Detailed information for compound 1292092

Basic information

Technical information
  • TDR Targets ID: 1292092
  • Name: 6-(4-chlorophenyl)-2-dimethylamino-8-(4-metho xyphenyl)pteridin-7-one
  • MW: 407.853 | Formula: C21H18ClN5O2
  • H donors: 0 H acceptors: 3 LogP: 3.76 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1c(=O)c(nc2c1nc(nc2)N(C)C)c1ccc(cc1)Cl
  • InChi: 1S/C21H18ClN5O2/c1-26(2)21-23-12-17-19(25-21)27(15-8-10-16(29-3)11-9-15)20(28)18(24-17)13-4-6-14(22)7-5-13/h4-12H,1-3H3
  • InChiKey: RXRNPPONSDQSFF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(4-chlorophenyl)-2-dimethylamino-8-(4-methoxyphenyl)-7-pteridinone
  • NCGC00012892
  • PCOP-967896

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens caspase 7, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Starlite/ChEMBL No references
Homo sapiens caspase 1, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Brugia malayi Cell death protein 3 precursor caspase 7, apoptosis-related cysteine peptidase 303 aa 256 aa 37.1 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Echinococcus granulosus caspase 8 caspase 1, apoptosis-related cysteine peptidase 383 aa 312 aa 26.6 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.013 0.2053
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.004 0.0666
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0158 0.0594 1
Loa Loa (eye worm) proteasome 26S subunit 0.0017 0.0018 0.0018
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0187 0.0662
Trypanosoma brucei PAB1-binding protein , putative 0.0179 0.0676 1
Trypanosoma cruzi metacaspase, putative 0.0053 0.0166 0.245
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.004 0.014
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0023 0.004 0.0236
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.013 0.0648
Schistosoma mansoni tar DNA-binding protein 0.0661 0.2645 0.9352
Echinococcus granulosus GPCR family 2 0.0327 0.1281 0.4843
Brugia malayi Latrophilin receptor protein 2 0.0327 0.1281 0.1281
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0017 0.0018 0.0266
Schistosoma mansoni hypothetical protein 0.005 0.0151 0.0533
Schistosoma mansoni hypothetical protein 0.0706 0.2828 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0141 0.0524 0.1981
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.013 0.0491
Echinococcus multilocularis Smad4 0.0168 0.0633 0.2392
Loa Loa (eye worm) hypothetical protein 0.0103 0.0369 0.0369
Brugia malayi latrophilin 2 splice variant baaae 0.0706 0.2828 0.2828
Echinococcus multilocularis mothers against decapentaplegic 2 0.0075 0.0254 0.096
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0053 0.0166 0.0586
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0125 0.2106
Onchocerca volvulus 0.0043 0.0125 0.0983
Schistosoma mansoni inositol monophosphatase 0.0045 0.013 0.0458
Brugia malayi Cytochrome P450 family protein 0.0023 0.0043 0.0043
Plasmodium falciparum ornithine aminotransferase 0.0023 0.004 0.0229
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.013 0.205
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0247 0.3651
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0392 0.1482
Echinococcus multilocularis mothers against decapentaplegic 6 0.0075 0.0254 0.096
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0043 0.0043
Brugia malayi hypoxia-induced factor 1 0.0182 0.0689 0.0689
Onchocerca volvulus 0.0302 0.1181 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0081 0.0277 0.0277
Echinococcus multilocularis tissue type plasminogen activator 0.0019 0.0025 0.0093
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0166 0.245
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.013 0.2183
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0081 0.0277 0.3874
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0141 0.0524 0.1981
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0023 0.004 0.0151
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0327 0.1281 0.4843
Echinococcus granulosus ornithine aminotransferase 0.0023 0.004 0.015
Brugia malayi MH2 domain containing protein 0.0168 0.0633 0.0633
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0158 0.0594 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0247 0.4156
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0111 0.1862
Brugia malayi Cell death protein 3 precursor 0.0103 0.0369 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0166 0.2666
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.004 0.0229
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0053 0.0166 0.0166
Entamoeba histolytica hypothetical protein 0.0109 0.0392 0.2541
Brugia malayi MH1 domain containing protein 0.0168 0.0633 0.0633
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.004 0.0666
Echinococcus granulosus caspase 3 0.0088 0.0306 0.1157
Plasmodium vivax ataxin-2 like protein, putative 0.0179 0.0676 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0254 0.0254
Brugia malayi Protein kinase domain containing protein 0.0019 0.0025 0.0025
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0023 0.004 0.0666
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.013 0.1918
Loa Loa (eye worm) RNA binding protein 0.0661 0.2645 0.2645
Loa Loa (eye worm) Smad1 0.0168 0.0633 0.0633
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0166 0.2666
Echinococcus granulosus tar DNA binding protein 0.0661 0.2645 1
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0017 0.0018 0.0068
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0247 0.0933
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0025 0.0365
Schistosoma mansoni smad1 5 8 and 0.0168 0.0633 0.2237
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0166 0.2666
Schistosoma mansoni smad1 5 8 and 0.0168 0.0633 0.2237
Brugia malayi PAS domain containing protein 0.0059 0.0187 0.0187
Schistosoma mansoni hypothetical protein 0.0327 0.1281 0.4529
Schistosoma mansoni hypothetical protein 0.0327 0.1281 0.4529
Brugia malayi hypothetical protein 0.0109 0.0392 0.0392
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.023 0.3407
Leishmania major cytochrome p450-like protein 0.0023 0.0043 0.0638
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.013 0.1921
Echinococcus granulosus Smad4 0.0168 0.0633 0.2392
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.004 0.004
Brugia malayi N-terminal motif family protein 0.0181 0.0686 0.0686
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.004 0.0585
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.013 0.0795
Echinococcus granulosus apoptotic protease activating factor 1 0.005 0.0151 0.057
Loa Loa (eye worm) hypothetical protein 0.0179 0.0676 0.0676
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0211 0.0211
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.013 0.0491
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0017 0.0018 0.0137
Trypanosoma brucei metacaspase MCA2 0.0053 0.0166 0.245
Entamoeba histolytica hypothetical protein 0.0103 0.0368 0.2368
Brugia malayi Kringle domain containing protein 0.0019 0.0025 0.0025
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.0689 0.0689
Brugia malayi mothers against decapentaplegic homolog 3 0.0075 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0053 0.0166 0.0166
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0023 0.004 0.004
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.001 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0327 0.1281 0.4843
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.013 0.0459
Echinococcus granulosus smad 0.0168 0.0633 0.2392
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0166 0.245
Echinococcus multilocularis caspase 0.0141 0.0524 0.1981
Schistosoma mansoni Smad4 0.0075 0.0254 0.0897
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0023 0.004 0.0236
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0017 0.0018 0.0068
Onchocerca volvulus Cell death protein 3 homolog 0.0103 0.0369 0.3062
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0362 0.1426 1
Brugia malayi Inositol-1 0.0045 0.013 0.013
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.023 0.0871
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0166 0.2666
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0081 0.0277 0.4665
Loa Loa (eye worm) hypothetical protein 0.0045 0.013 0.013
Mycobacterium ulcerans acetylornithine aminotransferase 0.0023 0.004 0.0666
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0125 0.0125
Toxoplasma gondii proteasome regulatory subunit 0.0023 0.004 0.0592
Loa Loa (eye worm) hypothetical protein 0.1033 0.4162 0.4162
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.001 0.0038
Schistosoma mansoni hypothetical protein 0.008 0.0274 0.097
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0023 0.004 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.013 0.1918
Onchocerca volvulus 0.0019 0.0025 0.0126
Plasmodium falciparum ataxin-2 like protein, putative 0.0179 0.0676 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.001 0.0038
Mycobacterium ulcerans L-lysine aminotransferase 0.0023 0.004 0.0666
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.004 0.0666
Brugia malayi hypothetical protein 0.0302 0.1181 0.1181
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.023 0.0871
Echinococcus granulosus caspase 0.0141 0.0524 0.1981
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0166 0.2666
Loa Loa (eye worm) inositol-1 0.0045 0.013 0.013
Loa Loa (eye worm) MH1 domain-containing protein 0.0075 0.0254 0.0254
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.013 0.0647
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0023 0.004 0.004
Toxoplasma gondii kringle domain-containing protein 0.0019 0.0025 0.0365
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0081 0.0277 0.4098
Leishmania major metacaspase, putative 0.0053 0.0166 0.245
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0166 0.2164
Mycobacterium leprae Possible regulatory protein 0.0015 0.001 0.0168
Schistosoma mansoni tar DNA-binding protein 0.0661 0.2645 0.9352
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.013 0.2053
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0023 0.004 0.0666
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.013 1
Echinococcus granulosus single minded 2 0.0043 0.0125 0.0473
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0661 0.2645 0.2645
Trypanosoma cruzi PAB1-binding protein , putative 0.0179 0.0676 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0081 0.0277 0.098
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.013 0.0491
Brugia malayi isocitrate dehydrogenase 0.0081 0.0277 0.0277
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0043 0.0727
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0043 0.0043
Loa Loa (eye worm) latrophilin receptor protein 2 0.0327 0.1281 0.1281
Echinococcus granulosus mothers against decapentaplegic 5 0.0168 0.0633 0.2392
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.008 0.0274 0.1037
Loa Loa (eye worm) MH1 domain-containing protein 0.0168 0.0633 0.0633
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.023 0.3878
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0166 0.2666
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0043 0.0638
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0017 0.0018 0.0266
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.013 0.1921
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0168 0.0633 0.2237
Schistosoma mansoni tar DNA-binding protein 0.0661 0.2645 0.9352
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0166 0.2666
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.001 0.0148
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0081 0.0277 0.1047
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0043 0.0638
Trypanosoma brucei Metacaspase-4 0.0053 0.0166 0.245
Schistosoma mansoni smad1 5 8 and 0.0168 0.0633 0.2237
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0023 0.004 0.0666
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0158 0.0594 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0327 0.1281 0.1281
Entamoeba histolytica hypothetical protein 0.0109 0.0392 0.2541
Brugia malayi MH2 domain containing protein 0.0168 0.0633 0.0633
Loa Loa (eye worm) MH2 domain-containing protein 0.0168 0.0633 0.0633
Brugia malayi hypothetical protein 0.0179 0.0676 0.0676
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.013 0.049
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0023 0.004 0.0666
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0017 0.0018 0.0137
Brugia malayi Cytochrome P450 family protein 0.0023 0.0043 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0661 0.2645 0.9352
Schistosoma mansoni caspase-7 (C14 family) 0.0103 0.0369 0.1303
Schistosoma mansoni Smad4 0.0075 0.0254 0.0897
Mycobacterium tuberculosis Probable aminotransferase 0.0158 0.0594 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0166 0.2666
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0081 0.0277 0.1047
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.023 0.3878
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0125 0.0473
Echinococcus granulosus mothers against decapentaplegic 2 0.0075 0.0254 0.096
Brugia malayi Smad1 0.0168 0.0633 0.0633
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.023 0.023
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0081 0.0277 0.4098
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0327 0.1281 0.4843
Plasmodium falciparum ataxin-2 like protein, putative 0.0179 0.0676 1
Brugia malayi hypothetical protein 0.0197 0.0752 0.0752
Toxoplasma gondii isocitrate dehydrogenase 0.0081 0.0277 0.4098
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.013 0.205
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.013 0.0459
Loa Loa (eye worm) hypothetical protein 0.0327 0.1281 0.1281
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.001 0.0148
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.013 0.1921
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.013 0.2053
Schistosoma mansoni caspase-7 (C14 family) 0.0141 0.0524 0.1852
Brugia malayi MH1 domain containing protein 0.0093 0.0326 0.0326
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0081 0.0277 0.4098
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.001 0.0148
Loa Loa (eye worm) hypothetical protein 0.0093 0.0326 0.0326
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0166 0.2666
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.023 0.0814
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.013 0.0491
Loa Loa (eye worm) hypothetical protein 0.0181 0.0686 0.0686
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0392 0.1386
Loa Loa (eye worm) hypothetical protein 0.005 0.0151 0.0151
Brugia malayi hypothetical protein 0.005 0.0151 0.0151
Mycobacterium ulcerans hypothetical protein 0.0158 0.0594 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0081 0.0277 0.4098
Leishmania major hypothetical protein, conserved 0.0179 0.0676 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.0752 0.0752
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0017 0.0018 0.0137
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0081 0.0277 0.3874
Echinococcus granulosus caspase 2 0.0103 0.0369 0.1394
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0327 0.1281 0.4843
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0017 0.0018 0.0266
Trypanosoma cruzi PAB1-binding protein , putative 0.0179 0.0676 1
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0043 0.0043
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.004 0.0666
Trypanosoma brucei metacaspase 0.0053 0.0166 0.245
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0075 0.0254 0.2082
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0111 0.1862
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.001 0.0148
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.013 0.205
Echinococcus multilocularis Aminotransferase class III 0.0023 0.004 0.015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1033 0.4162 0.4162
Schistosoma mansoni Smad4 0.0168 0.0633 0.2237
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0247 0.3651
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0166 0.2666
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0166 0.2666
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.013 0.0491
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0247 0.4156
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.0087
Loa Loa (eye worm) hypothetical protein 0.0302 0.1181 0.1181
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0023 0.004 0.004
Echinococcus multilocularis isocitrate dehydrogenase 0.0081 0.0277 0.1047
Brugia malayi Isocitrate dehydrogenase 0.0081 0.0277 0.0277
Schistosoma mansoni hypothetical protein 0.0327 0.1281 0.4529
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0166 0.2666
Loa Loa (eye worm) MH2 domain-containing protein 0.0075 0.0254 0.0254
Brugia malayi RNA recognition motif domain containing protein 0.0661 0.2645 0.2645
Brugia malayi MH2 domain containing protein 0.0075 0.0254 0.0254
Leishmania major protein kinase, putative 0.0015 0.001 0.0148
Leishmania major protein kinase, putative 0.0019 0.0026 0.0383
Echinococcus multilocularis smad 0.0168 0.0633 0.2392
Toxoplasma gondii LsmAD domain-containing protein 0.0179 0.0676 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0166 0.245
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.004 0.015
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.023 0.3878
Brugia malayi MH1 domain containing protein 0.0168 0.0633 0.0633
Schistosoma mansoni smad 0.0075 0.0254 0.0897
Plasmodium falciparum metacaspase-like protein 0.0053 0.0166 0.2164
Onchocerca volvulus 0.005 0.0151 0.1201
Trypanosoma brucei metacaspase 5, putative 0.0053 0.0166 0.245
Echinococcus granulosus caspase 8 0.0053 0.0166 0.0626
Brugia malayi TAR-binding protein 0.0661 0.2645 0.2645
Schistosoma mansoni hypothetical protein 0.0327 0.1281 0.4529
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1033 0.4162 0.4162
Echinococcus multilocularis caspase 2 0.0103 0.0369 0.1394
Brugia malayi hypothetical protein 0.0115 0.0418 0.0418
Giardia lamblia DNA repair protein RAD52 0.0362 0.1426 1
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0023 0.004 0.0666
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0166 0.245
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.013 0.1918
Echinococcus granulosus mothers against decapentaplegic 6 0.0075 0.0254 0.096
Trypanosoma cruzi metacaspase, putative 0.0053 0.0166 0.245
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.008 0.0274 0.1037
Echinococcus multilocularis caspase 8 0.0053 0.0166 0.0626
Entamoeba histolytica hypothetical protein 0.0109 0.0392 0.2541
Schistosoma mansoni hypothetical protein 0.0109 0.0392 0.1386
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0166 0.2666
Toxoplasma gondii isocitrate dehydrogenase 0.0081 0.0277 0.4098
Entamoeba histolytica hypothetical protein 0.0109 0.0392 0.2541
Plasmodium vivax metacaspase 1, putative 0.0053 0.0166 0.2164
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0081 0.0277 0.1047
Brugia malayi Calcitonin receptor-like protein seb-1 0.1033 0.4162 0.4162
Echinococcus multilocularis tar DNA binding protein 0.0661 0.2645 1
Schistosoma mansoni tar DNA-binding protein 0.0661 0.2645 0.9352
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.001 0.0038
Echinococcus granulosus Aminotransferase class III 0.0023 0.004 0.015
Schistosoma mansoni caspase-3 (C14 family) 0.0141 0.0524 0.1852
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.001 0.0038
Echinococcus multilocularis mothers against decapentaplegic 5 0.0168 0.0633 0.2392
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0081 0.0277 0.4098
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0168 0.0633 0.2392
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.004 0.0666
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0103 0.0368 0.2368
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.001 0.0148
Loa Loa (eye worm) hypothetical protein 0.0706 0.2828 0.2828
Trypanosoma cruzi metacaspase, putative 0.0053 0.0166 0.245
Echinococcus multilocularis caspase 3 0.0088 0.0306 0.1157
Schistosoma mansoni single-minded 0.0059 0.0187 0.0662
Plasmodium falciparum metacaspase 1 0.0053 0.0166 0.2164
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.001 0.0148
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0017 0.0018 0.0266
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.013 0.1918
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0158 0.0594 1
Echinococcus granulosus tissue type plasminogen activator 0.0019 0.0025 0.0093
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.013 0.1921
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.0686 0.5776
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.004 0.015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0247 0.4156
Loa Loa (eye worm) TK/ROR protein kinase 0.0019 0.0025 0.0025
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0166 0.2666
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0023 0.004 0.0151
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.013 0.0491
Echinococcus multilocularis GPCR, family 2 0.0327 0.1281 0.4843
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0247 0.0873
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0392 0.1482
Trypanosoma brucei metacaspase MCA3 0.0053 0.0166 0.245
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.004 0.0666
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.013 0.013
Echinococcus granulosus TGF beta signal transducer SmadC 0.0168 0.0633 0.2392
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0247 0.0873
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0247 0.0933
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0043 0.0638
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.001 0.0148
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.013 0.1918
Loa Loa (eye worm) nuclear factor I 0.0093 0.0326 0.0326
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0081 0.0277 0.1047
Brugia malayi MH1 domain containing protein 0.0093 0.0326 0.0326
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0166 0.2666
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0081 0.0277 0.1047
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0247 0.4156
Brugia malayi RNA binding protein 0.0661 0.2645 0.2645
Leishmania major hypothetical protein, conserved 0.0019 0.0025 0.0365
Echinococcus multilocularis apoptotic protease activating factor 1 0.005 0.0151 0.057
Schistosoma mansoni inositol monophosphatase 0.0045 0.013 0.0458
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.013 0.049
Schistosoma mansoni smad 0.0168 0.0633 0.2237
Trypanosoma cruzi metacaspase, putative 0.0053 0.0166 0.245
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0166 0.245
Loa Loa (eye worm) TAR-binding protein 0.0661 0.2645 0.2645

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.511886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 10 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 915 ] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 914 ] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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