Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.0421 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0999 | 0.0999 |
Schistosoma mansoni | hypothetical protein | 0.0583 | 0.6631 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.0421 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0583 | 0.6631 | 0.6631 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0086 | 0.0421 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0465 | 0.5156 | 0.7775 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0059 | 0.0091 | 0.0176 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0761 | 0.8858 | 0.8858 |
Loa Loa (eye worm) | TAR-binding protein | 0.0465 | 0.5156 | 0.5156 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.027 | 0.2721 | 0.5278 |
Echinococcus multilocularis | tar DNA binding protein | 0.0465 | 0.5156 | 1 |
Schistosoma mansoni | hypothetical protein | 0.027 | 0.2721 | 0.4104 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0132 | 0.0999 | 1 |
Brugia malayi | TAR-binding protein | 0.0465 | 0.5156 | 0.5156 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.027 | 0.2721 | 0.5278 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.027 | 0.2721 | 0.5278 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.0421 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.0421 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.2721 | 0.2721 |
Schistosoma mansoni | hypothetical protein | 0.027 | 0.2721 | 0.4104 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0056 | 0.0053 | 0.0102 |
Brugia malayi | RNA binding protein | 0.0465 | 0.5156 | 0.5156 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0086 | 0.0421 | 0.0817 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0465 | 0.5156 | 0.5156 |
Brugia malayi | Latrophilin receptor protein 2 | 0.027 | 0.2721 | 0.2721 |
Echinococcus granulosus | tar DNA binding protein | 0.0465 | 0.5156 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.0421 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.027 | 0.2721 | 0.5278 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0086 | 0.0421 | 0.0817 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0056 | 0.0053 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0056 | 0.0053 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0059 | 0.0091 | 0.0137 |
Brugia malayi | Probable ClpP-like protease | 0.0086 | 0.0421 | 0.0421 |
Echinococcus multilocularis | GPCR, family 2 | 0.027 | 0.2721 | 0.5278 |
Echinococcus granulosus | GPCR family 2 | 0.027 | 0.2721 | 0.5278 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.027 | 0.2721 | 0.2721 |
Brugia malayi | hypothetical protein | 0.0132 | 0.0999 | 0.0999 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.027 | 0.2721 | 0.2721 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0132 | 0.0999 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0465 | 0.5156 | 0.7775 |
Schistosoma mansoni | hypothetical protein | 0.027 | 0.2721 | 0.4104 |
Loa Loa (eye worm) | hypothetical protein | 0.0583 | 0.6631 | 0.6631 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0132 | 0.0999 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0465 | 0.5156 | 0.7775 |
Brugia malayi | MH2 domain containing protein | 0.0761 | 0.8858 | 0.8858 |
Schistosoma mansoni | tar DNA-binding protein | 0.0465 | 0.5156 | 0.7775 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0132 | 0.0999 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0059 | 0.0091 | 0.0176 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.0421 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0465 | 0.5156 | 0.5156 |
Brugia malayi | hypothetical protein | 0.0085 | 0.0415 | 0.0415 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0761 | 0.8858 | 0.8858 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0056 | 0.0053 | 0.0102 |
Leishmania major | hypothetical protein, conserved | 0.0132 | 0.0999 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0465 | 0.5156 | 0.5156 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0132 | 0.0999 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0465 | 0.5156 | 0.7775 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0132 | 0.0999 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0132 | 0.0999 | 1 |
Schistosoma mansoni | hypothetical protein | 0.027 | 0.2721 | 0.4104 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0086 | 0.0421 | 0.0635 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.