Detailed information for compound 1291218

Basic information

Technical information
  • TDR Targets ID: 1291218
  • Name: [2-(2,4-dimethoxyphenyl)-2-oxoethyl] 2-(methy l-phenylcarbamoyl)benzoate
  • MW: 433.453 | Formula: C25H23NO6
  • H donors: 0 H acceptors: 3 LogP: 4.15 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1C(=O)COC(=O)c1ccccc1C(=O)N(c1ccccc1)C
  • InChi: 1S/C25H23NO6/c1-26(17-9-5-4-6-10-17)24(28)19-11-7-8-12-20(19)25(29)32-16-22(27)21-14-13-18(30-2)15-23(21)31-3/h4-15H,16H2,1-3H3
  • InChiKey: XITSGKHCAGEHRB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(2,4-dimethoxyphenyl)-2-oxo-ethyl] 2-(methyl-phenyl-carbamoyl)benzoate
  • 2-[(methyl-phenylamino)-oxomethyl]benzoic acid [2-(2,4-dimethoxyphenyl)-2-oxoethyl] ester
  • 2-(methyl-phenyl-carbamoyl)benzoic acid [2-(2,4-dimethoxyphenyl)-2-keto-ethyl] ester
  • T5514238

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0025 0.0012 0.0198
Echinococcus multilocularis transient receptor potential ion channel A 0.168 0.3052 0.3051
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.007 0.2374
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0018 0.0051
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0104 0.082
Echinococcus granulosus zinc finger protein 0.0027 0.0014 0.003
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0018 0.0016
Plasmodium falciparum DNA topoisomerase 2 0.0038 0.0034 0.0643
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.002 0.0002 0.0003
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.03 0.0517 0.1668
Loa Loa (eye worm) ICD-1 protein 0.0023 0.0008 0.0022
Schistosoma mansoni aldehyde dehydrogenase 0.0041 0.004 0.0091
Schistosoma mansoni calcium-activated potassium channel 0.0066 0.0086 0.02
Entamoeba histolytica hypothetical protein 0.0023 0.0008 0.074
Mycobacterium ulcerans isocitrate lyase AceAb 0.1702 0.3091 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0071 0.0164
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0024 0.001 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.1141
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0027 0.0015 0.0262
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0074 0.0101 0.2667
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0066 0.0086 0.02
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.007 0.0161
Loa Loa (eye worm) hypothetical protein 0.006 0.0075 0.0232
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0066 0.0086 0.068
Toxoplasma gondii hypothetical protein 0.0036 0.0032 0.0594
Toxoplasma gondii phosphofructokinase PFKII 0.0022 0.0006 0.0081
Brugia malayi hypothetical protein 0.026 0.0443 0.353
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.003 0.0067
Loa Loa (eye worm) hypothetical protein 0.0036 0.0032 0.0096
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0022 0.0005 0.0076
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0066 0.0086 0.02
Leishmania major cysteine peptidase A (CPA) 0.0035 0.003 0.0795
Schistosoma mansoni voltage-dependent calcium channel 0.0066 0.0086 0.02
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0066 0.0086 0.02
Echinococcus granulosus neuropeptide receptor A26 0.0662 0.1182 0.2773
Brugia malayi hypothetical protein 0.0066 0.0086 0.068
Echinococcus granulosus dna polymerase eta 0.0053 0.0063 0.0146
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0053
Leishmania major cathepsin L-like protease 0.0134 0.0212 0.5603
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0021 0.0721
Echinococcus granulosus histone lysine methyltransferase setb 0.0039 0.0037 0.0084
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0066 0.0086 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0001 0.0045
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0066 0.0086 0.068
Mycobacterium tuberculosis Conserved hypothetical protein 0.0118 0.0183 0.0587
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0161 0.026 0.0817
Echinococcus multilocularis thioredoxin glutathione reductase 0.0213 0.0357 0.0356
Brugia malayi intermediate filament protein 0.006 0.0075 0.0588
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0018 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0407 0.0713 0.1671
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0066 0.0086 0.02
Schistosoma mansoni aryl hydrocarbon receptor 0.0077 0.0108 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Loa Loa (eye worm) voltage-gated potassium channel 0.0066 0.0086 0.0268
Echinococcus multilocularis ryanodine receptor 44f 0.0066 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.026 0.0443 0.1392
Brugia malayi Isocitrate dehydrogenase 0.0022 0.0005 0.0031
Toxoplasma gondii HEAT repeat-containing protein 0.0023 0.0008 0.0131
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0032 0.0099
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0066 0.0086 0.0085
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0066 0.0086 0.02
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.003 0.0091
Echinococcus multilocularis short transient receptor potential channel 6 0.1307 0.2366 0.2365
Echinococcus granulosus dna polymerase kappa 0.0036 0.0032 0.0072
Loa Loa (eye worm) hypothetical protein 0.002 0.0002 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0002 0.0081
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0031 0.0022 0.0586
Schistosoma mansoni ap endonuclease 0.0057 0.007 0.0161
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0069
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.003 0.0067
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0066 0.0086 0.02
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0044 0.0047 0.0045
Leishmania major DNA topoisomerase ii 0.0034 0.0028 0.0728
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.003 0.0029
Onchocerca volvulus 0.0035 0.003 0.0909
Echinococcus granulosus transient receptor potential cation channel 0.0066 0.0086 0.02
Loa Loa (eye worm) fibroinase 0.0035 0.003 0.0091
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0036 0.0032 0.0596
Echinococcus multilocularis lamin 0.006 0.0075 0.0074
Leishmania major cathepsin L-like protease 0.0035 0.003 0.0795
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0036 0.0032 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.03 0.0517 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0505 0.0893 0.0892
Onchocerca volvulus 0.0035 0.003 0.0909
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0034 0.0032
Schistosoma mansoni vesicular amine transporter 0.0066 0.0086 0.02
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0034 0.0028 0.0027
Schistosoma mansoni hypothetical protein 0.16 0.2905 0.6818
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0066 0.0086 0.02
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0001 0.0035
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0074 0.0172
Echinococcus granulosus potassium voltage gated channel protein 0.0066 0.0086 0.02
Echinococcus multilocularis voltage gated potassium channel 0.0066 0.0086 0.0085
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0015 0.0393
Trypanosoma cruzi major cysteine proteinase, putative 0.0105 0.0159 0.4208
Echinococcus granulosus snurportin 1 0.0248 0.0421 0.0986
Echinococcus multilocularis isocitrate dehydrogenase 0.0022 0.0005 0.0004
Echinococcus granulosus cathepsin l1 0.0024 0.0009 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Schistosoma mansoni lamin 0.006 0.0075 0.0173
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0485 0.0857 0.2769
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.1141
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0022 0.0006 0.0081
Leishmania major basic transcription factor 3a, putative 0.0023 0.0008 0.0223
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.002 0.0002 0.0063
Loa Loa (eye worm) hypothetical protein 0.0192 0.0317 0.0997
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0036 0.0032 0.0596
Echinococcus multilocularis dna polymerase kappa 0.0036 0.0032 0.0031
Loa Loa (eye worm) glutathione reductase 0.0213 0.0356 0.1119
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0031 0.0022 0.0049
Brugia malayi Cathepsin L-like precursor 0.0035 0.003 0.023
Loa Loa (eye worm) calcium channel 0.0066 0.0086 0.0268
Brugia malayi Cathepsin L-like precursor 0.0035 0.003 0.023
Giardia lamblia PHD finger protein 15 0.0028 0.0018 0.164
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0066 0.0086 0.02
Entamoeba histolytica hypothetical protein 0.0024 0.001 0.085
Schistosoma mansoni ryanodine receptor related 0.0066 0.0086 0.02
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.03 0.0517 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0023 0.0008 0.0138
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.002 0.0001 0.0117
Onchocerca volvulus 0.006 0.0075 0.2325
Echinococcus granulosus hyperpolarization activated cyclic 0.0066 0.0086 0.02
Trypanosoma cruzi transcription factor btf3, putative 0.0023 0.0008 0.0223
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.0006 0.0187
Brugia malayi Cathepsin L-like precursor 0.0024 0.0009 0.0059
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0086 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.003 0.1021
Echinococcus multilocularis short transient receptor potential channel 6 0.2338 0.426 0.426
Brugia malayi cation channel family protein 0.0066 0.0086 0.068
Echinococcus granulosus two pore calcium channel protein 1 0.0066 0.0086 0.02
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0037 0.0084
Loa Loa (eye worm) hypoxia-induced factor 1 0.024 0.0406 0.1275
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.003 0.002 0.0521
Onchocerca volvulus 0.0058 0.0071 0.221
Trypanosoma cruzi DNA topoisomerase II, putative 0.0034 0.0028 0.0728
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0013 0.0028
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0031 0.0022 0.0049
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0015 0.0504
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0285 0.049 0.1146
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.03 0.0517 0.0515
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0074 0.0101 0.193
Leishmania major cathepsin L-like protease 0.0035 0.003 0.0795
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.003 0.1021
Plasmodium vivax 6-phosphofructokinase, putative 0.0022 0.0006 0.0081
Schistosoma mansoni alpha glucosidase 0.0037 0.0034 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0022 0.0005 0.0004
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.003 0.0067
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0034 0.1141
Giardia lamblia DNA topoisomerase II 0.0036 0.0031 0.3023
Echinococcus multilocularis sodium leak channel non selective protein 0.0066 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.1241 0.2245 0.7076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.003 0.1021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Loa Loa (eye worm) hypothetical protein 0.0075 0.0104 0.0324
Brugia malayi CXXC zinc finger family protein 0.0134 0.0212 0.1683
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.003 0.0066
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.009 0.2379
Echinococcus granulosus peptidase Clp S14 family 0.0197 0.0327 0.0764
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0066 0.0086 0.068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0066 0.0086 0.0085
Echinococcus multilocularis phd:f box containing protein 0.0035 0.003 0.0028
Echinococcus multilocularis geminin 0.0761 0.1362 0.1361
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0034 0.0889
Echinococcus multilocularis GPCR, family 2 0.0035 0.003 0.0028
Echinococcus multilocularis 6 phosphofructokinase 0.0081 0.0114 0.0113
Plasmodium vivax glutathione reductase, putative 0.0213 0.0356 0.6886
Echinococcus multilocularis dna polymerase eta 0.0053 0.0063 0.0062
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0066 0.0086 0.02
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0074 0.0101 0.2667
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0066 0.0086 0.02
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0101 0.2667
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0081 0.0114 0.0364
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0018 0.0316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0212 0.5588
Loa Loa (eye worm) thioredoxin reductase 0.0213 0.0356 0.1119
Schistosoma mansoni jumonji domain containing protein 0.0035 0.003 0.0067
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0023
Schistosoma mansoni cpg binding protein 0.0143 0.0229 0.0534
Plasmodium falciparum mitochondrial ribosomal protein L41, putative 0.0283 0.0486 0.9403
Toxoplasma gondii hypothetical protein 0.0066 0.0086 0.1651
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.03 0.0517 0.121
Echinococcus multilocularis microtubule associated protein 2 0.1016 0.1832 0.1831
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0032 0.0813
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0018 0.0316
Echinococcus multilocularis cysteine protease 0.0035 0.003 0.0029
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.002 0.0002 0.0063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0024 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0505 0.0893 0.2811
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0091
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0074 0.0101 0.2667
Toxoplasma gondii hypothetical protein 0.0103 0.0155 0.2988
Loa Loa (eye worm) inositol-1 0.0027 0.0015 0.0043
Leishmania major ATP-dependent phosphofructokinase 0.0081 0.0114 0.3013
Echinococcus multilocularis transfer RNA-Lys 0.0057 0.0071 0.0069
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0225 0.0378 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0066 0.0086 0.0085
Loa Loa (eye worm) voltage-gated calcium channel 0.0066 0.0086 0.0268
Echinococcus granulosus inositol monophosphatase 1 0.0027 0.0015 0.0032
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0248 0.0421 0.1324
Echinococcus granulosus potassium voltage gated channel protein 0.0066 0.0086 0.02
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0032 0.0023 0.0586
Entamoeba histolytica hypothetical protein 0.0024 0.001 0.085
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0103 0.0155 0.2988
Loa Loa (eye worm) voltage-gated potassium channel 0.0066 0.0086 0.0268
Loa Loa (eye worm) hypothetical protein 0.1746 0.3173 1
Toxoplasma gondii 6-phosphofructokinase 0.0022 0.0006 0.0081
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.003 0.009
Loa Loa (eye worm) RNA binding protein 0.0161 0.026 0.0817
Brugia malayi jmjC domain containing protein 0.0141 0.0224 0.178
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.1141
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.009 0.7897
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0238 0.0403 0.0944
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0066 0.0086 0.0085
Echinococcus granulosus cathepsin l1 0.0035 0.003 0.0067
Echinococcus granulosus transient receptor potential cation channel 0.0066 0.0086 0.02
Brugia malayi 6-phosphofructokinase 0.0081 0.0114 0.09
Echinococcus multilocularis transient receptor potential cation channel 0.0066 0.0086 0.0085
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.0168 0.1333
Plasmodium vivax mitochondrial ribosomal protein L41, putative 0.0283 0.0486 0.9403
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0071 0.022
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0029 0.0019 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0008 0.0286
Entamoeba histolytica thioredoxin reductase, putative 0.002 0.0001 0.0117
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0407 0.0713 0.0712
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0001 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0021 0.0721
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0025 0.0012 0.0024
Echinococcus granulosus potassium voltage gated channel protein 0.0066 0.0086 0.02
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0038 0.0037
Onchocerca volvulus Huntingtin homolog 0.0192 0.0317 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.003 0.0028
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0238 0.0403 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0021 0.0721
Schistosoma mansoni two-pore calcium channel 0.0066 0.0086 0.02
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0036 0.0032 0.1085
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0001 0.0045
Echinococcus multilocularis zinc finger protein 0.0027 0.0014 0.0013
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0066 0.0086 0.02
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0071 0.0164
Giardia lamblia NADH oxidase lateral transfer candidate 0.0074 0.0101 1
Brugia malayi isocitrate dehydrogenase 0.0022 0.0005 0.0031
Echinococcus granulosus jumonji domain containing protein 0.004 0.0038 0.0086
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.007 0.2374
Trichomonas vaginalis bromodomain-containing protein, putative 0.0036 0.0032 0.1089
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0034 0.1141
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0407 0.0713 0.569
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.007 0.1849
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.002 0.0001 0.0035
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0066 0.0086 0.2286
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0081 0.0114 0.2988
Echinococcus granulosus hyperpolarization activated cyclic 0.0066 0.0086 0.02
Brugia malayi PHD-finger family protein 0.0031 0.0022 0.0166
Toxoplasma gondii DNA topoisomerase 2, putative 0.0038 0.0034 0.0643
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0539 0.0956 0.3091
Schistosoma mansoni transient receptor potential channel 4 0.1746 0.3173 0.7446
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0066 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.0045 0.0049 0.015
Loa Loa (eye worm) ctsf protein 0.0035 0.003 0.0091
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0001 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0101 0.2667
Leishmania major hypothetical protein, conserved 0.0035 0.003 0.0789
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0022 0.0006 0.0187
Schistosoma mansoni voltage-gated ion channel 0.0066 0.0086 0.02
Onchocerca volvulus 0.0035 0.003 0.0909
Onchocerca volvulus Cathepsin F homolog 0.0035 0.003 0.0909
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.009
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0071 0.221
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0022 0.0752
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0066 0.0086 0.2935
Echinococcus granulosus microtubule associated protein 2 0.1016 0.1832 0.4298
Mycobacterium ulcerans hypothetical protein 0.0118 0.0183 0.0587
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0036 0.0032 0.0072
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0081 0.0114 0.0364
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0018 0.0316
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0071 0.0164
Brugia malayi Pre-SET motif family protein 0.0158 0.0255 0.2029
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0034 0.0102
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0066 0.0086 0.02
Entamoeba histolytica phosphofructokinase, putative 0.0081 0.0114 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0041 0.004 0.0091
Trichomonas vaginalis phosphofructokinase, putative 0.0081 0.0114 0.3869
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.003 0.1021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.003 0.1021
Plasmodium vivax vivapain-2 0.0035 0.003 0.0557
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0022 0.0005 0.0004
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0074 0.0101 0.193
Brugia malayi beta-NAC-like protein 0.0023 0.0008 0.0057
Leishmania major DNA polymerase eta, putative 0.0053 0.0063 0.1675
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Trichomonas vaginalis guanylate cyclase, putative 0.002 0.0002 0.0081
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0024 0.0072
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.0006 0.0187
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0022 0.0005 0.0139
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0015 0.0504
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.0273 0.0637
Trichomonas vaginalis phosphofructokinase, putative 0.0081 0.0114 0.3869
Giardia lamblia Histone acetyltransferase GCN5 0.0031 0.0023 0.2201
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0034 0.295
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.009 0.2379
Trypanosoma brucei DNA topoisomerase ii 0.003 0.002 0.0488
Echinococcus granulosus sodium channel protein 0.0066 0.0086 0.02
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0273 0.0271
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0022 0.0005 0.0004
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0022 0.0005 0.0076
Entamoeba histolytica transcription factor BTF3, putative 0.0023 0.0008 0.074
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0041 0.004 0.0039
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.007 0.6891
Echinococcus multilocularis calcium activated potassium channel 0.0066 0.0086 0.0085
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.002 0.0001 0.0035
Trypanosoma cruzi trypanothione reductase, putative 0.0213 0.0356 0.9423
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0066 0.0086 0.2259
Echinococcus granulosus phd:f box containing protein 0.0035 0.003 0.0067
Loa Loa (eye worm) hypothetical protein 0.0053 0.0063 0.0195
Echinococcus granulosus histone acetyltransferase KAT2B 0.0036 0.0032 0.0072
Loa Loa (eye worm) ion channel NompC 0.0066 0.0086 0.0268
Trichomonas vaginalis phosphofructokinase, putative 0.0081 0.0114 0.3869
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.003 0.009
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0031 0.0022 0.0166
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0086 0.1651
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0001 0.0045
Plasmodium vivax basic transcription factor 3b, putative 0.0023 0.0008 0.0138
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0033
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0034 0.0028 0.0027
Echinococcus granulosus potassium large conductance calcium activated 0.0066 0.0086 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0011 0.0264
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0066 0.0086 0.0085
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.0161 0.425
Schistosoma mansoni cpg binding protein 0.0134 0.0212 0.0494
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0066 0.0086 0.2286
Mycobacterium ulcerans 6-phosphofructokinase 0.0081 0.0114 0.0364
Echinococcus granulosus GPCR family 2 0.0035 0.003 0.0066
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0031 0.0022 0.1944
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0011 0.0264
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.002 0.0002 0.0081
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0066 0.0086 0.0085
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0018 0.0017
Onchocerca volvulus 0.0035 0.003 0.0909
Onchocerca volvulus 0.0057 0.0071 0.2195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0407 0.0713 0.1671
Brugia malayi 6-phosphofructokinase 0.0081 0.0114 0.09
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0032 0.0023 0.0619
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0022 0.0006 0.0081
Schistosoma mansoni inositol monophosphatase 0.0027 0.0015 0.0032
Schistosoma mansoni hypothetical protein 0.0024 0.001 0.002
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0022 0.0006 0.0483
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0066 0.0086 0.2692
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.002 0.0002 0.0002
Brugia malayi RNA recognition motif domain containing protein 0.0161 0.026 0.2072
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.0001 0.0035
Plasmodium falciparum glutathione reductase 0.0213 0.0356 0.6886
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0013 0.0028
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.0006 0.0187
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0021 0.0721
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0021 0.0721
Brugia malayi hypothetical protein 0.0024 0.001 0.0067
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0022 0.0005 0.0139
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0066 0.0086 0.02
Echinococcus multilocularis hyperpolarization activated cyclic 0.0066 0.0086 0.0085
Brugia malayi olfactory channel protein osm-9 0.0066 0.0086 0.068
Echinococcus multilocularis transient receptor potential gamma protein 0.1746 0.3173 0.3172
Brugia malayi mbt repeat family protein 0.0058 0.0071 0.0559
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.1141
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0143 0.0228 0.1811
Brugia malayi cathepsin L-like precursor 0.0024 0.0009 0.0059
Echinococcus granulosus transient receptor potential cation channel 0.0066 0.0086 0.02
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.0212 0.5603
Echinococcus granulosus aryl hydrocarbon receptor 0.002 0.0002 0.0002
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0066 0.0086 0.068
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0028 0.0017 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0021 0.0721
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.03 0.0517 1
Brugia malayi Transient-receptor-potential like protein 0.0505 0.0893 0.7128
Schistosoma mansoni 6-phosphofructokinase 0.0081 0.0114 0.0264
Onchocerca volvulus Cathepsin L homolog 0.0035 0.003 0.0909
Echinococcus granulosus TRP transient receptor potential channel 0.0505 0.0893 0.2093
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0022 0.0006 0.0081
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0032 0.0023 0.0619
Trypanosoma brucei importin beta-1 subunit, putative 0.0023 0.0008 0.0179
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0074 0.0101 0.193
Echinococcus granulosus ubiquitin specific protease 41 0.0031 0.0022 0.0049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0141 0.0224 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0212 0.5588
Loa Loa (eye worm) CXXC zinc finger family protein 0.0134 0.0212 0.0664
Onchocerca volvulus 0.002 0.0002 0.0033
Brugia malayi Latrophilin receptor protein 2 0.0035 0.003 0.0225
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0001 0.0035
Schistosoma mansoni transcription factor LCR-F1 0.0024 0.001 0.002
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0015 0.0447
Mycobacterium ulcerans DNA polymerase IV 0.0036 0.0032 0.0099
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.03 0.0517 0.1668
Toxoplasma gondii hypothetical protein 0.0066 0.0086 0.1651
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0066 0.0086 0.02
Echinococcus granulosus neuropeptide s receptor 0.0662 0.1182 0.2773
Leishmania major hypothetical protein, unknown function 0.0066 0.0086 0.2286
Brugia malayi hypothetical protein 0.0192 0.0317 0.2527
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0021 0.0005 0.0008
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0074 0.0101 0.0322
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.002 0.0001 0.0117
Plasmodium vivax thioredoxin reductase, putative 0.0213 0.0356 0.6886
Echinococcus multilocularis snurportin 1 0.0248 0.0421 0.042
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0066 0.0086 0.068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.009
Brugia malayi PHD-finger family protein 0.0028 0.0018 0.013
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0018 0.0038
Echinococcus multilocularis tar DNA binding protein 0.0161 0.026 0.0259
Loa Loa (eye worm) isocitrate dehydrogenase 0.0022 0.0005 0.0012
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.002 0.0002 0.0081
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0038 0.0034 0.0265
Schistosoma mansoni hypothetical protein 0.0761 0.1362 0.3195
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0015 0.0393
Schistosoma mansoni tar DNA-binding protein 0.0161 0.026 0.0608
Onchocerca volvulus 0.0035 0.003 0.0909
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0168 0.0526
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.003 0.002 0.0521
Brugia malayi voltage-dependent calcium channel 0.0066 0.0086 0.068
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0032 0.0023 0.0619
Brugia malayi glutathione reductase 0.0213 0.0356 0.2837
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.0273 0.217
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Toxoplasma gondii NAC domain-containing protein 0.0023 0.0008 0.0138
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0032 0.0813
Schistosoma mansoni DNA topoisomerase II 0.0038 0.0034 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.003 0.1021
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.007 0.133
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0074 0.0101 0.2641
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0066 0.0086 0.02
Echinococcus multilocularis sodium channel protein 0.0066 0.0086 0.0085
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0066 0.0086 0.02
Loa Loa (eye worm) histone methyltransferase 0.0042 0.0043 0.0132
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.002 0.0002 0.0081
Loa Loa (eye worm) acetyltransferase 0.0119 0.0184 0.0574
Echinococcus multilocularis transient receptor potential cation channel 0.0066 0.0086 0.0085
Toxoplasma gondii isocitrate dehydrogenase 0.0022 0.0005 0.0076
Loa Loa (eye worm) hypothetical protein 0.0058 0.0073 0.0225
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.002 0.0002 0.0063
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0021 0.0721
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0035 0.003 0.0553
Loa Loa (eye worm) MH2 domain-containing protein 0.0087 0.0125 0.0391
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.002 0.0002 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.003 0.0089
Trichomonas vaginalis apoptosis inducing factor, putative 0.002 0.0001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0212 0.5588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0009 0.0295
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0074 0.0101 0.2641
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.009 0.0208
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0036 0.0032 0.0596
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.003 0.0067
Plasmodium vivax importin-beta 2, putative 0.0023 0.0008 0.0131
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0073 0.0227
Echinococcus multilocularis conserved hypothetical protein 0.0066 0.0086 0.0085
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.0212 0.5603
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0022 0.0005 0.0104
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0022 0.0005 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Echinococcus granulosus sodium leak channel non selective protein 0.0066 0.0086 0.02
Echinococcus multilocularis transient receptor potential cation channel 0.0066 0.0086 0.0085
Plasmodium falciparum cysteine proteinase falcipain 3 0.0035 0.003 0.0557
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0018 0.004
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0074 0.0101 0.193
Onchocerca volvulus 0.0025 0.0012 0.0323
Echinococcus granulosus lysine specific demethylase 5A 0.0141 0.0224 0.0523
Echinococcus granulosus lamin dm0 0.006 0.0075 0.0173
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0066 0.0086 0.02
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0022 0.0005 0.0139
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0043 0.0045 0.0103
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.0212 0.5603
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.004 0.0126
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.003 0.0067
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0022 0.0005 0.0079
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0029 0.0019 0.0018
Onchocerca volvulus 0.0035 0.003 0.0909
Brugia malayi PAS domain containing protein 0.0077 0.0108 0.0851
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0071 0.0164
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0015 0.0447
Echinococcus granulosus voltage dependent calcium channel 0.0066 0.0086 0.02
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0051
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0031 0.0022 0.0021
Brugia malayi Cathepsin L-like precursor 0.0024 0.0009 0.0059
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0066 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.0439 0.0772 0.2429
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.007 0.0548
Echinococcus multilocularis inositol monophosphatase 1 0.0027 0.0015 0.0014
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0074 0.0101 0.193
Mycobacterium tuberculosis Probable oxidoreductase 0.0539 0.0956 0.3091
Schistosoma mansoni tar DNA-binding protein 0.0161 0.026 0.0608
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0031 0.0022 0.0586
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0086 0.0198
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0066 0.0086 0.02
Brugia malayi Inositol-1 0.0027 0.0015 0.0108
Trypanosoma cruzi DNA polymerase kappa, putative 0.0036 0.0032 0.0845
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0066 0.0086 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0161 0.026 0.0608
Echinococcus multilocularis potassium voltage gated channel protein 0.0066 0.0086 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0212 0.5588
Loa Loa (eye worm) ryanodine receptor 0.0066 0.0086 0.0268
Toxoplasma gondii transporter, cation channel family protein 0.0066 0.0086 0.1651
Leishmania major DNA polymerase kappa, putative 0.0036 0.0032 0.0845
Trypanosoma cruzi DNA polymerase kappa, putative 0.0036 0.0032 0.0845
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0485 0.0857 0.2769
Schistosoma mansoni hypothetical protein 0.0035 0.003 0.0066
Echinococcus granulosus intermediate filament protein 0.006 0.0075 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0021 0.0721
Trypanosoma cruzi DNA polymerase kappa, putative 0.0036 0.0032 0.0845
Plasmodium falciparum importin beta, putative 0.0023 0.0008 0.0131
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0022 0.0006 0.0081
Trypanosoma brucei transcription factor BTF3, putative 0.0023 0.0008 0.0188
Toxoplasma gondii isocitrate dehydrogenase 0.0022 0.0005 0.0076
Schistosoma mansoni transient receptor potential channel 0.1746 0.3173 0.7446
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Echinococcus multilocularis musashi 0.006 0.0075 0.0074
Leishmania major cathepsin L-like protease 0.0035 0.003 0.0795
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.002 0.0001 0.0045
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0034 0.295
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.003 0.0553
Echinococcus multilocularis transcription factor btf3 0.0023 0.0008 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0212 0.5588
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0066 0.0086 0.02
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0539 0.0956 0.3091
Schistosoma mansoni cpg binding protein 0.0143 0.0229 0.0534
Leishmania major NADH dehydrogenase, putative 0.002 0.0001 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0032 0.0813
Onchocerca volvulus Cathepsin L homolog 0.0035 0.003 0.0909
Echinococcus multilocularis potassium voltage gated channel protein 0.0066 0.0086 0.0085
Echinococcus granulosus voltage gated potassium channel 0.0066 0.0086 0.02
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.002 0.0002 0.0063
Plasmodium falciparum phd finger protein, putative 0.0028 0.0018 0.0316
Trypanosoma brucei trypanothione reductase 0.0213 0.0356 0.9421
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0031 0.0022 0.0752
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Echinococcus granulosus dnaJ subfamily B 0.16 0.2905 0.6818
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.0161 0.425
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Echinococcus granulosus tar DNA binding protein 0.0161 0.026 0.0608
Schistosoma mansoni importin beta-1 0.0023 0.0008 0.0016
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.003 0.023
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0027 0.0015 0.0044
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.007 0.1849
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0074 0.0101 0.2667
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0035 0.003 0.0557
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.002 0.0001 0.0035
Loa Loa (eye worm) phosphofructokinase 0.0081 0.0114 0.0355
Onchocerca volvulus 0.0035 0.003 0.0909
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0031 0.0022 0.0752
Plasmodium falciparum histone acetyltransferase GCN5 0.0031 0.0023 0.0425
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0034 0.0889
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0066 0.0086 0.02
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0034 0.1141
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0074 0.0101 0.0322
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0066 0.0086 0.02
Schistosoma mansoni protein phosphatase 2C 0.0035 0.003 0.0067
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0066 0.0086 0.2286
Toxoplasma gondii transporter, cation channel family protein 0.0066 0.0086 0.1651
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0009 0.0762
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.007 0.133
Leishmania major mitochondrial DNA topoisomerase II 0.003 0.002 0.0521
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0197 0.0327 0.1053
Echinococcus multilocularis transient receptor potential cation channel 0.0066 0.0086 0.0085
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.002 0.0001 0.0035
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0081 0.0114 0.2184
Echinococcus multilocularis neuropeptide receptor A26 0.0662 0.1182 0.1181
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.002 0.0001 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.003 0.1021
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0066 0.0086 0.0085
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.002 0.0002 0.0063
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.003 0.0067
Echinococcus granulosus peregrin 0.0033 0.0026 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0032 0.0813
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.007 0.0222
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0103 0.0155 0.2988
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0011 0.0264
Loa Loa (eye worm) hypothetical protein 0.0058 0.0072 0.0222
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0066 0.0086 0.02
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.03 0.0517 1
Leishmania major protein kinase, putative 0.002 0.0002 0.0063
Schistosoma mansoni lamin 0.006 0.0075 0.0173
Brugia malayi Pre-SET motif family protein 0.0025 0.0012 0.0082
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0066 0.0086 0.2259
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.003 0.0029
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0168 0.1333
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0036 0.0032 0.1089
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0197 0.0327 0.1053
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0024 0.001 0.0027
Loa Loa (eye worm) intermediate filament protein 0.006 0.0075 0.0232
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.009 0.0089
Echinococcus granulosus two pore calcium channel protein 2 0.0066 0.0086 0.02
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0023
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.03 0.0517 1
Brugia malayi Cathepsin L-like precursor 0.0035 0.003 0.023
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Echinococcus granulosus lamin 0.006 0.0075 0.0173
Schistosoma mansoni transcription factor btf3 0.0023 0.0008 0.0017
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.003 0.264
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.007 0.133
Brugia malayi ion channel NompC 0.0066 0.0086 0.068
Entamoeba histolytica phosphofructokinase, putative 0.0081 0.0114 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.002 0.0001 0.0045
Echinococcus granulosus calcium activated potassium channel 0.0066 0.0086 0.02
Mycobacterium ulcerans putative regulatory protein 0.0057 0.0071 0.0225
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0034 0.0028 0.0063
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.0001 0.0117
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.03 0.0517 0.1668
Plasmodium vivax SET domain protein, putative 0.0025 0.0012 0.0198
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0066 0.0086 0.02
Brugia malayi jmjC domain containing protein 0.0035 0.003 0.0228
Echinococcus granulosus hypothetical protein 0.0066 0.0086 0.02
Echinococcus multilocularis lamin dm0 0.006 0.0075 0.0074
Schistosoma mansoni aldehyde dehydrogenase 0.0041 0.004 0.0091
Echinococcus granulosus short transient receptor potential channel 6 0.2338 0.426 1
Brugia malayi jmjC domain containing protein 0.019 0.0315 0.2507
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Onchocerca volvulus 0.0066 0.0086 0.2692
Loa Loa (eye worm) hypothetical protein 0.03 0.0517 0.1625
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0074 0.0101 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0212 0.5588
Schistosoma mansoni DNA polymerase eta 0.0053 0.0063 0.0146
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0081 0.0114 0.3013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0021 0.0721
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0027 0.0015 0.0262
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0037 0.0085
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.007 0.6136
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0213 0.0356 0.1148
Brugia malayi MH2 domain containing protein 0.0087 0.0125 0.0991
Echinococcus granulosus voltage gated potassium channel 0.0066 0.0086 0.02
Plasmodium falciparum glutathione reductase 0.0074 0.0101 0.193
Schistosoma mansoni hypothetical protein 0.0035 0.003 0.0066
Toxoplasma gondii histone lysine methyltransferase SET1 0.026 0.0443 0.8563
Trypanosoma cruzi DNA polymerase eta, putative 0.0028 0.0017 0.046
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0106 0.0161 0.423
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.1141
Trichomonas vaginalis mercuric reductase, putative 0.0074 0.0101 0.3424
Echinococcus multilocularis lysine specific demethylase 5A 0.0132 0.0207 0.0206
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0036 0.0032 0.0845
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.009 0.2379
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0001 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.003 0.1021
Loa Loa (eye worm) cysteine protease 0.0035 0.003 0.0091
Schistosoma mansoni hypothetical protein 0.0028 0.0018 0.0038
Echinococcus granulosus single minded 2 0.0057 0.0071 0.0163
Trypanosoma cruzi DNA topoisomerase II, putative 0.0034 0.0028 0.0728
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.1702 0.3091 1
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0071 0.007
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0066 0.0086 0.02
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.003 0.1021
Leishmania major cathepsin L-like protease 0.0134 0.0212 0.5603
Brugia malayi Bromodomain containing protein 0.0072 0.0097 0.0769
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.002 0.0001 0.0035
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0033
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0066 0.0086 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0212 0.5588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0212 0.5588
Echinococcus multilocularis transfer RNA-Gly 0.0066 0.0086 0.0085
Toxoplasma gondii aldehyde dehydrogenase 0.0041 0.004 0.0753
Echinococcus granulosus potassium voltage gated channel protein 0.0066 0.0086 0.02
Brugia malayi phosphofructokinase 0.0081 0.0114 0.09
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0031 0.0022 0.0049
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.019 0.0315 0.0736
Mycobacterium ulcerans DNA polymerase IV 0.0036 0.0032 0.0099
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0407 0.0713 0.2244
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0066 0.0086 0.2935
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0225 0.0378 1
Schistosoma mansoni zinc finger protein 0.0027 0.0014 0.003
Onchocerca volvulus 0.0143 0.0228 0.7165
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.03 0.0517 1
Echinococcus multilocularis cpg binding protein 0.0143 0.0229 0.0227
Brugia malayi Cathepsin L-like precursor 0.0035 0.003 0.023
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Trichomonas vaginalis inositol monophosphatase, putative 0.0027 0.0015 0.0504
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.1702 0.3091 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.003 0.0029
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0034 0.0028 0.0695
Schistosoma mansoni survival motor neuron protein 0.0143 0.0228 0.0532
Echinococcus multilocularis transient receptor potential cation channel 0.0066 0.0086 0.0085
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0119 0.0184 0.0428
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0089
Schistosoma mansoni peptidase Clp (S14 family) 0.03 0.0517 0.121
Echinococcus granulosus transient receptor potential gamma protein 0.1746 0.3173 0.7446
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0485 0.0857 0.2769
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.1702 0.3091 1
Brugia malayi jmjC domain containing protein 0.0035 0.003 0.0228
Onchocerca volvulus 0.0134 0.0212 0.666
Brugia malayi TAR-binding protein 0.0161 0.026 0.2072
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.003 0.0789
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.009 0.0708
Brugia malayi RNA, U transporter 1 0.0066 0.0087 0.0683
Brugia malayi jmjC domain containing protein 0.0035 0.003 0.0228
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0054 0.0065 0.0508
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.0009 0.0059
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.003 0.264
Schistosoma mansoni hypothetical protein 0.0075 0.0104 0.0241
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0066 0.0086 0.068
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0022 0.0006 0.0081
Schistosoma mansoni transient receptor potential channel 0.2338 0.426 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0168 0.0526
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.007 0.0222
Schistosoma mansoni single-minded 0.0077 0.0108 0.025
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0066 0.0086 0.02
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.009 0.0208
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0034 0.0076
Brugia malayi Thioredoxin reductase 0.0213 0.0356 0.2837
Trypanosoma brucei glucosidase, putative 0.0037 0.0034 0.0857
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0197 0.0327 0.1053
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0024 0.0181
Schistosoma mansoni hypothetical protein 0.0066 0.0086 0.02
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0021 0.0721
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0025 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0021
Brugia malayi Importin beta-1 subunit 0.0023 0.0008 0.0054
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.03 0.0517 1
Echinococcus granulosus voltage dependent calcium channel 0.0066 0.0086 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0032 0.0813
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.0273 0.0856
Leishmania major cathepsin L-like protease 0.0134 0.0212 0.5603
Mycobacterium leprae Isocitrate lyase 0.0798 0.143 0.4626
Echinococcus multilocularis potassium voltage gated channel protein 0.0066 0.0086 0.0085
Echinococcus multilocularis potassium large conductance calcium activated 0.0066 0.0086 0.0085
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0022 0.0005 0.0009
Entamoeba histolytica disulphide oxidoreductase, putative 0.002 0.0001 0.0117
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0066 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.07 0.1252 0.3943
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0032 0.0813
Loa Loa (eye worm) hypothetical protein 0.0058 0.0071 0.022
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0021 0.0721
Schistosoma mansoni ap endonuclease 0.0057 0.007 0.0161
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0038 0.0034 0.0033
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0031 0.0022 0.0049
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0071 0.007
Trypanosoma cruzi cruzipain precursor, putative 0.0134 0.0212 0.5603
Onchocerca volvulus 0.006 0.0075 0.2325
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.003 0.0028
Echinococcus granulosus potassium voltage gated channel protein 0.0066 0.0086 0.02
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0042 0.0043 0.0042
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0103 0.0155 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0032 0.0813
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Trichomonas vaginalis DNA polymerase eta, putative 0.0036 0.0032 0.1085
Echinococcus multilocularis peptidase Clp (S14 family) 0.0197 0.0327 0.0325
Leishmania major hypothetical protein, conserved 0.002 0.0001 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0012 0.0024
Loa Loa (eye worm) MBCTL1 0.0066 0.0086 0.0266
Entamoeba histolytica hypothetical protein 0.0024 0.001 0.085
Leishmania major hypothetical protein, conserved 0.002 0.0001 0.0035
Echinococcus granulosus transient receptor potential ion channel A 0.168 0.3052 0.7162
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Brugia malayi RNA binding protein 0.0161 0.026 0.2072
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0034 0.0626
Trichomonas vaginalis DNA topoisomerase II, putative 0.0038 0.0034 0.117
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0066 0.0086 0.02
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0074 0.0101 0.0234
Onchocerca volvulus 0.0024 0.0009 0.0232
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0074 0.0101 0.0795
Entamoeba histolytica DNA topoisomerase II, putative 0.0038 0.0034 0.3025
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.0006 0.0187
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0038 0.0034 0.0078
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0485 0.0857 0.2769
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0074 0.0101 0.0322
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0103 0.0155 0.2988
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0023
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0038 0.0034 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0021 0.0721
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0158 0.0255 0.08
Trypanosoma cruzi DNA polymerase kappa, putative 0.0036 0.0032 0.0845
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.03 0.0517 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.002 0.0002 0.0063
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0066 0.0086 0.068
Echinococcus multilocularis transient receptor potential cation channel 0.0066 0.0086 0.0085
Trichomonas vaginalis glutathione reductase, putative 0.0074 0.0101 0.3424
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0086 0.0676
Trypanosoma cruzi transcription factor btf3, putative 0.0023 0.0008 0.0223
Schistosoma mansoni 60S ribosomal protein L21 0.0066 0.0086 0.02
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0066 0.0086 0.068
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0022 0.0005 0.0004
Brugia malayi Probable DNA topoisomerase II 0.0038 0.0034 0.0265
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0075 0.0588
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0101 0.2667
Trypanosoma cruzi DNA polymerase eta, putative 0.0053 0.0063 0.1675
Trypanosoma cruzi trypanothione reductase, putative 0.0074 0.0101 0.2667
Schistosoma mansoni hypothetical protein 0.0362 0.063 0.1475
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.003 0.0028
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0539 0.0956 0.3091
Toxoplasma gondii 60S ribosomal protein L27, putative 0.0283 0.0486 0.9403
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.003 0.0067
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0031 0.0022 0.0552
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0101 0.2667
Onchocerca volvulus Alhambra homolog 0.0028 0.0018 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0002 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Loa Loa (eye worm) transcription factor SMAD2 0.0087 0.0125 0.0391
Brugia malayi cation channel family protein 0.0066 0.0086 0.068
Schistosoma mansoni hypothetical protein 0.0248 0.0421 0.0986
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0038 0.0036 0.0955
Loa Loa (eye worm) 6-phosphofructokinase 0.0081 0.0114 0.0355
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0066 0.0086 0.02
Plasmodium falciparum thioredoxin reductase 0.0074 0.0101 0.193
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0054 0.0065 0.0508
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.007 0.182
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.009 0.0279
Plasmodium vivax JmjC domain containing protein 0.0035 0.003 0.0553
Brugia malayi Cathepsin L-like precursor 0.0035 0.003 0.023
Plasmodium falciparum JmjC domain-containing protein, putative 0.0035 0.003 0.0553
Echinococcus granulosus histone acetyltransferase KAT2B 0.0114 0.0174 0.0405
Echinococcus granulosus cpg binding protein 0.0143 0.0229 0.0534
Echinococcus multilocularis voltage dependent calcium channel 0.0066 0.0086 0.0085
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0001 0.0045
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.019 0.0315 0.0314
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0021 0.0721
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0407 0.0713 0.1671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0009 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0021 0.0721
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0212 0.5588
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0101 0.2667
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0034 0.0028 0.0695
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.004 0.0126
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0001 0.0045
Brugia malayi hypothetical protein 0.07 0.1252 1
Brugia malayi acetyltransferase, GNAT family protein 0.0119 0.0184 0.1457
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0034 0.0889
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0123 0.019 0.5038
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0027 0.0015 0.1303
Leishmania major trypanothione reductase 0.0213 0.0356 0.9423
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0022 0.0005 0.0104
Mycobacterium leprae Possible regulatory protein 0.002 0.0002 0.0003
Schistosoma mansoni voltage-gated cation channel 0.0066 0.0086 0.02
Mycobacterium tuberculosis Probable dehydrogenase 0.0485 0.0857 0.2769
Brugia malayi bHLH-PAS transcription factor 0.0057 0.0071 0.0555
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0047
Echinococcus granulosus thioredoxin glutathione reductase 0.0213 0.0357 0.0835
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0485 0.0857 0.2769
Echinococcus multilocularis peregrin 0.0033 0.0026 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0002 0.0081
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0192 0.0317 0.0997
Brugia malayi F/Y-rich N-terminus family protein 0.0053 0.0062 0.0486
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0063 0.0496
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0066 0.0086 0.068
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0035 0.003 0.0557
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.003 0.0789
Schistosoma mansoni hypothetical protein 0.0143 0.0228 0.0532
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.004 0.0126
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0022 0.0006 0.042
Brugia malayi Bromodomain containing protein 0.0033 0.0026 0.0201
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0071 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0021 0.0721
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0032 0.0813
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0066 0.0086 0.068
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0066 0.0086 0.02
Trichomonas vaginalis phosphofructokinase, putative 0.0081 0.0114 0.3869
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0273 0.0271
Loa Loa (eye worm) hypothetical protein 0.0039 0.0037 0.0113
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0225 0.0378 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0022 0.0006 0.0081
Leishmania major cathepsin L-like protease 0.0035 0.003 0.0795
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0066 0.0086 0.068
Entamoeba histolytica acetyltransferase, GNAT family 0.0031 0.0023 0.204
Trypanosoma brucei importin beta-1 subunit, putative 0.0023 0.0008 0.0179
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Mycobacterium ulcerans isocitrate lyase Icl 0.1702 0.3091 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.0001 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0032 0.0813
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.009 0.2352
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Echinococcus multilocularis ubiquitin specific protease 41 0.0031 0.0022 0.0021
Trichomonas vaginalis adenylate cyclase, putative 0.002 0.0002 0.0081
Echinococcus multilocularis neuropeptide s receptor 0.0662 0.1182 0.1181
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0066 0.0086 0.068
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0032 0.0813
Echinococcus multilocularis potassium voltage gated channel protein 0.0066 0.0086 0.0085
Schistosoma mansoni microtubule-associated protein tau 0.1016 0.1832 0.4298
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0066 0.0086 0.02
Onchocerca volvulus 0.0097 0.0143 0.4487
Schistosoma mansoni alpha-glucosidase 0.0144 0.023 0.0537
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0074 0.0101 0.2667
Toxoplasma gondii NADPH-glutathione reductase 0.0074 0.0101 0.193
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0161 0.026 0.0608
Giardia lamblia DINP protein human, muc B family 0.0036 0.0032 0.3078
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.007 0.1849
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.003 0.0067
Plasmodium vivax 6-phosphofructokinase, putative 0.0022 0.0006 0.0081
Echinococcus multilocularis aryl hydrocarbon receptor 0.002 0.0002 0.0001
Leishmania major protein kinase, putative 0.002 0.0002 0.0063
Echinococcus granulosus transcription factor btf3 0.0023 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0047
Entamoeba histolytica deoxycytidyl transferase, putative 0.0036 0.0032 0.2806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0021 0.0721
Echinococcus granulosus transient receptor potential cation channel 0.0066 0.0086 0.02
Entamoeba histolytica hypothetical protein 0.0024 0.001 0.085
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0066 0.0086 0.02
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0407 0.0713 0.1671
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0074 0.0073
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0086 0.0085
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.003 0.0029
Echinococcus multilocularis cysteine protease 0.0035 0.003 0.0029
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0034 0.0258
Brugia malayi Cyclic-nucleotide gated cation channel 0.0066 0.0086 0.068
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.003 0.1021
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.007 0.133
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0066 0.0086 0.02
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0041 0.004 0.1062
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0074 0.0101 0.2641
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0066 0.0086 0.2692
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.003 0.1021
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Brugia malayi hypoxia-induced factor 1 0.024 0.0406 0.3235
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0066 0.0086 0.068
Schistosoma mansoni alpha-glucosidase 0.0144 0.023 0.0537
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.003 0.009
Schistosoma mansoni tar DNA-binding protein 0.0161 0.026 0.0608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Loa Loa (eye worm) hypothetical protein 0.0075 0.0103 0.0319
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.0001 0.0035
Entamoeba histolytica phosphofructokinase, putative 0.0081 0.0114 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0008 0.0286
Leishmania major mitochondrial DNA polymerase beta 0.0225 0.0378 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0008 0.0286
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0066 0.0086 0.02
Trypanosoma brucei unspecified product 0.0025 0.0011 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0032 0.0813
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0074 0.0101 0.193
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0001 0.0035
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0015 0.0393
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0066 0.0086 0.02
Brugia malayi Probable ClpP-like protease 0.03 0.0517 0.4121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0212 0.5588
Onchocerca volvulus 0.0179 0.0294 0.9271
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Loa Loa (eye worm) voltage-dependent calcium channel 0.0066 0.0086 0.0268
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0074 0.0101 0.0234
Onchocerca volvulus Huntingtin homolog 0.0192 0.0317 1
Echinococcus granulosus survival motor neuron protein 1 0.07 0.1252 0.2936
Loa Loa (eye worm) 6-phosphofructokinase 0.0081 0.0114 0.0355
Toxoplasma gondii thioredoxin reductase 0.0213 0.0356 0.6886
Schistosoma mansoni hypothetical protein 0.0761 0.1362 0.3195
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.003 0.0066
Schistosoma mansoni inositol monophosphatase 0.0027 0.0015 0.0032
Echinococcus granulosus importin subunit beta 1 0.0023 0.0008 0.0016
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0086 0.0198
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.007 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0032 0.0813
Trichomonas vaginalis set domain proteins, putative 0.0179 0.0294 1
Treponema pallidum NADH oxidase 0.0074 0.0101 0.193
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0027 0.0015 0.0447
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0037 0.0084
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0268
Leishmania major hypothetical protein, conserved 0.002 0.0001 0.0035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0101 0.2667
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.0006 0.0187
Schistosoma mansoni phd/f-box containing protein 0.0035 0.003 0.0067
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0119 0.0184 0.0182
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0042 0.0043 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Echinococcus granulosus voltage gated hydrogen channel 1 0.0066 0.0086 0.02
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0015 0.0359
Echinococcus granulosus 6 phosphofructokinase 0.0081 0.0114 0.0264
Chlamydia trachomatis DNA gyrase subunit B 0.002 0.0003 0.003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.003 0.0225
Echinococcus granulosus transient receptor potential cation channel 0.0066 0.0086 0.02
Schistosoma mansoni 6-phosphofructokinase 0.0081 0.0114 0.0264
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.002 0.0002 0.0063
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0009 0.0017
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.003 0.0067
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0044 0.0047 0.0107
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0066 0.0086 0.068
Echinococcus granulosus shaker cognate 0.0066 0.0086 0.02
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.0006 0.0187
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0031 0.0022 0.0586
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0066 0.0086 0.0085
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0066 0.0086 0.0268
Echinococcus multilocularis dnaJ subfamily B 0.16 0.2905 0.2904
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.003 0.1021
Echinococcus granulosus transient receptor potential cation channel 0.0066 0.0086 0.02
Schistosoma mansoni transient receptor potential channel 0.1307 0.2366 0.5553
Plasmodium vivax DNA topoisomerase II, putative 0.0038 0.0034 0.0643
Brugia malayi ImpB/MucB/SamB family protein 0.0036 0.0032 0.0245
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0024 0.001 0.0027
Leishmania major cathepsin L-like protease 0.0035 0.003 0.0795
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.002 0.0002 0.0081
Plasmodium vivax vivapain-2 0.0035 0.003 0.0557
Schistosoma mansoni jumonji domain containing protein 0.0171 0.028 0.0654
Toxoplasma gondii exonuclease III APE 0.0057 0.007 0.133
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.003 0.0091
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0074 0.0101 0.193
Leishmania major hypothetical protein, conserved 0.0066 0.0086 0.2286
Schistosoma mansoni intermediate filament proteins 0.006 0.0075 0.0173
Schistosoma mansoni hypothetical protein 0.0035 0.003 0.0066
Brugia malayi Bromodomain containing protein 0.0034 0.0028 0.0215
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0066 0.0086 0.0268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0407 0.0713 0.0712
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0036 0.0032 0.0031
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0031 0.0022 0.2091
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0266
Trypanosoma brucei unspecified product 0.0025 0.0011 0.0264
Echinococcus multilocularis two pore calcium channel protein 1 0.0066 0.0086 0.0085
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0066 0.0086 0.068
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0074 0.0101 0.193
Trichomonas vaginalis guanylate cyclase, putative 0.002 0.0002 0.0081
Schistosoma mansoni hypothetical protein 0.0035 0.003 0.0066
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0036 0.0032 0.0097
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0001 0.0045
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.1702 0.3091 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0407 0.0713 0.1671
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0066 0.0086 0.02
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.002 0.0002 0.0081
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0036 0.0032 0.0072
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0075 0.0232
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0031 0.0022 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0021 0.0721
Trypanosoma brucei DNA polymerase eta, putative 0.0053 0.0063 0.1646
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.003 0.0756
Mycobacterium tuberculosis Probable reductase 0.0485 0.0857 0.2769
Toxoplasma gondii cathepsin CPL 0.0035 0.003 0.0557
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0039 0.0037 0.0036
Schistosoma mansoni terminal deoxycytidyl transferase 0.0036 0.0032 0.0072
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.003 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0032 0.0813
Loa Loa (eye worm) TAR-binding protein 0.0161 0.026 0.0817
Trichomonas vaginalis helicase, putative 0.003 0.0021 0.0721
Schistosoma mansoni bromodomain containing protein 0.0062 0.008 0.0184
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.007 0.0216
Loa Loa (eye worm) jmjC domain-containing protein 0.0141 0.0224 0.0702
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0066 0.0086 0.0085
Echinococcus granulosus short transient receptor potential channel 6 0.1307 0.2366 0.5553
Echinococcus granulosus ryanodine receptor 44f 0.0066 0.0086 0.02
Brugia malayi mbt repeat family protein 0.0058 0.0071 0.0559
Echinococcus multilocularis voltage gated potassium channel 0.0066 0.0086 0.0085
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0066 0.0086 0.0085
Echinococcus multilocularis importin subunit beta 1 0.0023 0.0008 0.0007
Toxoplasma gondii transporter, cation channel family protein 0.0066 0.0086 0.1651
Echinococcus multilocularis survival motor neuron protein 1 0.07 0.1252 0.1251
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0086 0.02
Entamoeba histolytica cysteine protease, putative 0.0035 0.003 0.264
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0074 0.0101 0.2641
Echinococcus multilocularis shaker cognate 0.0066 0.0086 0.0085
Plasmodium falciparum thioredoxin reductase 0.0213 0.0356 0.6886
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0086 0.1651
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0034 0.1141
Leishmania major DNA polymerase eta, putative 0.0028 0.0017 0.046
Brugia malayi jmjC domain containing protein 0.0035 0.003 0.0228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0212 0.5588
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0066 0.0086 0.0085
Brugia malayi Cathepsin L-like precursor 0.0035 0.003 0.023
Echinococcus multilocularis voltage dependent calcium channel 0.0066 0.0086 0.0085
Schistosoma mansoni jumonji/arid domain-containing protein 0.0141 0.0224 0.0523
Echinococcus granulosus mixed lineage leukemia protein mll 0.0034 0.0028 0.0063
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0074 0.0101 0.2667
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.003 0.0795
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0074 0.0101 0.0322
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0013 0.0012
Trypanosoma brucei unspecified product 0.0036 0.0032 0.0813
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0066 0.0086 0.0268
Echinococcus granulosus geminin 0.0761 0.1362 0.3195
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0086 0.0198
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0022 0.0005 0.0009
Loa Loa (eye worm) TOPoisomerase family member 0.0038 0.0034 0.0104
Echinococcus multilocularis two pore calcium channel protein 2 0.0066 0.0086 0.0085
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0041 0.004 0.0126
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0037 0.0036

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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