Detailed information for compound 1288106

Basic information

Technical information
  • TDR Targets ID: 1288106
  • Name: 2-chloro-N-[(2S)-1-oxo-1-[2-(4-sulfamoylpheny l)ethylamino]propan-2-yl]benzamide
  • MW: 409.887 | Formula: C18H20ClN3O4S
  • H donors: 3 H acceptors: 4 LogP: 2.09 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H](NC(=O)c1ccccc1Cl)C)NCCc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C18H20ClN3O4S/c1-12(22-18(24)15-4-2-3-5-16(15)19)17(23)21-11-10-13-6-8-14(9-7-13)27(20,25)26/h2-9,12H,10-11H2,1H3,(H,21,23)(H,22,24)(H2,20,25,26)/t12-/m0/s1
  • InChiKey: YTARBHUZDIYHDX-LBPRGKRZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-N-[(1S)-1-methyl-2-oxo-2-[2-(4-sulfamoylphenyl)ethylamino]ethyl]benzamide
  • 2-chloro-N-[(1S)-2-keto-1-methyl-2-[2-(4-sulfamoylphenyl)ethylamino]ethyl]benzamide
  • ZINC02640952
  • T5237067

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0104 0.0089
Schistosoma mansoni hypothetical protein 0.0148 0.53 0.7558
Brugia malayi Calcitonin receptor-like protein seb-1 0.0216 0.7891 0.7887
Echinococcus multilocularis geminin 0.0193 0.7008 1
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0104 0.0127
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0104 0.0092
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.2293 0.3257
Schistosoma mansoni coup transcription factor 0.0011 0.0104 0.0127
Schistosoma mansoni zinc finger protein 0.0015 0.0287 0.0388
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0331 0.045
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.2123 0.2111
Brugia malayi latrophilin 2 splice variant baaae 0.0148 0.53 0.5292
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0104 0.0127
Loa Loa (eye worm) hypothetical protein 0.0068 0.2293 0.2281
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0104 0.0092
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0042 0.0037
Echinococcus multilocularis cpg binding protein 0.0039 0.1164 0.1642
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.0404 0.0555
Loa Loa (eye worm) RNA binding protein 0.0064 0.2123 0.2111
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0042 0.0037
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.0404 0.0555
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0104 0.0127
Brugia malayi hypothetical protein 0.0119 0.4213 0.4204
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0042 0.0037
Onchocerca volvulus 0.0034 0.0979 0.1001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0104 0.0089
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2123 0.3014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0104 0.0089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0104 0.0127
Brugia malayi hypothetical protein 0.0009 0.0042 0.0026
Echinococcus multilocularis GPCR, family 2 0.0068 0.2293 0.3257
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0104 0.0089
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0104 0.0127
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0075 0.0084
Loa Loa (eye worm) hypothetical protein 0.0011 0.0104 0.0089
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0104 0.0127
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.2293 0.2281
Schistosoma mansoni smad1 5 8 and 0.0019 0.0404 0.0555
Brugia malayi TAR-binding protein 0.0064 0.2123 0.2111
Brugia malayi MH1 domain containing protein 0.001 0.009 0.0075
Brugia malayi MH2 domain containing protein 0.0019 0.0404 0.0389
Schistosoma mansoni dep domain containing protein 0.0009 0.0042 0.0037
Schistosoma mansoni hypothetical protein 0.0068 0.2293 0.3257
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0331 0.045
Brugia malayi MH2 domain containing protein 0.0019 0.0404 0.0389
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0042 0.0037
Schistosoma mansoni cpg binding protein 0.0039 0.1164 0.1642
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0904 0.1271
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0104 0.0127
Echinococcus granulosus smad 0.0019 0.0404 0.0555
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0155 0.0199
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0042 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0104 0.0089
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.2059 0.2922
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0354 0.0484
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0042 0.0026
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0354 0.0484
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0042 0.0037
Entamoeba histolytica hypothetical protein 0.0119 0.4213 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0104 0.0089
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0042 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0104 0.0089
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0075 0.0084
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0104 0.0127
Loa Loa (eye worm) hypothetical protein 0.0182 0.6602 0.6596
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0331 1
Entamoeba histolytica hypothetical protein 0.0119 0.4213 0.5
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0377 0.0362
Echinococcus granulosus Smad4 0.0019 0.0404 0.0555
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.2293 0.3257
Schistosoma mansoni cpg binding protein 0.0039 0.1164 0.1642
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0639 0.0891
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0104 0.0127
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2123 0.3014
Brugia malayi steroid hormone receptor 0.0011 0.0104 0.0089
Trichomonas vaginalis set domain proteins, putative 0.0262 0.9634 1
Echinococcus granulosus tar DNA binding protein 0.0064 0.2123 0.3014
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.1631 0.231
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0104 0.0127
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0104 0.0127
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0331 0.045
Brugia malayi CXXC zinc finger family protein 0.0035 0.1016 0.1002
Schistosoma mansoni dishevelled 0.0009 0.0042 0.0037
Loa Loa (eye worm) hypothetical protein 0.0148 0.53 0.5292
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0331 0.5
Echinococcus multilocularis smad 0.0019 0.0404 0.0555
Loa Loa (eye worm) hypothetical protein 0.0011 0.0104 0.0089
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0331 0.1264
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0104 0.0089
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.0404 0.0555
Plasmodium vivax SET domain protein, putative 0.0034 0.0979 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0404 0.0389
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0042 0.0037
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0331 0.045
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1016 0.1002
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.2123 0.2111
Loa Loa (eye worm) TAR-binding protein 0.0064 0.2123 0.2111
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0104 0.0127
Brugia malayi hypothetical protein 0.0009 0.0042 0.0026
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0075 0.0084
Brugia malayi MH1 domain containing protein 0.0019 0.0404 0.0389
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.1076 0.1516
Loa Loa (eye worm) hypothetical protein 0.0045 0.1407 0.1393
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.2293 0.3257
Loa Loa (eye worm) nuclear factor I 0.001 0.009 0.0075
Schistosoma mansoni hypothetical protein 0.0193 0.7008 1
Schistosoma mansoni hypothetical protein 0.0068 0.2293 0.3257
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0104 0.0127
Echinococcus multilocularis zinc finger protein 0.0022 0.0525 0.0729
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0216 0.7891 0.7887
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0104 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0104 0.0089
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0331 0.045
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0104 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0104 0.0089
Onchocerca volvulus 0.0035 0.1016 0.104
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.2293 0.3257
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0331 0.0315
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.2293 0.2281
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0104 0.0089
Brugia malayi MH1 domain containing protein 0.0019 0.0404 0.0389
Onchocerca volvulus 0.0009 0.0042 0.0027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.2535 0.3603
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0331 0.0315
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0354 0.0484
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0331 0.045
Loa Loa (eye worm) hypothetical protein 0.0051 0.1631 0.1617
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0979 0.1377
Brugia malayi Pre-SET motif family protein 0.0034 0.0979 0.0965
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0104 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0104 0.0089
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0104 0.0127
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0104 0.0127
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0104 0.0089
Loa Loa (eye worm) hypothetical protein 0.0041 0.1259 0.1245
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0104 0.0127
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.8432 0.8429
Brugia malayi ecdysteroid receptor 0.0011 0.0104 0.0089
Brugia malayi isocitrate dehydrogenase 0.0017 0.0331 0.0315
Schistosoma mansoni zinc finger protein 0.0022 0.0525 0.0729
Loa Loa (eye worm) hypothetical protein 0.0011 0.0104 0.0089
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.1076 0.1516
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0104 0.0127
Brugia malayi Bromodomain containing protein 0.0078 0.2644 0.2632
Schistosoma mansoni hypothetical protein 0.0193 0.7008 1
Brugia malayi MH1 domain containing protein 0.001 0.009 0.0075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0104 0.0089
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0119 0.4213 0.6003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0216 0.7891 0.7887
Brugia malayi Bromodomain containing protein 0.0039 0.1166 0.1152
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0075 0.0084
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0331 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0104 0.0127
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2123 0.3014
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0104 0.0127
Brugia malayi N-terminal motif family protein 0.0182 0.6602 0.6596
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0104 0.0127
Schistosoma mansoni hypothetical protein 0.0021 0.0491 0.0679
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0404 0.0389
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0639 0.0891
Onchocerca volvulus 0.0011 0.0104 0.0092
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0155 0.0139
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0119 0.4213 0.6003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0104 0.0089
Brugia malayi Smad1 0.0019 0.0404 0.0389
Schistosoma mansoni Smad4 0.0019 0.0404 0.0555
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.2328 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0354 0.0484
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0104 0.0089
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0331 1
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0042 0.0037
Schistosoma mansoni smad1 5 8 and 0.0019 0.0404 0.0555
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0104 0.0127
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0331 1
Schistosoma mansoni transcription factor LCR-F1 0.0119 0.4213 0.6003
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0042 0.0026
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0042 0.0037
Loa Loa (eye worm) Smad1 0.0019 0.0404 0.0389
Onchocerca volvulus 0.0262 0.9634 1
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0104 0.0127
Brugia malayi DIX domain containing protein 0.0009 0.0042 0.0026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0104 0.0127
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0104 0.0127
Schistosoma mansoni dishevelled 0.0009 0.0042 0.0037
Entamoeba histolytica hypothetical protein 0.0119 0.4213 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0075
Schistosoma mansoni hypothetical protein 0.0068 0.2293 0.3257
Loa Loa (eye worm) hypothetical protein 0.0011 0.0104 0.0089
Schistosoma mansoni smad1 5 8 and 0.0019 0.0404 0.0555
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0104 0.0127
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.0404 0.0555
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.1631 0.231
Loa Loa (eye worm) hypothetical protein 0.0039 0.1169 0.1155
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0331 1
Entamoeba histolytica hypothetical protein 0.0119 0.4213 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0104 0.0089
Schistosoma mansoni smad 0.0019 0.0404 0.0555
Schistosoma mansoni bromodomain containing protein 0.0066 0.2196 0.3118
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0104 0.0089
Loa Loa (eye worm) hypothetical protein 0.0011 0.0104 0.0089
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2123 0.3014
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0104 0.0089
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0979 0.1377
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0042 0.0037
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0104 0.0127
Echinococcus granulosus cpg binding protein 0.0039 0.1164 0.1642
Echinococcus granulosus geminin 0.0193 0.7008 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.2059 0.2922
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0104 0.0089
Schistosoma mansoni hypothetical protein 0.0119 0.4213 0.6003
Loa Loa (eye worm) hypothetical protein 0.0216 0.7891 0.7887
Brugia malayi RNA binding protein 0.0064 0.2123 0.2111
Echinococcus multilocularis tar DNA binding protein 0.0064 0.2123 0.3014
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0155 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0104 0.0089
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0104 0.0127
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.0404 0.0555
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0104 0.0092
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.6602 0.6848
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0331 1
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0223 0.0207
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0042 0.0027
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0639 0.0891
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0104 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0104 0.0089
Schistosoma mansoni hypothetical protein 0.0015 0.0287 0.0388
Schistosoma mansoni cpg binding protein 0.0035 0.1016 0.1431
Brugia malayi nuclear hormone receptor 0.0011 0.0104 0.0089
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.1631 0.231
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0104 0.0127
Brugia malayi nuclear receptor NHR-88 0.0011 0.0104 0.0089
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0042 0.0037
Echinococcus granulosus zinc finger protein 0.0022 0.0525 0.0729
Schistosoma mansoni hypothetical protein 0.0068 0.2293 0.3257
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0075 0.0084
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0026
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0331 0.045
Brugia malayi Latrophilin receptor protein 2 0.0068 0.2293 0.2281
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0104 0.0127
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0042 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0104 0.0089
Echinococcus multilocularis Smad4 0.0019 0.0404 0.0555
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0979 0.4099
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0491 0.0476
Echinococcus granulosus GPCR family 2 0.0068 0.2293 0.3257
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.1631 0.231
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0042 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0979 0.1377
Loa Loa (eye worm) hypothetical protein 0.0011 0.0104 0.0089
Brugia malayi Pre-SET motif family protein 0.023 0.8432 0.8429
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0042 0.0026
Brugia malayi PHD-finger family protein 0.0027 0.0729 0.0715
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2123 0.3014
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0331 0.1264
Loa Loa (eye worm) hypothetical protein 0.0071 0.2405 0.2393
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0042 0.0026

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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