Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | RecQ helicase-like | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Giardia lamblia | U5 small nuclear ribonucleoprotein 200 kDa helicase, putative | RecQ helicase-like | 649 aa | 521 aa | 19.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.6522 | 0.6433 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.6522 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.6522 | 0.397 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0024 | 0.6522 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.6522 | 0.397 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.6522 | 0.397 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.6522 | 0.6433 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.6522 | 0.6433 |
Entamoeba histolytica | recQ family helicase, putative | 0.0024 | 0.6522 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.6522 | 0.6522 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0248 | 0.0248 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0024 | 0.6522 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.6522 | 0.6522 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.6522 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.1025 | 0.1239 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.6522 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.0012 | 0.0248 | 0.0381 |
Schistosoma mansoni | DNA helicase recq1 | 0.0024 | 0.6522 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0012 | 0.0248 | 0.0248 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0012 | 0.0248 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.6522 | 0.5 |
Schistosoma mansoni | DNA helicase recq5 | 0.0024 | 0.6522 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0248 | 0.0000000054104 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0024 | 0.6522 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0024 | 0.6522 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0024 | 0.6522 | 0.5 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0024 | 0.6522 | 0.6433 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.6522 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.7079 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.