Detailed information for compound 1293068

Basic information

Technical information
  • TDR Targets ID: 1293068
  • Name: ethyl 3-(butanoylamino)-1H-indole-2-carboxyla te
  • MW: 274.315 | Formula: C15H18N2O3
  • H donors: 2 H acceptors: 2 LogP: 3.16 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)Nc1c([nH]c2c1cccc2)C(=O)OCC
  • InChi: 1S/C15H18N2O3/c1-3-7-12(18)17-13-10-8-5-6-9-11(10)16-14(13)15(19)20-4-2/h5-6,8-9,16H,3-4,7H2,1-2H3,(H,17,18)
  • InChiKey: LGDFKYPXZCOFKP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(1-oxobutylamino)-1H-indole-2-carboxylic acid ethyl ester
  • 3-butyramido-1H-indole-2-carboxylic acid ethyl ester
  • ZINC00326018
  • 3-Butyrylamino-1H-indole-2-carboxylic acid ethyl ester
  • BAS 00416353
  • MLS000101430
  • SMR000015414
  • Oprea1_752897
  • STOCK1S-07498
  • Oprea1_800847

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) inositol-1 0.0045 0.0274 0.0654
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0083 0.0655 0.0652
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0259 0.0617
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0444 0.2063
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0274 0.3155
Echinococcus granulosus GPCR family 2 0.0096 0.0783 0.0781
Loa Loa (eye worm) hypothetical protein 0.0037 0.0196 0.0467
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.059 0.6795
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0887 0.8563 0.8563
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0869 0.2862
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0231 0.1069
Schistosoma mansoni transient receptor potential channel 0.0063 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0042
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0444 0.0442
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0231 0.266
Loa Loa (eye worm) hypothetical protein 0.0037 0.0196 0.0467
Echinococcus granulosus fetal alzheimer antigen falz 0.003 0.0128 0.0126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0336 0.3142 0.3142
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.011 0.0915 0.3118
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0869 0.668
Schistosoma mansoni hypothetical protein 0.0045 0.0282 0.0282
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0454 0.0452
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0231 0.2665
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0869 0.2946
Loa Loa (eye worm) hypothetical protein 0.0035 0.0183 0.0435
Echinococcus multilocularis expressed conserved protein 0.0103 0.0849 0.0847
Brugia malayi Fli-1 protein 0.0243 0.2226 0.5354
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0196 0.0196
Giardia lamblia DINP protein human, muc B family 0.004 0.0231 0.0445
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0306 0.192
Loa Loa (eye worm) hypothetical protein 0.0065 0.0475 0.1139
Loa Loa (eye worm) hypothetical protein 0.0053 0.036 0.086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0336 0.3142 0.3142
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0196 0.0345
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.003 0.0128 0.0128
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0114 0.0118
Brugia malayi Bromodomain containing protein 0.0091 0.0731 0.1754
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0869 0.1771
Schistosoma mansoni hypothetical protein 0.0023 0.0058 0.0058
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0765 1
Loa Loa (eye worm) hypothetical protein 0.0304 0.2832 0.6814
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0141 0.0333
Leishmania major DNA polymerase eta, putative 0.0037 0.0202 0.2326
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0083 0.0506
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.074 0.0738
Brugia malayi Inositol-1 0.0045 0.0274 0.0654
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.1376 0.1373
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0202 0.2326
Echinococcus multilocularis dnaJ subfamily B 0.0848 0.8182 0.8182
Brugia malayi Probable ClpP-like protease 0.0094 0.0765 0.1835
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0114 0.0171
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0231 0.1069
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0765 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0114 0.1466
Trypanosoma brucei unspecified product 0.0028 0.0108 0.1248
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0196 0.0905
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0496 0.0493
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1662 0.3453
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0298 0.0296
Entamoeba histolytica hypothetical protein 0.026 0.2395 0.8666
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1662 0.3453
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0869 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.1259 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0196 0.0345
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0174 0.0171
Loa Loa (eye worm) hypothetical protein 0.0094 0.0765 0.1835
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0114 0.0707
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0342 0.3201 0.7703
Schistosoma mansoni transient receptor potential channel 0.0095 0.0771 0.0771
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0114 0.1466
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0342 0.3201 0.3201
Schistosoma mansoni hypothetical protein 0.0208 0.1884 0.1884
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.0771 0.0769
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0083 0.0655 0.0655
Schistosoma mansoni tar DNA-binding protein 0.0342 0.3201 0.3201
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.275 1
Brugia malayi Ets-domain containing protein 0.008 0.0622 0.1493
Trichomonas vaginalis set domain proteins, putative 0.0499 0.4749 1
Schistosoma mansoni ets-related 0.0243 0.2226 0.2226
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0196 0.0905
Echinococcus granulosus dna polymerase eta 0.0065 0.0475 0.0473
Brugia malayi intermediate filament protein 0.0027 0.0096 0.0225
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0276 0.0273
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.1376 0.1376
Trypanosoma brucei unspecified product 0.0028 0.0108 0.1248
Onchocerca volvulus Glucosylceramidase homolog 0.0186 0.1662 0.3384
Schistosoma mansoni hypothetical protein 0.0096 0.0783 0.0783
Leishmania major hypothetical protein, conserved 0.0077 0.059 0.6795
Loa Loa (eye worm) hypothetical protein 0.0208 0.1884 0.453
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0222 0.022
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0063 0.0145
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0274 0.0272
Echinococcus multilocularis lamin dm0 0.0027 0.0096 0.0093
Entamoeba histolytica hypothetical protein 0.026 0.2395 0.8666
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0231 0.1067
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0869 0.2086
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0231 0.0557
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0228 0.1235
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0231 0.0418
Leishmania major hypothetical protein, conserved 0.0037 0.0196 0.2262
Brugia malayi hypothetical protein 0.005 0.0323 0.0771
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0196 0.2262
Echinococcus granulosus intermediate filament protein 0.0027 0.0096 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1662 0.3453
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0306 0.0577
Brugia malayi hypothetical protein 0.026 0.2395 0.5761
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.275 0.5762
Schistosoma mansoni ap endonuclease 0.004 0.0231 0.0231
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0306 0.192
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.1308 0.1305
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0196 0.0345
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0202 0.1262
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0259 0.0617
Toxoplasma gondii histone lysine methyltransferase SET1 0.0178 0.1583 1
Echinococcus multilocularis dna polymerase eta 0.0065 0.0475 0.0473
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0496 0.0496
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0231 0.2665
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1662 0.3453
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0783 0.0781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.001 0.0035
Loa Loa (eye worm) hypothetical protein 0.0068 0.0508 0.1218
Mycobacterium ulcerans lipase LipD 0.0037 0.0196 0.1422
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0083 0.0506
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.2144 1
Onchocerca volvulus 0.0089 0.0713 0.135
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.002 0.0231
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0231 0.2665
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0336 0.3142 0.314
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0496 0.1188
Onchocerca volvulus Alhambra homolog 0.0031 0.0141 0.0125
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.059 0.7712
Loa Loa (eye worm) hypothetical protein 0.0296 0.2751 0.6619
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0869 0.2946
Loa Loa (eye worm) hypothetical protein 0.0048 0.0311 0.0744
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0231 0.0443
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0108 0.1248
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0837 0.0835
Schistosoma mansoni tar DNA-binding protein 0.0342 0.3201 0.3201
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.1259 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0141 0.0138
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0566 0.0563
Echinococcus multilocularis protein patched 0.0047 0.0298 0.0296
Brugia malayi PHD-finger family protein 0.0036 0.0191 0.0453
Trichomonas vaginalis esterase, putative 0.0037 0.0196 0.0345
Echinococcus multilocularis Niemann Pick C1 protein 0.0157 0.1378 0.1375
Brugia malayi CHE-14 protein 0.0047 0.0298 0.0712
Loa Loa (eye worm) beta-lactamase 0.0037 0.0196 0.0467
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0439 0.4155 1
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.059 0.6795
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0276 0.0658
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0765 0.0765
Echinococcus granulosus cpg binding protein 0.0096 0.0783 0.0781
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.275 0.5762
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0869 0.1771
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0042
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0205 0.0203
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0231 0.055
Schistosoma mansoni hypothetical protein 0.0043 0.0259 0.0259
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.275 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0231 0.2665
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0231 0.0229
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0114 0.0171
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.275 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.0713 0.171
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0471 0.0469
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0243 0.316
Echinococcus multilocularis fetal alzheimer antigen, falz 0.003 0.0128 0.0126
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0114 0.1264
Schistosoma mansoni lamin 0.0027 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0096 0.0783 0.0783
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0869 0.0869
Echinococcus multilocularis GA binding protein alpha chain 0.008 0.0622 0.062
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0141 0.0138
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0454 0.0452
Echinococcus granulosus dna polymerase kappa 0.004 0.0231 0.0229
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0058 0.0132
Brugia malayi follicle stimulating hormone receptor 0.028 0.2588 0.6227
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0566 0.0563
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0003 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1662 0.3453
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0083 0.0375
Loa Loa (eye worm) fli-1 protein 0.0243 0.2226 0.5354
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0231 0.2665
Echinococcus granulosus lamin dm0 0.0027 0.0096 0.0093
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0141 0.0141
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0231 0.266
Schistosoma mansoni inositol monophosphatase 0.0045 0.0274 0.0274
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.275 0.5762
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0003 0.003
Mycobacterium ulcerans hypothetical protein 0.0037 0.0196 0.1422
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0765 1
Schistosoma mansoni tar DNA-binding protein 0.0342 0.3201 0.3201
Mycobacterium leprae Probable lipase LipE 0.0037 0.0196 0.0966
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.0915 0.0912
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0096 0.0225
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.026 0.2395 0.2393
Schistosoma mansoni transient receptor potential channel 0.0063 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0095 0.0771 0.1852
Loa Loa (eye worm) hypothetical protein 0.0077 0.059 0.1415
Loa Loa (eye worm) TAR-binding protein 0.0342 0.3201 0.7703
Loa Loa (eye worm) RNA binding protein 0.0342 0.3201 0.7703
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0076 0.0073
Brugia malayi Bromodomain containing protein 0.0037 0.0204 0.0484
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0231 0.2665
Echinococcus multilocularis GPCR, family 2 0.0096 0.0783 0.0781
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0183 0.0181
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0042
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0306 0.3982
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0083 0.0506
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0231 0.2665
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0004 0.0002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0231 0.0229
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0471 0.2964
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0259 0.3361
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0231 0.2665
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1662 0.3453
Loa Loa (eye worm) hypothetical protein 0.006 0.0423 0.1013
Brugia malayi beta-lactamase 0.0037 0.0196 0.0467
Echinococcus granulosus peregrin 0.0037 0.0204 0.0201
Brugia malayi jmjC domain containing protein 0.0045 0.0276 0.0658
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.176 0.3662
Onchocerca volvulus 0.0027 0.0096 0.0028
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0213
Brugia malayi phosphofructokinase 0.0105 0.0869 0.2086
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0765 0.0762
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2619 0.5484
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0111 0.0931 0.0931
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0003 0.003
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0496 0.5708
Brugia malayi 6-phosphofructokinase 0.0105 0.0869 0.2086
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0496 0.5708
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0869 0.0869
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1662 0.3453
Schistosoma mansoni hypothetical protein 0.0045 0.0282 0.0282
Mycobacterium tuberculosis Conserved protein 0.0037 0.0196 0.0905
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0155 0.0156
Brugia malayi hypothetical protein 0.0077 0.059 0.1415
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0274 0.0509
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0196 0.0345
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0631 0.0631
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0274 0.1718
Toxoplasma gondii exonuclease III APE 0.004 0.0231 0.1446
Entamoeba histolytica hypothetical protein 0.026 0.2395 0.8666
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0003 0.003
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0218 0.0215
Onchocerca volvulus 0.0037 0.0196 0.0243
Echinococcus multilocularis tumor protein p63 0.0392 0.3695 0.3694
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0019 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0083 0.0506
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0869 0.2946
Echinococcus granulosus tar DNA binding protein 0.0342 0.3201 0.3199
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.059 0.7712
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.026 0.2395 0.2393
Schistosoma mansoni inositol monophosphatase 0.0045 0.0274 0.0274
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0196 0.0194
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0019 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0083 0.0193
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0004 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0196 0.2262
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0231 0.2665
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0196 0.0196
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0083 0.0375
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.0475 0.5473
Echinococcus multilocularis peregrin 0.0037 0.0204 0.0201
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0043 0.0259 0.162
Schistosoma mansoni transcription factor LCR-F1 0.026 0.2395 0.2395
Schistosoma mansoni ap endonuclease 0.004 0.0231 0.0231
Onchocerca volvulus 0.0296 0.2751 0.5718
Brugia malayi RNA recognition motif domain containing protein 0.0342 0.3201 0.7703
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0231 0.0419
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.176 0.3662
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0231 0.2665
Mycobacterium ulcerans beta-lactamase 0.0037 0.0196 0.1422
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0083 0.0954
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0083 0.0954
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0141 0.1816
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0231 0.2998
Mycobacterium tuberculosis Conserved protein 0.0037 0.0196 0.0905
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0196 0.0905
Echinococcus granulosus dnaJ subfamily B 0.0848 0.8182 0.8182
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0114 0.0171
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.059 0.3719
Echinococcus granulosus Niemann Pick C1 protein 0.0157 0.1378 0.1375
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0141 0.0875
Brugia malayi 6-phosphofructokinase 0.0105 0.0869 0.2086
Loa Loa (eye worm) hypothetical protein 0.011 0.0915 0.2196
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0155 0.2004
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0114 0.1466
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0231 0.0231
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.001 0.0035
Loa Loa (eye worm) hypothetical protein 0.0058 0.0403 0.0963
Brugia malayi RNA binding protein 0.0342 0.3201 0.7703
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0869 0.4045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.001 0.0035
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0114 0.0171
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0076 0.0073
Brugia malayi Ets-domain containing protein 0.008 0.0622 0.1493
Schistosoma mansoni tar DNA-binding protein 0.0342 0.3201 0.3201
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0196 0.0905
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0196 0.2262
Echinococcus multilocularis zinc finger protein 0.003 0.0133 0.0131
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0174 0.0171
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0496 0.0493
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0274 0.0509
Onchocerca volvulus 0.0057 0.04 0.068
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0183 0.0435
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0276 0.0276
Schistosoma mansoni intermediate filament proteins 0.0027 0.0096 0.0096
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0765 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0183 0.0181
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0083 0.0506
Echinococcus multilocularis lamin 0.0027 0.0096 0.0093
Schistosoma mansoni hypothetical protein 0.026 0.2395 0.2395
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0276 0.0276
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0261 0.0258
Echinococcus granulosus lamin 0.0027 0.0096 0.0093
Loa Loa (eye worm) hypothetical protein 0.0083 0.0655 0.1571
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0155 0.2004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0083 0.0655 0.0655
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.074 0.0738
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0765 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0035 0.0176 0.0176
Plasmodium falciparum phd finger protein, putative 0.0031 0.0141 0.1816
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0869 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0231 0.0229
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0765 0.5795
Entamoeba histolytica hypothetical protein 0.026 0.2395 0.8666
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0467 0.1118
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0869 0.0866
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0869 0.2086
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0304 0.2832 0.6814
Brugia malayi Calcitonin receptor-like protein seb-1 0.0304 0.2832 0.6814
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0231 0.1705
Brugia malayi Bromodomain containing protein 0.0046 0.0285 0.068
Leishmania major DNA polymerase kappa, putative 0.004 0.0231 0.2665
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0191 0.1719 0.1719
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0274 0.2049
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0869 0.1771
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0869 0.2086
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0336 0.3142 0.7561
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0274 0.0272
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0231 0.1702
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0231 0.0419
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.1376 0.3307
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0869 0.0866
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0274 0.0509
Loa Loa (eye worm) hypothetical protein 0.0037 0.0196 0.0467
Loa Loa (eye worm) hypothetical protein 0.0032 0.0152 0.036
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0306 0.0304
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0783 0.188
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0196 0.1422
Onchocerca volvulus 0.0037 0.0196 0.0243
Brugia malayi Pre-SET motif family protein 0.0065 0.0471 0.1128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0336 0.3142 0.3142
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.008 0.0622 0.1493
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0196 0.1422
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0259 0.3361
Loa Loa (eye worm) hypothetical protein 0.0042 0.0249 0.0593
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.059 0.7712
Schistosoma mansoni cpg binding protein 0.0096 0.0783 0.0783
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0475 0.1139
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0231 0.0443
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.275 0.5762
Schistosoma mansoni hypothetical protein 0.0096 0.0783 0.0783
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0444 0.0442
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0304 0.2832 0.6814
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0114 0.1466
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1083 0.2602
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0231 0.055
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0196 0.0905
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0114 0.1264
Loa Loa (eye worm) hypothetical protein 0.0057 0.04 0.0957
Loa Loa (eye worm) hypothetical protein 0.0037 0.0196 0.0467
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0765 0.6008
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0114 0.0707
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0783 0.0781
Loa Loa (eye worm) hypothetical protein 0.0056 0.0382 0.0914
Schistosoma mansoni zinc finger protein 0.003 0.0133 0.0133
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0218 0.0215
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0765 0.6008
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0765 0.4822
Toxoplasma gondii hypothetical protein 0.0033 0.0155 0.0966
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0129 0.0127
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0336 0.3142 0.314
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0196 0.2544
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.275 0.5762
Schistosoma mansoni hypothetical protein 0.0031 0.0141 0.0141
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0274 0.0717
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0083 0.0506
Loa Loa (eye worm) hypothetical protein 0.0027 0.0096 0.0225
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0025 0.0083 0.0193
Schistosoma mansoni hypothetical protein 0.0848 0.8182 0.8182
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0444 0.3073
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0108 0.1248
Loa Loa (eye worm) hypothetical protein 0.0037 0.0196 0.0467
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0196 0.0467
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.2588 0.6227
Echinococcus granulosus tumor protein p63 0.0392 0.3695 0.3694
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0765 0.2467
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0083 0.0506
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0083 0.0193
Echinococcus multilocularis dna polymerase kappa 0.004 0.0231 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0298 0.0561
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0231 0.266
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2619 0.5484
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0231 0.2665
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0454 0.0452
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0231 0.0418
Echinococcus multilocularis cpg binding protein 0.0096 0.0783 0.0781
Brugia malayi CXXC zinc finger family protein 0.0089 0.0713 0.171
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0765 0.0762
Brugia malayi beta-lactamase family protein 0.0037 0.0196 0.0467
Brugia malayi PHD-finger family protein 0.0017 0.0006 0.0007
Onchocerca volvulus 0.0027 0.0096 0.0028
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0083 0.0193
Echinococcus multilocularis musashi 0.0027 0.0096 0.0093
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0129 0.0127
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.001 0.0035
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0283 0.2619 0.6302
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0114 0.0171
Loa Loa (eye worm) hypothetical protein 0.0025 0.0083 0.0193
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0196 0.0345
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0114 0.0707
Brugia malayi TAR-binding protein 0.0342 0.3201 0.7703
Trypanosoma brucei unspecified product 0.004 0.0231 0.2665
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0471 0.0471
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.275 1
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0869 0.1771
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0196 0.0905
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0869 1
Schistosoma mansoni DNA polymerase eta 0.0065 0.0475 0.0475
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.0771 0.0769
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0243 0.049
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0298 0.0296
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0076 0.0073
Leishmania major DNA polymerase eta, putative 0.0065 0.0475 0.5473
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0222 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0231 0.2665
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0243 0.0602
Echinococcus granulosus expressed conserved protein 0.0103 0.0849 0.0847
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0196 0.0905
Brugia malayi jmjC domain containing protein 0.0102 0.0837 0.201
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0259 0.0256
Schistosoma mansoni hypothetical protein 0.0045 0.0282 0.0282
Plasmodium vivax SET domain protein, putative 0.0065 0.0471 0.6147
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1083 0.2602
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0231 0.0551
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0007
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0274 0.3155
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0019 0.0019
Mycobacterium ulcerans hypothetical protein 0.0025 0.0083 0.0506
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0274 0.3155
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0231 0.2665
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2619 0.5484
Schistosoma mansoni hypothetical protein 0.0045 0.0282 0.0282
Schistosoma mansoni lamin 0.0027 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0077 0.0598 0.1433
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.0771 0.0771
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.275 0.5762
Onchocerca volvulus 0.0499 0.4749 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0496 0.5708
Loa Loa (eye worm) hypothetical protein 0.0037 0.0196 0.0467
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.002 0.0231
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0259 0.0617
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0306 0.0577
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2619 0.5484
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0869 0.6848
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0114 0.0171
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0231 0.266
Schistosoma mansoni patched 1 0.0047 0.0298 0.0298
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0765 0.4822
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0141 0.0875
Schistosoma mansoni gabp alpha 0.008 0.0622 0.0622
Echinococcus granulosus GA binding protein alpha chain 0.008 0.0622 0.062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0336 0.3142 0.314
Toxoplasma gondii ABC1 family protein 0.0037 0.0196 0.1226
Schistosoma mansoni bromodomain containing protein 0.0078 0.0604 0.0604
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0336 0.3142 0.314
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.002 0.0082
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0231 0.2665
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.0915 0.0912
Loa Loa (eye worm) hypothetical protein 0.0096 0.0783 0.188
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2619 0.5484
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0019 0.0016
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0496 0.1188
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0076 0.0073
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0231 0.2665
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0196 0.0966
Loa Loa (eye worm) histone methyltransferase 0.003 0.0129 0.0305
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0096 0.0225
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0083 0.0954
Brugia malayi beta-lactamase family protein 0.0037 0.0196 0.0467
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2619 0.5484
Brugia malayi hypothetical protein 0.0039 0.0218 0.0518
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0003 0.003
Brugia malayi MH2 domain containing protein 0.0127 0.1083 0.2602
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0231 0.0551
Schistosoma mansoni hypothetical protein 0.0096 0.0783 0.0783
Mycobacterium tuberculosis Conserved protein 0.0037 0.0196 0.0905
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0429 0.0427
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0231 0.2665
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0231 0.2998
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0783 0.0781
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0783 0.188
Brugia malayi Pre-SET motif family protein 0.0439 0.4155 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0083 0.0193
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0231 0.1705
Loa Loa (eye worm) acetyltransferase 0.0156 0.1376 0.3307
Giardia lamblia PHD finger protein 15 0.0031 0.0141 0.0101
Brugia malayi F/Y-rich N-terminus family protein 0.0042 0.0246 0.0587
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0096 0.0225
Onchocerca volvulus 0.0037 0.0196 0.0243
Schistosoma mansoni cpg binding protein 0.0089 0.0713 0.0713
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0261 0.0258
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0783 0.188
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0231 0.0556
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.275 0.5762
Onchocerca volvulus 0.0065 0.0471 0.0832
Brugia malayi latrophilin 2 splice variant baaae 0.0208 0.1884 0.453
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.1259 0.5868
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0475 0.5473
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0444 0.2063
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0298 0.0296
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0298 0.0712
Brugia malayi hypothetical protein 0.0296 0.2751 0.6619
Brugia malayi Niemann-Pick C1 protein precursor 0.011 0.0915 0.2196
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0274 0.0806
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0003 0.0003
Echinococcus granulosus zinc finger protein 0.003 0.0133 0.0131
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0155 0.0616
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0837 0.0835
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0196 0.0194
Echinococcus multilocularis tar DNA binding protein 0.0342 0.3201 0.3199
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0231 0.2665
Brugia malayi PHD-finger family protein 0.0031 0.0141 0.0333
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.275 0.5762
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0274 0.3155
Brugia malayi hypothetical protein 0.0039 0.0218 0.0518
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0231 0.2665
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0108 0.1248
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0336 0.3142 0.7561
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0471 0.0471
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0228 0.1053
Echinococcus multilocularis protein dispatched 1 0.0054 0.0364 0.0361
Schistosoma mansoni cpg binding protein 0.0096 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.0047 0.0298 0.0712
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0496 0.5708
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0114 0.0171
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.059 0.6795
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0783 0.0781
Echinococcus granulosus histone lysine methyltransferase setb 0.0083 0.0655 0.0652
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0042
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0196 0.0467
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0454 0.0452
Loa Loa (eye worm) hypothetical protein 0.0043 0.0259 0.0617
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0231 0.0229
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0333
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0496 0.1548
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0283 0.2619 0.6302

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1032 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 23.7558 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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