Detailed information for compound 1290256

Basic information

Technical information
  • TDR Targets ID: 1290256
  • Name: N-(1,3-benzodioxol-5-yl)-3-(4-methoxyphenyl)p ropanamide
  • MW: 299.321 | Formula: C17H17NO4
  • H donors: 1 H acceptors: 1 LogP: 2.77 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CCC(=O)Nc1ccc2c(c1)OCO2
  • InChi: 1S/C17H17NO4/c1-20-14-6-2-12(3-7-14)4-9-17(19)18-13-5-8-15-16(10-13)22-11-21-15/h2-3,5-8,10H,4,9,11H2,1H3,(H,18,19)
  • InChiKey: ANHCSBRBPQQMSS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(1,3-benzodioxol-5-yl)-3-(4-methoxyphenyl)propionamide
  • ST033011
  • BAS 12773244
  • N-Benzo[1,3]dioxol-5-yl-3-(4-methoxy-phenyl)-propionamide
  • MLS001208804
  • SMR000525001
  • Oprea1_807848
  • ZINC00037079
  • AO-548/41445417

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0363 0.0331
Loa Loa (eye worm) RNA binding protein 0.0076 0.4047 0.4039
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0363 0.035
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0033 0.002
Loa Loa (eye worm) RecQ helicase 0.0029 0.1325 0.1313
Brugia malayi ecdysteroid receptor 0.0012 0.0363 0.0331
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0551 0.5
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0349 0.5
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.1325 1
Onchocerca volvulus 0.0012 0.0363 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0363 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0363 0.0331
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0363 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0363 0.0331
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0551 0.5
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0349 0.0317
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.1123 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0363 0.035
Brugia malayi nuclear receptor NHR-88 0.0012 0.0363 0.0331
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0363 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0363 0.035
Brugia malayi TAR-binding protein 0.0076 0.4047 0.4027
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0349 0.0337
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0363 0.0867
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0349 0.0317
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0551 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0363 0.0331
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0975 0.2385
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0363 0.0331
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0349 0.4422
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0363 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4047 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0363 0.0331
Schistosoma mansoni DNA helicase recq1 0.0012 0.0349 0.0833
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0033 0.0049
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0363 0.0331
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.4047 0.4027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0363 0.0331
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.002
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0363 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4047 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.8025 0.8022
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0363 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0363 0.035
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0363 0.035
Echinococcus granulosus bloom syndrome protein 0.0029 0.1325 0.1296
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0363 0.0867
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0363 0.0331
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.1325 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4047 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0363 0.0867
Schistosoma mansoni DNA helicase recq5 0.0012 0.0349 0.0833
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0349 0.4422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0363 0.035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0363 0.035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0363 0.035
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0349 0.0317
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0363 0.0867
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0363 0.0331
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0774 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.4047 0.4039
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0363 0.0331
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0349 0.0317
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0363 0.0331
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0363 0.035
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0363 0.0331
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0363 0.035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0363 0.035
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0363 0.0331
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0363 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4047 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0033 0.0049
Brugia malayi steroid hormone receptor 0.0012 0.0363 0.0331
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0551 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0349 0.0317
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0363 0.0867
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0363 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0363 0.035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0363 0.0331
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.4047 0.4039
Treponema pallidum ATP-dependent DNA helicase 0.0006 0.0013 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0363 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0363 0.035
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0363 0.0331
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0363 0.0867
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0363 0.0867
Loa Loa (eye worm) hypothetical protein 0.0012 0.0349 0.0337
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0363 0.0867
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0363 0.0331
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0363 0.0867
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0363 0.0331
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0363 0.0867
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0787 1
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0013 0.0241
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0363 0.0331
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0363 0.0867
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.1325 0.1296
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4047 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0363 0.0331
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0363 0.0867
Echinococcus granulosus tar DNA binding protein 0.0076 0.4047 0.4027
Brugia malayi RNA binding protein 0.0076 0.4047 0.4027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0363 0.035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0363 0.0331
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0363 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0363 0.0331
Echinococcus multilocularis bloom syndrome protein 0.0029 0.1325 0.1296
Brugia malayi nuclear hormone receptor 0.0012 0.0363 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0363 0.0331
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0363 0.0331
Loa Loa (eye worm) hypothetical protein 0.0012 0.0363 0.035
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0363 0.5
Echinococcus multilocularis tar DNA binding protein 0.0076 0.4047 0.4027
Schistosoma mansoni coup transcription factor 0.0012 0.0363 0.0867
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0349 0.0317
Loa Loa (eye worm) hypothetical protein 0.0012 0.0363 0.035
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0363 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0363 0.0331

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 10 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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