Detailed information for compound 1292463

Basic information

Technical information
  • TDR Targets ID: 1292463
  • Name: 1-cycloheptyl-4,6-dimethyl-2H-pyrazolo[5,4-b] pyridin-3-one
  • MW: 259.347 | Formula: C15H21N3O
  • H donors: 1 H acceptors: 2 LogP: 3.67 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c2c(n1)n([nH]c2=O)C1CCCCCC1
  • InChi: 1S/C15H21N3O/c1-10-9-11(2)16-14-13(10)15(19)17-18(14)12-7-5-3-4-6-8-12/h9,12H,3-8H2,1-2H3,(H,17,19)
  • InChiKey: GRKGZJNNTAODIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC01423998
  • A3541/0150079
  • Pyrazolo[3,4-b]pyridin-3-one, 1-cycloheptyl-4,6-dimethyl-1,2-dihydro-
  • STOCK4S-25418
  • EU-0050460
  • ZINC00217316
  • 1-cycloheptyl-4,6-dimethyl-1H-pyrazolo[3,4-b]pyridin-3-ol
  • MLS000693811
  • SMR000299819
  • ChemDiv2_001773

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH1 domain containing protein 0.0016 0.0054 0.0101
Schistosoma mansoni smad1 5 8 and 0.0016 0.0054 0.0013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0286 0.0828
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0085 0.0813
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.1764 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0203 0.0163
Brugia malayi intermediate filament protein 0.0026 0.0203 0.0535
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0014 0.004
Leishmania major glucose transporter, lmgt3 0.0033 0.0302 0.4764
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0089 0.0883
Loa Loa (eye worm) hypothetical protein 0.0026 0.02 0.0577
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.2314 0.5495
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.1365 0.1359
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0168 0.0128
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0089 0.0366
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0509 0.0503
Echinococcus granulosus solute carrier family 22 0.0015 0.0041 0.0034
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0296 0.0404
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0054 0.0047
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0286 0.1033
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3461 0.3434
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0054 0.0155
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.1365 0.1359
Brugia malayi Thioredoxin reductase 0.0053 0.0589 0.1657
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0041 0.0118
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0089 0.0883
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0296 0.0256
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.1365 0.1359
Trypanosoma cruzi hexose transporter 0.0033 0.0302 0.4764
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0126 0.0641
Brugia malayi hypothetical protein 0.0015 0.0041 0.0064
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0168 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0296 0.0404
Echinococcus multilocularis lamin 0.0026 0.0203 0.0196
Echinococcus multilocularis tar DNA binding protein 0.0251 0.3461 0.3456
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.1365 0.1359
Toxoplasma gondii protein kinase, putative 0.0301 0.4178 1
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3461 0.3434
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0302 0.4764
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0302 0.1973
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0054 0.0013
Schistosoma mansoni hypothetical protein 0.0102 0.1304 0.1269
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0296 0.0404
Trypanosoma brucei glucose transporter, putative 0.0033 0.0302 0.4764
Echinococcus multilocularis lamin dm0 0.0026 0.0203 0.0196
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0089 0.0883
Echinococcus granulosus solute carrier family 22 0.0015 0.0041 0.0034
Loa Loa (eye worm) hypothetical protein 0.0102 0.1304 0.3769
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0168 0.0308
Leishmania major glucose transporter, lmgt2 0.0033 0.0302 0.4764
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0089 0.0883
Leishmania major protein kinase, putative 0.0033 0.0296 0.4653
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Treponema pallidum NADH oxidase 0.0018 0.0089 0.5
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0363 0.5876
Echinococcus granulosus GPCR family 2 0.0047 0.0509 0.0503
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0589 0.0867
Loa Loa (eye worm) sugar transporter 0.0015 0.0041 0.0118
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0296 0.0855
Trypanosoma brucei glucose transporter, putative 0.0033 0.0302 0.4764
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0089 0.0883
Schistosoma mansoni glucose transport protein 0.0106 0.1365 0.133
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.1569 0.887
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0089 0.0883
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0302 0.1973
Echinococcus granulosus lamin dm0 0.0026 0.0203 0.0196
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.1569 0.887
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0296 0.0289
Brugia malayi major facilitator superfamily protein 0.0015 0.0041 0.0064
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0089 0.3806
Schistosoma mansoni Smad4 0.0016 0.0054 0.0013
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0168 0.0128
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0296 0.0289
Loa Loa (eye worm) hypothetical protein 0.0026 0.0196 0.0566
Echinococcus multilocularis General substrate transporter 0.0091 0.1148 0.1142
Plasmodium falciparum hexose transporter 0.0106 0.1365 0.2094
Trypanosoma brucei trypanothione reductase 0.0053 0.0589 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0041 0.0034
Brugia malayi RNA binding protein 0.0251 0.3461 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0089 1
Schistosoma mansoni hypothetical protein 0.0047 0.0509 0.047
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0168 0.2321
Echinococcus multilocularis tumor protein p63 0.0679 0.9664 0.9664
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0089 0.0883
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.1365 0.1359
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0302 0.4764
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3461 0.3434
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0168 0.0961
Trypanosoma brucei glucose transporter, putative 0.0033 0.0302 0.4764
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Trypanosoma brucei glucose transporter, putative 0.0033 0.0302 0.4764
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.3191 0.9222
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0027 0.0024
Plasmodium vivax glutathione reductase, putative 0.0053 0.0589 0.0867
Mycobacterium tuberculosis Probable reductase 0.0121 0.1569 0.887
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.2314 0.3595
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0089 0.0082
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0041 0.0064
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0168 0.2321
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0089 0.0077
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0089 0.1972
Schistosoma mansoni smad1 5 8 and 0.0016 0.0054 0.0013
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0296 0.4653
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0168 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0296 0.0617
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0296 0.0289
Loa Loa (eye worm) TAR-binding protein 0.0251 0.3461 1
Schistosoma mansoni hypothetical protein 0.0047 0.0509 0.047
Schistosoma mansoni lamin 0.0026 0.0203 0.0163
Loa Loa (eye worm) Smad1 0.0016 0.0054 0.0155
Entamoeba histolytica protein kinase, putative 0.0033 0.0296 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Echinococcus granulosus solute carrier family 22 0.0015 0.0041 0.0034
Onchocerca volvulus 0.0026 0.0203 0.1325
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0089 0.3806
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0089 0.0883
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0089 0.0883
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.1365 0.1359
Toxoplasma gondii thioredoxin reductase 0.0053 0.0589 0.1326
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0589 1
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0363 0.051
Schistosoma mansoni glucose transport protein 0.0106 0.1365 0.133
Brugia malayi RNA recognition motif domain containing protein 0.0251 0.3461 1
Echinococcus multilocularis Smad4 0.0016 0.0054 0.0047
Brugia malayi Smad1 0.0016 0.0054 0.0101
Brugia malayi major facilitator superfamily protein 0.0015 0.0041 0.0064
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0589 0.0583
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0302 0.1973
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0286 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.1365 1
Brugia malayi Sugar transporter family protein 0.0106 0.1365 0.3912
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0363 0.5876
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0116 0.0438
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0302 0.4764
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0363 0.5876
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0168 0.5182
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0302 0.4764
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0509 0.0503
Echinococcus granulosus Smad4 0.0016 0.0054 0.0047
Plasmodium falciparum thioredoxin reductase 0.0018 0.0089 0.0077
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0302 0.4764
Brugia malayi hypothetical protein 0.0015 0.0041 0.0064
Echinococcus granulosus solute carrier family 22 0.0015 0.0041 0.0034
Schistosoma mansoni protein kinase 0.0033 0.0296 0.0256
Schistosoma mansoni hypothetical protein 0.0047 0.0509 0.047
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0363 0.051
Brugia malayi MH1 domain containing protein 0.0016 0.0054 0.0101
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0296 0.0404
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0296 0.0404
Loa Loa (eye worm) RNA binding protein 0.0251 0.3461 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1989 0.5725
Loa Loa (eye worm) hypothetical protein 0.0026 0.0203 0.0586
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0589 0.0583
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0296 0.0404
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0089 0.0883
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0296 0.0404
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.2314 0.3595
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0168 0.0434
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.1365 0.1359
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0203 0.0586
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0302 0.4764
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0589 0.1703
Plasmodium falciparum protein kinase 7 0.0301 0.4178 0.6542
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0089 0.0077
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0041 0.0034
Echinococcus multilocularis musashi 0.0026 0.0203 0.0196
Echinococcus granulosus tar DNA binding protein 0.0251 0.3461 0.3456
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0041 0.0034
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0286 0.0777
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0267 0.026
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0041 0.0118
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0296 0.0805
Echinococcus granulosus lamin 0.0026 0.0203 0.0196
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0286 0.0247
Leishmania major glucose transporter, lmgt1 0.0033 0.0302 0.4764
Plasmodium falciparum protein kinase 6 0.0452 0.6365 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0286 0.0777
Brugia malayi glutathione reductase 0.0053 0.0589 0.1657
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0286 0.9253
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0509 0.1425
Schistosoma mansoni smad 0.0016 0.0054 0.0013
Plasmodium falciparum thioredoxin reductase 0.0053 0.0589 0.0867
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0089 0.0883
Trypanosoma brucei glucose transporter 2A 0.0033 0.0302 0.4764
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0089 0.0883
Loa Loa (eye worm) hypothetical protein 0.0033 0.0296 0.0855
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.1764 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.1569 0.8818
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0296 0.0289
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0302 0.1973
Echinococcus multilocularis solute carrier family 22 0.0015 0.0041 0.0034
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1989 0.5725
Loa Loa (eye worm) hypothetical protein 0.0047 0.0509 0.1471
Echinococcus multilocularis smad 0.0016 0.0054 0.0047
Onchocerca volvulus 0.0099 0.1264 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0589 0.3182
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0302 0.1973
Echinococcus granulosus smad 0.0016 0.0054 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0286 0.1855
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0089 0.0883
Schistosoma mansoni protein kinase 0.0033 0.0296 0.0256
Plasmodium falciparum glutathione reductase 0.0053 0.0589 0.0867
Loa Loa (eye worm) hypothetical protein 0.0099 0.1264 0.3653
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Entamoeba histolytica protein kinase, putative 0.0033 0.0296 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0203 0.0535
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1989 0.5748
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0089 0.0077
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0267 0.026
Brugia malayi MH2 domain containing protein 0.0016 0.0054 0.0101
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0089 0.3806
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0286 0.028
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.1569 0.887
Trypanosoma brucei glucose transporter 1E 0.0033 0.0302 0.4764
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0089 0.0049
Echinococcus multilocularis solute carrier family 22 0.0015 0.0041 0.0034
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0302 0.4764
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0296 0.0404
Brugia malayi Sugar transporter family protein 0.0015 0.0041 0.0064
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0203 0.0586
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0296 0.0289
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Echinococcus multilocularis solute carrier family 22 0.0015 0.0041 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0089 0.0883
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3461 0.3434
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0089 0.0366
Trypanosoma brucei glucose transporter, putative 0.0033 0.0302 0.4764
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0168 0.0161
Echinococcus granulosus tumor protein p63 0.0679 0.9664 0.9664
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0089 0.0883
Schistosoma mansoni lamin 0.0026 0.0203 0.0163
Brugia malayi MH2 domain containing protein 0.0233 0.3191 0.9218
Brugia malayi hypothetical protein 0.0015 0.0041 0.0064
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.1764 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0302 0.1973
Trypanosoma brucei glucose transporter, putative 0.0033 0.0302 0.4764
Trypanosoma brucei glucose transporter, putative 0.0033 0.0302 0.4764
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0041 0.0064
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0168 0.0201
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0089 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0296 0.0289
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3461 0.3434
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0363 0.0779
Onchocerca volvulus 0.0026 0.0203 0.1325
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0089 0.0883
Schistosoma mansoni protein kinase 0.0033 0.0296 0.0256
Schistosoma mansoni smad1 5 8 and 0.0016 0.0054 0.0013
Schistosoma mansoni hypothetical protein 0.0047 0.0509 0.047
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0286 0.028
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0168 0.0201
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0251 0.3461 1
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.3191 0.9222
Loa Loa (eye worm) sugar transporter 0.0106 0.1365 0.3945
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0054 0.0047
Brugia malayi Sugar transporter family protein 0.0015 0.0041 0.0064
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0296 0.0617
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0296 0.0617
Schistosoma mansoni hypothetical protein 0.0106 0.1365 0.133
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0168 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0296 0.0289
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0089 0.0077
Echinococcus multilocularis GPCR, family 2 0.0047 0.0509 0.0503
Brugia malayi TAR-binding protein 0.0251 0.3461 1
Loa Loa (eye worm) glutathione reductase 0.0053 0.0589 0.1703
Echinococcus granulosus intermediate filament protein 0.0026 0.0203 0.0196
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0168 0.2321
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1304 0.3734
Loa Loa (eye worm) hypothetical protein 0.015 0.1989 0.5748
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0054 0.0047
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0296 0.0289
Loa Loa (eye worm) hypothetical protein 0.0024 0.0168 0.0486
Plasmodium vivax hexose transporter 0.0106 0.1365 0.2094
Trypanosoma brucei glucose transporter, putative 0.0033 0.0302 0.4764
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0054 0.0155
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.1365 0.3201
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0116 0.0438
Echinococcus multilocularis solute carrier family 22 0.0015 0.0041 0.0034
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.1365 0.1359
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0118
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.1764 1
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0296 0.1927
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.002
Plasmodium falciparum glutathione reductase 0.0018 0.0089 0.0077
Echinococcus granulosus General substrate transporter 0.0091 0.1148 0.1142
Schistosoma mansoni glucose transport protein 0.0106 0.1365 0.133
Brugia malayi MH2 domain containing protein 0.0016 0.0054 0.0101
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0363 0.5876
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0509 0.0503
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0089 0.0204
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0041 0.0034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0509 0.0503
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0089 0.0082
Plasmodium vivax CDK-related protein kinase 6, putative 0.0452 0.6365 1
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0168 0.0161
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0089 0.0281
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.1569 0.887
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0041 0.0064
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0509 0.1425
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.1569 0.887
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0089 0.0117
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0296 0.0855
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0089 0.0117
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0168 0.0315
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0363 0.5876
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0509 0.1471
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0296 0.0404
Leishmania major trypanothione reductase 0.0053 0.0589 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0302 0.1973
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0286 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0286 0.0828
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.1264 0.1229
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0027 0.0078
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0089 0.0883
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0054 0.0047
Brugia malayi Cam kinase protein 1 0.0033 0.0296 0.0805

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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