Detailed information for compound 1292441

Basic information

Technical information
  • TDR Targets ID: 1292441
  • Name: T5263273
  • MW: 385.391 | Formula: C19H15NO6S
  • H donors: 1 H acceptors: 5 LogP: 1.98 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CC1)COC(=O)c1ccc2c(c1)S(=O)(=O)c1c(C2=O)cccc1
  • InChi: 1S/C19H15NO6S/c21-17(20-12-6-7-12)10-26-19(23)11-5-8-14-16(9-11)27(24,25)15-4-2-1-3-13(15)18(14)22/h1-5,8-9,12H,6-7,10H2,(H,20,21)
  • InChiKey: QBRPGNXWYBIMAE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_175706
  • MLS001003838
  • SMR000377660
  • ZINC02623787

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0148 0.0285 0.5034
Loa Loa (eye worm) hypothetical protein 0.0282 0.0559 0.1648
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0115 0.034
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0282 0.0559 0.1648
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0282 0.0559 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0008 0.0023
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0017 0.06
Echinococcus granulosus cpg binding protein 0.0031 0.0046 0.0137
Trypanosoma cruzi UDP-galactopyranose mutase 0.0066 0.0117 0.1759
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0102 0.0192 0.101
Echinococcus multilocularis traf and tnf receptor associated protein 0.0028 0.004 0.004
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0028 0.004 0.0116
Loa Loa (eye worm) hypothetical protein 0.0099 0.0185 0.0546
Loa Loa (eye worm) hypothetical protein 0.1669 0.3392 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0028 0.004 0.0116
Schistosoma mansoni ran 0.0045 0.0076 0.0223
Plasmodium vivax SET domain protein, putative 0.0033 0.0051 0.1489
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0008 0.0023
Brugia malayi Muscleblind-like protein 0.018 0.0351 0.1036
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0028 0.004 0.1178
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0133 0.0619
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0054 0.0093 0.0278
Loa Loa (eye worm) hypothetical protein 0.0033 0.0051 0.0149
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0066 0.0117 0.3725
Echinococcus granulosus BC026374 protein S09 family 0.0282 0.0559 0.1648
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1669 0.3392 1
Loa Loa (eye worm) hypothetical protein 0.0282 0.0559 0.1648
Echinococcus granulosus geminin 0.1238 0.2511 0.7401
Schistosoma mansoni hypothetical protein 0.0068 0.0121 0.0358
Onchocerca volvulus 0.0282 0.0559 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0208 0.1102
Echinococcus granulosus acetylcholinesterase 0.1669 0.3392 1
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0028 0.004 0.111
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0233 0.1247
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0683 0.1379 0.7861
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0028 0.004 0.0116
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0028 0.004 0.0116
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0208 0.1102
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0028 0.004 0.1308
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0004 0.0004
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0028 0.004 0.0568
Loa Loa (eye worm) acetyltransferase 0.0172 0.0334 0.0985
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0012 0.0008 0.0021
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0067 0.0887
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0008 0.0023
Schistosoma mansoni peroxidasin 0.0065 0.0115 0.034
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0085 0.1421
Echinococcus granulosus translational activator gcn1 0.0012 0.0007 0.002
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0156 0.0302 1
Echinococcus multilocularis importin 5 0.0012 0.0007 0.0007
Giardia lamblia Fructose-bisphosphate aldolase 0.0148 0.0285 1
Trypanosoma cruzi mitochondrial protein 99, putative 0.0028 0.004 0.0396
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0028 0.004 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.0583 1
Echinococcus granulosus expressed protein 0.0012 0.0008 0.0023
Onchocerca volvulus 0.0065 0.0115 0.2062
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0078 0.2724
Loa Loa (eye worm) hypothetical protein 0.0156 0.0302 0.089
Schistosoma mansoni amine oxidase 0.0066 0.0117 0.0344
Echinococcus granulosus carboxylesterase 5A 0.1669 0.3392 1
Schistosoma mansoni ran 0.0045 0.0076 0.0223
Onchocerca volvulus Peroxidase homolog 0.0065 0.0115 0.2062
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0017 0.0179
Echinococcus multilocularis GPCR, family 2 0.0031 0.0047 0.0047
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0137 0.0263 0.8692
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0115 0.034
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0086 0.1438
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0133 0.0667
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0082 0.2534
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0086 0.2854
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0185 0.0546
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0028 0.004 0.004
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.0583 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0017 0.0017
Schistosoma mansoni peptidase Clp (S14 family) 0.0156 0.0302 0.089
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0133 0.0391
Echinococcus multilocularis snurportin 1 0.066 0.133 0.133
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0056 0.0225
Leishmania major hypothetical protein, conserved 0.0028 0.004 0.0568
Echinococcus multilocularis deoxyribonuclease 1 2 0.0028 0.004 0.004
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0115 0.034
Chlamydia trachomatis protoporphyrinogen oxidase 0.0066 0.0117 0.3498
Brugia malayi beta-lactamase family protein 0.0036 0.0056 0.0165
Brugia malayi Carboxylesterase family protein 0.0282 0.0559 0.1648
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0051 0.0149
Schistosoma mansoni ap endonuclease 0.0137 0.0263 0.0776
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0028 0.004 0.1308
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.0302 1
Loa Loa (eye worm) kap beta 3 protein 0.0012 0.0007 0.002
Brugia malayi Carboxylesterase family protein 0.0282 0.0559 0.1648
Mycobacterium ulcerans hypothetical protein 0.0155 0.0299 0.1512
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0115 0.034
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0028 0.004 0.0396
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0066 0.0117 0.0459
Mycobacterium ulcerans oxidoreductase 0.0066 0.0117 0.0534
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0008 0.0021
Echinococcus granulosus snurportin 1 0.066 0.133 0.3921
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0067 0.105
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0017 0.0179
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0133 0.0391
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0028 0.004 0.1178
Echinococcus granulosus para nitrobenzyl esterase 0.0282 0.0559 0.1648
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0051 0.1679
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0008 0.0024
Echinococcus multilocularis protoporphyrinogen oxidase 0.0066 0.0117 0.0117
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0233 0.1247
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0017 0.0179
Echinococcus multilocularis transportin 1 0.0012 0.0007 0.0007
Schistosoma mansoni acetylcholinesterase 0.0282 0.0559 0.1648
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0076 0.1036
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0137 0.0263 0.4449
Echinococcus multilocularis para nitrobenzyl esterase 0.0282 0.0559 0.0559
Toxoplasma gondii hypothetical protein 0.0054 0.0093 0.3074
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0208 0.1102
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0004 0.0012
Toxoplasma gondii histone lysine-specific demethylase 0.0066 0.0117 0.3866
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0028 0.004 0.0568
Loa Loa (eye worm) carboxylesterase 0.1669 0.3392 1
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0115 0.034
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0008 0.0008
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.0008 0.0023
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0028 0.004 0.0116
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0109 0.1774
Schistosoma mansoni hypothetical protein 0.0031 0.0047 0.0138
Echinococcus granulosus muscleblind protein 0.018 0.0351 0.1036
Brugia malayi amine oxidase, flavin-containing family protein 0.0066 0.0117 0.0344
Schistosoma mansoni hypothetical protein 0.1238 0.2511 0.7401
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0028 0.004 0.0396
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0172 0.0334 0.0985
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0137 0.0263 0.4449
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0008 0.0023
Loa Loa (eye worm) importin-beta domain-containing protein 0.0012 0.0007 0.002
Leishmania major hypothetical protein, conserved 0.0028 0.004 0.0568
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0056 0.0165
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0282 0.0559 0.1648
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0076 0.0223
Giardia lamblia Inositol 5-phosphatase 4 0.0028 0.004 0.1388
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0109 0.1774
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0017 0.035
Toxoplasma gondii ABC1 family protein 0.0036 0.0056 0.1855
Schistosoma mansoni BC026374 protein (S09 family) 0.0282 0.0559 0.1648
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0344
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0137 0.0263 0.9249
Onchocerca volvulus 0.0259 0.0512 0.9158
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0085 0.1421
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0028 0.004 0.0116
Brugia malayi RNA, U transporter 1 0.0176 0.0342 0.1007
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0047 0.0138
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0066 0.0117 0.0534
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0028 0.004 0.1178
Echinococcus granulosus importin 5 0.0012 0.0007 0.002
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0117 0.3725
Brugia malayi Thioredoxin reductase 0.0048 0.0082 0.024
Echinococcus multilocularis muscleblind protein 0.018 0.0351 0.0351
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.0008 0.0023
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Onchocerca volvulus 0.0029 0.0043 0.0769
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0047 0.0138
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0172 0.0334 0.0334
Onchocerca volvulus 0.0282 0.0559 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0056 0.0687
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0285 0.0565 0.1666
Trichomonas vaginalis set domain proteins, putative 0.0259 0.0512 0.9148
Brugia malayi Peroxidasin 0.0065 0.0115 0.034
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0028 0.004 0.111
Onchocerca volvulus 0.0012 0.0008 0.0141
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0115 0.034
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0028 0.004 0.1308
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0047 0.0047
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0078 0.2547
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0076 0.2338
Onchocerca volvulus 0.0036 0.0056 0.1002
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0007 0.0224
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0148 0.0285 0.5034
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0008 0.0023
Loa Loa (eye worm) hypothetical protein 0.0028 0.004 0.0116
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0137 0.0263 0.1421
Echinococcus multilocularis translational activator gcn1 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0056 0.0165
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0028 0.004 0.0116
Echinococcus multilocularis acetylcholinesterase 0.1669 0.3392 0.3392
Loa Loa (eye worm) hypothetical protein 0.0028 0.004 0.0116
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.093 0.1883 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0066 0.0117 0.0344
Onchocerca volvulus Peroxidasin homolog 0.0065 0.0115 0.2062
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0008 0.0024
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0233 0.1247
Trichomonas vaginalis spcc417.12 protein, putative 0.0282 0.0559 1
Schistosoma mansoni nocturnin 0.0028 0.004 0.0116
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0008 0.0023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0043 0.0127
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0156 0.0302 1
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0012 0.0008 0.0021
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0102 0.0192 0.101
Echinococcus multilocularis geminin 0.1238 0.2511 0.2511
Entamoeba histolytica G protein alpha subunit, putative 0.0012 0.0008 0.0041
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0047 0.0138
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0285 0.0565 0.0565
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.0008 0.0023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.045 0.25
Onchocerca volvulus 0.0065 0.0115 0.2062
Schistosoma mansoni hypothetical protein 0.0031 0.0047 0.0138
Brugia malayi EGF-like domain containing protein 0.0008 0.0000000027852 0.0000000082111
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0056 0.0225
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0082 0.024
Trichomonas vaginalis ran, putative 0.0045 0.0076 0.125
Loa Loa (eye worm) blistered cuticle protein 3 0.0065 0.0115 0.034
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0056 0.0165
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0017 0.0179
Schistosoma mansoni cript-related 0.0028 0.004 0.0116
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0017 0.0187
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0115 0.034
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0028 0.004 0.0568
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0028 0.004 0.0593
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0008 0.0023
Trypanosoma brucei trypanothione reductase 0.0048 0.0082 0.1297
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0008 0.0021
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0066 0.0117 0.0117
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0133 0.0619
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0285 0.0565 0.1666
Loa Loa (eye worm) hypothetical protein 0.0036 0.0056 0.0165
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0056 0.0056
Schistosoma mansoni synaptojanin 0.0028 0.004 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.0565 0.1666
Plasmodium falciparum thioredoxin reductase 0.0048 0.0082 0.2534
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0076 0.2509
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0056 0.0225
Plasmodium falciparum thioredoxin reductase 0.0017 0.0017 0.035
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0299 0.1629
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0086 0.1213
Trichomonas vaginalis esterase, putative 0.0036 0.0056 0.0892
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0028 0.004 0.0396
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0028 0.004 0.0593
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0067 0.0887
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.0448 0.132
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0028 0.004 0.1178
Onchocerca volvulus 0.0282 0.0559 1
Brugia malayi hypothetical protein 0.0066 0.0117 0.0344
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.0008 0.0008
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0282 0.0559 0.1648
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0017 0.005
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Brugia malayi beta-lactamase family protein 0.0036 0.0056 0.0165
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0028 0.004 0.0396
Trypanosoma cruzi UDP-galactopyranose mutase 0.0066 0.0117 0.1759
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0137 0.0263 0.0263
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0156 0.0302 0.089
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0028 0.004 0.1308
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0008 0.0023
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0344
Schistosoma mansoni cpg binding protein 0.0031 0.0046 0.0137
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0047 0.0138
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0028 0.004 0.111
Mycobacterium ulcerans hypothetical protein 0.0036 0.0056 0.0209
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0028 0.004 0.1178
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0017 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0051 0.0149
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0017 0.035
Loa Loa (eye worm) hypothetical protein 0.0031 0.0047 0.0138
Entamoeba histolytica hypothetical protein 0.005 0.0085 0.2822
Echinococcus granulosus neuroligin 0.0282 0.0559 0.1648
Leishmania major UDP-galactopyranose mutase 0.0066 0.0117 0.1907
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0148 0.0285 0.5034
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0683 0.1379 1
Schistosoma mansoni synaptojanin 0.0028 0.004 0.0116
Leishmania major hypothetical protein, conserved 0.0028 0.004 0.0568
Echinococcus multilocularis muscleblind protein 1 0.018 0.0351 0.0351
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0066 0.0117 0.3725
Echinococcus multilocularis carboxylesterase 5A 0.1669 0.3392 0.3392
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0028 0.004 0.0568
Brugia malayi CCR4 0.0028 0.004 0.0116
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0028 0.004 0.0116
Loa Loa (eye worm) hypothetical protein 0.0036 0.0056 0.0165
Trypanosoma cruzi mitochondrial protein 99, putative 0.0028 0.004 0.0396
Brugia malayi G-protein alpha subunit 0.0012 0.0008 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0051 0.0149
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0028 0.004 0.1178
Loa Loa (eye worm) hypothetical protein 0.0282 0.0559 0.1648
Loa Loa (eye worm) hypothetical protein 0.0008 0.0000000027852 0.0000000082111
Loa Loa (eye worm) hypothetical protein 0.0036 0.0056 0.0165
Mycobacterium ulcerans beta-lactamase 0.0036 0.0056 0.0209
Schistosoma mansoni hypothetical protein 0.1238 0.2511 0.7401
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0000000027852 0.0000000082111
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0012 0.0008 0.0021
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0282 0.0559 0.3128
Leishmania major hypothetical protein, conserved 0.0036 0.0056 0.0854
Mycobacterium tuberculosis Carboxylesterase LipT 0.0282 0.0559 0.3128
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0028 0.004 0.0568
Toxoplasma gondii HEAT repeat-containing protein 0.0062 0.0109 0.3612
Brugia malayi Pre-SET motif family protein 0.0228 0.0448 0.132
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0156 0.0302 0.1859
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0012 0.0008 0.0021
Brugia malayi SWIRM domain containing protein 0.0066 0.0117 0.0344
Brugia malayi kap beta 3 protein 0.0012 0.0007 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0148 0.0285 0.5034
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0008 0.0008
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0156 0.0302 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0344
Loa Loa (eye worm) hypothetical protein 0.0282 0.0559 0.1648
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0000000027852 0.0000000027852
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0185 0.0546
Schistosoma mansoni neutral sphingomyelinase 0.0028 0.004 0.0116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0148 0.0285 0.5034
Onchocerca volvulus Putative neutral sphingomyelinase 0.0028 0.004 0.0707
Loa Loa (eye worm) hypothetical protein 0.0282 0.0559 0.1648
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0093 0.2915
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0028 0.004 0.0593
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0017 0.0179
Brugia malayi Carboxylesterase family protein 0.1669 0.3392 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0047 0.0047
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0056 0.0165
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0017 0.005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0056 0.0209
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0282 0.0559 0.3128
Schistosoma mansoni importin beta-1 0.0062 0.0109 0.0322
Loa Loa (eye worm) hypothetical protein 0.0068 0.0121 0.0358
Onchocerca volvulus 0.0028 0.004 0.0707
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0086 0.269
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0344
Mycobacterium tuberculosis Probable exported protein 0.0028 0.004 0.0129
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0004 0.0011
Echinococcus granulosus dnaJ subfamily B 0.0419 0.0839 0.2473
Leishmania major importin beta-1 subunit, putative 0.005 0.0085 0.136
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0056 0.0225
Treponema pallidum fructose-bisphosphate aldolase 0.0148 0.0285 0.9395
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0008 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0148 0.0285 0.5034
Brugia malayi Importin beta-1 subunit 0.0062 0.0109 0.0322
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0076 0.0223
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0282 0.0559 0.1648
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0056 0.0225
Echinococcus granulosus importin subunit beta 1 0.0062 0.0109 0.0322
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0148 0.0285 0.5034
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.0583 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0285 0.0565 0.1666
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.0302 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0056 0.0854
Onchocerca volvulus 0.0282 0.0559 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0094 0.0175 0.6038
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0148 0.0285 1
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0028 0.004 0.0568
Plasmodium falciparum DNase I-like protein, putative 0.0028 0.004 0.111
Mycobacterium tuberculosis Probable reductase 0.011 0.0208 0.1102
Loa Loa (eye worm) hypothetical protein 0.0094 0.0175 0.0515
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0133 0.2183
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0137 0.0263 0.4348
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0066 0.0117 0.3725
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0344
Plasmodium vivax glutathione reductase, putative 0.0048 0.0082 0.2534
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.0008 0.0023
Onchocerca volvulus 0.0033 0.0051 0.0907
Plasmodium falciparum glutathione reductase 0.0048 0.0082 0.2534
Mycobacterium tuberculosis Conserved hypothetical protein 0.0066 0.0117 0.0575
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0008 0.0008
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.0008 0.0023
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.0839 0.0839
Brugia malayi CXXC zinc finger family protein 0.0029 0.0043 0.0127
Echinococcus multilocularis 0.0066 0.0117 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0051 0.0149
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0115 0.034
Trichomonas vaginalis ap endonuclease, putative 0.0137 0.0263 0.4646
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0028 0.004 0.0116
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.0008 0.0023
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0028 0.004 0.0116
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0093 0.2915
Loa Loa (eye worm) hypothetical protein 0.018 0.0351 0.1036
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0156 0.0302 0.0302
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0076 0.2338
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0108 0.357
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0066 0.0117 0.3725
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0008 0.0023
Schistosoma mansoni hypothetical protein 0.0031 0.0047 0.0138
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0028 0.004 0.004
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0028 0.004 0.111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0051 0.0149
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0117 0.3725
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0865 0.1749 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0008 0.0023
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0028 0.004 0.0593
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0017 0.0179
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0017 0.0179
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0267 0.4515
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.093 0.1883 1
Schistosoma mansoni importin-beta 2 0.0012 0.0007 0.002
Plasmodium falciparum glutathione reductase 0.0017 0.0017 0.035
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Mycobacterium tuberculosis Conserved protein 0.0036 0.0056 0.0225
Leishmania major endonuclease/exonuclease protein-like protein 0.0028 0.004 0.0568
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0028 0.004 0.0116
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.0302 1
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0028 0.004 0.0396
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0267 0.4415
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0028 0.004 0.0116
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0133 0.0391
Toxoplasma gondii thioredoxin reductase 0.0048 0.0082 0.2701
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0028 0.004 0.1178
Onchocerca volvulus 0.0282 0.0559 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0086 0.2854
Plasmodium vivax exodeoxyribonuclease III, putative 0.0028 0.004 0.111
Echinococcus granulosus neutral sphingomyelinase 0.0028 0.004 0.0116
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0028 0.004 0.1308
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0082 0.1139
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0028 0.004 0.0593
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0102 0.0192 0.1028
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0028 0.004 0.1308
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0056 0.0892
Echinococcus granulosus transportin 1 0.0012 0.0007 0.002
Schistosoma mansoni gliotactin 0.0282 0.0559 0.1648
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0008 0.0023
Mycobacterium ulcerans lipase LipD 0.0036 0.0056 0.0209
Loa Loa (eye worm) beta-lactamase 0.0036 0.0056 0.0165
Plasmodium falciparum importin beta, putative 0.0062 0.0109 0.3466
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0208 0.1102
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0028 0.004 0.1178
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0028 0.004 0.0116
Echinococcus granulosus acetylcholinesterase 0.1669 0.3392 1
Loa Loa (eye worm) hypothetical protein 0.0282 0.0559 0.1648
Schistosoma mansoni hypothetical protein 0.0031 0.0047 0.0138
Brugia malayi Pre-SET motif family protein 0.0033 0.0051 0.0149
Echinococcus granulosus synaptojanin 1 0.0028 0.004 0.0116
Schistosoma mansoni peroxidasin 0.0065 0.0115 0.034
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0076 0.0076
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0028 0.004 0.0116
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0683 0.1379 0.7297
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0028 0.004 0.111
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0056 0.0165
Loa Loa (eye worm) hypothetical protein 0.0028 0.004 0.0116
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0028 0.004 0.004
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0017 0.005
Echinococcus multilocularis synaptojanin 1 0.0028 0.004 0.004
Echinococcus multilocularis neuroligin 0.0282 0.0559 0.0559
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0028 0.004 0.0593
Schistosoma mansoni hypothetical protein 0.0028 0.004 0.0116
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0008 0.0023
Echinococcus multilocularis peptidase Clp (S14 family) 0.0102 0.0192 0.0192
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0051 0.0051
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0007 0.0224
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0133 0.0133
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0008 0.0023
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0137 0.0263 0.0776
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0056 0.0165
Onchocerca volvulus Chorion peroxidase homolog 0.0065 0.0115 0.2062
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0185 0.0546
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0028 0.004 0.1308
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0028 0.004 0.0396
Echinococcus multilocularis neutral sphingomyelinase 0.0028 0.004 0.004
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0056 0.1669
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0208 0.1102
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Trichomonas vaginalis ap endonuclease, putative 0.0137 0.0263 0.4646
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0008 0.0000000027852 0.000000049832
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0028 0.004 0.1178
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0094 0.0175 0.6038
Echinococcus multilocularis peroxidasin 0.0065 0.0115 0.0115
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0028 0.004 0.0568
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0028 0.004 0.0396
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0047 0.0138
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.0302 0.1526
Giardia lamblia hypothetical protein 0.0028 0.004 0.1388
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0076 0.1036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.0565 0.1666
Brugia malayi exodeoxyribonuclease III family protein 0.0137 0.0263 0.0776
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0285 0.0565 0.1666
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0056 0.0225
Loa Loa (eye worm) hypothetical protein 0.1669 0.3392 1
Brugia malayi beta-lactamase 0.0036 0.0056 0.0165
Plasmodium vivax hypothetical protein, conserved 0.0028 0.004 0.111
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0023
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0028 0.004 0.0593
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0008 0.0023
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0028 0.004 0.1178
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0008 0.0021
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0093 0.2658
Brugia malayi Carboxylesterase family protein 0.0282 0.0559 0.1648
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0028 0.004 0.0568
Schistosoma mansoni hypothetical protein 0.0419 0.0839 0.2473
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0051 0.0051
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.0008 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0028 0.004 0.0396
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0148 0.0285 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0282 0.0559 0.1648
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0115 0.034
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0017 0.0566
Leishmania major trypanothione reductase 0.0048 0.0082 0.1297
Plasmodium falciparum protoporphyrinogen oxidase 0.0066 0.0117 0.3725
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0056 0.0225
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0208 0.1149
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0285 0.0565 0.0565
Brugia malayi hypothetical protein 0.0012 0.0008 0.0023
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0344
Echinococcus multilocularis acetylcholinesterase 0.1669 0.3392 0.3392
Trichomonas vaginalis Phospholipase C precursor, putative 0.0028 0.004 0.0593
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.0085 0.1203
Loa Loa (eye worm) histone methyltransferase 0.001 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0282 0.0559 0.1648
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0056 0.0892
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0028 0.004 0.0116
Plasmodium vivax importin-beta 2, putative 0.0062 0.0109 0.3466
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.0008 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0023
Echinococcus multilocularis importin subunit beta 1 0.0062 0.0109 0.0109
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0017 0.035
Echinococcus multilocularis expressed protein 0.0012 0.0008 0.0008
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0056 0.0209
Loa Loa (eye worm) carboxylesterase 0.0282 0.0559 0.1648
Schistosoma mansoni carbon catabolite repressor protein 0.0028 0.004 0.0116
Echinococcus granulosus lysine specific histone demethylase 1A 0.0066 0.0117 0.0344
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0017 0.0179
Schistosoma mansoni ap endonuclease 0.0137 0.0263 0.0776
Brugia malayi notch-like transmembrane receptor 0.0008 0.0000000027852 0.0000000082111
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0156 0.0302 1
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0017 0.0566
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0056 0.0892
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0028 0.004 0.0116
Schistosoma mansoni amine oxidase 0.0066 0.0117 0.0344
Schistosoma mansoni hypothetical protein 0.066 0.133 0.3921
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0023
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.0583 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0067 0.012 0.3987
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0008 0.0023
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0121 0.0358
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0028 0.004 0.0396
Echinococcus granulosus peptidase Clp S14 family 0.0102 0.0192 0.0566
Brugia malayi hypothetical protein 0.0065 0.0115 0.034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0056 0.0165
Brugia malayi Blistered cuticle protein 3 0.0065 0.0115 0.034
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0028 0.004 0.1178
Onchocerca volvulus 0.0012 0.0008 0.0141
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0008 0.0008
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0078 0.2399
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.0008 0.0023
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0233 0.1339
Onchocerca volvulus Peroxidasin homolog 0.0065 0.0115 0.2062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0148 0.0285 0.5034
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0047 0.0138
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.0302 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0066 0.0117 0.0575
Brugia malayi hypothetical protein 0.0282 0.0559 0.1648
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0023
Leishmania major GTP-binding protein, putative 0.0045 0.0076 0.1197
Onchocerca volvulus Peroxidase homolog 0.0065 0.0115 0.2062
Echinococcus granulosus histone acetyltransferase KAT2B 0.0167 0.0324 0.0956
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.0008 0.0023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0086 0.0254
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0082 0.0372
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0028 0.004 0.0116
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0267 0.4515
Toxoplasma gondii exonuclease III APE 0.0137 0.0263 0.8721
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.0008 0.0023
Toxoplasma gondii hypothetical protein 0.0047 0.008 0.2641
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0008 0.0023
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0056 0.0687
Onchocerca volvulus 0.0036 0.0056 0.1002
Mycobacterium ulcerans dehydrogenase 0.0066 0.0117 0.0534
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0076 0.1197
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0137 0.0263 0.9231
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0113 0.0333
Echinococcus granulosus peroxidasin 0.0065 0.0115 0.034
Echinococcus granulosus traf and tnf receptor associated protein 0.0028 0.004 0.0116
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.066 0.133 0.3921
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0056 0.0892
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0067 0.0887
Trichomonas vaginalis importin beta-1, putative 0.005 0.0085 0.1421
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.0008 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.0565 0.1666
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0028 0.004 0.0396
Entamoeba histolytica Ran family GTPase 0.0045 0.0076 0.2482
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0137 0.0263 0.132
Echinococcus granulosus GPCR family 2 0.0031 0.0047 0.0138
Brugia malayi Carboxylesterase family protein 0.1669 0.3392 1
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0008 0.0023
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0086 0.1438
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0023
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0028 0.004 0.111
Leishmania major RNA-editing complex protein MP100, putative 0.0028 0.004 0.0568
Brugia malayi Probable ClpP-like protease 0.0156 0.0302 0.089
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.0008 0.0023
Onchocerca volvulus 0.0066 0.0117 0.2088
Echinococcus multilocularis BC026374 protein (S09 family) 0.0282 0.0559 0.0559
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0028 0.004 0.0396
Onchocerca volvulus 0.0036 0.0056 0.1002
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0082 0.024
Onchocerca volvulus Dual oxidase homolog 0.0065 0.0115 0.2062
Schistosoma mansoni cpg binding protein 0.0031 0.0046 0.0137
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0066 0.0117 0.0344
Leishmania major pantothenate kinase subunit, putative 0.0028 0.004 0.0568
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0137 0.0263 0.8692
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0133 0.4393
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0017 0.035
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0056 0.0892
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0008 0.0023
Onchocerca volvulus 0.0028 0.004 0.0707
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0137 0.0263 0.8644
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.0008 0.0023
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.0302 0.1526
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0076 0.2661
Mycobacterium tuberculosis Conserved protein 0.0036 0.0056 0.0225
Onchocerca volvulus 0.0012 0.0008 0.0141
Trypanosoma brucei RNA editing exonuclease 2 0.0028 0.004 0.0568
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0282 0.0559 0.0559
Loa Loa (eye worm) hypothetical protein 0.0028 0.004 0.0116
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0028 0.004 0.0116
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0028 0.004 0.0568
Schistosoma mansoni cpg binding protein 0.0029 0.0043 0.0127
Mycobacterium ulcerans carboxylesterase, LipT 0.0282 0.0559 0.2904
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.034
Loa Loa (eye worm) hypothetical protein 0.0062 0.0109 0.0322
Onchocerca volvulus 0.0065 0.0115 0.2062
Echinococcus granulosus lysine specific histone demethylase 1A 0.0066 0.0117 0.0344
Loa Loa (eye worm) carboxylesterase 0.0282 0.0559 0.1648
Brugia malayi acetyltransferase, GNAT family protein 0.0172 0.0334 0.0985
Loa Loa (eye worm) hypothetical protein 0.0036 0.0056 0.0165
Mycobacterium ulcerans monoamine oxidase 0.0066 0.0117 0.0534
Brugia malayi Carboxylesterase family protein 0.0282 0.0559 0.1648
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0137 0.0263 0.4348
Echinococcus multilocularis cpg binding protein 0.0031 0.0046 0.0046
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0133 0.0619
Loa Loa (eye worm) glutathione reductase 0.0048 0.0082 0.024
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0028 0.004 0.0593
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0028 0.004 0.0396
Brugia malayi glutathione reductase 0.0048 0.0082 0.024
Loa Loa (eye worm) acetylcholinesterase 1 0.1669 0.3392 1
Treponema pallidum hypothetical protein 0.0028 0.004 0.0787
Mycobacterium tuberculosis Conserved protein 0.0036 0.0056 0.0225
Onchocerca volvulus Neurogenic locus notch homolog 0.0008 0.0000000027852 0.000000049832
Loa Loa (eye worm) hypothetical protein 0.018 0.0351 0.1036
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0076 0.0223
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0137 0.0263 0.0776
Treponema pallidum exodeoxyribonuclease (exoA) 0.0137 0.0263 0.8644

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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