Detailed information for compound 1287393

Basic information

Technical information
  • TDR Targets ID: 1287393
  • Name: hydron; N-(3-imidazol-1-ylpropyl)-9H-xanthene -9-carboxamide; chloride
  • MW: 369.845 | Formula: C20H20ClN3O2
  • H donors: 1 H acceptors: 2 LogP: 3.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1c2ccccc2Oc2c1cccc2)NCCCn1cncc1.Cl
  • InChi: 1S/C20H19N3O2.ClH/c24-20(22-10-5-12-23-13-11-21-14-23)19-15-6-1-3-8-17(15)25-18-9-4-2-7-16(18)19;/h1-4,6-9,11,13-14,19H,5,10,12H2,(H,22,24);1H
  • InChiKey: ZKVWMISJYVBBFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-imidazol-1-ylpropyl)-9H-xanthene-9-carboxamide hydrochloride
  • hydron; N-[3-(1-imidazolyl)propyl]-9H-xanthene-9-carboxamide; chloride
  • N-[3-(1-imidazolyl)propyl]-9H-xanthene-9-carboxamide hydrochloride
  • MLS000080338
  • SMR000035568

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0082 0.0082
Trypanosoma brucei unspecified product 0.0271 0.1722 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0053 0.0053
Mycobacterium ulcerans DNA polymerase IV 0.0271 0.1722 1
Brugia malayi hypothetical protein 0.0058 0.0189 0.0558
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0082 0.0243
Schistosoma mansoni hypothetical protein 0.0099 0.048 0.048
Echinococcus multilocularis expressed protein 0.0411 0.2724 0.2724
Plasmodium vivax importin-beta 2, putative 0.0035 0.0022 0.0577
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0751 0.0751
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0082 0.0243
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0082 0.0082
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0312 0.2011 0.5949
Echinococcus multilocularis snurportin 1 0.0372 0.2443 0.2443
Brugia malayi ImpB/MucB/SamB family protein 0.0271 0.1722 0.5093
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.0751 0.222
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0082 0.0243
Brugia malayi PHD-finger family protein 0.0032 0.0004 0.0012
Leishmania major DNA polymerase eta, putative 0.0084 0.0377 0.2188
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0082 0.0243
Mycobacterium ulcerans DNA polymerase IV 0.0271 0.1722 1
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0043 0.0082 0.0243
Echinococcus multilocularis dna polymerase kappa 0.0271 0.1722 0.1722
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0022 0.0577
Trypanosoma cruzi DNA polymerase kappa, putative 0.0271 0.1722 1
Brugia malayi nuclear receptor NHR-88 0.0043 0.0082 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0082 0.0243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0082 0.0243
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0082 0.0082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0082 0.0243
Brugia malayi RNA, U transporter 1 0.0099 0.0483 0.1429
Leishmania major DNA damage repair protein, putative 0.0084 0.0377 0.2188
Loa Loa (eye worm) hypothetical protein 0.0099 0.048 0.142
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0073 0.0299 0.0299
Trypanosoma brucei DNA damage repair protein, putative 0.0084 0.0377 0.2188
Loa Loa (eye worm) hypothetical protein 0.0043 0.0082 0.0243
Trypanosoma cruzi hypothetical protein 0.0073 0.0299 0.1739
Schistosoma mansoni DNA polymerase eta 0.0271 0.1722 0.1722
Brugia malayi jmjC domain containing protein 0.0106 0.0533 0.1576
Brugia malayi latrophilin 2 splice variant baaae 0.0213 0.1303 0.3853
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.0533 0.0533
Trypanosoma brucei DNA polymerase kappa, putative 0.0271 0.1722 1
Echinococcus granulosus sentrin specific protease 8 0.0073 0.0299 0.0299
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0053 0.0156
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0751 0.0751
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0082 0.0082
Echinococcus multilocularis peregrin 0.0032 0.0004 0.0004
Schistosoma mansoni jumonji domain containing protein 0.0084 0.0376 0.0376
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0022 0.0022
Loa Loa (eye worm) Ulp1 protease 0.0073 0.0299 0.0885
Brugia malayi Calcitonin receptor-like protein seb-1 0.0312 0.2011 0.5949
Trypanosoma brucei DNA polymerase IV, putative 0.0271 0.1722 1
Onchocerca volvulus 0.0043 0.0082 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0271 0.1722 1
Schistosoma mansoni coup transcription factor 0.0043 0.0082 0.0082
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0479 0.3217 0.3217
Echinococcus granulosus dna polymerase kappa 0.0271 0.1722 0.1722
Trypanosoma brucei DNA polymerase kappa, putative 0.0271 0.1722 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0502 0.3381 0.3381
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0251 0.0744
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0082 0.0243
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0751 0.0751
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0043 0.0082 0.0243
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0082 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0751 0.0751
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0271 0.1722 1
Trypanosoma brucei chrX additional, unordered contigs 0.0084 0.0377 0.2188
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.048 0.142
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0082 0.0082
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0082 0.0082
Trypanosoma cruzi DNA polymerase kappa, putative 0.0271 0.1722 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0082 0.0082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0082 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0271 0.1722 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0082 0.0243
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0082 0.0243
Trypanosoma cruzi DNA polymerase eta, putative 0.0271 0.1722 1
Trypanosoma brucei hypothetical protein, conserved 0.0084 0.0377 0.2188
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0082 0.0243
Schistosoma mansoni terminal deoxycytidyl transferase 0.0271 0.1722 0.1722
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0004 0.0105
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0082 0.0082
Schistosoma mansoni DNA polymerase IV / kappa 0.0084 0.0377 0.0377
Echinococcus granulosus GPCR family 2 0.0099 0.048 0.048
Echinococcus granulosus tar DNA binding protein 0.0136 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0064
Loa Loa (eye worm) TAR-binding protein 0.0136 0.0751 0.222
Schistosoma mansoni hypothetical protein 0.0213 0.1303 0.1303
Trypanosoma brucei unspecified product 0.0187 0.1117 0.6484
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0082 0.0243
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0189 0.1096
Schistosoma mansoni hypothetical protein 0.0032 0.0004 0.0004
Trypanosoma brucei PAB1-binding protein , putative 0.0058 0.0189 0.1096
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0189 0.5008
Loa Loa (eye worm) hypothetical protein 0.0043 0.0082 0.0243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0082 0.0243
Plasmodium falciparum DNA repair protein REV1, putative 0.0084 0.0377 1
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0082 0.0082
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0004 0.0105
Trypanosoma brucei DNA damage repair protein, putative 0.0084 0.0377 0.2188
Brugia malayi jmjC domain containing protein 0.0039 0.0053 0.0156
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0082 0.0243
Trypanosoma cruzi DNA polymerase kappa, putative 0.0271 0.1722 1
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0082 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0271 0.1722 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0271 0.1722 0.1722
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0082 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0189 0.5008
Trypanosoma cruzi DNA polymerase eta, putative 0.0084 0.0377 0.2188
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0022 0.0126
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0084 0.0377 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0271 0.1722 1
Echinococcus granulosus dna polymerase eta 0.0271 0.1722 0.1722
Echinococcus granulosus peregrin 0.0032 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0502 0.3381 1
Brugia malayi polk-prov protein 0.0084 0.0377 0.1115
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0377 0.2188
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0082 0.0082
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0004 0.0004
Giardia lamblia DNA damage repair protein 0.0084 0.0377 0.2171
Plasmodium vivax ataxin-2 like protein, putative 0.0058 0.0189 0.5008
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0084 0.0377 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0189 0.1096
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0082 0.0243
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0271 0.1722 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0084 0.0377 0.2188
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0043 0.0082 0.0243
Schistosoma mansoni hypothetical protein 0.0099 0.048 0.048
Trypanosoma brucei DNA polymerase kappa, putative 0.0271 0.1722 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0082 0.0082
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0082 0.0082
Giardia lamblia DINP protein human, muc B family 0.0271 0.1722 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0502 0.3381 1
Schistosoma mansoni importin beta-1 0.0035 0.0022 0.0022
Echinococcus granulosus expressed protein 0.0411 0.2724 0.2724
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0271 0.1722 0.5093
Leishmania major DNA polymerase eta, putative 0.0271 0.1722 1
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.0751 0.222
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.048 0.142
Loa Loa (eye worm) hypothetical protein 0.0271 0.1722 0.5093
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0082 0.0082
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0082 0.0082
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0004 0.0012
Toxoplasma gondii LsmAD domain-containing protein 0.0058 0.0189 0.5008
Trypanosoma cruzi DNA damage repair protein, putative 0.0084 0.0377 0.2188
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0312 0.2011 0.5949
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0082 0.0082
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0095 0.0095
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0082 0.0082
Brugia malayi Bromodomain containing protein 0.0032 0.0004 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0082 0.0243
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0082 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0187 0.1117 0.6484
Trypanosoma brucei DNA polymerase IV, putative 0.0271 0.1722 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0082 0.0082
Trypanosoma brucei hypothetical protein, conserved 0.0084 0.0377 0.2188
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0271 0.1722 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0053 0.0053
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0271 0.1722 0.1722
Brugia malayi hypothetical protein 0.0037 0.0041 0.0121
Echinococcus granulosus importin subunit beta 1 0.0035 0.0022 0.0022
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0082 1
Echinococcus multilocularis dna polymerase eta 0.0271 0.1722 0.1722
Loa Loa (eye worm) hypothetical protein 0.0032 0.0004 0.0012
Brugia malayi ImpB/MucB/SamB family protein 0.0271 0.1722 0.5093
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0082 0.0243
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2443 0.7226
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0751 0.0751
Brugia malayi steroid hormone receptor 0.0043 0.0082 0.0243
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0082 0.0082
Brugia malayi TAR-binding protein 0.0136 0.0751 0.222
Loa Loa (eye worm) hypothetical protein 0.0213 0.1303 0.3853
Trypanosoma brucei DNA polymerase eta, putative 0.0271 0.1722 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0082 0.0243
Leishmania major hypothetical protein, conserved 0.0058 0.0189 0.1096
Loa Loa (eye worm) hypothetical protein 0.0312 0.2011 0.5949
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0082 0.0082
Plasmodium vivax DNA repair protein REV1, putative 0.0084 0.0377 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0084 0.0377 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.0533 0.0533
Mycobacterium tuberculosis Conserved hypothetical protein 0.0271 0.1722 1
Brugia malayi Latrophilin receptor protein 2 0.0099 0.048 0.142
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0004 0.0105
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0502 0.3381 0.3381
Trypanosoma brucei DNA polymerase kappa, putative 0.0271 0.1722 1
Schistosoma mansoni hypothetical protein 0.0372 0.2443 0.2443
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0053 0.0053
Trypanosoma brucei unspecified product 0.0187 0.1117 0.6484
Trypanosoma brucei DNA polymerase IV, putative 0.0271 0.1722 1
Plasmodium falciparum phd finger protein, putative 0.0032 0.0004 0.0105
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0099 0.048 0.048
Trypanosoma brucei DNA polymerase kappa, putative 0.0271 0.1722 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0022 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0187 0.1117 0.6484
Echinococcus multilocularis tar DNA binding protein 0.0136 0.0751 0.0751
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0099 0.048 0.048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.048 0.048
Brugia malayi nuclear hormone receptor 0.0043 0.0082 0.0243
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0095 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0082 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0271 0.1722 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0082 0.0082
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0271 0.1722 0.1722
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0073 0.0299 0.0885
Loa Loa (eye worm) hypothetical protein 0.0043 0.0082 0.0243
Loa Loa (eye worm) hypothetical protein 0.0043 0.0082 0.0243
Echinococcus granulosus snurportin 1 0.0372 0.2443 0.2443
Echinococcus multilocularis GPCR, family 2 0.0099 0.048 0.048
Brugia malayi ecdysteroid receptor 0.0043 0.0082 0.0243
Schistosoma mansoni hypothetical protein 0.0099 0.048 0.048
Trypanosoma brucei DNA polymerase kappa, putative 0.0187 0.1117 0.6484
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0082 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0377 0.2188
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0377 0.2188
Plasmodium falciparum importin beta, putative 0.0035 0.0022 0.0577
Loa Loa (eye worm) RNA binding protein 0.0136 0.0751 0.222
Loa Loa (eye worm) hypothetical protein 0.0058 0.0189 0.0558
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0082 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0377 0.2188
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0053 0.0053
Leishmania major DNA polymerase kappa, putative 0.0084 0.0377 0.2188
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0082 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0082 0.0243
Entamoeba histolytica deoxycytidyl transferase, putative 0.0271 0.1722 1
Leishmania major DNA polymerase kappa, putative 0.0271 0.1722 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.0099 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0084 0.0377 0.1115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0082 0.0243
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0022 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0271 0.1722 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.048 0.048
Brugia malayi RNA binding protein 0.0136 0.0751 0.222
Echinococcus multilocularis sentrin specific protease 8 0.0073 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0055 0.017 0.0503
Trypanosoma brucei DNA polymerase kappa, putative 0.0271 0.1722 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.6109 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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