Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji domain containing protein | 0.0058 | 0.2288 | 0.7144 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0032 | 0.0947 | 0.0929 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0025 | 0.0558 | 0.1669 |
Brugia malayi | Pre-SET motif family protein | 0.0173 | 0.8151 | 0.8151 |
Onchocerca volvulus | 0.0032 | 0.0947 | 0.0567 | |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0014 | 0.0031 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0032 | 0.0947 | 1 |
Brugia malayi | RNA binding protein | 0.007 | 0.2874 | 0.2874 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0562 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0025 | 0.0558 | 0.1669 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0137 | 0.6316 | 0.6576 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0137 | 0.6316 | 0.6305 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.044 | 0.044 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0076 | 0.3191 | 0.3191 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0025 | 0.0558 | 0.1669 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0032 | 0.0947 | 0.0947 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0947 | 0.0947 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.2874 | 0.8998 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0032 | 0.0947 | 0.0929 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.2874 | 0.2874 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0032 | 0.0947 | 0.2899 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0022 | 0.044 | 0.1296 |
Trichomonas vaginalis | set domain proteins, putative | 0.0197 | 0.9376 | 0.9374 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0137 | 0.6316 | 0.6305 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0032 | 0.0947 | 0.0919 |
Mycobacterium tuberculosis | Conserved protein | 0.0032 | 0.0947 | 0.0929 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0032 | 0.0947 | 0.0929 |
Mycobacterium leprae | conserved hypothetical protein | 0.0032 | 0.0947 | 0.5 |
Schistosoma mansoni | lamin | 0.0026 | 0.0618 | 0.1859 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0076 | 0.3191 | 0.3191 |
Plasmodium vivax | hypothetical protein, conserved | 0.0032 | 0.0947 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0032 | 0.0947 | 0.0919 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2874 | 0.8998 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0074 | 0.3065 | 0.9602 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2874 | 0.8998 |
Brugia malayi | hypothetical protein | 0.0016 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0947 | 0.0947 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0137 | 0.6316 | 0.6305 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0014 | 0.0031 | 0.0031 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0031 | 0.0892 | 0.2726 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0014 | 0.0031 | 0.0031 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0022 | 0.044 | 0.4469 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0046 | 0.1669 | 0.1669 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0562 | 0.5796 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0032 | 0.0947 | 1 |
Onchocerca volvulus | 0.0032 | 0.0947 | 0.0567 | |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0618 | 0.1859 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0076 | 0.3191 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0025 | 0.0558 | 0.1669 |
Onchocerca volvulus | 0.0025 | 0.0558 | 0.0132 | |
Leishmania major | hypothetical protein, conserved | 0.0032 | 0.0947 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0618 | 0.1859 |
Brugia malayi | jmjC domain containing protein | 0.0027 | 0.0683 | 0.0683 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0137 | 0.6316 | 0.6305 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0144 | 0.6695 | 0.6684 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0144 | 0.6695 | 0.6684 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0173 | 0.8151 | 0.8151 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0032 | 0.0947 | 0.0947 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0014 | 0.0031 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0032 | 0.0947 | 0.0929 |
Brugia malayi | Bromodomain containing protein | 0.0022 | 0.044 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0947 | 0.0947 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0137 | 0.6316 | 0.6305 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0032 | 0.0947 | 1 |
Brugia malayi | beta-lactamase | 0.0032 | 0.0947 | 0.0947 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0618 | 0.0618 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0618 | 0.1859 |
Trichomonas vaginalis | esterase, putative | 0.0032 | 0.0947 | 0.0919 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0022 | 0.044 | 0.1296 |
Giardia lamblia | PHD finger protein 15 | 0.0022 | 0.044 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0076 | 0.3191 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0025 | 0.0558 | 0.1669 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0076 | 0.3191 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.2874 | 0.8998 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0562 | 0.5796 |
Plasmodium vivax | SET domain protein, putative | 0.0025 | 0.0558 | 0.5756 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0076 | 0.3191 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2874 | 0.8998 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0032 | 0.0947 | 1 |
Brugia malayi | PHD-finger family protein | 0.0022 | 0.044 | 0.044 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0618 | 0.1859 |
Brugia malayi | beta-lactamase family protein | 0.0032 | 0.0947 | 0.0947 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0618 | 0.0618 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0032 | 0.0947 | 0.0929 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0032 | 0.0947 | 0.0919 |
Onchocerca volvulus | 0.0026 | 0.0618 | 0.0199 | |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0562 | 0.5796 |
Mycobacterium ulcerans | hypothetical protein | 0.0032 | 0.0947 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0032 | 0.0947 | 0.0947 |
Onchocerca volvulus | 0.0197 | 0.9376 | 1 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0027 | 0.0683 | 0.2064 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0562 | 0.0562 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0032 | 0.0947 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0074 | 0.3065 | 0.9602 |
Toxoplasma gondii | ABC1 family protein | 0.0032 | 0.0947 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0032 | 0.0947 | 0.2899 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0618 | 0.0618 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1264 | 0.1264 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0618 | 0.0618 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0027 | 0.0683 | 0.2064 |
Brugia malayi | jmjC domain containing protein | 0.0074 | 0.3065 | 0.3065 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0562 | 0.5796 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.2874 | 0.2874 |
Mycobacterium tuberculosis | Conserved protein | 0.0032 | 0.0947 | 0.0929 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0947 | 0.0947 |
Brugia malayi | Pre-SET motif family protein | 0.0025 | 0.0558 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0947 | 0.0947 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0032 | 0.0947 | 0.2899 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0562 | 0.5796 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0014 | 0.0031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0558 | 0.0558 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0562 | 0.5796 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0137 | 0.6316 | 0.6305 |
Echinococcus granulosus | peregrin | 0.0022 | 0.044 | 0.1296 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.2874 | 0.2874 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2874 | 0.8998 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0022 | 0.044 | 0.1296 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0032 | 0.0947 | 0.0929 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0076 | 0.3191 | 1 |
Plasmodium falciparum | phd finger protein, putative | 0.0022 | 0.044 | 0.7711 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0025 | 0.0558 | 0.1669 |
Echinococcus multilocularis | peregrin | 0.0022 | 0.044 | 0.1296 |
Brugia malayi | TAR-binding protein | 0.007 | 0.2874 | 0.2874 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0032 | 0.0947 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0562 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0137 | 0.6316 | 0.6305 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0025 | 0.0558 | 0.1669 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0032 | 0.0947 | 0.0929 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0024 | 0.0511 | 0.1521 |
Echinococcus granulosus | lamin | 0.0026 | 0.0618 | 0.1859 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2874 | 0.8998 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0618 | 0.1859 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0025 | 0.0558 | 0.5756 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.044 | 0.1296 |
Onchocerca volvulus | 0.0032 | 0.0947 | 0.0567 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0947 | 0.0947 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0032 | 0.0947 | 0.0929 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0027 | 0.0683 | 0.2064 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0076 | 0.3191 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0032 | 0.0947 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0076 | 0.3191 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0032 | 0.0947 | 0.0919 |
Plasmodium vivax | hypothetical protein, conserved | 0.0022 | 0.044 | 0.4469 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.2874 | 0.2874 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0032 | 0.0947 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0594 | 0.0594 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0207 | 0.9894 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0032 | 0.0947 | 0.2899 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0562 | 0.0562 |
Mycobacterium leprae | Probable lipase LipE | 0.0032 | 0.0947 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.044 | 0.044 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0022 | 0.044 | 0.4469 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0618 | 0.0618 |
Echinococcus granulosus | jumonji domain containing protein | 0.0031 | 0.0892 | 0.2726 |
Brugia malayi | beta-lactamase family protein | 0.0032 | 0.0947 | 0.0947 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0618 | 0.1859 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0027 | 0.0683 | 0.2064 |
Schistosoma mansoni | lamin | 0.0026 | 0.0618 | 0.1859 |
Onchocerca volvulus | 0.0026 | 0.0618 | 0.0199 | |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0027 | 0.0683 | 0.0683 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.