Detailed information for compound 1288430

Basic information

Technical information
  • TDR Targets ID: 1288430
  • Name: ethyl 3-(thiophene-2-carbonylamino)benzoate
  • MW: 275.323 | Formula: C14H13NO3S
  • H donors: 1 H acceptors: 2 LogP: 2.99 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cccc(c1)NC(=O)c1cccs1
  • InChi: 1S/C14H13NO3S/c1-2-18-14(17)10-5-3-6-11(9-10)15-13(16)12-7-4-8-19-12/h3-9H,2H2,1H3,(H,15,16)
  • InChiKey: ZFIDIYIMLCNQDQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[oxo-(2-thienyl)methyl]amino]benzoic acid ethyl ester
  • 3-(thiophene-2-carbonylamino)benzoic acid ethyl ester
  • ethyl 3-(thiophen-2-ylcarbonylamino)benzoate
  • Oprea1_819804
  • MLS000070338
  • SMR000009182
  • Oprea1_123927
  • ST060638
  • AF-399/11136203
  • ZINC00146061
  • BAS 00570069
  • 3-[(Thiophene-2-carbonyl)-amino]-benzoic acid ethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0034 0.0058
Brugia malayi jmjC domain containing protein 0.0066 0.023 0.0455
Schistosoma mansoni regulator of G protein signaling 0.004 0.0109 0.0106
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1232 0.5702 0.9981
Trichomonas vaginalis CAMK family protein kinase 0.0492 0.223 0.3903
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.024 0.0418
Echinococcus multilocularis tensin 0.0022 0.0026 0.0023
Entamoeba histolytica hypothetical protein 0.004 0.0109 0.0186
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0015 0.0012
Brugia malayi jmjC domain containing protein 0.0066 0.023 0.0455
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0034 0.0058
Echinococcus granulosus chromobox protein 2 0.0024 0.0034 0.0032
Loa Loa (eye worm) heat shock protein 90 0.0078 0.0286 0.0567
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0033 0.012
Plasmodium vivax importin-beta 2, putative 0.0029 0.0056 0.0121
Mycobacterium tuberculosis Conserved protein 0.0051 0.0161 0.0586
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0033 0.012
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0082 0.0307 0.1111
Brugia malayi Heterochromatin protein 1 0.0147 0.0613 0.1219
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0047
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.006 0.013
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.012 0.0118
Mycobacterium leprae conserved hypothetical protein 0.0122 0.0493 0.1787
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0015 0.0025
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.004 0.0037
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0296 0.1311 0.1309
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0316 0.1406 0.3317
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0034 0.0075
Brugia malayi RNA, U transporter 1 0.0082 0.0304 0.0602
Echinococcus multilocularis Smad4 0.0025 0.004 0.0037
Toxoplasma gondii hypothetical protein 0.0055 0.0177 0.0412
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0122 0.0493 0.086
Entamoeba histolytica hypothetical protein 0.004 0.0109 0.0186
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0296 0.1311 0.1309
Schistosoma mansoni tar DNA-binding protein 0.0267 0.1174 0.1172
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0082 0.008
Brugia malayi nuclear hormone receptor 0.002 0.0015 0.0025
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0434 0.0432
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0015 0.0012
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0109 0.0106
Plasmodium falciparum histone acetyltransferase GCN5 0.0164 0.0692 0.1625
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.006 0.0102
Loa Loa (eye worm) hypothetical protein 0.0497 0.2252 0.4493
Onchocerca volvulus 0.0433 0.1954 0.3417
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.012 0.0235
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0051 0.0161 0.0586
Brugia malayi TAR-binding protein 0.0267 0.1174 0.2339
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.012 0.0118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0034 0.0058
Trichomonas vaginalis set domain proteins, putative 0.1234 0.5713 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0122 0.0493 0.1159
Mycobacterium ulcerans aldehyde dehydrogenase 0.0316 0.1406 0.3317
Schistosoma mansoni nuclear receptor 0.002 0.0015 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.012 0.0235
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0093 0.0091
Brugia malayi jmjC domain containing protein 0.0066 0.023 0.0455
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0212
Brugia malayi Hsp90 protein 0.0068 0.0241 0.0476
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.012 0.0206
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.012 0.0118
Trichomonas vaginalis heat shock protein, putative 0.0056 0.0186 0.0323
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.006
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0348
Brugia malayi Pre-SET motif family protein 0.1084 0.501 1
Brugia malayi Melibiase family protein 0.0068 0.024 0.0474
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0004
Brugia malayi TBC domain containing protein 0.0022 0.0026 0.0046
Loa Loa (eye worm) hypothetical protein 0.0074 0.027 0.0534
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.006 0.01
Loa Loa (eye worm) hypothetical protein 0.0433 0.1954 0.3897
Brugia malayi protein M110.5 0.0022 0.0026 0.0046
Echinococcus multilocularis carboxyl terminal PDZ ligand of neuronal nitric 0.0022 0.0026 0.0023
Plasmodium vivax heat shock protein, putative 0.0514 0.2333 0.5507
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0492 0.223 0.2228
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0066 0.023 0.0228
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0109 0.0106
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0063 0.012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.012 0.0118
Schistosoma mansoni phd/f-box containing protein 0.0066 0.023 0.0228
Schistosoma mansoni smad 0.0025 0.004 0.0037
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0066 0.023 0.0538
Loa Loa (eye worm) CHromoDomain protein family member 0.0024 0.0034 0.0063
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0051
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0434 0.0757
Echinococcus granulosus heat shock protein 90 0.0078 0.0286 0.0284
Brugia malayi hypothetical protein 0.0022 0.0026 0.0046
Echinococcus granulosus Chromo domain 0.0024 0.0034 0.0032
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0093 0.0215
Brugia malayi Protein cec-1. 0.0024 0.0034 0.0063
Echinococcus granulosus axis inhibition protein axin 0.004 0.0109 0.0106
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0109 0.0212
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0037
Schistosoma mansoni jumonji domain containing protein 0.0066 0.023 0.0228
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0034 0.0063
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.012 0.0235
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0026 0.0024
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.007 0.0252 0.0249
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0034 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0492 0.223 0.3903
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Trichomonas vaginalis heat shock protein, putative 0.0064 0.022 0.0384
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.012 0.0118
Schistosoma mansoni smad1 5 8 and 0.0025 0.004 0.0037
Schistosoma mansoni mannose-6-phosphate isomerase 0.0919 0.4232 0.4231
Schistosoma mansoni Smad4 0.0025 0.004 0.0037
Loa Loa (eye worm) TAR-binding protein 0.0267 0.1174 0.2339
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0126 0.0511 0.0508
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0034 0.0058
Plasmodium vivax heterochromatin protein 1, putative 0.0024 0.0034 0.007
Echinococcus multilocularis heat shock protein 90 0.007 0.0252 0.0249
Schistosoma mansoni nuclear hormone receptor 0.0042 0.012 0.0118
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0039 0.0081
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.012 0.0235
Trypanosoma brucei polo-like protein kinase 0.0492 0.223 0.5267
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0316 0.1406 0.1403
Trypanosoma brucei heat shock protein, putative 0.0078 0.0286 0.0671
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.012 0.0235
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0034 0.0055
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.012 0.0206
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0434 0.0758
Loa Loa (eye worm) hypothetical protein 0.0066 0.023 0.0455
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0492 0.223 0.5267
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0109 0.0188
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0017 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0212
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0015 0.0012
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0122 0.0493 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0056 0.0125
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0026 0.0024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.012 0.0118
Echinococcus multilocularis voltage dependent calcium channel 0.0296 0.1311 0.1309
Echinococcus multilocularis lysine specific demethylase 5A 0.0247 0.1081 0.1079
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0034 0.0075
Schistosoma mansoni chromobox protein 0.0147 0.0613 0.0611
Trypanosoma brucei heat shock protein, putative 0.0078 0.0286 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0034 0.0058
Loa Loa (eye worm) hypothetical protein 0.0042 0.012 0.0235
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.012 0.0118
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0082 0.016
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0034 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Brugia malayi acetyltransferase, GNAT family protein 0.0609 0.278 0.5547
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0156 0.0651 0.1533
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0434 0.1021
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0109 0.0106
Loa Loa (eye worm) endoplasmin 0.0078 0.0286 0.0567
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0609 0.278 0.2778
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.012 0.0118
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.027 0.0534
Schistosoma mansoni heat shock protein 0.0068 0.0241 0.0239
Echinococcus multilocularis X box binding protein 1 0.0287 0.1267 0.1264
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0035
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0109 0.0106
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0033 0.0072
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0066 0.023 0.0538
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0034 0.0058
Toxoplasma gondii heat shock protein HSP90 0.0078 0.0286 0.0671
Entamoeba histolytica heat shock protein 90, putative 0.0078 0.0286 0.0498
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0033 0.011
Schistosoma mansoni hypothetical protein 0.0074 0.027 0.0267
Brugia malayi Smad1 0.0025 0.004 0.0074
Brugia malayi M-phase phosphoprotein, mpp8 0.0024 0.0034 0.0063
Loa Loa (eye worm) MH2 domain-containing protein 0.0372 0.1665 0.3319
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0399 0.0397
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.006 0.0135
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0066 0.023 0.0538
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.012
Schistosoma mansoni tensin-related 0.0022 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0047
Trichomonas vaginalis importin beta-1, putative 0.0023 0.003 0.0051
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.004 0.0037
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0434 0.0757
Trypanosoma brucei heat shock protein 90, putative 0.0078 0.0286 0.0671
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0116 0.0114
Brugia malayi PXA domain containing protein 0.004 0.0109 0.0212
Trypanosoma cruzi heat shock protein 85, putative 0.007 0.0252 0.0589
Brugia malayi MH1 domain containing protein 0.0025 0.004 0.0074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0375 0.0373
Trichomonas vaginalis chromobox protein, putative 0.0089 0.0338 0.059
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0109 0.0106
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0015 0.0012
Schistosoma mansoni hypothetical protein 0.0024 0.0034 0.0032
Schistosoma mansoni intermediate filament proteins 0.003 0.0063 0.006
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0247 0.1081 0.1079
Mycobacterium ulcerans hypothetical protein 0.0051 0.0161 0.0374
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0122 0.0493 0.1159
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0109 0.0106
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0919 0.4232 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1232 0.5702 0.9981
Schistosoma mansoni shc transforming protein 0.0022 0.0026 0.0023
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0051 0.0161 0.0374
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0077 0.0284 0.0666
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0296 0.1311 0.1309
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Echinococcus granulosus voltage dependent calcium channel 0.0062 0.0212 0.0209
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0093 0.0162
Brugia malayi hypothetical protein 0.0022 0.0026 0.0047
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.012 0.0118
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0056 0.0125
Trichomonas vaginalis CAMK family protein kinase 0.0492 0.223 0.3903
Echinococcus multilocularis amyloid beta A4 protein 0.0212 0.0914 0.0912
Schistosoma mansoni hypothetical protein 0.0034 0.0082 0.008
Brugia malayi 6-phosphofructokinase 0.0109 0.0434 0.0862
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0602 0.2745 0.6484
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0015 0.0012
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0109 0.0212
Schistosoma mansoni protein phosphatase 2C 0.0066 0.023 0.0228
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1084 0.501 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0179 0.0762 0.1332
Plasmodium falciparum heterochromatin protein 1 0.0024 0.0034 0.007
Echinococcus granulosus lamin 0.003 0.0063 0.006
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0005 0.0017
Trichomonas vaginalis endoplasmin, putative 0.0064 0.022 0.0384
Loa Loa (eye worm) hypothetical protein 0.0062 0.0212 0.0418
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0434 0.0758
Schistosoma mansoni hypothetical protein 0.0034 0.0082 0.008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0316 0.1406 0.3317
Schistosoma mansoni endoplasmin 0.0078 0.0286 0.0284
Entamoeba histolytica hypothetical protein 0.0122 0.0493 0.086
Brugia malayi nuclear receptor NHR-88 0.002 0.0015 0.0025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0033 0.0053
Schistosoma mansoni nuclear hormone receptor 0.002 0.0015 0.0012
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.004 0.0037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0375 0.0373
Onchocerca volvulus 0.0024 0.0034 0.0055
Brugia malayi MH2 domain containing protein 0.0372 0.1665 0.3319
Plasmodium vivax heat shock protein 90, putative 0.0068 0.0241 0.0559
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0034 0.0058
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0602 0.2745 1
Schistosoma mansoni serine/threonine protein kinase 0.0492 0.223 0.2228
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.002 0.0041
Toxoplasma gondii aldehyde dehydrogenase 0.0316 0.1406 0.3317
Trichomonas vaginalis chromobox protein, putative 0.0089 0.0338 0.059
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0051 0.0161 0.0374
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0375 0.0744
Schistosoma mansoni axis inhibition protein axin 0.004 0.0109 0.0106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.012 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0034 0.0058
Brugia malayi RNA binding protein 0.0267 0.1174 0.2339
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0075 0.0265
Echinococcus granulosus GPCR family 2 0.0034 0.0082 0.008
Leishmania major heat shock protein, putative 0.0068 0.0241 0.0564
Plasmodium vivax endoplasmin, putative 0.0078 0.0286 0.0667
Trypanosoma brucei heat shock protein, putative 0.0078 0.0286 0.0671
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.023 0.0455
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0082 0.0307 0.6216
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0005 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.012 0.0235
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0015 0.0012
Trypanosoma brucei heat shock protein, putative 0.0078 0.0286 0.0671
Trichomonas vaginalis CAMK family protein kinase 0.0492 0.223 0.3903
Echinococcus multilocularis L aminoadipate semialdehyde 0.0433 0.1954 0.1952
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0066 0.023 0.0455
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0109 0.0106
Echinococcus granulosus importin subunit beta 1 0.0029 0.0056 0.0053
Loa Loa (eye worm) transcription factor SMAD2 0.0372 0.1665 0.3319
Schistosoma mansoni jumonji domain containing protein 0.0247 0.1081 0.1079
Echinococcus granulosus chromobox protein 1 0.0147 0.0613 0.0611
Trichomonas vaginalis ran, putative 0.0021 0.002 0.0033
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0075 0.0275
Brugia malayi nuclear receptor NHR-88 0.0042 0.012 0.0235
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0065 0.0225 0.0444
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0434 0.1021
Schistosoma mansoni aldehyde dehydrogenase 0.0316 0.1406 0.1403
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.012 0.0118
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0122 0.0493 0.1159
Toxoplasma gondii 6-phosphofructokinase 0.003 0.006 0.0135
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.018 0.0764 0.0762
Echinococcus multilocularis heat shock protein 0.0078 0.0286 0.0284
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0498 0.2258 0.8227
Schistosoma mansoni jumonji/arid domain-containing protein 0.0247 0.1081 0.1079
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0034 0.0058
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.006 0.1127
Echinococcus multilocularis lamin dm0 0.003 0.0063 0.006
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0311 0.0541
Treponema pallidum fructose-bisphosphate aldolase 0.1232 0.5702 1
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0051 0.0161 0.0374
Trypanosoma brucei hypothetical protein, conserved 0.0122 0.0493 0.1159
Brugia malayi Mammalian fe65 homolog protein 1 0.0022 0.0026 0.0046
Onchocerca volvulus 0.0065 0.0225 0.039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0316 0.1406 0.3317
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0015 0.0025
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0051 0.0161 0.0374
Trichomonas vaginalis heat shock protein, putative 0.0082 0.0307 0.0536
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0068 0.0241 0.0239
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.012 0.0118
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.006 0.0102
Schistosoma mansoni lamin 0.003 0.0063 0.006
Brugia malayi hypothetical protein 0.0259 0.1138 0.2268
Schistosoma mansoni hypothetical protein 0.0306 0.1359 0.1357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.012 0.0235
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1232 0.5702 0.9981
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0432 0.0857
Echinococcus granulosus axis inhibition protein axin 0.004 0.0109 0.0106
Brugia malayi nuclear receptor RXR 0.002 0.0015 0.0025
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0122 0.0493 0.1154
Schistosoma mansoni thyroid hormone receptor 0.0042 0.012 0.0118
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0375 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0034 0.0058
Schistosoma mansoni hypothetical protein 0.0287 0.1267 0.1264
Plasmodium falciparum heat shock protein 90, putative 0.0514 0.2333 0.5507
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.004 0.0074
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0077 0.0284 0.0666
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0034 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Echinococcus granulosus lamin dm0 0.003 0.0063 0.006
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.004 0.0037
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0919 0.4232 0.8447
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0122 0.0493 0.1795
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0066 0.023 0.0538
Schistosoma mansoni inositol monophosphatase 0.0037 0.0093 0.0091
Trichomonas vaginalis hypothetical protein 0.0024 0.0034 0.0058
Brugia malayi hypothetical protein 0.004 0.0109 0.0212
Trypanosoma cruzi hypothetical protein, conserved 0.0444 0.2004 0.4732
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0109 0.0188
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0156 0.0651 0.0648
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Echinococcus granulosus carboxyl terminal PDZ ligand of neuronal nitric 0.0022 0.0026 0.0023
Onchocerca volvulus 0.003 0.0063 0.0105
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0421 0.1895 0.332
Entamoeba histolytica hypothetical protein 0.004 0.0109 0.0186
Loa Loa (eye worm) X11 protein 0.0212 0.0914 0.1821
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0031
Brugia malayi hypothetical protein 0.0024 0.0034 0.0063
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0296 0.1311 0.1309
Schistosoma mansoni axis inhibition protein axin 0.004 0.0109 0.0106
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.006 0.0102
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.012 0.0118
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0919 0.4232 0.8447
Giardia lamblia Histone acetyltransferase GCN5 0.0164 0.0692 0.1209
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0434 0.1574
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0083 0.0309 0.0612
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.012 0.0235
Loa Loa (eye worm) hypothetical protein 0.0042 0.012 0.0235
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0919 0.4232 0.4231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0375 0.0373
Brugia malayi jmjC domain containing protein 0.0066 0.023 0.0455
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.0651 0.0648
Echinococcus multilocularis survival motor neuron protein 1 0.0265 0.1165 0.1163
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.006 0.0102
Echinococcus multilocularis lysine specific demethylase 6a 0.0066 0.023 0.0228
Trichomonas vaginalis CAMK family protein kinase 0.0492 0.223 0.3903
Trypanosoma cruzi heat shock protein, putative 0.0068 0.0241 0.0564
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0093 0.0162
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0296 0.1311 0.1309
Mycobacterium ulcerans hypothetical protein 0.0051 0.0161 0.0374
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0434 0.0432
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0017 0.0003 0.0009
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0015 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0034 0.0058
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0063 0.012
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0077 0.0284 0.1036
Onchocerca volvulus 0.0022 0.0026 0.0041
Toxoplasma gondii phosphomannose isomerase type I protein 0.0919 0.4232 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.012 0.0235
Echinococcus granulosus citrate lyase subunit beta protein 0.0051 0.0161 0.0158
Loa Loa (eye worm) helicase 0.0024 0.0034 0.0063
Echinococcus granulosus X box binding protein 1 0.0287 0.1267 0.1264
Entamoeba histolytica hypothetical protein 0.0024 0.0034 0.0055
Echinococcus multilocularis lamin 0.003 0.0063 0.006
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0296 0.1311 0.2613
Brugia malayi SET domain containing protein 0.003 0.0061 0.0117
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Schistosoma mansoni phosphatidylserine receptor 0.0066 0.023 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0109 0.0188
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0434 0.1021
Trypanosoma brucei heat shock protein, putative 0.0078 0.0286 0.0671
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0122 0.0493 0.1159
Loa Loa (eye worm) calcium channel 0.0296 0.1311 0.2613
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1794 0.8342 0.8341
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0102 0.0399 0.0397
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0034 0.0055
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0109 0.0106
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0063
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Trypanosoma cruzi Heat shock protein 83, putative 0.0078 0.0286 0.0671
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.015 0.0624 0.0621
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0033 0.0072
Schistosoma mansoni heat shock protein 0.0078 0.0286 0.0284
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0033 0.0072
Toxoplasma gondii melibiase subfamily protein 0.0102 0.0399 0.0938
Loa Loa (eye worm) hypothetical protein 0.0259 0.1138 0.2268
Brugia malayi hypothetical protein 0.015 0.0627 0.1247
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1232 0.5702 0.9981
Onchocerca volvulus 0.0024 0.0034 0.0055
Onchocerca volvulus 0.0497 0.2252 0.3939
Giardia lamblia Fructose-bisphosphate aldolase 0.1232 0.5702 1
Leishmania major hypothetical protein, conserved 0.0444 0.2004 0.4732
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0034 0.0058
Trichomonas vaginalis chromobox protein, putative 0.0147 0.0613 0.1071
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0033 0.0053
Echinococcus granulosus Chromobox protein 3 0.0024 0.0034 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.012 0.0235
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.012 0.0118
Echinococcus granulosus amyloid beta A4 protein 0.0212 0.0914 0.0912
Entamoeba histolytica phosphomannose isomerase, putative 0.0919 0.4232 0.7421
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0026 0.0047
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1232 0.5702 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.006
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.012 0.0118
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0015 0.0012
Echinococcus granulosus smad 0.0025 0.004 0.0037
Brugia malayi hypothetical protein 0.0203 0.0876 0.1743
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0033 0.011
Trypanosoma brucei hypothetical protein, conserved 0.0444 0.2004 0.4732
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.006 0.0102
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0189 0.081 0.1612
Schistosoma mansoni regulator of G protein signaling 0.0048 0.0147 0.0145
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0024 0.0034 0.0075
Schistosoma mansoni lamin 0.003 0.0063 0.006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0034 0.0058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0063
Echinococcus multilocularis snurportin 1 0.0306 0.1359 0.1357
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0033 0.0072
Schistosoma mansoni hypothetical protein 0.0054 0.0175 0.0172
Echinococcus granulosus L aminoadipate semialdehyde 0.0433 0.1954 0.1952
Trichomonas vaginalis CAMK family protein kinase 0.0492 0.223 0.3903
Brugia malayi chromobox protein homolog 3 0.0083 0.0309 0.0612
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0433 0.1954 0.3897
Schistosoma mansoni nuclear receptor 0.002 0.0015 0.0012
Brugia malayi conserved hypotetical protein 0.002 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0046
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0039 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0267 0.1174 0.1172
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0046
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0434 0.0432
Echinococcus multilocularis Protein lozenge 0.0062 0.0213 0.0211
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0212
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0093 0.0091
Entamoeba histolytica Ran family GTPase 0.0021 0.002 0.0031
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0316 0.1406 0.5121
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0082 0.008
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0066 0.023 0.0228
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0042 0.0116 0.0227
Entamoeba histolytica acetyltransferase, GNAT family 0.0164 0.0692 0.1209
Onchocerca volvulus 0.1234 0.5713 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0042 0.0116 0.0114
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0063
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0179 0.0762 0.1795
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.012 0.0235
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0017 0.0003 0.0009
Echinococcus granulosus lysine specific demethylase 6a 0.0066 0.023 0.0228
Giardia lamblia Heat shock protein HSP 90-alpha 0.0078 0.0286 0.0498
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.0651 0.0648
Schistosoma mansoni regulator of G protein signaling 0.004 0.0109 0.0106
Schistosoma mansoni numb 0.0022 0.0026 0.0023
Giardia lamblia Grp94/Hsp90 0.0082 0.0307 0.0534
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0311 0.0541
Echinococcus granulosus SHC transforming protein 3 0.0022 0.0026 0.0023
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.006 0.013
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0017 0.0003 0.0009
Toxoplasma gondii Hsp90 domain-containing protein 0.0514 0.2333 0.551
Echinococcus granulosus histone acetyltransferase KAT2B 0.0592 0.27 0.2698
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0434 0.1021
Brugia malayi nuclear receptor RXR 0.0022 0.0026 0.0047
Trypanosoma brucei heat shock protein 84, putative 0.0068 0.0241 0.0564
Echinococcus granulosus snurportin 1 0.0306 0.1359 0.1357
Trypanosoma cruzi hypothetical protein, conserved 0.0444 0.2004 0.4732
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0434 0.0757
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.002 0.0041
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0015 0.0012
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0399 0.0397
Entamoeba histolytica hypothetical protein 0.0024 0.0034 0.0055
Trypanosoma cruzi heat shock protein 85, putative 0.0078 0.0286 0.0671
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0156 0.0651 0.0648
Toxoplasma gondii transporter, cation channel family protein 0.0062 0.0212 0.0495
Brugia malayi jmjC domain containing protein 0.0247 0.1081 0.2154
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0017 0.0003 0.0009
Trichomonas vaginalis Heterochromatin protein, putative 0.0024 0.0034 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0244 0.1064 0.1861
Schistosoma mansoni jumonji/arid domain-containing protein 0.0247 0.1081 0.1079
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.006 0.01
Schistosoma mansoni aldehyde dehydrogenase 0.0316 0.1406 0.1403
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0077 0.0284 0.0563
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0212
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1232 0.5702 0.9981
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0034 0.0058
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.012 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.012 0.0235
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0399 0.0397
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0348
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0017 0.0003 0.0009
Toxoplasma gondii heat shock protein 75, putative 0.0068 0.0241 0.0564
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0093 0.1854
Toxoplasma gondii histone lysine methyltransferase SET1 0.0021 0.0018 0.0036
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.002 0.0037
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0109 0.0212
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0024 0.0034 0.0032
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0066 0.023 0.0538
Brugia malayi tailless protein 0.002 0.0015 0.0025
Trypanosoma brucei heat shock protein 90, putative 0.0078 0.0286 0.0671
Echinococcus multilocularis voltage dependent calcium channel 0.0296 0.1311 0.1309
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.006 0.01
Onchocerca volvulus Huntingtin homolog 0.0259 0.1138 0.1988
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0034 0.0058
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0051
Echinococcus granulosus beta-adrenergic receptor kinase 0.0042 0.0116 0.0114
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.012 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0109 0.0188
Giardia lamblia Kinase, PLK 0.0492 0.223 0.3909
Brugia malayi hypothetical protein 0.002 0.0015 0.0025
Plasmodium falciparum heat shock protein 90, putative 0.0056 0.0186 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0196 0.0341
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.002 0.0041
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.004 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Echinococcus granulosus protein numb 0.0022 0.0026 0.0023
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0434 0.1582
Trypanosoma cruzi polo-like protein kinase, putative 0.0492 0.223 0.5267
Entamoeba histolytica hypothetical protein 0.0023 0.003 0.0048
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0109 0.0106
Schistosoma mansoni zinc finger protein 0.002 0.0015 0.0012
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0068 0.0241 0.0418
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.012 0.0118
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0017 0.0003 0.0009
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0026 0.0047
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0033 0.0072
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0034 0.007
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0434 0.0758
Entamoeba histolytica heat shock protein 90, putative 0.0078 0.0286 0.0498
Schistosoma mansoni smad1 5 8 and 0.0025 0.004 0.0037
Loa Loa (eye worm) hypothetical protein 0.015 0.0627 0.1247
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0109 0.0106
Schistosoma mansoni kinase 0.025 0.1095 0.1092
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0116 0.0114
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0122 0.0493 0.1154
Echinococcus multilocularis phd:f box containing protein 0.0066 0.023 0.0228
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0046
Brugia malayi hypothetical protein 0.0022 0.0026 0.0047
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0017 0.0003 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0244 0.1064 0.1861
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0375 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0309 0.0539
Trypanosoma brucei heat shock protein, putative 0.0078 0.0286 0.0671
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0046
Leishmania major phosphopantetheinyl transferase-like protein 0.0122 0.0493 0.1159
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0034 0.0058
Trypanosoma brucei heat shock protein, putative 0.0078 0.0286 0.0671
Echinococcus multilocularis jumonji domain containing 1A 0.0066 0.023 0.0228
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0919 0.4232 0.7408
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.012 0.0118
Brugia malayi 6-phosphofructokinase 0.0109 0.0434 0.0862
Schistosoma mansoni importin beta-1 0.0029 0.0056 0.0053
Plasmodium vivax heat shock protein 86, putative 0.0078 0.0286 0.0667
Loa Loa (eye worm) hypothetical protein 0.0042 0.012 0.0235
Loa Loa (eye worm) acetyltransferase 0.0609 0.278 0.5547
Loa Loa (eye worm) Smad1 0.0025 0.004 0.0074
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0093 0.0215
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0034 0.0032
Schistosoma mansoni heat shock protein 0.0078 0.0286 0.0284
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0035
Schistosoma mansoni voltage-gated cation channel 0.0296 0.1311 0.1309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.012 0.0235
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.012 0.0235
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0109 0.0212
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0082 0.016
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0056 0.0125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1232 0.5702 0.9981
Echinococcus granulosus survival motor neuron protein 1 0.0265 0.1165 0.1163
Schistosoma mansoni lozenge 0.0062 0.0213 0.0211
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0046
Schistosoma mansoni ran 0.0021 0.002 0.0017
Trypanosoma cruzi heat shock protein 90, putative 0.0078 0.0286 0.0671
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0033 0.0072
Trypanosoma cruzi heat shock protein 85, putative 0.0078 0.0286 0.0671
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.006 0.0102
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.1359 0.2709
Schistosoma mansoni hypothetical protein 0.0022 0.0026 0.0023
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0434 0.0862
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0082 0.008
Loa Loa (eye worm) hypothetical protein 0.0265 0.1165 0.2322
Brugia malayi hypothetical protein 0.0265 0.1165 0.2322
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0051 0.0161 0.0374
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0015 0.0025
Trichomonas vaginalis heat shock protein, putative 0.007 0.0252 0.0439
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0434 0.0758
Plasmodium vivax JmjC domain containing protein 0.0066 0.023 0.0534
Onchocerca volvulus 0.0022 0.0026 0.0041
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0063
Toxoplasma gondii heat shock protein 90, putative 0.0078 0.0286 0.0671
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0109 0.0106
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.006 0.0102
Plasmodium vivax SET domain containing protein 0.0021 0.0018 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0309 0.0539
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0109 0.0188
Brugia malayi CED-6 protein 0.0022 0.0026 0.0046
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0093 0.0215
Schistosoma mansoni amyloid beta A4 protein related 0.0212 0.0914 0.0912
Brugia malayi MH2 domain containing protein 0.0025 0.004 0.0074
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0034 0.007
Trichomonas vaginalis heat shock protein, putative 0.0078 0.0286 0.05
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0212
Echinococcus multilocularis chromobox protein 2 0.0024 0.0034 0.0032
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0109 0.0212
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.003 0.0065
Echinococcus multilocularis tar DNA binding protein 0.0267 0.1174 0.1172
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0034 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0034 0.0058
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0432 0.0857
Echinococcus multilocularis SHC transforming protein 3 0.0022 0.0026 0.0023
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0093 0.0162
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0498 0.2258 0.8225
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0434 0.0432
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0296 0.1311 0.1309
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Plasmodium falciparum endoplasmin, putative 0.0064 0.022 0.051
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.006 0.0135
Brugia malayi jmjC domain containing protein 0.0247 0.1081 0.2154
Loa Loa (eye worm) hypothetical protein 0.0109 0.0432 0.0857
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0109 0.0106
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0015 0.0012
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0109 0.0106
Echinococcus granulosus Smad4 0.0025 0.004 0.0037
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0492 0.223 0.2228
Giardia lamblia Heat shock protein HSP 90-alpha 0.007 0.0252 0.0437
Loa Loa (eye worm) heterochromatin protein 1 0.0147 0.0613 0.1219
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0919 0.4232 1
Onchocerca volvulus 0.0054 0.0175 0.0301
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0046
Trypanosoma cruzi heat shock protein 90, putative 0.007 0.0252 0.0589
Schistosoma mansoni regulator of G protein signaling 0.004 0.0109 0.0106
Echinococcus granulosus voltage dependent calcium channel 0.0296 0.1311 0.1309
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0026 0.0047
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0034 0.0032
Echinococcus multilocularis chromobox protein 1 0.0147 0.0613 0.0611
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0015 0.0025
Trichomonas vaginalis chromobox protein, putative 0.0147 0.0613 0.1071
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.006 0.1127
Leishmania major importin beta-1 subunit, putative 0.0023 0.003 0.0065
Echinococcus granulosus mannose 6 phosphate isomerase 0.0919 0.4232 0.4231
Brugia malayi Inositol-1 0.0037 0.0093 0.0181
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0047
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0077 0.0284 0.0282
Loa Loa (eye worm) hypothetical protein 0.0083 0.0311 0.0616
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.012 0.0118
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0179 0.0762 0.1791
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0015 0.0022
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0033 0.0072
Entamoeba histolytica serine/threonine protein kinase, putative 0.0492 0.223 0.3909
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.0309 0.0536
Onchocerca volvulus 0.002 0.0015 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0034 0.0058
Brugia malayi RNA recognition motif domain containing protein 0.0267 0.1174 0.2339
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.012 0.0118
Loa Loa (eye worm) inositol-1 0.0037 0.0093 0.0181
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.012 0.0118
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1232 0.5702 1
Echinococcus granulosus chromobox protein 1 0.0147 0.0613 0.0611
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0602 0.2745 1
Onchocerca volvulus 0.003 0.0063 0.0105
Loa Loa (eye worm) hypothetical protein 0.0203 0.0876 0.1743
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0047
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0066 0.023 0.0228
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0434 0.0757
Brugia malayi heat shock protein 90 0.0078 0.0286 0.0567
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0109 0.0188
Trypanosoma cruzi polo-like protein kinase, putative 0.0492 0.223 0.5267
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0068 0.0241 0.0418
Echinococcus multilocularis smad 0.0025 0.004 0.0037
Schistosoma mansoni chromobox protein 0.0024 0.0034 0.0032
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.006 0.013
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0034 0.007
Echinococcus multilocularis heat shock protein 90 0.0078 0.0286 0.0284
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0039 0.0081
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0109 0.0212
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0109 0.0106
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.016
Echinococcus multilocularis endoplasmin 0.0082 0.0307 0.0305
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0109 0.0106
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0082 0.0307 0.072
Schistosoma mansoni regulator of G protein signaling 0.004 0.0109 0.0106
Schistosoma mansoni hypothetical protein 0.0034 0.0082 0.008
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0033 0.0072
Schistosoma mansoni coup transcription factor 0.0042 0.012 0.0118
Loa Loa (eye worm) hypothetical protein 0.0066 0.023 0.0455
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1232 0.5702 0.9981
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0093 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.012 0.0235
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.0115
Plasmodium falciparum importin beta, putative 0.0029 0.0056 0.0121
Onchocerca volvulus 0.002 0.0015 0.0022
Brugia malayi ecdysteroid receptor 0.0042 0.012 0.0235
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0033 0.006
Leishmania major hypothetical protein, conserved 0.0066 0.023 0.0538
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0919 0.4232 0.8447
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.012 0.0118
Brugia malayi MH1 domain containing protein 0.0025 0.004 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0497 0.2252 0.4493
Mycobacterium ulcerans heat shock protein 90 0.0082 0.0307 0.072
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0024 0.0034 0.007
Echinococcus multilocularis protein numb 0.0022 0.0026 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0375 0.0373
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.018 0.0766 0.1806
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.023 0.0455
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0116 0.0114
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0056 0.0053
Brugia malayi Importin beta-1 subunit 0.0029 0.0056 0.0106
Loa Loa (eye worm) hypothetical protein 0.0042 0.012 0.0235
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0034 0.0032
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0042 0.0116 0.0227
Echinococcus granulosus histone acetyltransferase KAT2B 0.0179 0.0762 0.0759
Brugia malayi Pre-SET motif family protein 0.0156 0.0651 0.1295
Loa Loa (eye worm) DR-78 0.002 0.0015 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.012 0.0118
Brugia malayi intermediate filament protein 0.003 0.0063 0.012
Schistosoma mansoni chromobox protein 0.0024 0.0034 0.0032
Loa Loa (eye worm) jmjC domain-containing protein 0.0247 0.1081 0.2154
Plasmodium falciparum heat shock protein 90 0.0078 0.0286 0.0667
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0296 0.1311 0.1309
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.012 0.0235
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0106
Loa Loa (eye worm) voltage-dependent calcium channel 0.0062 0.0212 0.0418
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.012 0.0235
Loa Loa (eye worm) AIDA-1b 0.0022 0.0026 0.0046
Schistosoma mansoni survival motor neuron protein 0.0054 0.0175 0.0172
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0033 0.006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0375 0.0744
Loa Loa (eye worm) hypothetical protein 0.0068 0.024 0.0474
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0609 0.278 0.2778
Loa Loa (eye worm) hypothetical protein 0.0259 0.1138 0.2268
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0102 0.0399 0.0397
Echinococcus multilocularis expressed protein 0.0779 0.3576 0.3575
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0015 0.0012
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0109 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.0492 0.223 0.3903
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.012 0.0235
Echinococcus granulosus FTZ F1 alpha 0.0042 0.012 0.0118
Loa Loa (eye worm) hypothetical protein 0.0042 0.012 0.0235
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0017 0.0003 0.0009
Echinococcus granulosus jumonji domain containing 1A 0.0066 0.023 0.0228
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0109 0.0106
Trypanosoma cruzi phosphomannose isomerase, putative 0.0919 0.4232 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.002 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.012 0.0235
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Echinococcus granulosus JmjC domain containing protein 4 0.0066 0.023 0.0228
Trichomonas vaginalis bromodomain-containing protein, putative 0.0179 0.0762 0.1332
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0212
Brugia malayi hypothetical protein 0.002 0.0015 0.0025
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0109 0.0106
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.012 0.0235
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0068 0.0241 0.0239
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0022 0.0046
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0432 0.0857
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.002 0.0041
Onchocerca volvulus 0.002 0.0014 0.002
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0247 0.1081 0.1079
Echinococcus granulosus intermediate filament protein 0.003 0.0063 0.006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0034 0.0058
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.004 0.0037
Echinococcus multilocularis GPCR, family 2 0.0034 0.0082 0.008
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0033 0.0072
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0082 0.016
Plasmodium vivax SET domain protein, putative 0.0156 0.0651 0.1529
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0093 0.0215
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.024 0.0237
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0034 0.0032
Brugia malayi hypothetical protein 0.0497 0.2252 0.4493
Brugia malayi MH2 domain containing protein 0.0025 0.004 0.0074
Loa Loa (eye worm) RGS-3 protein 0.004 0.0109 0.0212
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0077 0.0284 0.0666
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.002 0.0017
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0015 0.0022
Schistosoma mansoni thyroid hormone receptor 0.0042 0.012 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.012 0.0235
Onchocerca volvulus 0.018 0.0764 0.1334
Schistosoma mansoni smad1 5 8 and 0.0025 0.004 0.0037
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0017 0.0003 0.0009
Treponema pallidum heat shock protein 90 0.0082 0.0307 0.0534
Echinococcus granulosus heat shock protein 90 0.007 0.0252 0.0249
Loa Loa (eye worm) runx1 0.0062 0.0213 0.0421
Brugia malayi serine/threonine-protein kinase plk-2 0.0492 0.223 0.445
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1232 0.5702 0.9981
Brugia malayi Nuclear hormone receptor E75 0.002 0.0015 0.0025
Brugia malayi hypothetical protein 0.0025 0.0039 0.0072
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0024 0.0034 0.0032
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0399 0.0397
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0039 0.0081
Loa Loa (eye worm) hypothetical protein 0.0042 0.012 0.0235
Echinococcus multilocularis JmjC domain containing protein 4 0.0066 0.023 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0034 0.0058
Schistosoma mansoni endoplasmin 0.0078 0.0286 0.0284
Brugia malayi nuclear hormone receptor 0.0042 0.012 0.0235
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0004
Echinococcus granulosus histone lysine methyltransferase setb 0.0156 0.0651 0.0648
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.012 0.0118
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.012 0.0118
Schistosoma mansoni tensin-related 0.0022 0.0026 0.0023
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0039 0.0085
Brugia malayi hypothetical protein 0.004 0.0109 0.0212
Mycobacterium ulcerans hypothetical protein 0.0024 0.0033 0.0072
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0039 0.0085
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Onchocerca volvulus Serine\/threonine kinase homolog 0.0492 0.223 0.3902
Brugia malayi AIDA-1b 0.0022 0.0026 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0375 0.0373
Echinococcus multilocularis citrate lyase subunit beta protein 0.0051 0.0161 0.0158
Brugia malayi CHD4 protein 0.0024 0.0034 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.012 0.0235
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0179 0.0762 0.1795
Echinococcus granulosus heat shock protein 0.0078 0.0286 0.0284
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0051 0.0161 0.0374
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0034 0.0058
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0122 0.0493 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0033 0.0072
Schistosoma mansoni ran 0.0021 0.002 0.0017
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0082 0.0307 0.1119
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0063
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0109 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0267 0.1174 0.1172
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0109 0.0188
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0033 0.006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.012 0.0118
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0034 0.0032
Echinococcus multilocularis musashi 0.003 0.0063 0.006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0072
Trypanosoma brucei phosphomannose isomerase 0.0919 0.4232 1
Echinococcus multilocularis chromobox protein 1 0.0147 0.0613 0.0611
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.023 0.0455
Schistosoma mansoni inositol monophosphatase 0.0037 0.0093 0.0091
Onchocerca volvulus 0.0042 0.012 0.0206
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0224 0.0443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.012 0.0235
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.024 0.0237
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0102 0.0399 0.0397
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0033 0.0053
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0109 0.0212
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0063
Loa Loa (eye worm) intermediate filament protein 0.003 0.0063 0.012
Trypanosoma cruzi phosphomannose isomerase, putative 0.0919 0.4232 1
Leishmania major hypothetical protein, conserved 0.0025 0.0039 0.0085
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0267 0.1174 0.2339
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.012 0.0206
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0296 0.1311 0.1309
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0026 0.0024
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.012 0.0235
Echinococcus granulosus hypothetical protein 0.0022 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.0042 0.012 0.0235
Leishmania major GTP-binding protein, putative 0.0021 0.002 0.0041
Plasmodium falciparum JmjC domain-containing protein, putative 0.0066 0.023 0.0534
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0093 0.0159
Trypanosoma brucei Heat shock protein 83, putative 0.0078 0.0286 0.0671
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0034 0.0063
Echinococcus multilocularis sodium channel protein 0.0126 0.0511 0.0508
Brugia malayi phosphofructokinase 0.0109 0.0434 0.0862
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0047
Onchocerca volvulus Huntingtin homolog 0.0259 0.1138 0.1988
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0063
Echinococcus granulosus phd:f box containing protein 0.0066 0.023 0.0228
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0434 0.0862
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0196 0.0341
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0034 0.0058
Leishmania major phosphomannose isomerase 0.0919 0.4232 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0093 0.0215
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0082 0.008
Schistosoma mansoni chromobox protein 0.0147 0.0613 0.0611
Echinococcus multilocularis Chromo domain 0.0024 0.0034 0.0032
Echinococcus granulosus lysine specific demethylase 5A 0.0247 0.1081 0.1079
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0089 0.0338 0.0588
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0015 0.0012
Schistosoma mansoni nuclear hormone receptor 0.002 0.0015 0.0012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0034 0.0058
Entamoeba histolytica hypothetical protein 0.0024 0.0034 0.0055
Trypanosoma brucei heat shock protein, putative 0.0078 0.0286 0.0671
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0316 0.1406 0.1403
Loa Loa (eye worm) hypothetical protein 0.0296 0.1311 0.2613
Brugia malayi Endoplasmin precursor 0.0078 0.0286 0.0567
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0175 0.0344
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0042 0.0116 0.0227
Schistosoma mansoni hypothetical protein 0.0034 0.0082 0.008
Brugia malayi nuclear receptor NHR-67 0.002 0.0015 0.0025
Echinococcus granulosus endoplasmin 0.0082 0.0307 0.0305
Loa Loa (eye worm) RNA binding protein 0.0267 0.1174 0.2339
Brugia malayi PXA domain containing protein 0.004 0.0109 0.0212
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.006 0.013
Schistosoma mansoni tar DNA-binding protein 0.0267 0.1174 0.1172
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0077 0.0284 0.0282
Trypanosoma cruzi heat shock protein 85, putative 0.0078 0.0286 0.0671
Brugia malayi Nuclear hormone receptor E75 0.002 0.0015 0.0025
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0034 0.0063
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0919 0.4232 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0296 0.1311 0.1309
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0434 0.0862
Echinococcus granulosus expressed protein 0.0779 0.3576 0.3575
Schistosoma mansoni tar DNA-binding protein 0.0267 0.1174 0.1172
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0919 0.4232 0.8447
Trichomonas vaginalis heat shock protein, putative 0.0082 0.0307 0.0536
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0077 0.0284 0.0282
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0433 0.1954 0.1952
Leishmania major heat shock protein 83-1 0.0078 0.0286 0.0671
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0051 0.0161 0.028
Brugia malayi steroid hormone receptor 0.0042 0.012 0.0235
Brugia malayi ecdysone receptor 0.002 0.0015 0.0025
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0039 0.0085
Echinococcus granulosus tar DNA binding protein 0.0267 0.1174 0.1172
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.0651 0.0648
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0492 0.223 0.445
Onchocerca volvulus 0.0024 0.0033 0.0053
Loa Loa (eye worm) heat shock protein 75 0.0068 0.0241 0.0476
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0015 0.0025
Onchocerca volvulus 0.015 0.0627 0.1093
Loa Loa (eye worm) hypothetical protein 0.0156 0.0651 0.1295
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.018 0.0766 0.1806

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 50 um PUBCHEM_BIOASSAY: Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 633 (Primary screen preceding this dose response confirmation assay.)] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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