA synthetase, putative 0.007 0.0285 0.0399
Loa Loa (eye worm) nuclear factor I 0.0032 0.0085 0.0058
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0303 0.0287
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0042 0.0021
Onchocerca volvulus 0.0048 0.0168 0.0273
Loa Loa (eye worm) hypothetical protein 0.0903 0.4635 0.462
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0029
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0042 0.0014
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.0063 0.0023
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Leishmania major hypothetical protein, conserved 0.0053 0.0194 0.02
Schistosoma mansoni cpg binding protein 0.0044 0.015 0.0133
Schistosoma mansoni bromodomain containing protein 0.0037 0.011 0.0093
Loa Loa (eye worm) hexokinase 0.0652 0.3322 0.3303
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0643 0.3275 1
Schistosoma mansoni bromodomain containing 0.0027 0.006 0.0043
Loa Loa (eye worm) hypothetical protein 0.003 0.0077 0.0049
Trichomonas vaginalis hypothetical protein 0.0033 0.0093 0.0093
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0278 0.0251
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0265 0.0696
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0042 0.0021
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0091 0.0395 0.0378
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Entamoeba histolytica serine/threonine protein kinase, putative 0.0761 0.3893 0.5935
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0408 0.0382
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0014
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0063 0.0072
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.1321 0.6813 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0136 0.0136
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0042 0.0021
Schistosoma mansoni thyroid hormone receptor 0.005 0.018 0.0163
Brugia malayi Bromodomain containing protein 0.0027 0.006 0.0033
Leishmania major hypothetical protein, conserved 0.0027 0.006 0.0027
Onchocerca volvulus 0.0028 0.0063 0.0045
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.0071 0.0289 0.0405
Brugia malayi Bromodomain containing protein 0.0027 0.006 0.0033
Entamoeba histolytica hypothetical protein 0.0036 0.0106 0.0102
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0053 0.0194 0.0178
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0164 0.0201
Schistosoma mansoni bromodomain containing protein 0.0027 0.006 0.0043
Entamoeba histolytica bromodomain-containing protein 0.0027 0.006 0.0032
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0063 0.003
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0347 0.0471
Brugia malayi nuclear hormone receptor 0.005 0.018 0.0153
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0047 0.0164 0.0385
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0415 0.0399
Toxoplasma gondii bromodomain-containing protein 0.0027 0.006 0.0083
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.1321 0.6813 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0047 0.0164 0.0161
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.1186 0.6109 0.6098
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0761 0.3893 0.5697
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0408 0.037
Brugia malayi TAZ zinc finger family protein 0.0027 0.006 0.0033
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0256 0.1253 0.1806
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.3472 0.5077
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Schistosoma mansoni zinc finger protein 0.006 0.0235 0.0218
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0029
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0042 0.0014
Loa Loa (eye worm) hypothetical protein 0.007 0.0285 0.0258
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.0408 0.114
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0259 0.0232
Schistosoma mansoni jumonji domain containing protein 0.0053 0.0194 0.0178
Plasmodium falciparum M18 aspartyl aminopeptidase 0.0071 0.0289 0.037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0415 0.0389
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0408 0.0477
Trypanosoma cruzi phosphomannose isomerase, putative 0.1186 0.6109 0.7851
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0116 0.0525 0.0663
Echinococcus granulosus fetal alzheimer antigen falz 0.0091 0.0395 0.0541
Entamoeba histolytica hypothetical protein 0.0036 0.0106 0.0102
Chlamydia trachomatis 6-phosphogluconolactonase 0.005 0.0182 0.0211
Schistosoma mansoni smad1 5 8 and 0.0058 0.022 0.0203
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0063 0.0023
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0014
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0116 0.0525 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Schistosoma mansoni thyroid hormone receptor 0.005 0.018 0.0163
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Onchocerca volvulus Hexokinase homolog 0.0409 0.2054 0.438
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0761 0.3893 0.4988
Loa Loa (eye worm) hypothetical protein 0.018 0.0861 0.0836
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0408 0.037
Loa Loa (eye worm) oxidoreductase 0.0028 0.0063 0.0035
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0259 0.0243
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1424 0.1424
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0019 0.0019
Echinococcus multilocularis hexokinase 0.0652 0.3322 0.4855
Loa Loa (eye worm) hypothetical protein 0.0445 0.224 0.2218
Brugia malayi F/Y-rich N-terminus family protein 0.0056 0.0211 0.0183
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0027 0.006 0.0048
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0082
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0062 0.0244 0.0319
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0415 0.0571
Echinococcus multilocularis smad 0.0058 0.022 0.0283
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.3472 0.3461
Loa Loa (eye worm) hypothetical protein 0.005 0.018 0.0153
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Echinococcus multilocularis muscleblind protein 0.018 0.0861 0.1228
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0042 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.0761 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.0033
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.018 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.1321 0.6813 0.6807
Trichomonas vaginalis bromodomain containing protein, putative 0.0027 0.006 0.006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.018 0.0153
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.018 0.0224
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.0033
Echinococcus multilocularis zinc finger protein 0.0097 0.0426 0.0586
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.0194 0.0167
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.1321 0.6813 0.8768
Brugia malayi nuclear receptor NHR-88 0.005 0.018 0.0153
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0415 0.0571
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0053 0.0194 0.0272
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Echinococcus granulosus phosphomannomutase 0.0177 0.0844 0.1204
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.073 0.3728 0.5453
Schistosoma mansoni hypothetical protein 0.0038 0.0116 0.0099
Brugia malayi MH2 domain containing protein 0.0026 0.0054 0.0026
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0063 0.0072
Giardia lamblia PHD finger protein 15 0.0115 0.0521 0.0656
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0046 0.0161 0.0144
Onchocerca volvulus Brd8 homolog 0.0027 0.006 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1424 0.1424
Loa Loa (eye worm) acetyltransferase 0.073 0.3728 0.371
Leishmania major hexokinase, putative 0.0652 0.3322 0.4249
Schistosoma mansoni smad1 5 8 and 0.0058 0.022 0.0203
Loa Loa (eye worm) hypothetical protein 0.0119 0.0541 0.0515
Loa Loa (eye worm) MH1 domain-containing protein 0.0058 0.022 0.0192
Entamoeba histolytica aspartyl aminopeptidase, putative 0.0071 0.0289 0.0384
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0221 0.1074 0.1074
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0063 0.0003
Trypanosoma cruzi polo-like protein kinase, putative 0.0761 0.3893 0.4975
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Brugia malayi conserved hypotetical protein 0.0024 0.0042 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Echinococcus multilocularis lysine specific demethylase 6a 0.0053 0.0194 0.0245
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.0033
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0042 0.0021
Plasmodium falciparum bromodomain protein 2, putative 0.0027 0.006 0.0046
Echinococcus multilocularis chromobox protein 1 0.0069 0.0278 0.0369
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0043 0.0043
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC 0.0071 0.0289 0.0771
Giardia lamblia Glucosamine-6-phosphate deaminase 0.005 0.0182 0.0174
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.054 0.274 0.272
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0042 0.0021
Plasmodium falciparum acyl-CoA synthetase 0.007 0.0285 0.0364
Trypanosoma cruzi hexokinase, putative 0.0652 0.3322 0.4233
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0094 0.0408 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.012 0.012
Trichomonas vaginalis CAMK family protein kinase 0.0761 0.3893 0.3893
Trichomonas vaginalis hypothetical protein 0.0027 0.006 0.006
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.043 0.2162 0.2728
Brugia malayi acetyltransferase, GNAT family protein 0.073 0.3728 0.371
Schistosoma mansoni hypothetical protein 0.0112 0.0506 0.049
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0173 0.0823 0.242
Onchocerca volvulus 0.0028 0.0063 0.0045
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.1186 0.6109 0.6109
Schistosoma mansoni hypothetical protein 0.0243 0.1187 0.1172
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.018 0.0153
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0221 0.1074 0.1515
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Brugia malayi Bm-MIF-1, identical 0.1267 0.6533 0.6523
Trypanosoma brucei Bromodomain, putative 0.0027 0.006 0.0027
Brugia malayi hypothetical protein 0.0024 0.0042 0.0014
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Brugia malayi Isocitrate dehydrogenase 0.0047 0.0164 0.0137
Trichomonas vaginalis lymphoid specific helicase, putative 0.0027 0.006 0.006
Echinococcus granulosus aspartyl aminopeptidase 0.0071 0.0289 0.0385
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Plasmodium falciparum hexokinase 0.0652 0.3322 0.4673
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0275 0.0259
Plasmodium vivax bromodomain protein, putative 0.0027 0.006 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Loa Loa (eye worm) jmjC domain-containing protein 0.0238 0.1161 0.1136
Brugia malayi Hexokinase family protein 0.0652 0.3322 0.3303
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.0235 0.0208
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0438 0.2203 0.2782
Echinococcus granulosus 6 phosphofructokinase 0.043 0.2162 0.3145
Onchocerca volvulus Bile acid receptor homolog 0.005 0.018 0.03
Echinococcus granulosus chromobox protein 1 0.0069 0.0278 0.0369
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.1371 0.7076 1
Onchocerca volvulus 0.0027 0.006 0.0039
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.0063 0.0023
Loa Loa (eye worm) hypothetical protein 0.0115 0.0521 0.0494
Echinococcus multilocularis hexokinase 0.0652 0.3322 0.4855
Plasmodium falciparum phosphomannomutase, putative 0.0177 0.0844 0.1158
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0063 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0355 0.1774 0.1751
Trypanosoma cruzi PAB1-binding protein , putative 0.0127 0.0585 0.0681
Leishmania major hypothetical protein, conserved 0.0027 0.006 0.0027
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.018 0.0224
Brugia malayi Muscleblind-like protein 0.018 0.0861 0.0836
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0063 0.0023
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.1267 0.6533 0.6533
Trypanosoma cruzi ISWI complex protein 0.006 0.0235 0.0227
Echinococcus granulosus chromobox protein 1 0.0069 0.0278 0.0369
Trypanosoma brucei Bromodomain, putative 0.0027 0.006 0.0027
Entamoeba histolytica acyl-coA synthetase, putative 0.0094 0.0408 0.0568
Trypanosoma brucei hexokinase, putative 0.0652 0.3322 0.4249
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.018 0.0163
Mycobacterium ulcerans 6-phosphofructokinase 0.043 0.2162 0.213
Echinococcus multilocularis hexokinase type 2 0.0652 0.3322 0.4855
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0063 0.0003
Loa Loa (eye worm) phosphomannomutase 2 0.0177 0.0844 0.0819
Loa Loa (eye worm) bromodomain containing protein 0.0087 0.0376 0.0349
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0213 0.1031 0.1006
Echinococcus granulosus citrate lyase subunit beta protein 0.0173 0.0823 0.1172
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0028 0.0063 0.0023
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0232 0.0193
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Echinococcus multilocularis PHD finger protein rhinoceros 0.0115 0.0521 0.0727
Trypanosoma cruzi hypothetical protein, conserved 0.1503 0.7764 1
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.005 0.0182 0.0182
Mycobacterium tuberculosis Probable aminopeptidase PepC 0.0071 0.0289 0.0771
Leishmania major hexokinase, putative 0.0652 0.3322 0.4249
Schistosoma mansoni phd/f-box containing protein 0.0053 0.0194 0.0178
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Onchocerca volvulus 0.0082 0.0347 0.0665
Schistosoma mansoni Smad4 0.0026 0.0054 0.0037
Toxoplasma gondii hypothetical protein 0.0027 0.006 0.0083
Echinococcus granulosus Bromodomain containing protein 0.0027 0.006 0.0048
Trichomonas vaginalis bromodomain containing protein, putative 0.0027 0.006 0.006
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0741 0.3789 0.484
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0173 0.0823 0.0786
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0741 0.3789 0.484
Entamoeba histolytica hypothetical protein 0.0027 0.006 0.0032
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.005 0.0182 0.0185
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0063 0.0072
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0054 0.0026
Schistosoma mansoni methyl-cpg binding protein mbd 0.0067 0.0271 0.0255
Onchocerca volvulus 0.005 0.018 0.03
Brugia malayi CXXC zinc finger family protein 0.0035 0.01 0.0073
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0063 0.0063
Echinococcus multilocularis 6 phosphogluconolactonase 0.005 0.0182 0.0228
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0063 0.0035
Brugia malayi mothers against decapentaplegic homolog 3 0.0026 0.0054 0.0026
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0028 0.0063 0.0023
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0063 0.0036
Plasmodium vivax hypothetical protein, conserved 0.004 0.0127 0.0175
Plasmodium falciparum macrophage migration inhibitory factor 0.1267 0.6533 0.9229
Schistosoma mansoni Smad4 0.0058 0.022 0.0203
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0057 0.0029
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0042 0.0025
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0057 0.0218 0.028
Echinococcus multilocularis bromodomain containing 2 0.0027 0.006 0.0048
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.0057 0.0043
Giardia lamblia Transcription regulatory protein SNF2 0.0027 0.006 0.000000000029989
Trichomonas vaginalis bromodomain and PHD finger-containing protein, putative 0.0027 0.006 0.006
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0027 0.006 0.006
Echinococcus multilocularis global transcription activator snf2l2 0.0027 0.006 0.0048
Loa Loa (eye worm) hypothetical protein 0.007 0.0285 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0448 0.2256 0.2243
Brugia malayi hypothetical protein 0.0024 0.0042 0.0014
Plasmodium vivax hexokinase, putative 0.0652 0.3322 0.4692
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Schistosoma mansoni zinc finger protein 0.0024 0.0042 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0377 0.1886 0.1886
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0525 0.0525
Echinococcus multilocularis aspartyl aminopeptidase 0.0071 0.0289 0.0385
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0525 0.0525
Leishmania major hypothetical protein, conserved 0.006 0.0235 0.0253
Schistosoma mansoni survival motor neuron protein 0.0048 0.0168 0.0151
Echinococcus granulosus jumonji domain containing 1A 0.0053 0.0194 0.0245
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.1371 0.7076 1
Leishmania major ATP-dependent phosphofructokinase 0.043 0.2162 0.2747
Entamoeba histolytica phosphomannose isomerase, putative 0.1186 0.6109 0.9347
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0027 0.006 0.0043
Echinococcus multilocularis protein kinase C binding protein 1 0.0027 0.006 0.0048
Loa Loa (eye worm) CBP-B 0.0027 0.006 0.0033
Brugia malayi Bromodomain containing protein 0.0169 0.0801 0.0776
Echinococcus granulosus polybromo 1 0.0027 0.006 0.0048
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0761 0.3893 0.3876
Brugia malayi jmjC domain containing protein 0.0207 0.1 0.0975
Echinococcus granulosus mannose 6 phosphate isomerase 0.1186 0.6109 0.8962
Brugia malayi Bromodomain containing protein 0.0027 0.006 0.0033
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.005 0.0182 0.0166
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0063 0.0035
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0116 0.0525 0.074
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0136 0.0136
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0062 0.0244 0.0319
Echinococcus multilocularis bromodomain containing protein 8 0.0027 0.006 0.0048
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0054 0.0026
Brugia malayi RNA recognition motif domain containing protein 0.0448 0.2256 0.2235
Loa Loa (eye worm) aspartyl aminopeptidase 0.0071 0.0289 0.0262
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.0033
Schistosoma mansoni hypothetical protein 0.006 0.0235 0.0218
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0042 0.0025
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.005 0.0182 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.018 0.0153
Echinococcus granulosus hexokinase 0.0652 0.3322 0.4855
Onchocerca volvulus 0.0028 0.0063 0.0045
Schistosoma mansoni helicase 0.0027 0.006 0.0043
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0112 0.0506 0.048
Brugia malayi Hexokinase family protein 0.0202 0.0972 0.0947
Echinococcus granulosus GPCR family 2 0.0112 0.0506 0.0705
Plasmodium vivax 6-phosphofructokinase, putative 0.0116 0.0525 0.0738
Loa Loa (eye worm) hypothetical protein 0.0188 0.0901 0.0876
Echinococcus granulosus Bromodomain containing protein 0.0027 0.006 0.0048
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0028 0.0063 0.0072
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0014
Toxoplasma gondii bromodomain-containing protein 0.0027 0.006 0.0083
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0071 0.0289 0.0273
Brugia malayi Calcitonin receptor-like protein seb-1 0.0355 0.1774 0.1751
Schistosoma mansoni bromodomain containing protein 0.027 0.1327 0.1312
Brugia malayi Smad1 0.0058 0.022 0.0192
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0027 0.006 0.006
Brugia malayi Steroid receptor seven-up type 2 0.005 0.018 0.0153
Brugia malayi Bromodomain containing protein 0.0027 0.006 0.0033
Trichomonas vaginalis bromodomain-containing protein, putative 0.0221 0.1074 0.1074
Loa Loa (eye worm) MH2 domain-containing protein 0.0844 0.4327 0.4311
Schistosoma mansoni polybromo-1 0.0027 0.006 0.0043
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Loa Loa (eye worm) DR-78 0.0024 0.0042 0.0014
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0232 0.0594
Entamoeba histolytica acyl-CoA synthetase, putative 0.0094 0.0408 0.0568
Loa Loa (eye worm) hypothetical protein 0.0207 0.1001 0.0976
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0028 0.0063 0.0023
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0035
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0071 0.0289 0.0289
Loa Loa (eye worm) jmjC domain-containing protein 0.0207 0.1 0.0975
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.018 0.0224
Mycobacterium ulcerans hypothetical protein 0.0173 0.0823 0.0786
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0063 0.0072
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0019 0.0019
Schistosoma mansoni Smad4 0.0026 0.0054 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Echinococcus multilocularis Bromodomain containing protein 0.0027 0.006 0.0048
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0458 0.2311 0.702
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0278 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0042 0.0014
Schistosoma mansoni hypothetical protein 0.0027 0.006 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0063 0.0023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.018 0.0163
Entamoeba histolytica bromodomain-containing protein 0.0027 0.006 0.0032
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.0027 0.006 0.0048
Echinococcus multilocularis lysine specific demethylase 5A 0.0197 0.095 0.1359
Trypanosoma cruzi PAB1-binding protein , putative 0.0127 0.0585 0.0681
Echinococcus multilocularis FTZ F1 alpha 0.005 0.018 0.0224
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.018 0.03
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0862 0.4421 0.4399
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0408 0.0477
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0053 0.0194 0.0167
Brugia malayi Bromodomain containing protein 0.0142 0.0662 0.0636
Echinococcus multilocularis PH interacting protein 0.0027 0.006 0.0048
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.005 0.0182 0.022
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.018 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.012 0.012
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.018 0.0163
Brugia malayi MH2 domain containing protein 0.0058 0.022 0.0192
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0042 0.0014
Plasmodium falciparum bromodomain protein 1 0.0027 0.006 0.0046
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0173 0.0823 0.099
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.01 0.0073
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0042 0.0014
Plasmodium vivax 6-phosphofructokinase, putative 0.0116 0.0525 0.0738
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.005 0.0182 0.0158
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0091 0.0395 0.0541
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0027 0.006 0.0043
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0221 0.1074 0.1515
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.1371 0.7076 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.018 0.0153
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.1186 0.6109 0.8633
Brugia malayi bromodomain containing protein 0.0027 0.006 0.0033
Brugia malayi Bromodomain containing protein 0.0027 0.006 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0063 0.0023
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.0057 0.004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0112 0.0506 0.0705
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.1112 0.1087
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0053 0.0194 0.0167
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0136 0.0204
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0435 0.2192 0.319
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0047 0.0164 0.0194
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0415 0.0389
Leishmania major glucosamine-6-phosphate isomerase, putative 0.005 0.0182 0.0185
Echinococcus granulosus CREB binding protein 0.0027 0.006 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1424 0.1424
Leishmania major macrophage migration inhibitory factor-like protein 0.1267 0.6533 0.8405
Schistosoma mansoni chromobox protein 0.0069 0.0278 0.0262
Schistosoma mansoni hypothetical protein 0.0027 0.006 0.0043
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0285 0.0246
Loa Loa (eye worm) hypothetical protein 0.0071 0.0289 0.0262
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0058 0.022 0.0283
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0164 0.0137
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.1186 0.6109 0.6098
Schistosoma mansoni tar DNA-binding protein 0.0448 0.2256 0.2243
Leishmania major phosphomannomutase, putative 0.0177 0.0844 0.1042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0265 0.0696
Toxoplasma gondii histone lysine methyltransferase SET1 0.0093 0.0403 0.0567
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0164 0.0201
Loa Loa (eye worm) hypothetical protein 0.0047 0.0166 0.0138
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0448 0.2256 0.2235
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0058 0.022 0.0203
Echinococcus multilocularis 6 phosphofructokinase 0.043 0.2162 0.3145
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Brugia malayi jmjC domain containing protein 0.0053 0.0194 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0164 0.0201
Brugia malayi nuclear receptor RXR 0.0026 0.0057 0.0029
Echinococcus multilocularis mannose 6 phosphate isomerase 0.1186 0.6109 0.8962
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0063 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.1503 0.7764 1
Schistosoma mansoni phosphatidylserine receptor 0.0053 0.0194 0.0178
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0094 0.0408 0.037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0106 0.0115
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0042 0.0021
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Onchocerca volvulus Bromodomain adjacent to zinc finger domain protein 1A homolog 0.0027 0.006 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0062 0.0062
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0071 0.0289 0.0323
Brugia malayi MH1 domain containing protein 0.0058 0.022 0.0192
Schistosoma mansoni hypothetical protein 0.0036 0.0106 0.0089
Echinococcus multilocularis GPCR, family 2 0.0112 0.0506 0.0705
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.018 0.0163
Echinococcus multilocularis 0.0027 0.006 0.0048
Echinococcus multilocularis citrate lyase subunit beta protein 0.0173 0.0823 0.1172
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0027 0.006 0.006
Brugia malayi jmjC domain containing protein 0.0053 0.0194 0.0167
Entamoeba histolytica phosphofructokinase, putative 0.043 0.2162 0.3268
Echinococcus granulosus phd:f box containing protein 0.0053 0.0194 0.0245
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0347 0.0471
Schistosoma mansoni kinase 0.0387 0.1939 0.1925
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0063 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.018 0.0224
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Brugia malayi polybromodomain protein 0.0027 0.006 0.0033
Echinococcus granulosus muscleblind protein 0.018 0.0861 0.1228
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0094 0.0408 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Entamoeba histolytica bromodomain-containing protein 0.0027 0.006 0.0032
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.018 0.0153
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0862 0.4421 0.6248
Loa Loa (eye worm) MH2 domain-containing protein 0.0058 0.022 0.0192
Brugia malayi AF-10 protein 0.0038 0.0116 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.005 0.018 0.0153
Toxoplasma gondii phosphomannomutase 0.0177 0.0844 0.1191
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.018 0.0153
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0063 0.0052
Loa Loa (eye worm) hypothetical protein 0.0094 0.0408 0.0382
Schistosoma mansoni CREB-binding protein 2 0.0027 0.006 0.0043
Treponema pallidum hexokinase (hxk) 0.0652 0.3322 0.4846
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2498 0.364
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0259 0.0284
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0042 0.0014
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.1137 0.1635
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0063 0.0072
Schistosoma mansoni 6-phosphogluconolactonase 0.005 0.0182 0.0166
Entamoeba histolytica aminopeptidase, putative 0.0071 0.0289 0.0384
Trypanosoma cruzi ISWI complex protein 0.006 0.0235 0.0227
Echinococcus granulosus methyl CpG binding domain protein 2 0.0067 0.0271 0.0359
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0014
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.1424 0.1944
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.0194 0.0167
Onchocerca volvulus 0.0027 0.006 0.0039
Brugia malayi MH2 domain containing protein 0.0058 0.022 0.0192
Plasmodium falciparum ataxin-2 like protein, putative 0.0127 0.0585 0.079
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0063 0.0035
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Schistosoma mansoni cpg binding protein 0.0044 0.015 0.0133
Loa Loa (eye worm) Smad1 0.0058 0.022 0.0192
Plasmodium vivax JmjC domain containing protein 0.0053 0.0194 0.027
Schistosoma mansoni methyl-cpg binding protein mbd 0.0067 0.0271 0.0255
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0063 0.0052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0014
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.004 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.043 0.2162 0.2162
Schistosoma mansoni phosphomannomutase 0.0177 0.0844 0.0829
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Plasmodium vivax SET domain containing protein 0.0028 0.0064 0.0087
Echinococcus multilocularis CREB binding protein 0.0027 0.006 0.0048
Schistosoma mansoni jumonji domain containing protein 0.0358 0.1787 0.1773
Echinococcus multilocularis polybromo 1 0.0027 0.006 0.0048
Brugia malayi MH1 domain containing protein 0.0032 0.0085 0.0058
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.004 0.0053
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0042 0.0025
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0116 0.013
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006
Trichomonas vaginalis bromodomain-containing protein 3, brd3, putative 0.0027 0.006 0.006
Entamoeba histolytica phosphofructokinase, putative 0.043 0.2162 0.3268
Brugia malayi Hexokinase family protein 0.0409 0.2054 0.2032
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0355 0.1774 0.1751
Toxoplasma gondii phosphofructokinase PFKII 0.0116 0.0525 0.074
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0643 0.3275 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0026 0.0054 0.0038
Schistosoma mansoni hypothetical protein 0.0112 0.0506 0.049
Leishmania major hypothetical protein, conserved 0.0741 0.3789 0.4854
Echinococcus granulosus zinc finger protein 0.0097 0.0426 0.0586
Leishmania major phosphomannose isomerase 0.1186 0.6109 0.7857
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0028 0.0063 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.006 0.006
Brugia malayi jmjC domain containing protein 0.0435 0.2192 0.217
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0029
Echinococcus granulosus bloom syndrome protein 0.0024 0.0043 0.0022
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0654 0.0617
Loa Loa (eye worm) hexokinase 0.0652 0.3322 0.3303
Trypanosoma brucei hexokinase 0.0652 0.3322 0.4249
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0063 0.0085
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0521 0.0732
Brugia malayi BRM protein 0.0027 0.006 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0448 0.2256 0.2243
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1424 0.1424
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0525 0.0525
Entamoeba histolytica bromodomain-containing protein 0.0027 0.006 0.0032
Plasmodium vivax macrophage migration inhibitory factor, putative 0.1267 0.6533 0.9232
Loa Loa (eye worm) steroid hormone receptor 0.005 0.018 0.0153
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0014
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.006 0.006

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.7783 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 17.7828 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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