Detailed information for compound 1294290

Basic information

Technical information
  • TDR Targets ID: 1294290
  • Name: (5E)-3-(2-morpholin-4-yl-2-oxoethyl)-5-(pyrid in-4-ylmethylidene)-1,3-thiazolidine-2,4-dion e
  • MW: 333.362 | Formula: C15H15N3O4S
  • H donors: 0 H acceptors: 4 LogP: 0.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCOCC1)CN1C(=O)S/C(=C/c2ccncc2)/C1=O
  • InChi: 1S/C15H15N3O4S/c19-13(17-5-7-22-8-6-17)10-18-14(20)12(23-15(18)21)9-11-1-3-16-4-2-11/h1-4,9H,5-8,10H2/b12-9+
  • InChiKey: IFRBXVHZTBDYRJ-FMIVXFBMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5E)-3-(2-morpholino-2-oxo-ethyl)-5-(4-pyridylmethylene)thiazolidine-2,4-dione
  • (5E)-3-(2-morpholino-2-oxoethyl)-5-(4-pyridylmethylene)thiazolidine-2,4-dione
  • (5E)-3-(2-keto-2-morpholino-ethyl)-5-(4-pyridylmethylene)thiazolidine-2,4-quinone
  • (5E)-3-(2-morpholin-4-yl-2-oxo-ethyl)-5-(pyridin-4-ylmethylidene)-1,3-thiazolidine-2,4-dione
  • MLS000702699
  • SMR000229329
  • AN-989/41696512
  • ZINC01012906
  • 3-[2-(4-morpholinyl)-2-oxoethyl]-5-(4-pyridinylmethylene)-1,3-thiazolidine-2,4-dione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0376 0.1778 0.435
Echinococcus granulosus bloom syndrome protein 0.0045 0.0108 0.0265
Echinococcus multilocularis isocitrate dehydrogenase 0.0276 0.1273 0.3114
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0376 0.1778 0.435
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0108 0.0374
Brugia malayi MH1 domain containing protein 0.0117 0.047 0.047
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0249 0.061
Schistosoma mansoni Smad4 0.0052 0.0143 0.035
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.4088 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0376 0.1778 0.1778
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.0143 0.0143
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0276 0.1273 0.3114
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0276 0.1273 1
Schistosoma mansoni hypothetical protein 0.0376 0.1778 0.435
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0034 0.0048 0.1214
Loa Loa (eye worm) hypothetical protein 0.0208 0.093 0.093
Loa Loa (eye worm) glutaminase 2 0.059 0.2861 0.2861
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0034 0.0048 0.0048
Trypanosoma brucei PAB1-binding protein , putative 0.0208 0.093 0.73
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0278 0.0818
Echinococcus multilocularis tar DNA binding protein 0.0668 0.3255 0.7963
Loa Loa (eye worm) pax transcription factor protein 2 0.1253 0.621 0.621
Loa Loa (eye worm) MH1 domain-containing protein 0.0052 0.0143 0.0143
Brugia malayi hypothetical protein 0.0208 0.093 0.093
Trypanosoma cruzi PAB1-binding protein , putative 0.0208 0.093 0.73
Brugia malayi Probable isocitrate dehydrogenase 0.0034 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.1188 0.5882 0.5882
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0034 0.0141
Brugia malayi mothers against decapentaplegic homolog 3 0.0052 0.0143 0.0143
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.014 0.0754
Brugia malayi latrophilin 2 splice variant baaae 0.0812 0.3983 0.3983
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0276 0.1273 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0093 0.035 0.0857
Schistosoma mansoni smad 0.0052 0.0143 0.035
Brugia malayi MH1 domain containing protein 0.0065 0.0206 0.0206
Echinococcus multilocularis smad 0.0117 0.047 0.1149
Brugia malayi RNA recognition motif domain containing protein 0.0668 0.3255 0.3255
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0034 0.0048 0.0118
Brugia malayi MH2 domain containing protein 0.0117 0.047 0.047
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0276 0.1273 0.3114
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0034 0.0048 0.0163
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0276 0.1273 1
Echinococcus granulosus GPCR family 2 0.0376 0.1778 0.435
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0278 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0376 0.1778 0.435
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0183 0.0802 0.1962
Brugia malayi hypothetical protein 0.0073 0.0249 0.0249
Echinococcus granulosus mothers against decapentaplegic 5 0.0117 0.047 0.1149
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.014 0.4744
Toxoplasma gondii isocitrate dehydrogenase 0.0276 0.1273 1
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0183 0.0802 0.1962
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0278 0.068
Schistosoma mansoni smad1 5 8 and 0.0117 0.047 0.1149
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0668 0.3255 0.3255
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0034 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0376 0.1778 0.435
Loa Loa (eye worm) RecQ helicase 0.0045 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0079 0.0278 0.0278
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0376 0.1778 0.435
Loa Loa (eye worm) Smad1 0.0117 0.047 0.047
Loa Loa (eye worm) MH1 domain-containing protein 0.0117 0.047 0.047
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0249 0.061
Brugia malayi Latrophilin receptor protein 2 0.0376 0.1778 0.1778
Schistosoma mansoni smad1 5 8 and 0.0117 0.047 0.1149
Entamoeba histolytica hypothetical protein 0.0073 0.0249 1
Schistosoma mansoni Smad4 0.0117 0.047 0.1149
Brugia malayi MH2 domain containing protein 0.0052 0.0143 0.0143
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0183 0.0802 0.1962
Onchocerca volvulus 0.1253 0.621 0.621
Loa Loa (eye worm) nuclear factor I 0.0065 0.0206 0.0206
Loa Loa (eye worm) TAR-binding protein 0.0668 0.3255 0.3255
Brugia malayi MH2 domain containing protein 0.0117 0.047 0.047
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0276 0.1273 1
Loa Loa (eye worm) glutaminase 0.059 0.2861 0.2861
Echinococcus granulosus tar DNA binding protein 0.0668 0.3255 0.7963
Brugia malayi Probable ClpP-like protease 0.0079 0.0278 0.0278
Leishmania major hypothetical protein, conserved 0.0208 0.093 0.73
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.008 0.0511
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0278 0.068
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1188 0.5882 0.5882
Brugia malayi hypothetical protein 0.0134 0.0557 0.0557
Schistosoma mansoni hypothetical protein 0.0376 0.1778 0.435
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0276 0.1273 0.3114
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0278 0.2083
Loa Loa (eye worm) hypothetical protein 0.0812 0.3983 0.3983
Echinococcus multilocularis mothers against decapentaplegic 2 0.0052 0.0143 0.035
Brugia malayi glutaminase DH11.1 0.059 0.2861 0.2861
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.0108 0.0374
Schistosoma mansoni tar DNA-binding protein 0.0668 0.3255 0.7963
Echinococcus multilocularis mothers against decapentaplegic 5 0.0117 0.047 0.1149
Loa Loa (eye worm) pip kinase 2 0.0183 0.0802 0.0802
Leishmania major isocitrate dehydrogenase, putative 0.0034 0.0048 0.0367
Entamoeba histolytica hypothetical protein 0.0073 0.0249 1
Plasmodium vivax ataxin-2 like protein, putative 0.0208 0.093 0.7268
Schistosoma mansoni unc-13 (munc13) 0.0034 0.0048 0.0118
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0276 0.1273 0.3114
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1188 0.5882 0.5882
Trypanosoma cruzi PAB1-binding protein , putative 0.0208 0.093 0.73
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0034 0.0048 0.0118
Schistosoma mansoni tar DNA-binding protein 0.0668 0.3255 0.7963
Trichomonas vaginalis glutaminase, putative 0.059 0.2861 1
Brugia malayi Isocitrate dehydrogenase 0.0276 0.1273 0.1273
Schistosoma mansoni hypothetical protein 0.0093 0.035 0.0857
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.047 0.047
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0376 0.1778 0.1778
Toxoplasma gondii isocitrate dehydrogenase 0.0276 0.1273 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0052 0.0143 0.035
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0032 0.0126
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0278 0.0818
Toxoplasma gondii LsmAD domain-containing protein 0.0208 0.093 0.7268
Brugia malayi MH1 domain containing protein 0.0117 0.047 0.047
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0278 0.5
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0183 0.0802 0.1962
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.014 0.0344
Brugia malayi RNA binding protein 0.0668 0.3255 0.3255
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0034 0.0048 0.0118
Plasmodium falciparum ataxin-2 like protein, putative 0.0208 0.093 0.7268
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0276 0.1273 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0249 0.061
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.014 0.0754
Mycobacterium ulcerans glutaminase 0.059 0.2861 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0143 0.0143
Echinococcus granulosus smad 0.0117 0.047 0.1149
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0048
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.014 0.0344
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0034 0.0048 0.0048
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0276 0.1273 1
Schistosoma mansoni glutaminase 0.059 0.2861 0.6998
Echinococcus multilocularis bloom syndrome protein 0.0045 0.0108 0.0265
Plasmodium falciparum ataxin-2 like protein, putative 0.0208 0.093 0.7268
Entamoeba histolytica hypothetical protein 0.0073 0.0249 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0276 0.1273 0.3114
Brugia malayi Pip kinase protein 2 0.0183 0.0802 0.0802
Echinococcus granulosus microtubule associated protein 2 0.0833 0.4088 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0278 0.2083
Echinococcus multilocularis GPCR, family 2 0.0376 0.1778 0.435
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0278 0.5
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0034 0.0048 0.0048
Brugia malayi Pax transcription factor protein 2 0.1253 0.621 0.621
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0034 0.0048 0.0118
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0093 0.035 0.0857
Loa Loa (eye worm) hypothetical protein 0.0065 0.0206 0.0206
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0276 0.1273 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0278 1
Schistosoma mansoni tar DNA-binding protein 0.0668 0.3255 0.7963
Brugia malayi Smad1 0.0117 0.047 0.047
Brugia malayi Calcitonin receptor-like protein seb-1 0.1188 0.5882 0.5882
Schistosoma mansoni hypothetical protein 0.0812 0.3983 0.9742
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0376 0.1778 0.435
Loa Loa (eye worm) hypothetical protein 0.0138 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0183 0.0802 0.0802
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0052 0.0143 0.0143
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0276 0.1273 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0278 0.068
Schistosoma mansoni hypothetical protein 0.0073 0.0249 0.061
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0278 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0117 0.047 0.1149
Loa Loa (eye worm) isocitrate dehydrogenase 0.0276 0.1273 0.1273
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0278 0.2083
Loa Loa (eye worm) MH2 domain-containing protein 0.1718 0.8556 0.8556
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0278 0.2083
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0117 0.047 0.1149
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0034 0.0048 0.0118
Brugia malayi MH2 domain containing protein 0.1718 0.8556 0.8556
Brugia malayi MH1 domain containing protein 0.0065 0.0206 0.0206
Schistosoma mansoni smad1 5 8 and 0.0117 0.047 0.1149
Schistosoma mansoni tar DNA-binding protein 0.0668 0.3255 0.7963
Entamoeba histolytica hypothetical protein 0.0073 0.0249 1
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.0108 0.0108
Entamoeba histolytica tartrate dehydrogenase, putative 0.0034 0.0048 0.1882
Echinococcus multilocularis Smad4 0.0117 0.047 0.1149
Echinococcus granulosus Smad4 0.0117 0.047 0.1149
Schistosoma mansoni smad 0.0117 0.047 0.1149
Brugia malayi isocitrate dehydrogenase 0.0276 0.1273 0.1273
Loa Loa (eye worm) transcription factor SMAD2 0.1718 0.8556 0.8556
Schistosoma mansoni isocitrate dehydrogenase 0.0034 0.0048 0.0118
Schistosoma mansoni tar DNA-binding protein 0.0668 0.3255 0.7963
Onchocerca volvulus 0.0183 0.0802 0.0802
Echinococcus multilocularis mothers against decapentaplegic 6 0.0052 0.0143 0.035
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0117 0.047 0.1149
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.4088 1
Brugia malayi Probable isocitrate dehydrogenase 0.0034 0.0048 0.0048
Echinococcus granulosus mothers against decapentaplegic 2 0.0052 0.0143 0.035
Loa Loa (eye worm) hypothetical protein 0.0376 0.1778 0.1778
Loa Loa (eye worm) RNA binding protein 0.0668 0.3255 0.3255
Brugia malayi TAR-binding protein 0.0668 0.3255 0.3255
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.006 0.0147
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0276 0.1273 0.3114
Schistosoma mansoni Smad4 0.0052 0.0143 0.035

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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