Detailed information for compound 1292618

Basic information

Technical information
  • TDR Targets ID: 1292618
  • Name: N-[2-(1H-benzimidazol-2-yl)ethyl]-3,5-dinitro benzamide
  • MW: 355.305 | Formula: C16H13N5O5
  • H donors: 2 H acceptors: 6 LogP: 2.41 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(cc(c1)[N+](=O)[O-])[N+](=O)[O-])NCCc1nc2c([nH]1)cccc2
  • InChi: 1S/C16H13N5O5/c22-16(10-7-11(20(23)24)9-12(8-10)21(25)26)17-6-5-15-18-13-3-1-2-4-14(13)19-15/h1-4,7-9H,5-6H2,(H,17,22)(H,18,19)
  • InChiKey: XHFWWPFWSUJCDP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[2-(1H-benzimidazol-2-yl)ethyl]-3,5-dinitro-benzamide
  • STOCK2S-64835
  • Oprea1_248776
  • MLS000587614
  • N-[2-(1H-Benzoimidazol-2-yl)-ethyl]-3,5-dinitro-benzamide
  • SMR000211635
  • ZINC01750504

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0569 0.0652
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0569 0.0409
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0569 0.0652
Echinococcus multilocularis tar DNA binding protein 0.0067 0.2807 0.2685
Loa Loa (eye worm) hypothetical protein 0.0024 0.0569 0.0652
Brugia malayi steroid hormone receptor 0.0024 0.0569 0.0652
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0569 0.0652
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2807 0.2807
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.246 0.7098
Echinococcus multilocularis muscleblind protein 0.018 0.8732 0.871
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.7247 0.7247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0569 0.0652
Schistosoma mansoni thyroid hormone receptor 0.0176 0.8525 0.8525
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0569 0.0652
Leishmania major cathepsin L-like protease 0.0077 0.3323 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0569 0.0409
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.035 0.5
Echinococcus granulosus cathepsin l1 0.002 0.035 0.035
Schistosoma mansoni hypothetical protein 0.0017 0.0167 0.0167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2182 0.2182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.035 1
Onchocerca volvulus 0.002 0.035 0.6147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0569 0.0569
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0569 0.0652
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.035 0.0186
Loa Loa (eye worm) fibroinase 0.002 0.035 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0569 0.0652
Loa Loa (eye worm) hypothetical protein 0.0024 0.0569 0.0652
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0569 0.0652
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.035 0.035
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0569 0.0409
Brugia malayi Cathepsin L-like precursor 0.002 0.035 0.0401
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0569 0.0652
Onchocerca volvulus 0.002 0.035 0.6147
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2807 0.2807
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0569 0.0569
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0569 0.0652
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0569 0.0652
Loa Loa (eye worm) RNA binding protein 0.0067 0.2807 0.3214
Echinococcus multilocularis cysteine protease 0.002 0.035 0.0186
Loa Loa (eye worm) hypothetical protein 0.0024 0.0569 0.0652
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0569 0.0652
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.2182 0.2499
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0167 0.0191
Plasmodium vivax vivapain-2 0.002 0.035 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.2058 0.2357
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.2058 0.2357
Echinococcus multilocularis thyroid hormone receptor alpha 0.0176 0.8525 0.85
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3323 0.5
Brugia malayi Muscleblind-like protein 0.018 0.8732 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.2058 0.2357
Echinococcus granulosus GPCR family 2 0.0017 0.0167 0.0167
Echinococcus multilocularis cysteine protease 0.002 0.035 0.0186
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0167 0.0167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2182 0.205
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0569 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Onchocerca volvulus 0.002 0.035 0.6147
Loa Loa (eye worm) hypothetical protein 0.0024 0.0569 0.0652
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2182 0.2182
Onchocerca volvulus 0.002 0.035 0.6147
Schistosoma mansoni hypothetical protein 0.0017 0.0167 0.0167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.035 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.035 1
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0569 0.0652
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3323 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.035 0.0186
Brugia malayi Cathepsin L-like precursor 0.002 0.035 0.0401
Leishmania major cathepsin L-like protease 0.0077 0.3323 1
Schistosoma mansoni coup transcription factor 0.0024 0.0569 0.0569
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0569 0.0652
Brugia malayi Cathepsin L-like precursor 0.002 0.035 0.0401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3323 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3323 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2182 0.205
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.035 0.035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0569 0.0569
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2182 0.2182
Loa Loa (eye worm) hypothetical protein 0.0017 0.0167 0.0191
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0569 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0569 0.0652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3323 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0569 0.0652
Onchocerca volvulus Cathepsin L homolog 0.002 0.035 0.6147
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.3323 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0167 0.0191
Brugia malayi Cathepsin L-like precursor 0.002 0.035 0.0401
Schistosoma mansoni hypothetical protein 0.0036 0.1183 0.1183
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2807 0.2807
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0569 0.0569
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.035 1
Schistosoma mansoni thyroid hormone receptor 0.0176 0.8525 0.8525
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0569 0.0652
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0569 0.0652
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0569 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0569 1
Leishmania major cathepsin L-like protease 0.0077 0.3323 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.035 1
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0569 0.0652
Plasmodium vivax vivapain-2 0.002 0.035 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.2807 0.3214
Brugia malayi nuclear hormone receptor 0.0024 0.0569 0.0652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Loa Loa (eye worm) ctsf protein 0.002 0.035 0.0401
Brugia malayi Papain family cysteine protease containing protein 0.002 0.035 0.0401
Onchocerca volvulus 0.0024 0.0569 1
Onchocerca volvulus Cathepsin F homolog 0.002 0.035 0.6147
Loa Loa (eye worm) cysteine protease 0.002 0.035 0.0401
Onchocerca volvulus 0.002 0.035 0.6147
Loa Loa (eye worm) hypothetical protein 0.0024 0.0569 0.0652
Schistosoma mansoni hypothetical protein 0.0017 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0024 0.0569 0.0652
Loa Loa (eye worm) hypothetical protein 0.0036 0.1183 0.1354
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0569 0.0652
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0569 0.0569
Echinococcus granulosus tar DNA binding protein 0.0067 0.2807 0.2807
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.035 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.035 0.035
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.2973 0.8824
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.035 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3323 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.035 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0569 0.0652
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2182 0.2182
Onchocerca volvulus 0.002 0.035 0.6147
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0569 0.0569
Onchocerca volvulus 0.002 0.035 0.6147
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0569 1
Echinococcus granulosus muscleblind protein 0.018 0.8732 0.8732
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0569 0.0409
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0569 0.0569
Schistosoma mansoni hypothetical protein 0.0017 0.0167 0.0167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3323 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.2807 0.3214
Entamoeba histolytica cysteine proteinase, putative 0.002 0.035 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3323 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3323 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0569 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.035 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0569 0.0652
Schistosoma mansoni hypothetical protein 0.0152 0.7247 0.7247
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3323 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3323 0.5
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.035 0.0401
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.035 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.035 0.0401
Loa Loa (eye worm) hypothetical protein 0.018 0.8732 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0569 0.0652
Loa Loa (eye worm) hypothetical protein 0.0024 0.0569 0.0652
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.2182 0.2499
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0167 0.0191
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2182 0.2182
Brugia malayi ecdysteroid receptor 0.0024 0.0569 0.0652
Brugia malayi nuclear receptor NHR-88 0.0024 0.0569 0.0652
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0569 1
Brugia malayi Cathepsin L-like precursor 0.002 0.035 0.0401
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.035 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Loa Loa (eye worm) hypothetical protein 0.002 0.035 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Loa Loa (eye worm) TAR-binding protein 0.0067 0.2807 0.3214
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.7247 0.7201
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2807 0.2807
Entamoeba histolytica cysteine protease, putative 0.002 0.035 1
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0569 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Brugia malayi TAR-binding protein 0.0067 0.2807 0.3214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3323 0.5
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2807 0.2807
Echinococcus multilocularis muscleblind protein 1 0.018 0.8732 0.871
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0167 0.0167
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0569 0.0652
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0569 0.0409
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0569 0.0569
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.1183 0.1354
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0569 0.0409
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0569 0.0569
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0569 0.0569
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3323 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0569 0.0569
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0569 0.0409
Onchocerca volvulus Cathepsin L homolog 0.002 0.035 0.6147
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0569 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.035 1
Brugia malayi RNA binding protein 0.0067 0.2807 0.3214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.035 0.5
Brugia malayi Cathepsin L-like precursor 0.002 0.035 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.035 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3323 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.2058 0.2357
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0569 0.0652
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0569 0.0569
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.035 0.5
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0569 0.0569
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.035 0.035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.035 1
Loa Loa (eye worm) hypothetical protein 0.018 0.8732 1
Toxoplasma gondii cathepsin CPL 0.002 0.035 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.035 0.0186
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0569 0.0569

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0355 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] ChEMBL. No reference
Potency (binding) 3.9811 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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