Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Excitatory amino acid transporter | 0.0131 | 0.2687 | 0.2868 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.03 | 0.9372 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.6475 | 0.6909 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.9372 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0584 | 0.0623 |
Echinococcus multilocularis | sodium:dicarboxylate symporter | 0.0131 | 0.2687 | 0.2868 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.0131 | 0.2687 | 0.2868 |
Echinococcus multilocularis | excitatory amino acid transporter 3 | 0.0131 | 0.2687 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.6268 | 0.6688 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0151 | 0.348 | 0.3714 |
Loa Loa (eye worm) | excitatory amino acid transporter | 0.0131 | 0.2687 | 0.2868 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0584 | 0.0623 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.9372 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.6268 | 0.6688 |
Brugia malayi | Peptidase family M13 containing protein | 0.03 | 0.9372 | 1 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0151 | 0.348 | 0.3714 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.6475 | 0.6909 |
Brugia malayi | Carboxylesterase family protein | 0.0143 | 0.3132 | 0.3342 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.0073 | 0.0377 | 0.0402 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.0131 | 0.2687 | 0.2868 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.0131 | 0.2687 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.6475 | 0.6909 |
Schistosoma mansoni | solute carrier family 1 (glial high affinity glutamate transporter | 0.0131 | 0.2687 | 0.2868 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0131 | 0.2687 | 0.2868 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0073 | 0.0377 | 0.0402 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0073 | 0.0377 | 0.0402 |
Echinococcus granulosus | neutral amino acid transporter | 0.0131 | 0.2687 | 0.2868 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0151 | 0.348 | 0.3714 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0131 | 0.2687 | 0.2868 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0231 | 0.6631 | 0.5392 |
Echinococcus granulosus | acetylcholinesterase | 0.0143 | 0.3132 | 0.3342 |
Echinococcus granulosus | acetylcholinesterase | 0.0143 | 0.3132 | 0.3342 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.03 | 0.9372 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.6475 | 0.6909 |
Brugia malayi | Carboxylesterase family protein | 0.0143 | 0.3132 | 0.3342 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.0073 | 0.0377 | 0.0402 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0151 | 0.348 | 0.3714 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0222 | 0.6268 | 0.6688 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.0131 | 0.2687 | 0.2868 |
Loa Loa (eye worm) | carboxylesterase | 0.0143 | 0.3132 | 0.3342 |
Echinococcus granulosus | neutral amino acid transporter A | 0.0131 | 0.2687 | 0.2868 |
Schistosoma mansoni | neprilysin | 0.0078 | 0.0584 | 0.0623 |
Echinococcus granulosus | sodium:dicarboxylate symporter | 0.0131 | 0.2687 | 0.2868 |
Mycobacterium leprae | probable zinc metalloprotease | 0.03 | 0.9372 | 0.5 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.03 | 0.9372 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0584 | 0.0623 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0584 | 0.0623 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0073 | 0.0377 | 0.0402 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0222 | 0.6268 | 0.6688 |
Echinococcus multilocularis | acetylcholinesterase | 0.0143 | 0.3132 | 0.3342 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.6475 | 0.6909 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.6475 | 0.6909 |
Echinococcus multilocularis | neutral amino acid transporter excitatory amino acid transporter | 0.0131 | 0.2687 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.9372 | 1 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.03 | 0.9372 | 0.9141 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0143 | 0.3132 | 0.3342 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0078 | 0.0584 | 0.0623 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.0073 | 0.0377 | 0.0402 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0143 | 0.3132 | 0.3342 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0584 | 0.0623 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.0131 | 0.2687 | 0.2868 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.0131 | 0.2687 | 0.2868 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0151 | 0.348 | 0.3714 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.3132 | 0.3342 |
Chlamydia trachomatis | glutamate symporter | 0.0131 | 0.2687 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0584 | 0.0623 |
Echinococcus granulosus | neutral amino acid transporter A | 0.0131 | 0.2687 | 0.2868 |
Toxoplasma gondii | peptidase family M13 protein | 0.03 | 0.9372 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.3371 | 0.3598 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.0131 | 0.2687 | 0.2868 |
Echinococcus granulosus | excitatory amino acid transporter 3 | 0.0131 | 0.2687 | 0.2868 |
Echinococcus multilocularis | acetylcholinesterase | 0.0143 | 0.3132 | 0.3342 |
Onchocerca volvulus | 0.0149 | 0.3371 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.6268 | 0.6688 |
Brugia malayi | peptidase family M13 containing protein | 0.0073 | 0.0377 | 0.0402 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.03 | 0.9372 | 1 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0131 | 0.2687 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.6268 | 0.6688 |
Wolbachia endosymbiont of Brugia malayi | Na+/H+-dicarboxylate symporter | 0.0131 | 0.2687 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0143 | 0.3132 | 0.3342 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.0131 | 0.2687 | 0.2868 |
Echinococcus granulosus | carboxylesterase 5A | 0.0143 | 0.3132 | 0.3342 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0073 | 0.0377 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.3132 | 0.3342 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.