Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | multiple endocrine neoplasia I | No references | |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.0192 | 0.3837 | 1 |
Plasmodium falciparum | mannose-6-phosphate isomerase, putative | 0.0192 | 0.3837 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0662 | 0.0648 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0074 | 0.0194 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.1416 | 0.1403 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0074 | 0.0194 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0662 | 0.0578 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0622 | 0.132 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1411 | 0.1398 |
Onchocerca volvulus | Putative phosphomannomutase | 0.0042 | 0.0762 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0074 | 0.0194 |
Schistosoma mansoni | phosphomannomutase | 0.0042 | 0.0762 | 0.0748 |
Mycobacterium tuberculosis | Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho | 0.0104 | 0.2041 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.1411 | 0.2111 |
Mycobacterium leprae | probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO | 0.0104 | 0.2041 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0074 | 0.0194 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0074 | 0.0194 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0074 | 0.0194 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0192 | 0.3837 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.1411 | 0.1333 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0074 | 0.0194 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0074 | 0.0194 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.1411 | 0.1333 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0074 | 0.0194 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0622 | 0.1327 |
Loa Loa (eye worm) | phosphomannomutase 2 | 0.0042 | 0.0762 | 0.1698 |
Trichomonas vaginalis | phosphomannomutase, putative | 0.0042 | 0.0762 | 0.1986 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0192 | 0.3837 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.1411 | 0.2111 |
Brugia malayi | phosphomannomutase 2 | 0.0042 | 0.0762 | 0.1704 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0192 | 0.3837 | 1 |
Echinococcus granulosus | mannose 6 phosphate isomerase | 0.0192 | 0.3837 | 0.3781 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0192 | 0.3837 | 1 |
Schistosoma mansoni | mannose-6-phosphate isomerase | 0.0192 | 0.3837 | 0.3828 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0662 | 0.0648 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0074 | 0.0194 |
Entamoeba histolytica | phosphomannose isomerase, putative | 0.0192 | 0.3837 | 1 |
Plasmodium vivax | mannose-6-phosphate isomerase, putative | 0.0192 | 0.3837 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0074 | 0.0194 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0074 | 0.0194 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0074 | 0.0194 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.009 | 0.0074 |
Mycobacterium ulcerans | mannose-6-phosphate isomerase ManA | 0.0192 | 0.3837 | 1 |
Entamoeba histolytica | mannose-6-phosphate isomerase, putative | 0.0088 | 0.171 | 0.3084 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0074 | 0.0194 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0662 | 0.0578 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0622 | 0.0608 |
Toxoplasma gondii | phosphomannose isomerase type I protein | 0.0192 | 0.3837 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.1256 | 0.1605 |
Echinococcus multilocularis | mannose 6 phosphate isomerase | 0.0192 | 0.3837 | 0.3781 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0074 | 0.0194 |
Trichomonas vaginalis | mannose-6-phosphate isomerase, putative | 0.0192 | 0.3837 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0133 | 0.0044 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0133 | 0.0044 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0074 | 0.0194 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0074 | 0.0194 |
Echinococcus granulosus | phosphomannomutase | 0.0042 | 0.0762 | 0.0678 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0074 | 0.0194 |
Echinococcus multilocularis | phosphomannomutase | 0.0042 | 0.0762 | 0.0678 |
Trypanosoma brucei | phosphomannose isomerase | 0.0192 | 0.3837 | 1 |
Leishmania major | phosphomannose isomerase | 0.0192 | 0.3837 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1411 | 0.1398 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.0192 | 0.3837 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.9362 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.