TDR Targets

Basic information

Technical information

TDR Targets ID: 1292215
Name: T5262757
MW: 388.527 | Formula: C20H28N4O2S
H donors: 2 H acceptors: 4 LogP: 4.75 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCc1nnc(s1)NC(=O)[C@H](C(C)C)NC(=O)c1ccc(cc1)C(C)(C)C
InChi: 1S/C20H28N4O2S/c1-7-15-23-24-19(27-15)22-18(26)16(12(2)3)21-17(25)13-8-10-14(11-9-13)20(4,5)6/h8-12,16H,7H2,1-6H3,(H,21,25)(H,22,24,26)/t16-/m0/s1
InChiKey: IJSKZYYDBCECDJ-INIZCTEOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

MLS000389886
SMR000256160
ZINC02623238

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	hypothetical protein, conserved	0.0039	0.0427	0.5028
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0266	0.313
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0427	0.0427
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0081	0.1708	0.1708
Schistosoma mansoni	hypothetical protein	0.0183	0.4753	0.4753
Entamoeba histolytica	hypothetical protein	0.0041	0.0478	1
Trichomonas vaginalis	esterase, putative	0.0039	0.0427	0.0542
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0134	0.3289	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0059	0.102	0.102
Plasmodium falciparum	importin beta, putative	0.0033	0.0266	0.1555
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0053	0.0849	0.0671
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0051	0.0806	1
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0427	0.1016
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0081	0.1708	0.172
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0427	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1708	0.1708
Toxoplasma gondii	thioredoxin reductase	0.0053	0.0849	0.497
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0059	0.1026	0.1302
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0081	0.1708	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0146	0.0854
Brugia malayi	mbt repeat family protein	0.0051	0.0806	0.1023
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0075	0.0096
Schistosoma mansoni	tar DNA-binding protein	0.0137	0.3385	0.3385
Entamoeba histolytica	hypothetical protein	0.0041	0.0478	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0059	0.1026	0.1302
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0059	0.1026	0.1026
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0266	0.1555
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0121	0.2885	0.873
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0238	0.0302
Echinococcus granulosus	geminin	0.0183	0.4753	0.4753
Echinococcus granulosus	polycomb protein SCMH1	0.0051	0.0806	0.0806
Brugia malayi	beta-lactamase family protein	0.0039	0.0427	0.0542
Schistosoma mansoni	importin beta-1	0.0033	0.0266	0.0266
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0081	0.1708	1
Plasmodium vivax	glutathione reductase, putative	0.0053	0.0849	0.497
Echinococcus granulosus	lamin dm0	0.0033	0.0238	0.0238
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0081	0.1708	1
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0266	0.0266
Brugia malayi	intermediate filament protein	0.0033	0.0238	0.0302
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0075	0.0096
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0248	0.6716	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0028	0.0103	0.0603
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0053	0.0864	0.2389
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0053	0.0864	0.0696
Echinococcus granulosus	lamin	0.0033	0.0238	0.0238
Mycobacterium ulcerans	glutaminase	0.0287	0.7877	1
Echinococcus multilocularis	tar DNA binding protein	0.0137	0.3385	0.3385
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0427	0.5028
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0053	0.0849	0.0849
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0146	0.1718
Mycobacterium tuberculosis	Probable reductase	0.0121	0.2885	0.3908
Echinococcus granulosus	thioredoxin glutathione reductase	0.0053	0.0849	0.0849
Entamoeba histolytica	hypothetical protein	0.0027	0.0075	0.1577
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0121	0.2885	0.3908
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0081	0.1708	0.1708
Brugia malayi	Probable ClpP-like protease	0.0081	0.1708	0.2168
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0427	0.0427
Schistosoma mansoni	glutaminase	0.0287	0.7877	0.7877
Onchocerca volvulus		0.0051	0.0806	1
Echinococcus granulosus	peptidase Clp S14 family	0.0053	0.0864	0.0864
Schistosoma mansoni	lamin	0.0033	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0427	0.0427
Schistosoma mansoni	tar DNA-binding protein	0.0137	0.3385	0.3385
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0134	0.3289	0.4551
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0059	0.102	0.102
Brugia malayi	hypothetical protein	0.0041	0.0478	0.0606
Brugia malayi	TAR-binding protein	0.0137	0.3385	0.4298
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0146	0.1718
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0081	0.1708	0.5
Brugia malayi	Thioredoxin reductase	0.0053	0.0849	0.1078
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0053	0.0864	0.0696
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0427	0.0542
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0146	0.0854
Entamoeba histolytica	hypothetical protein	0.0041	0.0478	1
Loa Loa (eye worm)	RNA binding protein	0.0137	0.3385	0.3385
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0266	0.0266
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0121	0.2885	0.3908
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0427	0.5028
Onchocerca volvulus		0.0039	0.0427	0.3325
Schistosoma mansoni	tar DNA-binding protein	0.0137	0.3385	0.3385
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0467	0.0593
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0427	0.0427
Loa Loa (eye worm)	hypothetical protein	0.004	0.0467	0.0467
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0081	0.1708	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0427	0.0542
Schistosoma mansoni	sex comb on midleg homolog	0.0051	0.0806	0.0806
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0051	0.0806	0.0806
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0427	0.0427
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0238	0.0238
Brugia malayi	RNA, U transporter 1	0.0095	0.2121	0.2692
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0081	0.1708	0.5037
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0028	0.0103	0.0603
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0427	0.0542
Brugia malayi	glutaminase DH11.1	0.0287	0.7877	1
Plasmodium vivax	thioredoxin reductase, putative	0.0053	0.0849	0.497
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0238	0.0238
Brugia malayi	beta-lactamase	0.0039	0.0427	0.0542
Brugia malayi	glutathione reductase	0.0053	0.0849	0.1078
Schistosoma mansoni	lamin	0.0033	0.0238	0.0238
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0121	0.2885	0.3908
Echinococcus granulosus	histone acetyltransferase MYST2	0.0059	0.102	0.102
Toxoplasma gondii	hypothetical protein	0.0028	0.0103	0.0603
Echinococcus multilocularis	musashi	0.0033	0.0238	0.0238
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0146	0.1718
Echinococcus multilocularis	lamin	0.0033	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0806	0.0806
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0134	0.3289	0.4551
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0427	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0032	0.022	0.022
Loa Loa (eye worm)	glutaminase	0.0287	0.7877	0.7877
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0146	0.0854
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0081	0.1708	0.172
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0427	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0427	0.0427
Echinococcus multilocularis	geminin	0.0183	0.4753	0.4753
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0081	0.1708	0.5
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0053	0.0864	0.0864
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0075	0.0888
Brugia malayi	beta-lactamase family protein	0.0039	0.0427	0.0542
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0266	0.313
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0059	0.102	0.1295
Schistosoma mansoni	peptidase Clp (S14 family)	0.0081	0.1708	0.1708
Loa Loa (eye worm)	mbt repeat family protein	0.0051	0.0806	0.0806
Schistosoma mansoni	hypothetical protein	0.004	0.0467	0.0467
Loa Loa (eye worm)	thioredoxin reductase	0.0053	0.0849	0.0849
Mycobacterium tuberculosis	Probable dehydrogenase	0.0121	0.2885	0.3908
Schistosoma mansoni	tar DNA-binding protein	0.0137	0.3385	0.3385
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0075	0.0888
Loa Loa (eye worm)	glutathione reductase	0.0053	0.0849	0.0849
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0203	0.5353	0.5353
Brugia malayi	Importin beta-1 subunit	0.0033	0.0266	0.0337
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0427	0.1016
Leishmania major	trypanothione reductase	0.0053	0.0849	1
Loa Loa (eye worm)	MBCTL1	0.0059	0.102	0.102
Loa Loa (eye worm)	hypothetical protein	0.003	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0266	0.0266
Brugia malayi	RNA binding protein	0.0137	0.3385	0.4298
Onchocerca volvulus		0.0039	0.0427	0.3325
Trypanosoma brucei	trypanothione reductase	0.0053	0.0849	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0478	0.0478
Trypanosoma cruzi	trypanothione reductase, putative	0.0053	0.0849	1
Plasmodium falciparum	thioredoxin reductase	0.0053	0.0849	0.497
Onchocerca volvulus		0.0039	0.0427	0.3325
Schistosoma mansoni	tar DNA-binding protein	0.0137	0.3385	0.3385
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0146	0.0854
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0059	0.102	0.102
Trichomonas vaginalis	glutaminase, putative	0.0287	0.7877	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0478	0.0478
Echinococcus granulosus	SAM and MBT domain containing protein	0.0051	0.0806	0.0806
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0051	0.0806	0.0806
Brugia malayi	hypothetical protein	0.003	0.0146	0.0185
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0238	0.0238
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0427	0.2499
Echinococcus granulosus	tar DNA binding protein	0.0137	0.3385	0.3385
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0427	0.0542
Entamoeba histolytica	hypothetical protein	0.0041	0.0478	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1026	0.1026
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0266	0.1555
Mycobacterium tuberculosis	Probable oxidoreductase	0.0134	0.3289	0.4551
Loa Loa (eye worm)	TAR-binding protein	0.0137	0.3385	0.3385
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0081	0.1708	1
Echinococcus multilocularis	lamin dm0	0.0033	0.0238	0.0238
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0075	0.0096
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0478	0.0478
Schistosoma mansoni	hypothetical protein	0.0183	0.4753	0.4753
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0427	0.0427
Echinococcus granulosus	intermediate filament protein	0.0033	0.0238	0.0238
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0059	0.102	0.102
Plasmodium falciparum	glutathione reductase	0.0053	0.0849	0.497
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0121	0.2885	0.3908
Echinococcus multilocularis	polycomb protein SCMH1	0.0051	0.0806	0.0806
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0203	0.5353	0.5353
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0137	0.3385	0.3385
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0478	0.0478
Brugia malayi	RNA recognition motif domain containing protein	0.0137	0.3385	0.4298
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0427	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0059	0.102	0.102
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0427	0.5028
Schistosoma mansoni	hypothetical protein	0.0313	0.866	0.866
Leishmania major	hypothetical protein, conserved	0.003	0.0146	0.1718
Schistosoma mansoni	sex comb on midleg homolog	0.0051	0.0806	0.0806
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0427	0.0427
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0427	0.0427
Loa Loa (eye worm)	glutaminase 2	0.0287	0.7877	0.7877
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0081	0.1708	0.5
Brugia malayi	mbt repeat family protein	0.0051	0.0806	0.1023
Toxoplasma gondii	ABC1 family protein	0.0039	0.0427	0.2499
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0427	0.0542

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.7157 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	32.6427 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1398816

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1292215