Detailed information for compound 1290759

Basic information

Technical information
  • TDR Targets ID: 1290759
  • Name: [2-(furan-2-ylmethylamino)-2-oxoethyl] 2-[(2, 3-dimethylphenyl)amino]benzoate
  • MW: 378.421 | Formula: C22H22N2O4
  • H donors: 2 H acceptors: 2 LogP: 4.54 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccco1)COC(=O)c1ccccc1Nc1cccc(c1C)C
  • InChi: 1S/C22H22N2O4/c1-15-7-5-11-19(16(15)2)24-20-10-4-3-9-18(20)22(26)28-14-21(25)23-13-17-8-6-12-27-17/h3-12,24H,13-14H2,1-2H3,(H,23,25)
  • InChiKey: RXFGXTQEVAHUBM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(2-furylmethylamino)-2-oxo-ethyl] 2-[(2,3-dimethylphenyl)amino]benzoate
  • 2-[(2,3-dimethylphenyl)amino]benzoic acid [2-(2-furylmethylamino)-2-oxoethyl] ester
  • 2-[(2,3-dimethylphenyl)amino]benzoic acid [2-(2-furylmethylamino)-2-keto-ethyl] ester
  • [2-(furan-2-ylmethylamino)-2-oxo-ethyl] 2-[(2,3-dimethylphenyl)amino]benzoate
  • MLS000572136
  • SMR000151180

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0017 0.0033 0.0012
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0025 0.0088 0.1518
Loa Loa (eye worm) nuclear factor I 0.0019 0.0051 0.0051
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0004 0.0067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0103 0.0103
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0033 0.0048
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0064 0.1003
Schistosoma mansoni hypothetical protein 0.047 0.311 0.4566
Onchocerca volvulus 0.0027 0.0103 0.0151
Loa Loa (eye worm) Smad1 0.0035 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.047 0.311 0.311
Loa Loa (eye worm) RasGEF domain-containing protein 0.0027 0.0103 0.0103
Brugia malayi hypothetical protein 0.0038 0.0176 0.0151
Schistosoma mansoni Smad4 0.0016 0.0026 0.0038
Echinococcus granulosus bloom syndrome protein 0.0024 0.0083 0.01
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0026 0.0026
Schistosoma mansoni Smad4 0.0016 0.0026 0.0038
Mycobacterium ulcerans polyketide synthase 0.0027 0.0104 0.4868
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0033 0.0012
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0109 0.5236
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0017 0.0033 0.0012
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.027 0.0427
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0017 0.0033 0.0686
Brugia malayi Egg laying defective protein 4 0.0017 0.0033 0.0007
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0241 0.4738
Echinococcus multilocularis smad 0.0035 0.0157 0.0228
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0038 0.0176 0.0151
Schistosoma mansoni hypothetical protein 0.047 0.311 0.4566
Brugia malayi MH1 domain containing protein 0.0035 0.0157 0.0131
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0033 0.0012
Loa Loa (eye worm) cytochrome P450 0.0017 0.0037 0.0037
Brugia malayi Cyclic-nucleotide gated cation channel 0.0017 0.0033 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0017
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0017 0.0033 0.0012
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0103 0.4258
Brugia malayi MH2 domain containing protein 0.0509 0.3378 0.3361
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0083 0.1755
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0093 0.413
Loa Loa (eye worm) AGC/PKG protein kinase 0.0017 0.0033 0.0033
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0033 0.0012
Brugia malayi DIX domain containing protein 0.0038 0.0176 0.0151
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0017 0.0037 0.0276
Loa Loa (eye worm) RasGEF domain-containing protein 0.0027 0.0103 0.0103
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0033 0.0316
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0157 0.0228
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0109 0.2241
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0017 0.0033 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Schistosoma mansoni DNA helicase recq1 0.0024 0.0083 0.0122
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0083 0.3441
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0017 0.0033 0.0012
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0083 0.1147
Schistosoma mansoni hypothetical protein 0.1015 0.6811 1
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0026 0.0094 0.0137
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0157 0.0228
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0033 0.0033
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0017 0.0033 0.0686
Brugia malayi N-terminal motif family protein 0.0765 0.5112 0.5099
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0017 0.0037 0.0404
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0083 0.0083
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0088 0.1844
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0027 0.0103 0.2118
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.047 0.311 0.5391
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0017 0.0033 0.0624
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0017 0.0033 0.0316
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0027 0.0103 0.015
Onchocerca volvulus 0.0044 0.022 0.0381
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0103 0.4258
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.047 0.311 0.5391
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0008 0.0152
Schistosoma mansoni tar DNA-binding protein 0.0858 0.5747 0.8437
Brugia malayi RNA binding protein 0.0858 0.5747 0.5735
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0017 0.0037 0.0404
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0103 0.4258
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0017 0.0033 0.0316
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0017 0.0033 0.0012
Echinococcus multilocularis tar DNA binding protein 0.0858 0.5747 1
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0241 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0025 0.0088 0.1518
Brugia malayi Cytochrome P450 family protein 0.0028 0.0109 0.0083
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0103 0.4258
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0081 0.0473 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0103 0.4258
Schistosoma mansoni dep domain containing protein 0.0038 0.0176 0.0258
Brugia malayi Smad1 0.0035 0.0157 0.0131
Loa Loa (eye worm) hypothetical protein 0.0038 0.0176 0.0176
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0017 0.0037 0.0404
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0037 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0017 0.0033 0.0012
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0017 0.0037 0.0276
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0103 0.4258
Brugia malayi hypothetical protein 0.0016 0.0029 0.0002
Echinococcus granulosus son of sevenless 1 0.0027 0.0103 0.0134
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0064 0.2152
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.047 0.311 0.5391
Echinococcus granulosus smad 0.0035 0.0157 0.0228
Echinococcus multilocularis GPCR, family 2 0.047 0.311 0.5391
Brugia malayi hypothetical protein 0.0025 0.0088 0.0062
Brugia malayi hypothetical protein 0.0038 0.0176 0.0151
Onchocerca volvulus 0.0024 0.0082 0.0109
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0017 0.0033 0.0012
Toxoplasma gondii hypothetical protein 0.0038 0.0176 0.3725
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0017 0.0037 0.0404
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0017 0.0037 0.0276
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0033 0.0048
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0157 0.0229
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0017 0.0037 0.0276
Schistosoma mansoni dishevelled 0.0038 0.0176 0.0258
Brugia malayi Cytochrome P450 family protein 0.0063 0.035 0.0325
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0043 0.0904
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0038 0.0176 0.0258
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0033 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0017 0.0037 0.0404
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.047 0.311 0.5391
Echinococcus multilocularis Smad4 0.0035 0.0157 0.0228
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0157 0.0228
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0027 0.0103 0.2952
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0104 0.1869
Echinococcus granulosus Protein son of sevenless 0.0027 0.0103 0.0134
Echinococcus multilocularis 0.0017 0.0037 0.0019
Trypanosoma cruzi protein kinase A regulatory subunit 0.0017 0.0033 0.0624
Brugia malayi RasGEF domain containing protein 0.0027 0.0103 0.0077
Treponema pallidum cyclic nucleotide binding protein 0.0017 0.0033 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0032 0.0674
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0176 0.0176
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0027 0.0103 0.0151
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.027 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0017 0.0033 0.0686
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0104 0.4868
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0017 0.0037 0.0404
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0104 0.218
Brugia malayi latrophilin 2 splice variant baaae 0.1015 0.6811 0.6803
Brugia malayi MH2 domain containing protein 0.0035 0.0157 0.0131
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0021 0.0062 0.0944
Loa Loa (eye worm) DIX domain-containing protein 0.0038 0.0176 0.0176
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0176 0.0258
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0059 0.1811
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0081 0.0473 0.078
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0017 0.0033 0.0007
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.027 0.5716
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0017 0.0033 0.0012
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.0037 0.0091
Mycobacterium ulcerans polyketide synthase 0.0025 0.0093 0.413
Brugia malayi TAR-binding protein 0.0858 0.5747 0.5735
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0083 0.2421
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0017 0.0035 0.011
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0176 0.0263
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0017 0.0033 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0017 0.0037 0.0404
Trypanosoma cruzi cAMP response protein 1 0.0017 0.0033 0.0624
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0017 0.0033 0.0048
Schistosoma mansoni smad1 5 8 and 0.0035 0.0157 0.0229
Schistosoma mansoni hypothetical protein 0.047 0.311 0.4566
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0017 0.0033 0.0316
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0017 0.0037 0.0404
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0081 0.0473 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0017 0.0033 0.0012
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0033 0.0012
Mycobacterium ulcerans thioesterase 0.0021 0.0064 0.2152
Trichomonas vaginalis ras GTP exchange factor, putative 0.0027 0.0103 0.2952
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0017 0.0033 0.0686
Echinococcus granulosus ras GTP exchange factor 0.0027 0.0103 0.0134
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0176 0.0151
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0104 0.1869
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0017 0.0033 0.0048
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0033 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0082 0.0055
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0017 0.0037 0.0404
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.035 0.035
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0004 0.0067
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0104 0.4868
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1109 0.1628
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0109 0.0109
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0083 0.01
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0017 0.0033 0.0007
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0017 0.0033 0.0012
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0176 0.0258
Brugia malayi Latrophilin receptor protein 2 0.047 0.311 0.3092
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0088 0.1844
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0033
Trypanosoma cruzi hypothetical protein 0.0027 0.0103 0.2118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0033
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0017 0.0037 0.0276
Echinococcus granulosus Pleckstrin G protein interacting region 0.0038 0.0176 0.0263
Loa Loa (eye worm) hypothetical protein 0.0038 0.0176 0.0176
Echinococcus granulosus voltage gated potassium channel 0.0017 0.0033 0.0012
Brugia malayi RasGEF domain containing protein 0.0027 0.0103 0.0077
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0083 0.0057
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0044 0.0567
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0081 0.0473 0.078
Loa Loa (eye worm) transcription factor SMAD2 0.0509 0.3378 0.3378
Schistosoma mansoni tar DNA-binding protein 0.0858 0.5747 0.8437
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0033 0.0012
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0017 0.0033 0.0007
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0017 0.0035 0.011
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0088 0.1789
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0081 0.0473 1
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0027 0.0103 0.0134
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0104 0.4868
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0033 0.0316
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0027 0.0103 0.015
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0017 0.0033 0.0686
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0083 0.01
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0017 0.0033 0.0686
Echinococcus granulosus segment polarity protein dishevelled 0.0038 0.0176 0.0263
Brugia malayi RasGEF domain containing protein 0.0027 0.0103 0.0077
Loa Loa (eye worm) TAR-binding protein 0.0858 0.5747 0.5747
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0109 0.1725
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0017 0.0033 0.0686
Echinococcus multilocularis son of sevenless 1 0.0027 0.0103 0.0134
Loa Loa (eye worm) fatty acid synthase 0.0025 0.0091 0.0091
Echinococcus multilocularis segment polarity protein dishevelled 0.0038 0.0176 0.0263
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0037 0.0091
Schistosoma mansoni smad 0.0016 0.0026 0.0038
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0017 0.0037 0.0276
Trypanosoma cruzi cAMP response protein 1, putative 0.0017 0.0033 0.0624
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0027 0.0103 0.0134
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0017 0.0037 0.0404
Echinococcus granulosus GPCR family 2 0.047 0.311 0.5391
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0033 0.0048
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0093 0.413
Toxoplasma gondii isocitrate dehydrogenase 0.0081 0.0473 1
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0017 0.0033 0.0048
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0064 0.2152
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0017 0.0033 0.0048
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0081 0.0473 0.0693
Schistosoma mansoni smad1 5 8 and 0.0035 0.0157 0.0229
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0093 0.1634
Schistosoma mansoni dishevelled 0.0038 0.0176 0.0258
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0017 0.0037 0.0276
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0083 0.01
Treponema pallidum catabolite gene activator 0.0017 0.0033 1
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0027 0.0103 0.0134
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0081 0.0473 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0017 0.0033 0.0048
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0037 0.0709
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0088 0.1789
Loa Loa (eye worm) hypothetical protein 0.0027 0.0103 0.0103
Onchocerca volvulus Fatty acid synthase homolog 0.0046 0.0231 0.0402
Loa Loa (eye worm) RNA binding protein 0.0858 0.5747 0.5747
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0017 0.0037 0.0276
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0241 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0017 0.0037 0.0276
Echinococcus multilocularis segment polarity protein dishevelled 0.0038 0.0176 0.0263
Echinococcus granulosus segment polarity protein dishevelled 0.0038 0.0176 0.0263
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0083 0.2124
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0017 0.0037 0.0404
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0017 0.0033 0.0012
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0017 0.0037 0.0276
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0017 0.0033 0.0048
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0033 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0033 0.0048
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0037 0.0771
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0083 0.1147
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0027 0.0103 0.015
Echinococcus granulosus Smad4 0.0035 0.0157 0.0228
Entamoeba histolytica hypothetical protein 0.0027 0.0103 0.4258
Brugia malayi Cytochrome P450 family protein 0.0028 0.0109 0.0083
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0083 0.1147
Leishmania major cytochrome p450-like protein 0.0028 0.0109 0.1725
Trypanosoma cruzi Flagellar Member 6 0.0017 0.0033 0.0624
Mycobacterium leprae putative cytochrome p450 0.0017 0.0037 0.0276
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0088 0.1243
Loa Loa (eye worm) isocitrate dehydrogenase 0.0081 0.0473 0.0473
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0083 0.1755
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0017 0.0037 0.0404
Schistosoma mansoni ras GTP exchange factor 0.0027 0.0103 0.015
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1109 0.1893
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0104 0.4868
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0017 0.0037 0.0276
Brugia malayi MH1 domain containing protein 0.0019 0.0051 0.0025
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0081 0.0473 1
Loa Loa (eye worm) RecQ helicase 0.0024 0.0083 0.0083
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0157 0.0157
Echinococcus multilocularis expressed conserved protein 0.0017 0.0033 0.0012
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0017 0.0033 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0157 0.0157
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0033 0.0048
Schistosoma mansoni smad1 5 8 and 0.0035 0.0157 0.0229
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.0033 0.0012
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0083 0.1147
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0017 0.0033 0.0048
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0033 0.0048
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1109 0.1086
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0103 0.4258
Loa Loa (eye worm) latrophilin receptor protein 2 0.047 0.311 0.311
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0017 0.0033 0.0624
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0083 0.2124
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0038 0.0178 0.3506
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0017 0.0037 0.0404
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0017 0.0033 0.0686
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0103 0.4258
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0037 0.0709
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0017 0.0037 0.0404
Mycobacterium ulcerans polyketide synthase Pks13 0.0038 0.0178 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0083 0.1699
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0037 0.0709
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0017 0.0033 0.0624
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0088 0.1243
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0081 0.0473 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0083 0.0057
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0033 0.0048
Brugia malayi N-terminal motif family protein 0.0027 0.0103 0.0077
Brugia malayi MH1 domain containing protein 0.0019 0.0051 0.0025
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0059 0.1811
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0103 0.4258
Schistosoma mansoni cytochrome P450 0.0017 0.0037 0.0053
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0103 0.4258
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.047 0.311 0.3092
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0765 0.5112 1
Brugia malayi RNA recognition motif domain containing protein 0.0858 0.5747 0.5735
Brugia malayi isocitrate dehydrogenase 0.0081 0.0473 0.0448
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0104 0.1869
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0103 0.4258
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0858 0.5747 0.5747
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0088
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0017 0.0033 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0033 0.0048
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0033 0.0048
Trypanosoma cruzi cAMP binding protein, putative 0.0017 0.0033 0.0624
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0093 0.1634
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0081 0.0473 0.078
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0059 0.1811
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0026
Brugia malayi MH1 domain containing protein 0.0035 0.0157 0.0131
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0027 0.0103 0.015
Treponema pallidum cyclic nucleotide binding protein 0.0017 0.0033 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1076 0.1835
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0033 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0858 0.5747 0.8437
Brugia malayi N-terminal motif family protein 0.0027 0.0103 0.0077
Onchocerca volvulus 0.0017 0.0033 0.0013
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0038 0.0178 0.3506
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0033 0.0048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0081 0.0473 0.078
Echinococcus granulosus cGMP dependent protein kinase 1 0.0017 0.0033 0.0012
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0103 0.4258
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0017 0.0037 0.0276
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0083 0.01
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.027 1
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0038 0.0176 0.0295
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.021
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0093 0.413
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0081 0.0473 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.027 0.5716
Schistosoma mansoni hypothetical protein 0.0017 0.0037 0.0053
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0033 0.0048
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0083 0.0057
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0082 0.1385
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0017 0.0033 0.0007
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0017 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0051
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0017 0.0037 0.0404
Schistosoma mansoni tar DNA-binding protein 0.0858 0.5747 0.8437
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0081 0.0473 0.078
Loa Loa (eye worm) hypothetical protein 0.0038 0.0176 0.0176
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0033 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0858 0.5747 0.8437
Echinococcus multilocularis Protein son of sevenless 0.0027 0.0103 0.0134
Echinococcus multilocularis ras GTP exchange factor 0.0027 0.0103 0.0134
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0017 0.0037 0.0276
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0093 0.413
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0017 0.0037 0.0276
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0004 0.0005
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0104 0.4868
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0017 0.0033 0.0316
Echinococcus granulosus cGMP dependent protein kinase 0.0017 0.0033 0.0012
Echinococcus granulosus patatin phospholipase domain containing protein 0.0017 0.0033 0.0012
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0017 0.0037 0.0276
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0027 0.0103 0.0134
Onchocerca volvulus 0.0017 0.0033 0.0013
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0103 0.4258
Schistosoma mansoni Smad4 0.0035 0.0157 0.0229
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0093 0.413
Onchocerca volvulus 0.0038 0.0176 0.0295
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0017 0.0033 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0109 0.0109
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0017 0.0037 0.0276
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0176 0.0263
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0088 0.1243
Schistosoma mansoni smad 0.0035 0.0157 0.0229
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0082 0.0082
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0017 0.0033 0.0012
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0033 0.0012
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0017 0.0037 0.0276
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0176 0.0263
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0033 0.0048
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0033 0.0012
Brugia malayi MH2 domain containing protein 0.0035 0.0157 0.0131
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0017 0.0037 0.0404
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0176 0.0263
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0026 0.0026
Toxoplasma gondii isocitrate dehydrogenase 0.0081 0.0473 1
Brugia malayi Isocitrate dehydrogenase 0.0081 0.0473 0.0448
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0033 0.0012
Loa Loa (eye worm) RasGEF domain-containing protein 0.0027 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0048
Treponema pallidum catabolite gene activator (Crp) 0.0017 0.0033 1
Brugia malayi cytochrome P450 0.0017 0.0037 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0033
Echinococcus granulosus cGMP dependent protein kinase 1 0.0017 0.0033 0.0012
Echinococcus multilocularis isocitrate dehydrogenase 0.0081 0.0473 0.078
Loa Loa (eye worm) hypothetical protein 0.1015 0.6811 0.6811
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0093 0.0067
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0038 0.0176 0.0263
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0093 0.413
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0017 0.0033 0.0033
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0081 0.0473 1
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.0037 0.0276
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.027 0.5716
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0027 0.0103 0.2952
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0093 0.1634
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0109 0.0109
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0083 0.2124
Loa Loa (eye worm) hypothetical protein 0.0765 0.5112 0.5112
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0017 0.0033 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0017 0.0037 0.0404
Brugia malayi Cytochrome P450 family protein 0.0017 0.0037 0.0011
Mycobacterium leprae Polyketide synthase Pks13 0.0038 0.0178 1
Mycobacterium ulcerans polyketide synthase Pks9 0.0017 0.0035 0.011
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0017 0.0033 0.0048
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0033 0.0048
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0083 0.01
Leishmania major cytochrome p450-like protein 0.0017 0.0037 0.0091
Schistosoma mansoni hypothetical protein 0.047 0.311 0.4566
Mycobacterium tuberculosis Conserved protein 0.0017 0.0033 0.0316
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0017 0.0037 0.0276
Trypanosoma cruzi hypothetical protein 0.0027 0.0103 0.2118
Schistosoma mansoni DNA helicase recq5 0.0024 0.0083 0.0122
Loa Loa (eye worm) hypothetical protein 0.0024 0.0083 0.0083
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0017 0.0037 0.0404
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0017 0.0033 0.0012
Leishmania major hypothetical protein, conserved 0.0025 0.0088 0.1243
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0017 0.0037 0.0404
Loa Loa (eye worm) MH2 domain-containing protein 0.0509 0.3378 0.3378
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0004 0.0131
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0157 0.0228
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0033 0.0012
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0038 0.0176 0.0151
Echinococcus granulosus tar DNA binding protein 0.0858 0.5747 1
Trichomonas vaginalis ras GTP exchange factor, putative 0.0027 0.0103 0.2952
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0033 0.0624
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0109 0.2241
Loa Loa (eye worm) acetyltransferase 0.0175 0.1109 0.1109
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.0247 0.0221
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0017 0.0037 0.0276
Leishmania major cytochrome p450-like protein 0.0017 0.0037 0.0091
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0017 0.0037 0.0404
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0017 0.0037 0.0276

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 5.011872336 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 11.22018454 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 12.58925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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