Detailed information for compound 1291938

Basic information

Technical information
  • TDR Targets ID: 1291938
  • Name: 2,4,5-trimethoxy-N-(2,2,6,6-tetramethylpiperi din-4-yl)benzamide
  • MW: 350.453 | Formula: C19H30N2O4
  • H donors: 2 H acceptors: 1 LogP: 2.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)c(cc1C(=O)NC1CC(C)(C)NC(C1)(C)C)OC
  • InChi: 1S/C19H30N2O4/c1-18(2)10-12(11-19(3,4)21-18)20-17(22)13-8-15(24-6)16(25-7)9-14(13)23-5/h8-9,12,21H,10-11H2,1-7H3,(H,20,22)
  • InChiKey: VCQXNHXZRZZKPC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,4,5-trimethoxy-N-(2,2,6,6-tetramethyl-4-piperidyl)benzamide
  • 2,4,5-trimethoxy-N-(2,2,6,6-tetramethyl-4-piperidinyl)benzamide
  • MLS000063822
  • SMR000075688
  • STK151161
  • 2,4,5-Trimethoxy-N-(2,2,6,6-tetramethyl-piperidin-4-yl)-benzamide
  • BAS 07399027

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0047 0.0198 0.0198
Brugia malayi hypothetical protein 0.0047 0.0198 0.0198
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0034 0.0097 0.5
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0029 0.0029
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0029 0.0043
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0087 0.1591
Schistosoma mansoni dishevelled 0.0047 0.0198 0.0292
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0034 0.0097 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0034 0.0097 0.5
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0034 0.0097 0.0255
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0305 0.0803
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0305 0.0803
Schistosoma mansoni smad1 5 8 and 0.0025 0.0029 0.0043
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0097
Schistosoma mansoni dishevelled 0.0047 0.0198 0.0292
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0097
Loa Loa (eye worm) transcription factor SMAD2 0.0363 0.2543 0.2543
Entamoeba histolytica hypothetical protein 0.0034 0.0097 0.5
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0032 0.0085 0.0125
Brugia malayi Probable ClpP-like protease 0.0094 0.0547 0.0547
Toxoplasma gondii hypothetical protein 0.0047 0.0198 0.3621
Brugia malayi RNA recognition motif domain containing protein 0.0532 0.3802 0.3802
Brugia malayi latrophilin 2 splice variant baaae 0.0934 0.6787 0.6787
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0547 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0034 0.0097 0.0143
Echinococcus multilocularis ras GTP exchange factor 0.0034 0.0097 0.0255
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0547 1
Loa Loa (eye worm) DIX domain-containing protein 0.0047 0.0198 0.0198
Trypanosoma cruzi hypothetical protein 0.0034 0.0097 1
Brugia malayi regulator of G-protein signaling egl-10 0.0047 0.0198 0.0198
Schistosoma mansoni z-protein (S1r protein) 0.0047 0.0198 0.0292
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0547 0.144
Echinococcus multilocularis regulator of G protein signaling 7 0.0047 0.0198 0.0521
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0029 0.0076
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0547 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0034 0.0097 0.0143
Echinococcus multilocularis tar DNA binding protein 0.0532 0.3802 1
Schistosoma mansoni Smad4 0.0025 0.0029 0.0043
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0029 0.0029
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0034 0.0097 0.5
Brugia malayi Latrophilin receptor protein 2 0.0432 0.3058 0.3058
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0034 0.0097 0.5
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0547 0.144
Schistosoma mansoni smad1 5 8 and 0.0025 0.0029 0.0043
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0547 1
Schistosoma mansoni hypothetical protein 0.0432 0.3058 0.4506
Schistosoma mansoni hypothetical protein 0.0432 0.3058 0.4506
Echinococcus granulosus segment polarity protein dishevelled 0.0047 0.0198 0.0521
Loa Loa (eye worm) RNA binding protein 0.0532 0.3802 0.3802
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0547 0.5
Echinococcus granulosus Pleckstrin G protein interacting region 0.0047 0.0198 0.0521
Loa Loa (eye worm) hypothetical protein 0.0047 0.0198 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0532 0.3802 0.5602
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0034 0.0097 0.5
Loa Loa (eye worm) Smad1 0.0025 0.0029 0.0029
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0432 0.3058 0.8043
Echinococcus granulosus Protein son of sevenless 0.0034 0.0097 0.0255
Echinococcus granulosus regulator of G protein signaling 7 0.0047 0.0198 0.0521
Brugia malayi RasGEF domain containing protein 0.0034 0.0097 0.0097
Loa Loa (eye worm) RasGEF domain-containing protein 0.0034 0.0097 0.0097
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0547 1
Brugia malayi Smad1 0.0025 0.0029 0.0029
Echinococcus multilocularis smad 0.0025 0.0029 0.0076
Echinococcus granulosus segment polarity protein dishevelled 0.0047 0.0198 0.0521
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0965 0.7019 1
Echinococcus granulosus GPCR family 2 0.0432 0.3058 0.8043
Schistosoma mansoni tar DNA-binding protein 0.0532 0.3802 0.5602
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0305 1
Brugia malayi RasGEF domain containing protein 0.0034 0.0097 0.0097
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0047 0.0198 0.0198
Brugia malayi RNA binding protein 0.0532 0.3802 0.3802
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0532 0.3802 0.3802
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0034 0.0097 0.0138
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0087 0.1591
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0547 1
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0047 0.0198 0.0282
Echinococcus granulosus smad 0.0025 0.0029 0.0076
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0029 0.0076
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0432 0.3058 0.8043
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0034 0.0097 0.5
Echinococcus multilocularis son of sevenless 1 0.0034 0.0097 0.0255
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0034 0.0097 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0432 0.3058 0.8043
Brugia malayi MH1 domain containing protein 0.0025 0.0029 0.0029
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0547 1
Schistosoma mansoni tar DNA-binding protein 0.0532 0.3802 0.5602
Loa Loa (eye worm) hypothetical protein 0.0094 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.0965 0.7019 0.7019
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0034 0.0097 0.5
Echinococcus granulosus ras GTP exchange factor 0.0034 0.0097 0.0255
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0087 0.1591
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0034 0.0097 0.5
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0547 1
Echinococcus multilocularis Protein son of sevenless 0.0034 0.0097 0.0255
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0034 0.0097 0.5
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0034 0.0097 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0363 0.2543 0.2543
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0034 0.0097 0.5
Trypanosoma cruzi hypothetical protein 0.0034 0.0097 1
Loa Loa (eye worm) hypothetical protein 0.0432 0.3058 0.3058
Loa Loa (eye worm) hypothetical protein 0.0047 0.0198 0.0198
Brugia malayi N-terminal motif family protein 0.0034 0.0097 0.0097
Echinococcus multilocularis segment polarity protein dishevelled 0.0047 0.0198 0.0521
Schistosoma mansoni regulator of G protein signaling 0.0047 0.0198 0.0292
Echinococcus multilocularis segment polarity protein dishevelled 0.0047 0.0198 0.0521
Toxoplasma gondii hypothetical protein 0.0033 0.0087 0.1591
Echinococcus granulosus son of sevenless 1 0.0034 0.0097 0.0255
Trichomonas vaginalis ras GTP exchange factor, putative 0.0034 0.0097 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0034 0.0097 0.5
Brugia malayi MH1 domain containing protein 0.0025 0.0029 0.0029
Loa Loa (eye worm) RasGEF domain-containing protein 0.0034 0.0097 0.0097
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0432 0.3058 0.8043
Trichomonas vaginalis ras GTP exchange factor, putative 0.0034 0.0097 1
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0034 0.0097 0.0255
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0034 0.0097 0.5
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0029 0.0076
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0034 0.0097 0.0255
Echinococcus granulosus regulator of G protein signaling 7 0.0047 0.0198 0.0521
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0047 0.0198 0.0292
Onchocerca volvulus 0.0047 0.0198 0.0282
Brugia malayi hypothetical protein 0.0047 0.0198 0.0198
Brugia malayi DIX domain containing protein 0.0047 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0934 0.6787 0.6787
Brugia malayi MH2 domain containing protein 0.0363 0.2543 0.2543
Loa Loa (eye worm) TAR-binding protein 0.0532 0.3802 0.3802
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0547 1
Brugia malayi TAR-binding protein 0.0532 0.3802 0.3802
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0432 0.3058 0.3058
Echinococcus multilocularis Smad4 0.0025 0.0029 0.0076
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0034 0.0097 0.0143
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0034 0.0097 0.0255
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0047 0.0198 0.0521
Echinococcus granulosus Smad4 0.0025 0.0029 0.0076
Loa Loa (eye worm) hypothetical protein 0.0047 0.0198 0.0198
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0034 0.0097 0.5
Brugia malayi N-terminal motif family protein 0.0965 0.7019 0.7019
Brugia malayi RasGEF domain containing protein 0.0034 0.0097 0.0097
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0034 0.0097 0.0143
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0305 0.558
Echinococcus granulosus tar DNA binding protein 0.0532 0.3802 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0547 1
Schistosoma mansoni hypothetical protein 0.0934 0.6787 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0047 0.0198 0.0521
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0047 0.0198 0.0198
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0087 0.1591
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0547 0.0806
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0305 1
Schistosoma mansoni smad 0.0025 0.0029 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0532 0.3802 0.5602
Brugia malayi N-terminal motif family protein 0.0034 0.0097 0.0097
Brugia malayi MH2 domain containing protein 0.0025 0.0029 0.0029
Schistosoma mansoni dep domain containing protein 0.0047 0.0198 0.0292
Loa Loa (eye worm) latrophilin receptor protein 2 0.0432 0.3058 0.3058
Schistosoma mansoni tar DNA-binding protein 0.0532 0.3802 0.5602
Schistosoma mansoni hypothetical protein 0.0432 0.3058 0.4506
Schistosoma mansoni smad1 5 8 and 0.0025 0.0029 0.0043
Schistosoma mansoni hypothetical protein 0.0432 0.3058 0.4506
Echinococcus multilocularis GPCR, family 2 0.0432 0.3058 0.8043
Brugia malayi MH2 domain containing protein 0.0025 0.0029 0.0029
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0029 0.0076
Onchocerca volvulus 0.0034 0.0097 0.0138
Loa Loa (eye worm) RasGEF domain-containing protein 0.0034 0.0097 0.0097
Schistosoma mansoni ras GTP exchange factor 0.0034 0.0097 0.0143

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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