Detailed information for compound 1291318

Basic information

Technical information
  • TDR Targets ID: 1291318
  • Name: 6-[(E)-2-(4-methoxyphenyl)ethenyl]-4,5-dihydr o-2H-pyridazin-3-one
  • MW: 230.262 | Formula: C13H14N2O2
  • H donors: 1 H acceptors: 1 LogP: 1.32 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C/C1=NNC(=O)CC1
  • InChi: 1S/C13H14N2O2/c1-17-12-7-3-10(4-8-12)2-5-11-6-9-13(16)15-14-11/h2-5,7-8H,6,9H2,1H3,(H,15,16)/b5-2+
  • InChiKey: DCXOGDFXYWSZPU-GORDUTHDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-[2-(4-methoxyphenyl)ethenyl]-4,5-dihydro-2H-pyridazin-3-one
  • 6-[(E)-2-(4-methoxyphenyl)vinyl]-4,5-dihydro-2H-pyridazin-3-one
  • 6-[2-(4-methoxyphenyl)vinyl]-4,5-dihydro-2H-pyridazin-3-one
  • MLS000706842
  • SMR000334347
  • 10K-423S
  • ZINC01387468
  • 6-(4-methoxystyryl)-4,5-dihydro-3(2H)-pyridazinone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0033 0.0004 0.0004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0235 0.0363
Brugia malayi isocitrate dehydrogenase 0.0085 0.0355 0.0351
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0172 0.0946 1
Schistosoma mansoni hypothetical protein 0.0067 0.0235 0.0587
Echinococcus multilocularis tar DNA binding protein 0.0618 0.3947 0.6183
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0445 0.5
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0263 0.1557 0.5
Schistosoma mansoni hypothetical protein 0.0079 0.032 0.08
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0091 0.0395 0.1749
Loa Loa (eye worm) hypothetical protein 0.0066 0.0226 0.0226
Echinococcus granulosus TGF beta signal transducer SmadC 0.0103 0.0481 0.0901
Schistosoma mansoni smad1 5 8 and 0.0103 0.0481 0.1209
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0085 0.0355 0.6962
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0172 0.0946 0.4744
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.1314 0.2054
Trypanosoma brucei polo-like protein kinase 0.0098 0.0445 1
Brugia malayi jmjC domain containing protein 0.0071 0.0263 0.0259
Loa Loa (eye worm) nuclear factor I 0.0057 0.017 0.017
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.0758 0.0755
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0445 1
Brugia malayi Smad1 0.0103 0.0481 0.0477
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0445 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0263 0.1557 0.2435
Loa Loa (eye worm) MH2 domain-containing protein 0.0046 0.0096 0.0096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0235 0.0437
Echinococcus multilocularis FTZ F1 alpha 0.011 0.0525 0.0817
Echinococcus granulosus mothers against decapentaplegic 5 0.0103 0.0481 0.0901
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0263 0.0406
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0445 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0173 0.0314
Loa Loa (eye worm) hypothetical protein 0.0263 0.1557 0.1557
Loa Loa (eye worm) TAR-binding protein 0.0618 0.3947 0.3947
Brugia malayi MH2 domain containing protein 0.0046 0.0096 0.0092
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0226 0.0349
Brugia malayi mbt repeat family protein 0.0058 0.0173 0.0169
Loa Loa (eye worm) MH1 domain-containing protein 0.0103 0.0481 0.0481
Brugia malayi Calcitonin receptor-like protein seb-1 0.0211 0.1209 0.1206
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0172 0.0946 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0046 0.0096 0.0171
Schistosoma mansoni tar DNA-binding protein 0.0618 0.3947 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0046 0.0096 0.0173
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0226 0.0564
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0226 0.042
Schistosoma mansoni Smad4 0.0046 0.0096 0.0233
Brugia malayi hypothetical protein 0.0829 0.537 0.5368
Brugia malayi MH2 domain containing protein 0.0103 0.0481 0.0477
Echinococcus multilocularis smad 0.0103 0.0481 0.0747
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0177 0.0173
Brugia malayi MH1 domain containing protein 0.0103 0.0481 0.0477
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0263 0.1557 1
Schistosoma mansoni hypothetical protein 0.0058 0.0177 0.0439
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1708 0.3221
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0263 0.0406
Brugia malayi Probable ClpP-like protease 0.0263 0.1557 0.1554
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0103 0.0481 0.0747
Loa Loa (eye worm) MH1 domain-containing protein 0.0046 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0145 0.0758 0.1913
Brugia malayi RNA binding protein 0.0618 0.3947 0.3945
Giardia lamblia Kinase, PLK 0.0098 0.0445 0.5
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.1314 0.2475
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0263 0.0263
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0263 0.1557 1
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0173 0.0173
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0085 0.0355 0.6962
Schistosoma mansoni smad 0.0103 0.0481 0.1209
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0263 0.1557 0.2935
Echinococcus granulosus smad 0.0103 0.0481 0.0901
Loa Loa (eye worm) isocitrate dehydrogenase 0.0085 0.0355 0.0355
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0263 0.1557 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0173 0.0428
Brugia malayi MH1 domain containing protein 0.0103 0.0481 0.0477
Loa Loa (eye worm) hypothetical protein 0.0067 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.011 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0057 0.017 0.017
Schistosoma mansoni Smad4 0.0103 0.0481 0.1209
Schistosoma mansoni hypothetical protein 0.035 0.2143 0.5426
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0395 0.1749
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0085 0.0355 0.6962
Brugia malayi RNA recognition motif domain containing protein 0.0618 0.3947 0.3945
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0263 0.1557 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.0173 0.0173
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0235 0.0437
Echinococcus multilocularis mothers against decapentaplegic 2 0.0046 0.0096 0.0144
Brugia malayi jmjC domain containing protein 0.0071 0.0263 0.0259
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0085 0.0355 0.055
Echinococcus multilocularis GPCR, family 2 0.0067 0.0235 0.0363
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0445 0.0821
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0085 0.0355 0.089
Loa Loa (eye worm) hypothetical protein 0.0211 0.1209 0.1209
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0445 0.0441
Echinococcus granulosus mothers against decapentaplegic 6 0.0046 0.0096 0.0173
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0085 0.0355 0.6962
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0173 0.0319
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0263 0.1557 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0211 0.1209 0.1206
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0235 0.0231
Loa Loa (eye worm) RNA binding protein 0.0618 0.3947 0.3947
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0173 0.0264
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0445 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0263 0.1557 0.3939
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.011 0.0525 0.0985
Schistosoma mansoni hypothetical protein 0.0067 0.0235 0.0587
Onchocerca volvulus 0.0058 0.0177 0.0322
Brugia malayi MH2 domain containing protein 0.0103 0.0481 0.0477
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0226 0.042
Schistosoma mansoni Smad4 0.0046 0.0096 0.0233
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0263 0.1557 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0445 0.0445
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0226 0.0222
Brugia malayi hypothetical protein 0.0054 0.0149 0.0145
Toxoplasma gondii isocitrate dehydrogenase 0.0085 0.0355 0.1462
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0173 0.0428
Echinococcus granulosus FTZ F1 alpha 0.0818 0.5295 1
Brugia malayi MH1 domain containing protein 0.0057 0.017 0.0166
Echinococcus granulosus peptidase Clp S14 family 0.0172 0.0946 0.1781
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0085 0.0355 0.0663
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0085 0.0355 0.1462
Echinococcus granulosus tar DNA binding protein 0.0618 0.3947 0.7452
Loa Loa (eye worm) hypothetical protein 0.0145 0.0758 0.0758
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0445 0.0833
Echinococcus granulosus Smad4 0.0103 0.0481 0.0901
Echinococcus multilocularis peptidase Clp (S14 family) 0.0172 0.0946 0.1478
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0263 0.0657
Loa Loa (eye worm) hypothetical protein 0.0046 0.0096 0.0096
Brugia malayi mbt repeat family protein 0.0058 0.0173 0.0169
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0263 0.1557 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0445 1
Brugia malayi Isocitrate dehydrogenase 0.0085 0.0355 0.0351
Schistosoma mansoni smad1 5 8 and 0.0103 0.0481 0.1209
Brugia malayi mothers against decapentaplegic homolog 3 0.0046 0.0096 0.0092
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0103 0.0481 0.1209
Brugia malayi TAR-binding protein 0.0618 0.3947 0.3945
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0618 0.3947 0.3947
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0004 0.0004
Echinococcus multilocularis Smad4 0.0103 0.0481 0.0747
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.0525 0.0521
Schistosoma mansoni kinase 0.005 0.012 0.0294
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0173 0.0264
Schistosoma mansoni tar DNA-binding protein 0.0618 0.3947 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0226 0.0349
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0263 0.0657
Schistosoma mansoni smad1 5 8 and 0.0103 0.0481 0.1209
Toxoplasma gondii isocitrate dehydrogenase 0.0085 0.0355 0.1462
Echinococcus multilocularis mothers against decapentaplegic 5 0.0103 0.0481 0.0747
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0085 0.0355 0.055
Loa Loa (eye worm) hypothetical protein 0.0286 0.1708 0.1708
Brugia malayi MH1 domain containing protein 0.0057 0.017 0.0166
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0445 1
Echinococcus granulosus GPCR family 2 0.0067 0.0235 0.0437
Loa Loa (eye worm) hypothetical protein 0.0829 0.537 0.537
Loa Loa (eye worm) MH2 domain-containing protein 0.0103 0.0481 0.0481
Brugia malayi hypothetical protein 0.0035 0.002 0.0016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0085 0.0355 0.055
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0445 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0173 0.0428
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0445 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0149 0.0149
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0235 0.0363
Toxoplasma gondii hypothetical protein 0.0091 0.0395 0.1749
Schistosoma mansoni hypothetical protein 0.0067 0.0235 0.0587
Brugia malayi hypothetical protein 0.0286 0.1708 0.1705
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.0525 0.0521
Onchocerca volvulus 0.0058 0.0173 0.0314
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0235 0.0235
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0263 0.1557 0.5
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0263 0.1557 1
Schistosoma mansoni tar DNA-binding protein 0.0618 0.3947 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0085 0.0355 0.055
Loa Loa (eye worm) MBCTL1 0.0066 0.0226 0.0226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0211 0.1209 0.1209
Schistosoma mansoni smad 0.0046 0.0096 0.0233
Schistosoma mansoni survival motor neuron protein 0.0058 0.0177 0.0439
Loa Loa (eye worm) Smad1 0.0103 0.0481 0.0481
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0445 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0263 0.0657
Echinococcus multilocularis mothers against decapentaplegic 6 0.0046 0.0096 0.0144
Schistosoma mansoni tar DNA-binding protein 0.0618 0.3947 1
Schistosoma mansoni tar DNA-binding protein 0.0618 0.3947 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0263 0.1557 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0445 0.0691
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1708 0.2672
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0085 0.0355 0.055
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.011 0.0525 0.0817
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0235 0.0231
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0263 0.049
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0004 0.0004
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0173 0.0319
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6381 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0085 0.0355 0.6962
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0445 1
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0445 0.1118
Onchocerca volvulus 0.0829 0.537 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0085 0.0355 0.1462
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.011 0.0525 0.1322
Schistosoma mansoni hypothetical protein 0.0067 0.0235 0.0587
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0263 0.049

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 33.5875 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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