Detailed information for compound 1292884

Basic information

Technical information
  • TDR Targets ID: 1292884
  • Name: methyl 4-[(3-methylphenyl)methoxy]-2-methylsu lfanylquinoline-3-carboxylate
  • MW: 353.435 | Formula: C20H19NO3S
  • H donors: 0 H acceptors: 2 LogP: 4.72 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(SC)nc2c(c1OCc1cccc(c1)C)cccc2
  • InChi: 1S/C20H19NO3S/c1-13-7-6-8-14(11-13)12-24-18-15-9-4-5-10-16(15)21-19(25-3)17(18)20(22)23-2/h4-11H,12H2,1-3H3
  • InChiKey: KLMJMJCMHNFFTP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 4-[(3-methylphenyl)methoxy]-2-methylsulfanyl-quinoline-3-carboxylate
  • 4-[(3-methylphenyl)methoxy]-2-(methylthio)-3-quinolinecarboxylic acid methyl ester
  • 4-(3-methylbenzyl)oxy-2-(methylthio)quinoline-3-carboxylic acid methyl ester
  • G198-0007
  • NCGC00128949-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glutaminase 0.0555 0.1742 0.6564
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0042 0.0058 0.0332
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0158 0.0439 0.1653
Brugia malayi MH1 domain containing protein 0.0158 0.0439 0.0439
Schistosoma mansoni unc-13 (munc13) 0.0042 0.0058 0.0218
Brugia malayi TAR-binding protein 0.079 0.2511 0.2511
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0039 0.0148
Onchocerca volvulus 0.0286 0.0859 0.0859
Loa Loa (eye worm) hypothetical protein 0.0172 0.0486 0.0486
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0344 0.1048 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0344 0.1048 0.3948
Leishmania major hypothetical protein, conserved 0.0258 0.0766 0.7308
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0176 0.0662
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0176 0.0662
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0176 0.07
Schistosoma mansoni hypothetical protein 0.0035 0.0036 0.0134
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0042 0.0058 0.0218
Loa Loa (eye worm) hypothetical protein 0.0137 0.037 0.037
Brugia malayi mothers against decapentaplegic homolog 3 0.0071 0.0152 0.0152
Schistosoma mansoni smad1 5 8 and 0.0158 0.0439 0.1653
Schistosoma mansoni tar DNA-binding protein 0.079 0.2511 0.9462
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0039 0.0148
Brugia malayi MH1 domain containing protein 0.0087 0.0207 0.0207
Echinococcus multilocularis mothers against decapentaplegic 5 0.0158 0.0439 0.1653
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0176 0.5
Loa Loa (eye worm) RecQ helicase 0.0045 0.0069 0.0069
Brugia malayi glutaminase DH11.1 0.0555 0.1742 0.1742
Schistosoma mansoni hypothetical protein 0.0372 0.1142 0.4303
Brugia malayi Probable isocitrate dehydrogenase 0.0042 0.0058 0.0058
Loa Loa (eye worm) RNA binding protein 0.079 0.2511 0.2511
Loa Loa (eye worm) latrophilin receptor protein 2 0.0372 0.1142 0.1142
Entamoeba histolytica hypothetical protein 0.0035 0.0036 0.6167
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0116 0.03 0.113
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0176 0.1607
Brugia malayi MH2 domain containing protein 0.2317 0.752 0.752
Brugia malayi MH2 domain containing protein 0.0071 0.0152 0.0152
Echinococcus multilocularis Smad4 0.0158 0.0439 0.1653
Brugia malayi Smad1 0.0158 0.0439 0.0439
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0372 0.1142 0.4303
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0039 0.0148
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0116 0.03 0.113
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0176 0.07
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0172 0.0486 0.183
Trypanosoma brucei PAB1-binding protein , putative 0.0258 0.0766 0.7308
Brugia malayi Pax transcription factor protein 2 0.1258 0.4046 0.4046
Loa Loa (eye worm) MH1 domain-containing protein 0.0071 0.0152 0.0152
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.0038 0.0142
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0344 0.1048 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0036 0.0134
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0344 0.1048 0.3948
Schistosoma mansoni smad 0.0071 0.0152 0.0574
Schistosoma mansoni hypothetical protein 0.0804 0.2559 0.9642
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0039 0.0148
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0069 0.0395
Brugia malayi MH1 domain containing protein 0.0158 0.0439 0.0439
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0039 0.0148
Trypanosoma cruzi PAB1-binding protein , putative 0.0258 0.0766 0.7308
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.079 0.2511 0.2511
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2654 1
Brugia malayi RNA binding protein 0.079 0.2511 0.2511
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.0069 0.0395
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0035 0.0131
Schistosoma mansoni tar DNA-binding protein 0.079 0.2511 0.9462
Trichomonas vaginalis glutaminase, putative 0.0555 0.1742 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0152 0.0152
Echinococcus granulosus bloom syndrome protein 0.0045 0.0069 0.0259
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0039 0.0148
Onchocerca volvulus 0.0036 0.0039 0.0039
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0042 0.0058 0.0218
Echinococcus granulosus mothers against decapentaplegic 5 0.0158 0.0439 0.1653
Echinococcus multilocularis smad 0.0158 0.0439 0.1653
Brugia malayi hypothetical protein 0.0166 0.0466 0.0466
Echinococcus granulosus tar DNA binding protein 0.079 0.2511 0.9462
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0176 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0071 0.0152 0.0152
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0176 0.1607
Loa Loa (eye worm) hypothetical protein 0.0087 0.0207 0.0207
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0344 0.1048 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0176 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0344 0.1048 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0258 0.0766 0.7286
Brugia malayi Pre-SET motif family protein 0.0251 0.0745 0.0745
Plasmodium vivax ataxin-2 like protein, putative 0.0258 0.0766 0.7286
Loa Loa (eye worm) TAR-binding protein 0.079 0.2511 0.2511
Loa Loa (eye worm) hypothetical protein 0.0372 0.1142 0.1142
Onchocerca volvulus 0.1258 0.4046 0.4046
Echinococcus multilocularis GPCR, family 2 0.0372 0.1142 0.4303
Entamoeba histolytica hypothetical protein 0.0035 0.0036 0.6167
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0176 0.5
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.0069 0.0069
Loa Loa (eye worm) glutaminase 2 0.0555 0.1742 0.1742
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2654 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0158 0.0439 0.1653
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0036 0.0134
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0042 0.0058 0.2939
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0344 0.1048 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0088 0.0305
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0042 0.0058 0.0058
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0344 0.1048 1
Schistosoma mansoni isocitrate dehydrogenase 0.0042 0.0058 0.0218
Brugia malayi Probable ClpP-like protease 0.0078 0.0176 0.0176
Loa Loa (eye worm) transcription factor SMAD2 0.2317 0.752 0.752
Echinococcus granulosus TGF beta signal transducer SmadC 0.0158 0.0439 0.1653
Schistosoma mansoni Smad4 0.0158 0.0439 0.1653
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0344 0.1048 1
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0042 0.0058 0.0058
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0042 0.0058 0.0218
Brugia malayi latrophilin 2 splice variant baaae 0.0804 0.2559 0.2559
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0042 0.0058 0.0218
Loa Loa (eye worm) hypothetical protein 0.0042 0.0058 0.0058
Plasmodium vivax SET domain protein, putative 0.0036 0.0039 0.0293
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0372 0.1142 0.4303
Brugia malayi Calcitonin receptor-like protein seb-1 0.1177 0.378 0.378
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0372 0.1142 0.4303
Loa Loa (eye worm) pax transcription factor protein 2 0.1258 0.4046 0.4046
Loa Loa (eye worm) pip kinase 2 0.0172 0.0486 0.0486
Echinococcus granulosus Smad4 0.0158 0.0439 0.1653
Schistosoma mansoni hypothetical protein 0.0372 0.1142 0.4303
Brugia malayi Isocitrate dehydrogenase 0.0344 0.1048 0.1048
Echinococcus granulosus smad 0.0158 0.0439 0.1653
Plasmodium falciparum ataxin-2 like protein, putative 0.0258 0.0766 0.7286
Brugia malayi Pip kinase protein 2 0.0172 0.0486 0.0486
Echinococcus multilocularis isocitrate dehydrogenase 0.0344 0.1048 0.3948
Echinococcus granulosus GPCR family 2 0.0372 0.1142 0.4303
Echinococcus multilocularis mothers against decapentaplegic 6 0.0071 0.0152 0.0574
Brugia malayi Pre-SET motif family protein 0.0036 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0036 0.0039 0.0039
Entamoeba histolytica hypothetical protein 0.0035 0.0036 0.6167
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0344 0.1048 0.3948
Loa Loa (eye worm) MH1 domain-containing protein 0.0158 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.1177 0.378 0.378
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0176 0.1607
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0088 0.0305
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0088 0.0332
Loa Loa (eye worm) glutaminase 0.0555 0.1742 0.1742
Brugia malayi isocitrate dehydrogenase 0.0344 0.1048 0.1048
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0172 0.0486 0.183
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0042 0.0058 0.0058
Schistosoma mansoni smad 0.0158 0.0439 0.1653
Brugia malayi Probable isocitrate dehydrogenase 0.0042 0.0058 0.0058
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0176 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0071 0.0152 0.0574
Brugia malayi hypothetical protein 0.0258 0.0766 0.0766
Brugia malayi MH2 domain containing protein 0.0158 0.0439 0.0439
Entamoeba histolytica tartrate dehydrogenase, putative 0.0042 0.0058 1
Loa Loa (eye worm) nuclear factor I 0.0087 0.0207 0.0207
Loa Loa (eye worm) Smad1 0.0158 0.0439 0.0439
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0036 0.0134
Toxoplasma gondii isocitrate dehydrogenase 0.0344 0.1048 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0344 0.1048 0.3948
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0042 0.0058 0.0058
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0071 0.0152 0.0152
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0172 0.0486 0.183
Loa Loa (eye worm) MH2 domain-containing protein 0.0158 0.0439 0.0439
Brugia malayi MH2 domain containing protein 0.0158 0.0439 0.0439
Mycobacterium ulcerans glutaminase 0.0555 0.1742 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0176 0.1607
Schistosoma mansoni Smad4 0.0071 0.0152 0.0574
Schistosoma mansoni hypothetical protein 0.0372 0.1142 0.4303
Loa Loa (eye worm) hypothetical protein 0.0258 0.0766 0.0766
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0172 0.0486 0.183
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0372 0.1142 0.4303
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.002 0.0106
Schistosoma mansoni Smad4 0.0071 0.0152 0.0574
Echinococcus multilocularis bloom syndrome protein 0.0045 0.0069 0.0259
Loa Loa (eye worm) MH2 domain-containing protein 0.2317 0.752 0.752
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0344 0.1048 0.3948
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0021 0.0117
Schistosoma mansoni tar DNA-binding protein 0.079 0.2511 0.9462
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1177 0.378 0.378
Toxoplasma gondii isocitrate dehydrogenase 0.0344 0.1048 1
Onchocerca volvulus 0.0172 0.0486 0.0486
Toxoplasma gondii LsmAD domain-containing protein 0.0258 0.0766 0.7286
Brugia malayi RNA recognition motif domain containing protein 0.079 0.2511 0.2511
Leishmania major isocitrate dehydrogenase, putative 0.0042 0.0058 0.0553
Schistosoma mansoni smad1 5 8 and 0.0158 0.0439 0.1653
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0051 0.0405
Loa Loa (eye worm) hypothetical protein 0.0804 0.2559 0.2559
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0176 0.0662
Brugia malayi Latrophilin receptor protein 2 0.0372 0.1142 0.1142
Loa Loa (eye worm) isocitrate dehydrogenase 0.0344 0.1048 0.1048
Echinococcus granulosus mothers against decapentaplegic 2 0.0071 0.0152 0.0574
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0039 0.0148
Echinococcus multilocularis mothers against decapentaplegic 2 0.0071 0.0152 0.0574
Entamoeba histolytica hypothetical protein 0.0035 0.0036 0.6167
Schistosoma mansoni hypothetical protein 0.0116 0.03 0.113
Schistosoma mansoni hypothetical protein 0.0372 0.1142 0.4303
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0088 0.4744
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0344 0.1048 1
Echinococcus multilocularis tar DNA binding protein 0.079 0.2511 0.9462
Schistosoma mansoni tar DNA-binding protein 0.079 0.2511 0.9462
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0042 0.0058 0.0218
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0039 0.0293
Trypanosoma cruzi PAB1-binding protein , putative 0.0258 0.0766 0.7308
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1177 0.378 0.378
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0372 0.1142 0.1142
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0344 0.1048 0.3948
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0859 0.4931
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2654 1
Brugia malayi hypothetical protein 0.0035 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0078 0.0176 0.0176
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0088 0.0332
Schistosoma mansoni tar DNA-binding protein 0.079 0.2511 0.9462
Brugia malayi MH1 domain containing protein 0.0087 0.0207 0.0207
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0745 0.0745
Schistosoma mansoni smad1 5 8 and 0.0158 0.0439 0.1653

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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