TDR Targets

Basic information

Technical information

TDR Targets ID: 1292704
Name: ethyl 1-[1-(3-chloro-4-ethoxyphenyl)sulfonylp iperidine-3-carbonyl]piperidine-4-carboxylate
MW: 487.009 | Formula: C22H31ClN2O6S
H donors: 0 H acceptors: 4 LogP: 2.7 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1CCN(CC1)C(=O)C1CCCN(C1)S(=O)(=O)c1ccc(c(c1)Cl)OCC
InChi: 1S/C22H31ClN2O6S/c1-3-30-20-8-7-18(14-19(20)23)32(28,29)25-11-5-6-17(15-25)21(26)24-12-9-16(10-13-24)22(27)31-4-2/h7-8,14,16-17H,3-6,9-13,15H2,1-2H3
InChiKey: ZCTJQLGMQUVEFV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 1-[1-(3-chloro-4-ethoxy-phenyl)sulfonylpiperidine-3-carbonyl]piperidine-4-carboxylate
1-[[1-(3-chloro-4-ethoxyphenyl)sulfonyl-3-piperidinyl]-oxomethyl]-4-piperidinecarboxylic acid ethyl ester
1-[1-(3-chloro-4-ethoxy-phenyl)sulfonylpiperidine-3-carbonyl]isonipecotic acid ethyl ester
ethyl 1-[1-(3-chloro-4-ethoxy-phenyl)sulfonylpiperidin-3-yl]carbonylpiperidine-4-carboxylate
ASN 13357509

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	MH2 domain containing protein	0.0506	0.5119	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.002	0.0099	0.0309
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.0099	0.0193
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0315	0.3145	0.6144
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.01	0.0919	0.0919
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0099	0.0099
Echinococcus granulosus	Smad4	0.0035	0.0246	0.0769
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0099	0.0193
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0099	0.0309
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0099	0.0309
Loa Loa (eye worm)	hypothetical protein	0.002	0.0099	0.0193
Schistosoma mansoni	steroid hormone receptor ad4bp	0.002	0.0099	0.0309
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.0099	0.0099
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.0099	0.0193
Brugia malayi	MH1 domain containing protein	0.0019	0.0086	0.0169
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.011	0.103	0.3225
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.01	0.0919	0.288
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0315	0.3145	0.6144
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0099	0.0309
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0099	0.0193
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.0099	0.0193
Echinococcus multilocularis	smad	0.0035	0.0246	0.0246
Brugia malayi	MH1 domain containing protein	0.0035	0.0246	0.048
Echinococcus multilocularis	isocitrate dehydrogenase	0.0032	0.0218	0.0218
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0099	0.0193
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.0099	0.0193
Loa Loa (eye worm)	MH2 domain-containing protein	0.0015	0.0049	0.0095
Schistosoma mansoni	coup transcription factor	0.002	0.0099	0.0309
Brugia malayi	steroid hormone receptor	0.002	0.0099	0.0193
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.01	0.0919	0.0919
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0032	0.0218	0.5
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0218	0.0218
Onchocerca volvulus	Bile acid receptor homolog	0.002	0.0099	0.0284
Brugia malayi	N-terminal motif family protein	0.0186	0.1814	0.3544
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.0099	0.0193
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.0099	0.0099
Loa Loa (eye worm)	MH2 domain-containing protein	0.0035	0.0246	0.048
Schistosoma mansoni	smad1 5 8 and	0.0035	0.0246	0.0769
Loa Loa (eye worm)	nuclear factor I	0.0019	0.0086	0.0169
Schistosoma mansoni	smad	0.0015	0.0049	0.0152
Echinococcus multilocularis	Smad4	0.0035	0.0246	0.0246
Loa Loa (eye worm)	MH2 domain-containing protein	0.0506	0.5119	1
Brugia malayi	nuclear receptor NHR-88	0.002	0.0099	0.0193
Loa Loa (eye worm)	latrophilin receptor protein 2	0.01	0.0919	0.1796
Echinococcus granulosus	mothers against decapentaplegic 2	0.0015	0.0049	0.0152
Echinococcus granulosus	tar DNA binding protein	0.032	0.3193	1
Schistosoma mansoni	Smad4	0.0015	0.0049	0.0152
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0099	0.0193
Brugia malayi	Smad1	0.0035	0.0246	0.048
Brugia malayi	MH2 domain containing protein	0.0035	0.0246	0.048
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0218	0.0218
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0218	0.0218
Brugia malayi	Steroid receptor seven-up type 2	0.011	0.103	0.2012
Brugia malayi	nuclear hormone receptor	0.002	0.0099	0.0193
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.002	0.0099	0.0309
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0099	0.0193
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0099	0.0193
Loa Loa (eye worm)	hypothetical protein	0.01	0.0919	0.1796
Loa Loa (eye worm)	TAR-binding protein	0.032	0.3193	0.6238
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0315	0.3145	0.6144
Schistosoma mansoni	hypothetical protein	0.01	0.0919	0.288
Schistosoma mansoni	tar DNA-binding protein	0.032	0.3193	1
Brugia malayi	MH1 domain containing protein	0.0019	0.0086	0.0169
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0099	0.0193
Brugia malayi	Latrophilin receptor protein 2	0.01	0.0919	0.1796
Onchocerca volvulus		0.002	0.0099	0.0284
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0032	0.0218	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.002	0.0099	0.0309
Brugia malayi	mothers against decapentaplegic homolog 3	0.0015	0.0049	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0931	0.1819
Loa Loa (eye worm)	hypothetical protein	0.002	0.0099	0.0193
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.002	0.0099	0.0284
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.0099	0.0099
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0015	0.0049	0.0049
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.032	0.3193	0.6238
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0099	0.0193
Brugia malayi	isocitrate dehydrogenase	0.0032	0.0218	0.0426
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0218	0.5
Schistosoma mansoni	tar DNA-binding protein	0.032	0.3193	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0099	0.0193
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0035	0.0246	0.0769
Loa Loa (eye worm)	Smad1	0.0035	0.0246	0.048
Brugia malayi	latrophilin 2 splice variant baaae	0.0216	0.2115	0.4132
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0086	0.0169
Schistosoma mansoni	hypothetical protein	0.0216	0.2115	0.6624
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0049	0.0095
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0032	0.0218	0.5
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0186	0.1814	1
Brugia malayi	RNA recognition motif domain containing protein	0.032	0.3193	0.6238
Schistosoma mansoni	retinoic acid receptor RXR	0.002	0.0099	0.0309
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.0099	0.0099
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0032	0.0218	0.0426
Schistosoma mansoni	smad	0.0035	0.0246	0.0769
Loa Loa (eye worm)	MH1 domain-containing protein	0.0035	0.0246	0.048
Loa Loa (eye worm)	nuclear hormone receptor	0.01	0.0919	0.1796
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.0099	0.0309
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.0099	0.0193
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0218	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0099	0.0193
Schistosoma mansoni	hypothetical protein	0.01	0.0919	0.288
Brugia malayi	ecdysteroid receptor	0.002	0.0099	0.0193
Echinococcus granulosus	mothers against decapentaplegic 6	0.0015	0.0049	0.0152
Echinococcus granulosus	smad	0.0035	0.0246	0.0769
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0032	0.0218	0.5
Loa Loa (eye worm)	MH1 domain-containing protein	0.0015	0.0049	0.0095
Schistosoma mansoni	RAR-like nuclear receptor	0.002	0.0099	0.0309
Loa Loa (eye worm)	hypothetical protein	0.002	0.0099	0.0193
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.0099	0.0309
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0099	0.0193
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0218	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.002	0.0099	0.0099
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.0099	0.0309
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0099	0.0193
Schistosoma mansoni	tar DNA-binding protein	0.032	0.3193	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.002	0.0099	0.0309
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0099	0.0309
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.0099	0.0193
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.011	0.103	0.103
Schistosoma mansoni	smad1 5 8 and	0.0035	0.0246	0.0769
Echinococcus multilocularis	tar DNA binding protein	0.032	0.3193	0.3193
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.01	0.0919	0.288
Brugia malayi	RNA binding protein	0.032	0.3193	0.6238
Brugia malayi	Isocitrate dehydrogenase	0.0032	0.0218	0.0426
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0099	0.0099
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0032	0.0218	0.0683
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0032	0.0218	0.0683
Schistosoma mansoni	Smad4	0.0035	0.0246	0.0769
Echinococcus multilocularis	GPCR, family 2	0.01	0.0919	0.0919
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0099	0.0193
Schistosoma mansoni	hypothetical protein	0.01	0.0919	0.288
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0035	0.0246	0.0246
Schistosoma mansoni	hypothetical protein	0.01	0.0919	0.288
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0035	0.0246	0.0246
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0032	0.0218	0.0218
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0218	0.5
Loa Loa (eye worm)	RNA binding protein	0.032	0.3193	0.6238
Brugia malayi	photoreceptor-specific nuclear receptor	0.0257	0.2544	0.497
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0218	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.0099	0.0309
Loa Loa (eye worm)	hypothetical protein	0.002	0.0099	0.0193
Schistosoma mansoni	tar DNA-binding protein	0.032	0.3193	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.0099	0.0193
Loa Loa (eye worm)	hypothetical protein	0.002	0.0099	0.0193
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0099	0.0309
Echinococcus granulosus	mothers against decapentaplegic 5	0.0035	0.0246	0.0769
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.01	0.0919	0.1796
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.0099	0.0193
Schistosoma mansoni	Smad4	0.0015	0.0049	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1814	0.3544
Loa Loa (eye worm)	hypothetical protein	0.0216	0.2115	0.4132
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0015	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0315	0.3145	0.6144
Loa Loa (eye worm)	hypothetical protein	0.002	0.0099	0.0193
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0032	0.0218	0.5
Echinococcus granulosus	GPCR family 2	0.01	0.0919	0.288
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.0099	0.0309
Brugia malayi	MH1 domain containing protein	0.0035	0.0246	0.048
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.0099	0.0309
Schistosoma mansoni	tar DNA-binding protein	0.032	0.3193	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.002	0.0099	0.0284
Echinococcus granulosus	FTZ F1 alpha	0.002	0.0099	0.0309
Loa Loa (eye worm)	transcription factor SMAD2	0.0506	0.5119	1
Brugia malayi	MH2 domain containing protein	0.0035	0.0246	0.048
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0035	0.0246	0.0769
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0099	0.0193
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.002	0.0099	0.0309
Brugia malayi	MH2 domain containing protein	0.0015	0.0049	0.0095
Schistosoma mansoni	smad1 5 8 and	0.0035	0.0246	0.0769
Loa Loa (eye worm)	hypothetical protein	0.0257	0.2544	0.497
Brugia malayi	TAR-binding protein	0.032	0.3193	0.6238

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.4467 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	0.9196 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1409191

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1292704