Detailed information for compound 1293677

Basic information

Technical information
  • TDR Targets ID: 1293677
  • Name: [2-(tert-butylcarbamoylamino)-2-oxoethyl] 2-b enzo[e][1]benzoxol-1-ylacetate
  • MW: 382.41 | Formula: C21H22N2O5
  • H donors: 2 H acceptors: 3 LogP: 3.85 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(=O)NC(C)(C)C)COC(=O)Cc1coc2c1c1ccccc1cc2
  • InChi: 1S/C21H22N2O5/c1-21(2,3)23-20(26)22-17(24)12-28-18(25)10-14-11-27-16-9-8-13-6-4-5-7-15(13)19(14)16/h4-9,11H,10,12H2,1-3H3,(H2,22,23,24,26)
  • InChiKey: AGWZYGJLFCPJMD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(tert-butylcarbamoylamino)-2-oxo-ethyl] 2-benzo[e]benzofuran-1-ylacetate
  • 2-(1-benzo[e]benzofuranyl)acetic acid [2-[[(tert-butylamino)-oxomethyl]amino]-2-oxoethyl] ester
  • 2-benzo[e]benzofuran-1-ylacetic acid [2-(tert-butylcarbamoylamino)-2-keto-ethyl] ester
  • [2-(tert-butylcarbamoylamino)-2-oxo-ethyl] 2-benzo[e][1]benzoxol-1-ylethanoate
  • SMR000255874
  • ZINC03306362
  • T5219445
  • MLS000389600

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi CXXC zinc finger family protein 0.0029 0.027 0.0473
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0037 0.0018
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.002 0.0003
Trichomonas vaginalis dullard protein, putative 0.0027 0.0237 0.0389
Trypanosoma brucei DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Onchocerca volvulus 0.0017 0.0122 0.0171
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0225 0.037
Loa Loa (eye worm) beta-lactamase 0.0079 0.0859 0.1583
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0114 0.0159
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0224 0.2581 0.5275
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.002 0.0041
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0382 0.0943
Onchocerca volvulus 0.0091 0.0994 0.1611
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0382 0.0627
Trypanosoma cruzi DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0114 0.0187
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2253 0.2239
Loa Loa (eye worm) hypothetical protein 0.0039 0.0382 0.0684
Trypanosoma brucei DNA polymerase kappa, putative 0.0155 0.1756 0.4507
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0439 0.0721
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0457 0.5333 1
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.04 0.0718
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.1675 0.3409
Echinococcus granulosus CTD small phosphatase protein like 0.0027 0.0237 0.0451
Onchocerca volvulus 0.0016 0.0108 0.0148
Schistosoma mansoni carbon catabolite repressor protein 0.0008 0.0018 0.0037
Echinococcus multilocularis expressed protein 0.0008 0.002 0.0002
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0237 0.0389
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0091 0.0994 0.1837
Schistosoma mansoni terminal deoxycytidyl transferase 0.0224 0.2581 0.5293
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0408 0.1521
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.002 0.0002
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0382 0.0943
Trichomonas vaginalis DNA polymerase eta, putative 0.0224 0.2581 0.4246
Loa Loa (eye worm) hypothetical protein 0.0079 0.0859 0.1583
Echinococcus granulosus MAM 0.0017 0.0122 0.0214
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.002 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0452 0.0743
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0382 0.0364
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0008 0.002 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0845 1
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.002 0.0041
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0225 0.037
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.1725 0.3212
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0859 0.1731
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0114 0.0249
Loa Loa (eye worm) hypothetical protein 0.0079 0.0859 0.1583
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0179 0.204 1
Mycobacterium ulcerans hypothetical protein 0.007 0.0747 0.2221
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0027 0.0237 0.2742
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2253 0.4206
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0008 0.002 0.0032
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0008 0.002 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0747 0.1891
Leishmania major DNA polymerase kappa, putative 0.007 0.0747 0.1891
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0008 0.0018 0.0029
Echinococcus multilocularis cpg binding protein 0.0031 0.0289 0.0272
Onchocerca volvulus 0.0016 0.0108 0.0148
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0382 0.0364
Plasmodium vivax exodeoxyribonuclease III, putative 0.0008 0.0018 0.0189
Onchocerca volvulus 0.0066 0.0704 0.1132
Echinococcus granulosus snurportin 1 0.0337 0.392 0.803
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0859 0.1583
Mycobacterium tuberculosis Conserved protein 0.0079 0.0859 0.1427
Loa Loa (eye worm) hypothetical protein 0.0078 0.0845 0.1556
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0114 0.0187
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.0169
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.04 0.4613
Schistosoma mansoni hypothetical protein 0.0008 0.0018 0.0037
Loa Loa (eye worm) hypothetical protein 0.0091 0.0994 0.1837
Loa Loa (eye worm) hypothetical protein 0.0032 0.0296 0.0523
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.002 0.0004
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0114 0.0249
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0747 0.1891
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0439 0.0721
Brugia malayi ImpB/MucB/SamB family protein 0.0333 0.3874 0.7255
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0008 0.002 0.0003
Echinococcus granulosus dnaJ subfamily B 0.0418 0.4877 1
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0008 0.002 0.0041
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0114 0.0187
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0296 0.1375
Trypanosoma brucei DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0008 0.0018 0.0029
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0008 0.0018 0.0029
Trypanosoma brucei DNA polymerase IV, putative 0.0224 0.2581 0.6648
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0845 0.4091
Plasmodium falciparum DNA repair protein REV1, putative 0.007 0.0747 0.8814
Schistosoma mansoni cpg binding protein 0.0029 0.027 0.0553
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0223 0.0532
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0439 0.0721
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0056 0.0072
Brugia malayi hypothetical protein 0.0078 0.0845 0.1556
Trypanosoma brucei unspecified product 0.0155 0.1756 0.4507
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0223 0.0348
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0382 0.0943
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0704 0.1444
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0193 0.2211 0.4126
Schistosoma mansoni hypothetical protein 0.0365 0.425 0.8713
Onchocerca volvulus 0.0016 0.0108 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0439 0.0721
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.002 0.0002
Giardia lamblia DINP protein human, muc B family 0.0224 0.2581 1
Brugia malayi Importin beta-1 subunit 0.0032 0.0296 0.0523
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0197 0.0465
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0223 0.1015
Schistosoma mansoni DNA polymerase IV / kappa 0.007 0.0747 0.1532
Schistosoma mansoni ran 0.0023 0.0197 0.0404
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0382 0.0749
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0859 0.1427
Trypanosoma cruzi DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0439 0.0721
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0018 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0439 0.1642
Leishmania major GTP-binding protein, putative 0.0023 0.0197 0.0465
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.002 0.0032
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.002 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0747 0.1891
Plasmodium falciparum flap endonuclease 1 0.0027 0.0246 0.2752
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0859 0.1413
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0382 0.0627
Trichomonas vaginalis Phospholipase C precursor, putative 0.0008 0.0018 0.0029
Trichomonas vaginalis dullard protein, putative 0.0027 0.0237 0.0389
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2253 0.2239
Schistosoma mansoni hypothetical protein 0.0017 0.0122 0.025
Schistosoma mansoni hypothetical protein 0.0016 0.0108 0.0221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.2211 0.4534
Mycobacterium ulcerans hypothetical protein 0.0079 0.0859 0.2698
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.002 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0704 0.1444
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.002 0.0041
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0018 0.0029
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0382 0.0749
Brugia malayi Pre-SET motif family protein 0.0066 0.0704 0.1291
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.0169
Echinococcus multilocularis dna polymerase kappa 0.0224 0.2581 0.2568
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0027 0.0237 0.0568
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0408 0.1521
Schistosoma mansoni hypothetical protein 0.0035 0.0336 0.0689
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0224 0.2581 0.4823
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0008 0.0018 0.0029
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.007 0.0747 0.3606
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0859 0.1427
Brugia malayi hypothetical protein 0.0008 0.002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0079 0.0859 0.1583
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.0412
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0382 0.0364
Loa Loa (eye worm) G protein alpha subunit 3 0.0008 0.002 0.0003
Mycobacterium tuberculosis Conserved protein 0.0079 0.0859 0.1427
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0027 0.0237 0.2647
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0704 0.0687
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0237 0.0389
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0859 0.2182
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0003
Trypanosoma cruzi DNA polymerase eta, putative 0.0333 0.3874 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.04 0.0989
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0237 0.0389
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.04 0.0785
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0225 0.0537
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0859 0.1413
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0439 0.0721
Onchocerca volvulus 0.052 0.608 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0382 0.0943
Schistosoma mansoni hypothetical protein 0.0017 0.0122 0.025
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0037 0.0038
Schistosoma mansoni synaptojanin 0.0008 0.0018 0.0037
Loa Loa (eye worm) DOMON domain-containing protein 0.0016 0.0108 0.0169
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0018 0.0189
Entamoeba histolytica G protein alpha subunit, putative 0.0008 0.002 0.0007
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0027 0.0237 0.0412
Brugia malayi hypothetical protein 0.005 0.0518 0.094
Leishmania major DNA polymerase eta, putative 0.0333 0.3874 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0859 0.1762
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0859 0.1427
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0224 0.2581 0.6648
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0859 0.2698
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.002 0.0004
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0008 0.002 0.0003
Onchocerca volvulus 0.0029 0.027 0.0415
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0223 0.2582
Schistosoma mansoni ap endonuclease 0.004 0.04 0.0819
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0439 0.0721
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.002 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0018 0.0189
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.002 0.0041
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.027 0.0473
Brugia malayi RNA, U transporter 1 0.009 0.0987 0.1822
Echinococcus multilocularis L aminoadipate semialdehyde 0.0091 0.0994 0.0978
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0859 0.1427
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0246 0.059
Trypanosoma brucei DNA damage repair protein, putative 0.007 0.0747 0.1891
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0008 0.002 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0845 0.2145
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0382 0.0749
Giardia lamblia DNA damage repair protein 0.007 0.0747 0.2844
Trypanosoma cruzi DNA polymerase eta, putative 0.0179 0.204 0.5243
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0452 0.2147
Leishmania major DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0008 0.002 0.0032
Schistosoma mansoni hypothetical protein 0.0365 0.425 0.8713
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.04 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0747 0.1891
Echinococcus granulosus dna polymerase eta 0.0333 0.3874 0.7935
Onchocerca volvulus 0.0008 0.002 0.0003
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0008 0.0018 0.0029
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0114 0.0249
Schistosoma mansoni hypothetical protein 0.0418 0.4877 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0408 0.4712
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.2211 0.2197
Leishmania major hypothetical protein, conserved 0.0079 0.0859 0.2182
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0654 0.3143
Trypanosoma brucei DNA polymerase IV, putative 0.0224 0.2581 0.6648
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0439 0.0866
Echinococcus multilocularis snurportin 1 0.0337 0.392 0.3909
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0246 0.0888
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0704 0.0687
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0246 0.059
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0114 0.0187
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0704 0.1412
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0246 0.0403
Trypanosoma brucei chrX additional, unordered contigs 0.007 0.0747 0.1891
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0114 0.0375
Loa Loa (eye worm) hypothetical protein 0.007 0.0747 0.1372
Plasmodium vivax SET domain protein, putative 0.0066 0.0704 0.819
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0008 0.002 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0747 0.1891
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.2211 0.4534
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0018 0.0029
Brugia malayi Protein kinase domain containing protein 0.0017 0.0122 0.0195
Brugia malayi polk-prov protein 0.007 0.0747 0.1372
Schistosoma mansoni hypothetical protein 0.0026 0.0233 0.0478
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.002 0.0002
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0859 0.1427
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0506 0.5914 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.007 0.0747 0.3606
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0008 0.002 0.0003
Onchocerca volvulus 0.0016 0.0108 0.0148
Echinococcus granulosus L aminoadipate semialdehyde 0.0091 0.0994 0.2009
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0008 0.002 0.0041
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0223 0.0532
Trypanosoma brucei DNA polymerase kappa, putative 0.0155 0.1756 0.4507
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0296 0.0721
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0197 0.2278
Brugia malayi ImpB/MucB/SamB family protein 0.0224 0.2581 0.4823
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0859 0.2698
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0224 0.2581 0.2568
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0859 0.1413
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0439 0.2082
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.002 0.0041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.04 0.0989
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0223 0.5379
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0246 0.1126
Echinococcus granulosus dna polymerase kappa 0.0224 0.2581 0.5275
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0859 0.0843
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0859 0.1427
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0859 0.1583
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0296 0.0721
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2253 0.46
Trypanosoma brucei unspecified product 0.0155 0.1756 0.4507
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0296 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0155 0.1756 0.4507
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0439 0.0721
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0027 0.0237 0.0854
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0008 0.002 0.0003
Schistosoma mansoni cript-related 0.0008 0.0018 0.0037
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0091 0.0994 0.2039
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.4877 0.4868
Schistosoma mansoni ran 0.0023 0.0197 0.0404
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0845 0.2145
Leishmania major hypothetical protein, conserved 0.0078 0.0845 0.2145
Entamoeba histolytica hypothetical protein 0.0026 0.0225 0.0808
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0859 0.1427
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0704 0.1444
Schistosoma mansoni cpg binding protein 0.0031 0.0289 0.0593
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0027 0.0237 0.0486
Loa Loa (eye worm) hypothetical protein 0.0066 0.0704 0.1291
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.002 0.0032
Echinococcus granulosus expressed protein 0.0008 0.002 0.0004
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0246 0.059
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.04 0.0989
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.04 0.1488
Loa Loa (eye worm) hypothetical protein 0.0016 0.0114 0.0181
Onchocerca volvulus 0.0079 0.0859 0.1388
Leishmania major DNA polymerase eta, putative 0.0179 0.204 0.5243
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.2211 0.4534
Trichomonas vaginalis ap endonuclease, putative 0.004 0.04 0.0657
Mycobacterium ulcerans DNA polymerase IV 0.0224 0.2581 1
Echinococcus multilocularis MAM 0.0017 0.0122 0.0104
Brugia malayi hypothetical protein 0.0017 0.0122 0.0195
Echinococcus multilocularis geminin 0.0365 0.425 0.4239
Trypanosoma cruzi DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0037 0.0038
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0336 0.0654
Echinococcus granulosus importin subunit beta 1 0.0032 0.0296 0.0572
Schistosoma mansoni synaptojanin 0.0008 0.0018 0.0037
Loa Loa (eye worm) hypothetical protein 0.0079 0.0859 0.1583
Schistosoma mansoni alpha-glucosidase 0.0169 0.1929 0.3954
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0246 0.0428
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.002 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Trypanosoma brucei DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.002 0.0041
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0747 0.1891
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.002 0.0032
Brugia malayi beta-lactamase 0.0079 0.0859 0.1583
Leishmania major hypothetical protein, conserved 0.0027 0.0237 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0439 0.1092
Onchocerca volvulus 0.0079 0.0859 0.1388
Onchocerca volvulus 0.0079 0.0859 0.1388
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0439 0.1092
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0859 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0114 0.0181
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0008 0.0012 0.0025
Schistosoma mansoni cpg binding protein 0.0031 0.0289 0.0593
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.1725 0.171
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0197 0.0465
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0859 0.1413
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0382 0.0684
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.002 0.0041
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0037 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Onchocerca volvulus 0.0016 0.0108 0.0148
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0193 0.2211 0.4126
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0704 0.1444
Loa Loa (eye worm) hypothetical protein 0.0079 0.0859 0.1583
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0003
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0439 0.1092
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0027 0.0237 0.0854
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0197 0.0179
Schistosoma mansoni alpha-glucosidase 0.0169 0.1929 0.3954
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.04 0.1488
Loa Loa (eye worm) hypothetical protein 0.0333 0.3874 0.7255
Onchocerca volvulus 0.0017 0.0122 0.0171
Schistosoma mansoni nocturnin 0.0008 0.0018 0.0037
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.002 0.0004
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0018 0.0189
Loa Loa (eye worm) hypothetical protein 0.0017 0.0122 0.0195
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0122 0.0195
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0114 0.0249
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0439 0.0422
Onchocerca volvulus 0.0114 0.127 0.2066
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0008 0.002 0.0003
Trichomonas vaginalis set domain proteins, putative 0.052 0.608 1
Trypanosoma brucei glucosidase, putative 0.0044 0.0439 0.1092
Entamoeba histolytica deoxycytidyl transferase, putative 0.0224 0.2581 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0452 0.2147
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0337 0.392 0.7342
Schistosoma mansoni neutral sphingomyelinase 0.0008 0.0018 0.0037
Mycobacterium ulcerans lipase LipD 0.0079 0.0859 0.2698
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0008 0.0018 0.0037
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.002 0.0003
Schistosoma mansoni DNA polymerase eta 0.0333 0.3874 0.7943
Brugia malayi Flap endonuclease-1 0.0027 0.0246 0.0428
Toxoplasma gondii ABC1 family protein 0.0079 0.0859 0.4162
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0859 0.1413
Onchocerca volvulus 0.0008 0.002 0.0003
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0027 0.0237 0.2742
Trichomonas vaginalis dullard protein, putative 0.0027 0.0237 0.0389
Mycobacterium ulcerans DNA polymerase IV 0.0224 0.2581 1
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0008 0.002 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.2211 0.2197
Leishmania major importin beta-1 subunit, putative 0.0026 0.0225 0.0537
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0197 0.0337
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.04 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0114 0.0187
Echinococcus multilocularis dna polymerase eta 0.0333 0.3874 0.3863
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0223 0.5
Brugia malayi SEA domain containing protein 0.0016 0.0108 0.0169
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0439 0.0721
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0027 0.0237 0.0219
Plasmodium vivax importin-beta 2, putative 0.0032 0.0296 0.3431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0382 0.0627
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0037 0.0075
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0845 0.2145
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0225 0.037
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.04 0.0647
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0058 0.0082
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0452 0.0743
Mycobacterium tuberculosis Conserved protein 0.0079 0.0859 0.1427
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0845 0.9833
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0237 0.0389
Entamoeba histolytica Ran family GTPase 0.0023 0.0197 0.0699
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.04 0.4638
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0114 0.0187
Schistosoma mansoni alpha glucosidase 0.0044 0.0439 0.09
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2253 0.4206
Mycobacterium ulcerans beta-lactamase 0.0079 0.0859 0.2698
Brugia malayi Muscle positioning protein 4 0.0016 0.0108 0.0169
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0008 0.002 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0859 0.2182
Toxoplasma gondii exonuclease III APE 0.004 0.04 0.1887
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0003
Brugia malayi beta-lactamase family protein 0.0079 0.0859 0.1583
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.04 0.0382
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0027 0.0237 0.1083
Schistosoma mansoni flap endonuclease-1 0.0025 0.0215 0.044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.2211 0.4513
Echinococcus granulosus flap endonuclease 1 0.0027 0.0246 0.0468
Loa Loa (eye worm) acetyltransferase 0.0152 0.1725 0.3212
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0246 0.2843
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0223 0.2482
Brugia malayi G-protein alpha subunit 0.0008 0.002 0.0003
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0197 0.0699
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.002 0.0004
Entamoeba histolytica hypothetical protein 0.0025 0.0223 0.0801
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0859 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0114 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.04 0.0989
Trichomonas vaginalis esterase, putative 0.0079 0.0859 0.1413
Schistosoma mansoni ap endonuclease 0.004 0.04 0.0819
Loa Loa (eye worm) hypothetical protein 0.0017 0.0122 0.0195
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0197 0.0337
Trypanosoma brucei unspecified product 0.0224 0.2581 0.6648
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0859 0.2182
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0027 0.0237 0.0451
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.04 0.0748
Echinococcus multilocularis 0.0027 0.0237 0.0219
Leishmania major DNA damage repair protein, putative 0.007 0.0747 0.1891
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0704 0.3394
Trypanosoma brucei DNA polymerase IV, putative 0.0224 0.2581 0.6648
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.002 0.0041
Plasmodium falciparum importin beta, putative 0.0032 0.0296 0.3362
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0027 0.0237 0.0486
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0008 0.002 0.0003
Trypanosoma cruzi DNA damage repair protein, putative 0.007 0.0747 0.1891
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0382 0.0783
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0336 0.0318
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0223 0.1015
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0382 0.1419
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0224 0.2581 0.5293
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0668 0.1338
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0197 0.2166
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0688 0.1411
Mycobacterium leprae Probable lipase LipE 0.0079 0.0859 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.04 0.0718
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.0405
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0197 0.0369
Trypanosoma cruzi DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0452 0.5249
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.002 0.0041
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.1725 0.3538
Trichomonas vaginalis ran, putative 0.0023 0.0197 0.0324
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0058 0.0075
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0382 0.1419
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0439 0.0792
Trypanosoma brucei DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0197 0.0465
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0845 1
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0246 0.0228
Echinococcus granulosus cpg binding protein 0.0031 0.0289 0.0558
Schistosoma mansoni hypothetical protein 0.0337 0.392 0.8037
Plasmodium vivax DNA repair protein REV1, putative 0.007 0.0747 0.869
Schistosoma mansoni importin beta-1 0.0032 0.0296 0.0607
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0058 0.004
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0224 0.2581 0.4246
Trypanosoma cruzi DNA damage repair protein, putative 0.007 0.0747 0.1891
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0237 0.0568
Trichomonas vaginalis ap endonuclease, putative 0.004 0.04 0.0657
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.2211 0.4513
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0859 0.1762
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0224 0.2581 0.4348
Onchocerca volvulus 0.0008 0.002 0.0003
Loa Loa (eye worm) TK/ALK protein kinase 0.0017 0.0122 0.0195
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0246 0.0888
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0197 0.0886
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0114 0.0187
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0008 0.002 0.0002
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0439 0.1642
Trypanosoma brucei DNA polymerase eta, putative 0.0333 0.3874 1
Brugia malayi Pre-SET motif family protein 0.0457 0.5333 1
Trypanosoma brucei DNA damage repair protein, putative 0.007 0.0747 0.1891
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0452 0.0893
Trypanosoma brucei DNA polymerase kappa, putative 0.0224 0.2581 0.6648
Echinococcus granulosus geminin 0.0365 0.425 0.8708
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0439 0.0792
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0008 0.002 0.0032
Brugia malayi beta-lactamase family protein 0.0079 0.0859 0.1583
Loa Loa (eye worm) hypothetical protein 0.0079 0.0859 0.1583
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0382 0.0783
Mycobacterium tuberculosis Conserved hypothetical protein 0.0224 0.2581 0.4348

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.15 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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