Detailed information for compound 1290459

Basic information

Technical information
  • TDR Targets ID: 1290459
  • Name: 5-(2-hydroxyethyl)-1,3,5-triazinan-2-one
  • MW: 145.16 | Formula: C5H11N3O2
  • H donors: 3 H acceptors: 2 LogP: -1.31 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CNC(=O)NC1
  • InChi: 1S/C5H11N3O2/c9-2-1-8-3-6-5(10)7-4-8/h9H,1-4H2,(H2,6,7,10)
  • InChiKey: XWAUFZXBGKOTGL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2580-58-7
  • NSC47881
  • Tetrahydro-5-(2-hydroxyethyl)-1,3,5-triazin-2(1H)-one
  • 1,3,5-Triazin-2(1H)-one, tetrahydro-5-(2-hydroxyethyl)-
  • 5-(2-Hydroxyethyl)-1,2,3,4,5,6-hexahydro-1,3,5-triazine-2-one
  • MLS000736631
  • SMR000528227
  • EINECS 219-944-1
  • AIDS-018822
  • AIDS018822
  • Tetrahydro-5-(2-hydroxyethyl)-s-triaz-2(1H)-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.2264 0.6991
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.2264 0.6991
Loa Loa (eye worm) hypothetical protein 0.0024 0.0283 0.0283
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0356 0.4285
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.1376 0.4155
Loa Loa (eye worm) TAR-binding protein 0.0131 0.3207 0.3207
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0019 0.0121 0.1147
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0043 0.0783 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0121
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0074 0.0514
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0074 0.0074
Trypanosoma brucei P-type H+-ATPase, putative 0.0027 0.0356 0.3976
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0316 0.0774
Echinococcus multilocularis nervana 2 0.0064 0.1376 0.4155
Leishmania major hypothetical protein, conserved 0.0024 0.0283 0.2956
Plasmodium vivax P-type ATPase4, putative 0.0043 0.0783 1
Brugia malayi MH1 domain containing protein 0.0026 0.0316 0.0316
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0034 0.0548 0.1514
Echinococcus multilocularis tar DNA binding protein 0.0131 0.3207 1
Brugia malayi calcium ATPase 0.0015 0.0035 0.0035
Toxoplasma gondii P-type ATPase4, putative 0.0043 0.0783 1
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0029 0.0406 1
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0029 0.0406 0.0406
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0043 0.0783 1
Schistosoma mansoni smad1 5 8 and 0.0026 0.0316 0.046
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3207 0.5942
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0043 0.0783 1
Trypanosoma cruzi calcium-transporting ATPase, putative 0.002 0.0172 0.1822
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0043 0.0783 0.2262
Loa Loa (eye worm) hypothetical protein 0.0304 0.8002 0.8002
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0064 0.1376 0.4155
Echinococcus multilocularis nervana 2 0.0064 0.1376 0.4155
Echinococcus multilocularis calcium transporting atpase 0.0034 0.0548 0.1514
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0304 0.8002 0.8002
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0783 1
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0019 0.0121 0.0121
Trypanosoma brucei calcium-translocating P-type ATPase 0.0034 0.0548 0.6692
Echinococcus granulosus calcium transporting atpase 0.0034 0.0548 0.1514
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0304 0.8002 0.8002
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0316 0.046
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0043 0.0783 1
Leishmania major calcium motive p-type ATPase, putative 0.0034 0.0548 0.6692
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0043 0.0783 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3207 0.5942
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0074 0.0514
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0034 0.0548 0.09
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0019 0.0121 0.0121
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0029 0.0406 0.5
Echinococcus multilocularis nervana 2 0.0064 0.1376 0.4155
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0034 0.0548 0.09
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0043 0.0783 1
Brugia malayi Smad1 0.0026 0.0316 0.0316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1131 0.3375
Trichomonas vaginalis cation-transporting ATPase, putative 0.0043 0.0783 1
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.1376 0.2469
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.3207 0.3207
Brugia malayi latrophilin 2 splice variant baaae 0.0208 0.5347 0.5347
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0034 0.0548 0.1514
Brugia malayi Membrane calcium atpase protein 3 0.0034 0.0548 0.0548
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.1376 0.2469
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0783 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.1376 0.4155
Loa Loa (eye worm) RNA binding protein 0.0131 0.3207 0.3207
Brugia malayi isocitrate dehydrogenase 0.0017 0.0074 0.0074
Echinococcus granulosus Smad4 0.0026 0.0316 0.0774
Brugia malayi Na,K-ATPase alpha subunit 0.0043 0.0783 0.0783
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0316 0.0774
Loa Loa (eye worm) hypothetical protein 0.0257 0.6708 0.6708
Brugia malayi calcium ATPase 0.0019 0.0121 0.0121
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0283 0.2956
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0043 0.0783 0.2262
Schistosoma mansoni hypothetical protein 0.0096 0.2264 0.4154
Echinococcus multilocularis smad 0.0026 0.0316 0.0774
Echinococcus granulosus smad 0.0026 0.0316 0.0774
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0043 0.0783 1
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0034 0.0548 0.1514
Onchocerca volvulus 0.0064 0.1376 1
Schistosoma mansoni hypothetical protein 0.0096 0.2264 0.4154
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0283 0.2956
Echinococcus multilocularis Smad4 0.0026 0.0316 0.0774
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0043 0.0783 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0548 0.4509
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0043 0.0783 1
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0043 0.0783 1
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0019 0.0121 0.0668
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0034 0.0548 0.1514
Leishmania major P-type H -ATPase, putative 0.0027 0.0356 0.3976
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0316 0.0316
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0024 0.027 0.027
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3207 0.5942
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0043 0.0783 0.2262
Onchocerca volvulus 0.0064 0.1376 1
Echinococcus granulosus tar DNA binding protein 0.0131 0.3207 1
Brugia malayi hypothetical protein 0.0016 0.0044 0.0044
Brugia malayi hypothetical protein 0.0024 0.0283 0.0283
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1131 0.2006
Brugia malayi TAR-binding protein 0.0131 0.3207 0.3207
Loa Loa (eye worm) Smad1 0.0026 0.0316 0.0316
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0024 0.027 0.2249
Leishmania major calcium-transporting ATPase, putative 0.0034 0.0548 0.6692
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0064 0.1376 0.4155
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1131 0.1131
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1131 0.1131
Schistosoma mansoni ATPase 0.0043 0.0783 0.1344
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0783 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.2264 0.2264
Leishmania major P-type H -ATPase, putative 0.0027 0.0356 0.3976
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.2264 0.6991
Brugia malayi MH1 domain containing protein 0.0026 0.0316 0.0316
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0034 0.0548 0.1514
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3207 0.5942
Trypanosoma brucei calcium-transporting ATPase, putative 0.002 0.0172 0.1379
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0043 0.0783 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.1376 0.4155
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0024 0.027 0.2249
Schistosoma mansoni smad1 5 8 and 0.0026 0.0316 0.046
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0043 0.0783 1
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0034 0.0548 0.09
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0043 0.0783 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3207 0.5942
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0043 0.0783 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1131 0.2006
Echinococcus granulosus GPCR family 2 0.0096 0.2264 0.6991
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.1376 0.4155
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0043 0.0783 0.2262
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0034 0.0548 0.6692
Loa Loa (eye worm) hypothetical protein 0.0208 0.5347 0.5347
Loa Loa (eye worm) hypothetical protein 0.0064 0.1376 0.1376
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.2264 0.2264
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0034 0.0548 0.6862
Loa Loa (eye worm) hypothetical protein 0.0043 0.0783 0.0783
Schistosoma mansoni smad 0.0026 0.0316 0.046
Loa Loa (eye worm) hypothetical protein 0.0096 0.2264 0.2264
Trichomonas vaginalis cation-transporting ATPase, putative 0.0043 0.0783 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0316 0.0316
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0029 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0035
Brugia malayi photoreceptor-specific nuclear receptor 0.0257 0.6708 0.6708
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0074 0.0074
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0783 1
Echinococcus granulosus nervana 2 0.0064 0.1376 0.4155
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0034 0.0548 0.6862
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.1376 0.2469
Schistosoma mansoni Smad4 0.0026 0.0316 0.046
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0283 0.3318
Leishmania major calcium-translocating P-type ATPase 0.0043 0.0783 1
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0034 0.0548 0.09
Echinococcus granulosus nervana 2 0.0064 0.1376 0.4155
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0043 0.0783 1
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0043 0.0783 0.0783
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0034 0.0548 0.09
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1131 0.3375
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0043 0.0783 1
Echinococcus multilocularis nervana 2 0.0064 0.1376 0.4155
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0283 0.2956
Echinococcus multilocularis GPCR, family 2 0.0096 0.2264 0.6991
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0283 0.3318
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0043 0.0783 1
Brugia malayi E1-E2 ATPase family protein 0.0027 0.0356 0.0356
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1131 0.2006
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0783 1
Plasmodium falciparum calcium-transporting ATPase 0.0034 0.0548 0.6692
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0043 0.0783 1
Brugia malayi Latrophilin receptor protein 2 0.0096 0.2264 0.2264
Loa Loa (eye worm) hypothetical protein 0.0043 0.0783 0.0783
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0034 0.0548 0.6692
Echinococcus granulosus nervana 2 0.0064 0.1376 0.4155
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.1376 0.4155
Leishmania major P-type ATPase, putative 0.0034 0.0548 0.6692
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0043 0.0783 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.3207 0.3207
Trypanosoma cruzi P-type H+-ATPase, putative 0.0019 0.0121 0.1147
Echinococcus granulosus Na:K ATPase alpha subunit 0.0034 0.0548 0.1514
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0356 0.4285
Loa Loa (eye worm) hypothetical protein 0.0064 0.1376 0.1376
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0043 0.0783 0.1344
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0034 0.0548 0.0548
Schistosoma mansoni hypothetical protein 0.0096 0.2264 0.4154
Schistosoma mansoni smad1 5 8 and 0.0026 0.0316 0.046
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.2264 0.6991
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0043 0.0783 0.2262
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0283 0.2956
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0043 0.0783 0.2262
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0064 0.1376 0.2469
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0316 0.0774
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.002 0.0172 0.0172
Toxoplasma gondii P-type ATPase PMA1 0.0027 0.0356 0.3976
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0283 0.2956
Schistosoma mansoni hypothetical protein 0.0208 0.5347 1
Loa Loa (eye worm) calcium ATPase 0.0024 0.027 0.027
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0316 0.0774
Schistosoma mansoni ATPase 0.0043 0.0783 0.1344
Trichomonas vaginalis cation-transporting ATPase, putative 0.0043 0.0783 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0304 0.8002 0.8002
Echinococcus granulosus nervana 2 0.0064 0.1376 0.4155
Brugia malayi MH2 domain containing protein 0.0026 0.0316 0.0316
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1131 0.3375
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0019 0.0121 0.1147
Schistosoma mansoni transmemberane protein 0.0064 0.1376 0.2469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1131 0.3375
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.1376 0.4155
Loa Loa (eye worm) E1-E2 ATPase 0.0027 0.0356 0.0356
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.002 0.0172 0.0172
Trypanosoma brucei P-type H+-ATPase, putative 0.0027 0.0356 0.3976
Brugia malayi RNA binding protein 0.0131 0.3207 0.3207
Schistosoma mansoni hypothetical protein 0.0096 0.2264 0.4154
Brugia malayi MH2 domain containing protein 0.0026 0.0316 0.0316
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0034 0.0548 0.09
Plasmodium vivax calcium-transporting ATPase, putative 0.0043 0.0783 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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