Detailed information for compound 1291984

Basic information

Technical information
  • TDR Targets ID: 1291984
  • Name: N-[(E)-1-(1H-benzimidazol-2-yl)-2-(4-chloroph enyl)ethenyl]furan-2-carboxamide
  • MW: 363.797 | Formula: C20H14ClN3O2
  • H donors: 2 H acceptors: 2 LogP: 4.45 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)/C=C(\c1nc2c([nH]1)cccc2)/NC(=O)c1ccco1
  • InChi: 1S/C20H14ClN3O2/c21-14-9-7-13(8-10-14)12-17(24-20(25)18-6-3-11-26-18)19-22-15-4-1-2-5-16(15)23-19/h1-12H,(H,22,23)(H,24,25)/b17-12+
  • InChiKey: RLPWQRBWANQTMU-SFQUDFHCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(E)-1-(1H-benzimidazol-2-yl)-2-(4-chlorophenyl)vinyl]furan-2-carboxamide
  • N-[(E)-1-(1H-benzimidazol-2-yl)-2-(4-chlorophenyl)vinyl]-2-furancarboxamide
  • N-[(E)-1-(1H-benzimidazol-2-yl)-2-(4-chlorophenyl)vinyl]-2-furamide
  • BIM-0027651.P001
  • MLS000579198
  • N-[1-(1H-benzimidazol-2-yl)-2-(4-chlorophenyl)vinyl]-2-furamide
  • SMR000186785
  • ZINC05018368

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0542 0.1309
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0082 0.1185 0.1185
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0619 1
Brugia malayi MH1 domain containing protein 0.0023 0.0233 0.0233
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0689 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.2895 0.2895
Echinococcus multilocularis tar DNA binding protein 0.0263 0.4138 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0159 0.0385
Brugia malayi MH2 domain containing protein 0.0042 0.0542 0.0542
Brugia malayi MH1 domain containing protein 0.0023 0.0233 0.0233
Schistosoma mansoni smad 0.0019 0.0159 0.0385
Loa Loa (eye worm) acetyltransferase 0.0175 0.2702 0.2702
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.022 0.5
Brugia malayi TAR-binding protein 0.0263 0.4138 0.4138
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.022 0.5
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0689 1
Echinococcus granulosus GPCR family 2 0.0082 0.1185 0.2863
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0259 0.4068 0.4068
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.2702 0.653
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.022 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.022 0.5
Echinococcus multilocularis Smad4 0.0042 0.0542 0.1309
Schistosoma mansoni hypothetical protein 0.0082 0.1185 0.2863
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0689 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0233 0.0233
Brugia malayi N-terminal motif family protein 0.0187 0.2895 0.2895
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.2622 0.6336
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0542 0.1309
Brugia malayi MH2 domain containing protein 0.0042 0.0542 0.0542
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0159 0.0385
Schistosoma mansoni hypothetical protein 0.0082 0.1185 0.2863
Brugia malayi MH1 domain containing protein 0.0042 0.0542 0.0542
Schistosoma mansoni tar DNA-binding protein 0.0263 0.4138 1
Brugia malayi Smad1 0.0042 0.0542 0.0542
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0542 0.1309
Echinococcus granulosus geminin 0.0205 0.3184 0.7695
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0263 0.4138 0.4138
Loa Loa (eye worm) Smad1 0.0042 0.0542 0.0542
Echinococcus multilocularis smad 0.0042 0.0542 0.1309
Brugia malayi Calcitonin receptor-like protein seb-1 0.0259 0.4068 0.4068
Schistosoma mansoni hypothetical protein 0.0082 0.1185 0.2863
Schistosoma mansoni smad1 5 8 and 0.0042 0.0542 0.1309
Schistosoma mansoni smad1 5 8 and 0.0042 0.0542 0.1309
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0689 1
Brugia malayi RNA binding protein 0.0263 0.4138 0.4138
Echinococcus granulosus smad 0.0042 0.0542 0.1309
Brugia malayi MH1 domain containing protein 0.0042 0.0542 0.0542
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0689 0.1665
Schistosoma mansoni Smad4 0.0042 0.0542 0.1309
Schistosoma mansoni smad1 5 8 and 0.0042 0.0542 0.1309
Schistosoma mansoni tar DNA-binding protein 0.0263 0.4138 1
Toxoplasma gondii exonuclease III APE 0.0023 0.022 0.3197
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.1185 0.2863
Schistosoma mansoni hypothetical protein 0.0082 0.1185 0.2863
Brugia malayi MH2 domain containing protein 0.0019 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0177 0.2733 0.6605
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.2702 0.2702
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.1185 0.2863
Loa Loa (eye worm) hypothetical protein 0.0259 0.4068 0.4068
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.1185 0.2863
Schistosoma mansoni Smad4 0.0019 0.0159 0.0385
Echinococcus granulosus tar DNA binding protein 0.0263 0.4138 1
Schistosoma mansoni ap endonuclease 0.0023 0.022 0.0532
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0619 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.022 0.5
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0542 0.1309
Schistosoma mansoni hypothetical protein 0.0205 0.3184 0.7695
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0019 0.0159 0.0159
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0019 0.0159 0.055
Echinococcus granulosus Smad4 0.0042 0.0542 0.1309
Schistosoma mansoni hypothetical protein 0.0205 0.3184 0.7695
Brugia malayi latrophilin 2 splice variant baaae 0.0177 0.2733 0.2733
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0159 0.0159
Loa Loa (eye worm) nuclear factor I 0.0023 0.0233 0.0233
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.1185 0.2863
Schistosoma mansoni tar DNA-binding protein 0.0263 0.4138 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.022 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0689 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0187 0.2895 1
Schistosoma mansoni Smad4 0.0019 0.0159 0.0385
Loa Loa (eye worm) hypothetical protein 0.0177 0.2733 0.2733
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.022 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0542 0.0542
Brugia malayi RNA recognition motif domain containing protein 0.0263 0.4138 0.4138
Schistosoma mansoni smad 0.0042 0.0542 0.1309
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.2702 0.653
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0619 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.022 0.0532
Loa Loa (eye worm) RNA binding protein 0.0263 0.4138 0.4138
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.022 0.022
Loa Loa (eye worm) TAR-binding protein 0.0263 0.4138 0.4138
Schistosoma mansoni tar DNA-binding protein 0.0263 0.4138 1
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0159 0.0385
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0159 0.0385
Echinococcus multilocularis geminin 0.0205 0.3184 0.7695
Schistosoma mansoni ap endonuclease 0.0023 0.022 0.0532
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.1185 0.1185
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.1185 0.1185
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0542 0.1309
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.022 0.022
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0542 0.0542
Echinococcus multilocularis GPCR, family 2 0.0082 0.1185 0.2863
Brugia malayi Latrophilin receptor protein 2 0.0082 0.1185 0.1185
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.022 0.5
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.022 0.0532
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0259 0.4068 0.4068
Schistosoma mansoni tar DNA-binding protein 0.0263 0.4138 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.01 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5012 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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