TDR Targets

Basic information

Technical information

TDR Targets ID: 1294176
Name: T5355240
MW: 294.346 | Formula: C15H22N2O4
H donors: 1 H acceptors: 3 LogP: 2.61 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NC1CCCCC1C)COC(=O)c1c(C)noc1C
InChi: 1S/C15H22N2O4/c1-9-6-4-5-7-12(9)16-13(18)8-20-15(19)14-10(2)17-21-11(14)3/h9,12H,4-8H2,1-3H3,(H,16,18)
InChiKey: YAVHRZAYRQCWQV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	l(3)mbt-like 1 (Drosophila)	Starlite/ChEMBL	No references
Homo sapiens	chromobox homolog 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus		Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus	Heterochromatin protein 1 homolog	Get druggable targets OG5_129545	All targets in OG5_129545
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Echinococcus multilocularis	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 3 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 4 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415
Schistosoma japonicum	Chromobox protein homolog 5, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_130415	All targets in OG5_130415
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Theileria parva	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Brugia malayi	Heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0058	0.1059	0.118
Schistosoma mansoni	hypothetical protein	0.0024	0.0048	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0745	0.0963
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0634	0.0706
Brugia malayi	Cell death protein 3 precursor	0.0065	0.1278	0.1653
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0058	0.0918
Loa Loa (eye worm)	hypothetical protein	0.007	0.1421	0.1583
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0634	0.082
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0634	1
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0634	1
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.1059	0.1059
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0634	0.0706
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0068	0.1373	0.153
Brugia malayi	Melibiase family protein	0.0081	0.1776	0.2297
Loa Loa (eye worm)	hypothetical protein	0.007	0.1421	0.1583
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0046	0.0723	0.0723
Echinococcus granulosus	endothelin converting enzyme 1	0.0092	0.2096	0.2335
Mycobacterium ulcerans	lipase LipD	0.0043	0.0634	0.082
Schistosoma mansoni	hypothetical protein	0.0024	0.0048	0.0048
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0122	0.3	0.3
Loa Loa (eye worm)	MBCTL1	0.0066	0.1299	0.1447
Brugia malayi	mbt repeat family protein	0.0058	0.1059	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1373	0.153
Onchocerca volvulus		0.0043	0.0634	0.031
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0634	0.0706
Echinococcus multilocularis	chromobox protein 1	0.0084	0.1857	0.207
Loa Loa (eye worm)	heterochromatin protein 1	0.0084	0.1857	0.207
Echinococcus granulosus	importin subunit beta 1	0.003	0.0229	0.0255
Brugia malayi	hypothetical protein	0.008	0.1744	0.2255
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2096	0.2335
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0068	0.1373	0.153
Loa Loa (eye worm)	hypothetical protein	0.007	0.1421	0.1583
Onchocerca volvulus	Cell death protein 3 homolog	0.0065	0.1278	0.1331
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0081	0.1776	0.2297
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0092	0.2096	0.2096
Echinococcus granulosus	caspase 2	0.0065	0.1278	0.1424
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0066	0.1299	0.1447
Toxoplasma gondii	peptidase family M13 protein	0.0092	0.2096	0.6985
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0321	0.8974	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0058	0.0075
Trichomonas vaginalis	glutaminase, putative	0.0279	0.7732	1
Brugia malayi	RNA binding protein	0.014	0.3546	0.4586
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0698	0.0778
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0634	0.0825
Onchocerca volvulus		0.0043	0.0634	0.031
Schistosoma mansoni	glutaminase	0.0279	0.7732	0.7732
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0066	0.1299	0.168
Mycobacterium leprae	probable zinc metalloprotease	0.0092	0.2096	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0227	0.0252
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0634	0.082
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0261	0.0291
Brugia malayi	beta-lactamase family protein	0.0043	0.0634	0.082
Leishmania major	hypothetical protein, conserved	0.0043	0.0634	1
Schistosoma mansoni	tar DNA-binding protein	0.014	0.3546	0.3546
Schistosoma mansoni	tar DNA-binding protein	0.014	0.3546	0.3546
Schistosoma mansoni	hypothetical protein	0.0024	0.0048	0.0048
Schistosoma mansoni	chromobox protein	0.0084	0.1857	0.1857
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0634	0.0825
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0229	0.3615
Mycobacterium ulcerans	zinc metalloprotease	0.0092	0.2096	0.2711
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0051	0.0852	0.0657
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0058	0.0918
Onchocerca volvulus		0.0058	0.1059	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1373	0.153
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0745	0.0963
Schistosoma mansoni	tar DNA-binding protein	0.014	0.3546	0.3546
Onchocerca volvulus		0.0043	0.0634	0.031
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0045	0.0675	0.0675
Trichomonas vaginalis	set domain proteins, putative	0.0247	0.675	0.8731
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0229	0.0764
Schistosoma mansoni	neprilysin	0.0024	0.0048	0.0048
Entamoeba histolytica	hypothetical protein	0.008	0.1744	1
Echinococcus granulosus	chromobox protein 1	0.0084	0.1857	0.207
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0122	0.3	0.3343
Mycobacterium ulcerans	glutaminase	0.0279	0.7732	1
Entamoeba histolytica	hypothetical protein	0.008	0.1744	1
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0634	0.0706
Brugia malayi	Heterochromatin protein 1	0.0084	0.1857	0.2402
Loa Loa (eye worm)	glutaminase 2	0.0279	0.7732	0.8615
Echinococcus granulosus	tar DNA binding protein	0.014	0.3546	0.3951
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0229	0.0255
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.1857	0.2402
Echinococcus multilocularis	snurportin 1	0.0321	0.8974	1
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0058	0.0075
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0634	0.0825
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0634	0.082
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0066	0.1299	0.1447
Brugia malayi	Peptidase family M13 containing protein	0.0092	0.2096	0.2711
Brugia malayi	Importin beta-1 subunit	0.003	0.0229	0.0296
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0634	0.082
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0255
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.033	0.0427
Toxoplasma gondii	ABC1 family protein	0.0043	0.0634	0.2113
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1776	0.1979
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0092	0.2096	0.2711
Echinococcus granulosus	apoptotic protease activating factor 1	0.0045	0.0692	0.0771
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0232	0.6293	0.7012
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0634	0.082
Schistosoma mansoni	caspase-7 (C14 family)	0.0065	0.1278	0.1278
Schistosoma mansoni	hypothetical protein	0.0024	0.0048	0.0048
Brugia malayi	Pre-SET motif family protein	0.0217	0.5849	0.7565
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0634	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.1421	0.1583
Echinococcus granulosus	histone acetyltransferase MYST2	0.0066	0.1299	0.1447
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0634	0.082
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2096	0.2335
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0122	0.3	0.3343
Onchocerca volvulus		0.0045	0.0675	0.0376
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0634	0.0825
Echinococcus granulosus	SAM and MBT domain containing protein	0.0058	0.1059	0.118
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0745	0.083
Schistosoma mansoni	tar DNA-binding protein	0.014	0.3546	0.3546
Brugia malayi	Pre-SET motif family protein	0.0031	0.0261	0.0338
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0024	0.0048	0.0048
Schistosoma mansoni	hypothetical protein	0.0045	0.0692	0.0692
Brugia malayi	chromobox protein homolog 3	0.0047	0.0745	0.0963
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.033	0.0427
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0092	0.2096	0.2727
Brugia malayi	mbt repeat family protein	0.0058	0.1059	0.1369
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0058	0.1059	0.1059
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0634	0.082
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0852	0.1102
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0046	0.0723	0.0723
Schistosoma mansoni	importin beta-1	0.003	0.0229	0.0229
Echinococcus granulosus	snurportin 1	0.0321	0.8974	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0122	0.3	0.3
Brugia malayi	TAR-binding protein	0.014	0.3546	0.4586
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0066	0.1299	0.1447
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.008	0.1744	0.1943
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0438	0.0488
Brugia malayi	RNA recognition motif domain containing protein	0.014	0.3546	0.4586
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0634	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1278	0.1424
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0058	0.1059	0.0984
Trichomonas vaginalis	esterase, putative	0.0043	0.0634	0.082
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0122	0.3	0.3
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1059	0.118
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0634	0.0706
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0852	0.1102
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0634	0.0706
Plasmodium vivax	SET domain protein, putative	0.0031	0.0261	0.4118
Onchocerca volvulus		0.0045	0.0692	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0692	0.0771
Brugia malayi	hypothetical protein	0.0045	0.0692	0.0894
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.008	0.1744	0.1943
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.1857	0.2402
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0081	0.1776	0.1776
Schistosoma mansoni	hypothetical protein	0.0024	0.0048	0.0048
Plasmodium falciparum	importin beta, putative	0.003	0.0229	1
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.1059	0.1059
Schistosoma mansoni	hypothetical protein	0.0024	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2096	0.2335
Onchocerca volvulus		0.0247	0.675	1
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0634	0.0825
Toxoplasma gondii	melibiase subfamily protein	0.0122	0.3	1
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0046	0.0723	0.0723
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0229	0.3615
Loa Loa (eye worm)	glutaminase	0.0279	0.7732	0.8615
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0122	0.3	0.3343
Echinococcus multilocularis	tar DNA binding protein	0.014	0.3546	0.3951
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0058	0.0075
Loa Loa (eye worm)	hypothetical protein	0.007	0.1421	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1373	0.153
Loa Loa (eye worm)	hypothetical protein	0.007	0.1421	0.1583
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0081	0.1776	0.1776
Schistosoma mansoni	chromobox protein	0.0084	0.1857	0.1857
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0046	0.0723	0.0723
Onchocerca volvulus		0.0046	0.0698	0.0412
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.0745	0.0486
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0634	0.0825
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0046	0.0723	0.0723
Loa Loa (eye worm)	TAR-binding protein	0.014	0.3546	0.3951
Echinococcus multilocularis	endothelin converting enzyme 1	0.0092	0.2096	0.2335
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0261	0.0261
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0634	0.0634
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0634	0.082
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0217	0.5849	0.6518
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0634	0.0706
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0634	0.082
Echinococcus multilocularis	chromobox protein 1	0.0084	0.1857	0.207
Echinococcus granulosus	polycomb protein SCMH1	0.0058	0.1059	0.118
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1299	0.1447
Schistosoma mansoni	hypothetical protein	0.0321	0.8974	0.8974
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0045	0.0692	0.0771
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0634	0.0706
Entamoeba histolytica	hypothetical protein	0.008	0.1744	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0634	0.0706
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0634	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0634	0.0706
Schistosoma mansoni	hypothetical protein	0.008	0.1744	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0261	0.0291
Schistosoma mansoni	tar DNA-binding protein	0.014	0.3546	0.3546
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0634	0.0825
Loa Loa (eye worm)	RNA binding protein	0.014	0.3546	0.3951
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.7685	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.014	0.3546	0.3951
Entamoeba histolytica	hypothetical protein	0.008	0.1744	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0261	0.0261
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0634	0.0825
Echinococcus multilocularis	polycomb protein SCMH1	0.0058	0.1059	0.118
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0261	0.0291
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0232	0.6293	0.7012
Brugia malayi	beta-lactamase	0.0043	0.0634	0.082
Plasmodium vivax	importin-beta 2, putative	0.003	0.0229	0.3615
Echinococcus granulosus	chromobox protein 1	0.0084	0.1857	0.207
Brugia malayi	RNA, U transporter 1	0.0085	0.1896	0.2452
Entamoeba histolytica	hypothetical protein	0.0024	0.0058	0.0334
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0261	0.0291
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0634	0.082
Brugia malayi	glutaminase DH11.1	0.0279	0.7732	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1373	0.153
Schistosoma mansoni	transcription factor LCR-F1	0.008	0.1744	0.1744
Loa Loa (eye worm)	mbt repeat family protein	0.0058	0.1059	0.118
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0066	0.1299	0.1299
Echinococcus multilocularis	caspase 2	0.0065	0.1278	0.1424
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0634	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0261	0.087
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0261	0.0261
Brugia malayi	beta-lactamase family protein	0.0043	0.0634	0.082
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0634	0.0825
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0122	0.3	0.3

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3548 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	= 0.5623 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	= 0.7079 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	100 uM	PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1397943

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1294176