Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 0.3639 | 0.7674 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0281 | 0.4742 | 0.4742 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 0.3639 | 0.7674 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0281 | 0.4742 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0281 | 0.4742 | 0.4742 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0281 | 0.4742 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 0.3639 | 0.7674 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0281 | 0.4742 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 0.3639 | 0.7674 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.0374 | 0.0788 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0281 | 0.4742 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0281 | 0.4742 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 0.3639 | 0.7674 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0281 | 0.4742 | 0.4742 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0281 | 0.4742 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0281 | 0.4742 | 0.4742 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0281 | 0.4742 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0281 | 0.4742 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0281 | 0.4742 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0281 | 0.4742 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0281 | 0.4742 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0281 | 0.4742 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0281 | 0.4742 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 0.3639 | 0.7674 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0281 | 0.4742 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0281 | 0.4742 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.4591 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0281 | 0.4742 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.0374 | 0.0788 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0281 | 0.4742 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0126 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.